Opaleye Management Inc. Quant / Systematic

Location: BOSTON, MA

CIK: 0001595855 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Apr 13, 2026

Total Value: $758M (100.0% shares, 0.0% debt)

Holdings (54)

HROW HARROW HEALTH INC 25.2%
Value $191M Shares 3,905,000 Est. Cost $6.33 Unrealized +562.8%
LQDA LIQUIDIA CORPORATION 11.2%
Value $84.98M Shares 2,435,000 Est. Cost $11.93 Unrealized +138.5%
ETON ETON PHARMACEUTICALS INC 6.4%
Value $48.36M Shares 2,860,000 Est. Cost $5.71 Unrealized +208.1%
RYTM RHYTHM PHARMACEUTICALS INC 4.7%
Value $35.32M Shares 330,000 Est. Cost $12.73 Unrealized +733.2%
APGE APOGEE THERAPEUTICS INC 3.9%
Value $29.31M Shares 388,257 Est. Cost $39.78 Unrealized +58.3%
SNWV SANUWAVE HEALTH INC 3.9%
Value $29.28M Shares 981,267 Est. Cost $28.49 Unrealized +12.6%
STOK STOKE THERAPEUTICS INC 2.9%
Value $22.06M Shares 695,000 Est. Cost $11.23 Unrealized +167.7%
OCUL OCULAR THERAPEUTIX INC 2.6%
Value $19.36M Shares 1,595,000 Est. Cost $5.10 Unrealized +138.4%
SLGL SOL GEL TECHNOLOGIES 2.5%
Value $19.12M Shares 453,739 Est. Cost $29.17 Unrealized +32.4%
CGON CG ONCOLOGY INC 2.2%
Value $17.02M Shares 410,000 Est. Cost $27.46 Unrealized +50.7%
TGTX TG THERAPEUTICS INC 2.1%
Value $15.95M Shares 535,000 Est. Cost $13.67 Unrealized +139.0%
IRON DISC MEDICINE INC 2.1%
Value $15.88M Shares 200,000 Est. Cost $52.27 Unrealized +61.7%
RZLT REZOLUTE INC 2.0%
Value $14.84M Shares 6,287,156 Est. Cost $7.31 Unrealized +7.2%
CBIO CRESCENT BIOPHARMA INC 1.8%
Value $13.97M Shares 1,178,300 Est. Cost $12.74 Unrealized 0.0%
ALKS ALKERMES PLC 1.8%
Value $13.71M Shares 490,000 Est. Cost $28.34 Unrealized +5.7%
ACOG ALPHA COGNITION INC 1.8%
Value $13.46M Shares 2,070,784 Est. Cost $6.47 Unrealized -2.4%
ANNX ANNEXON INC 1.7%
Value $13.05M Shares 2,600,000 Est. Cost $2.48 Unrealized +54.0%
EWTX EDGEWISE THERAPEUTICS INC 1.6%
Value $12.41M Shares 500,000 Est. Cost $11.02 Unrealized +82.1%
CDXS CODEXIS INC 1.5%
Value $11.07M Shares 6,789,738 Est. Cost $2.81 Unrealized -27.4%
PTGX PROTAGONIST THERAPEUTICS INC 1.2%
Value $9.171M Shares 105,000 Est. Cost $17.50 Unrealized +367.8%
GOSS GOSSAMER BIO INC 1.1%
Value $8.432M Shares 2,720,000 Est. Cost $1.01 Unrealized +183.2%
MBX MBX BIOSCIENCES INC 1.1%
Value $8.2M Shares 260,000 Est. Cost $11.09 Unrealized +118.8%
RVMD REVOLUTION MEDICINES INC 1.1%
Value $7.965M Shares 100,000 Est. Cost $38.42 Unrealized +70.7%
XOMA XOMA CORP DEL 1.0%
Value $7.78M Shares 292,590 Est. Cost $14.08 Unrealized +128.6%
DERM JOURNEY MEDICAL CORP 1.0%
Value $7.517M Shares 975,000 Est. Cost $7.08 Unrealized +10.8%
KPTI KARYOPHARM THERAPEUTICS INC 0.9%
Value $6.845M Shares 930,000 Est. Cost $6.12 Unrealized 0.0%
JBIO JADE BIOSCIENCES INC 0.9%
Value $6.598M Shares 427,608 Est. Cost $11.73 Unrealized 0.0%
URGN UROGEN PHARMA LTD 0.8%
Value $6.286M Shares 268,423 Est. Cost $21.69 Unrealized 0.0%
ALMS ALUMIS INC 0.7%
Value $5.222M Shares 535,000 Est. Cost $4.72 Unrealized +47.8%
CATX PERSPECTIVE THERAPEUTICS INC 0.7%
Value $4.99M Shares 1,184,500 Est. Cost $2.85 Unrealized 0.0%
VYGR VOYAGER THERAPEUTICS INC 0.6%
Value $4.704M Shares 1,196,904 Est. Cost $3.93 Unrealized
RLMD RELMADA THERAPEUTICS INC 0.6%
Value $4.516M Shares 935,000 Est. Cost $3.35 Unrealized 0.0%
TECX TECTONIC THERAPEUTICS INC 0.6%
Value $4.48M Shares 214,747 Est. Cost $18.58 Unrealized 0.0%
PLX PROTALIX BIOTHERAPEUTICS INC 0.6%
Value $4.461M Shares 2,478,176 Est. Cost $1.63 Unrealized +25.5%
TRVI TREVI THERAPEUTICS INC 0.6%
Value $4.321M Shares 345,100 Est. Cost $2.06 Unrealized +461.8%
FBIO FORTRESS BIOTECH INC 0.5%
Value $3.989M Shares 1,090,000 Est. Cost $2.85 Unrealized 0.0%
RCKT ROCKET PHARMACEUTICALS INC 0.4%
Value $3.352M Shares 955,000 Est. Cost $3.42 Unrealized 0.0%
MGTX MEIRAGTX HOLDINGS PLC 0.4%
Value $3.107M Shares 390,844 Est. Cost $8.31 Unrealized 0.0%
RIGL RIGEL PHARMACEUTICALS INC 0.4%
Value $2.998M Shares 70,000 Est. Cost $33.50 Unrealized +12.5%
ZYME ZYMEWORKS INC 0.4%
Value $2.868M Shares 108,929 Est. Cost $14.04 Unrealized +55.3%
ASSERTIO HOLDINGS INC 0.3%
Value $2.585M Shares 285,000 Est. Cost $9.07 Unrealized
VTYX VENTYX BIOSCIENCES INC 0.3%
Value $2.275M Shares 251,932 Est. Cost $7.47 Unrealized 0.0%
IRD OPUS GENETICS INC 0.3%
Value $2.251M Shares 1,120,000 Est. Cost $1.13 Unrealized +80.2%
STRO SUTRO BIOPHARMA INC 0.3%
Value $2.206M Shares 190,671 Est. Cost $9.49 Unrealized 0.0%
CABA CABALETTA BIO INC 0.3%
Value $1.971M Shares 900,000 Est. Cost $1.79 Unrealized +38.2%
ZNTL ZENTALIS PHARMACEUTICALS INC 0.2%
Value $1.891M Shares 1,400,906 Est. Cost $1.88 Unrealized -22.5%
GENERATION BIO CO 0.2%
Value $1.761M Shares 310,000 Est. Cost $5.68 Unrealized
BBIO BRIDGEBIO PHARMA INC 0.2%
Value $1.401M Shares 18,319 Est. Cost $65.64 Unrealized 0.0%
ENTA ENANTA PHARMACEUTICALS INC 0.2%
Value $1.183M Shares 75,000 Est. Cost $12.70 Unrealized 0.0%
QTTB Q32 BIO INC 0.1%
Value $708K Shares 213,363 Est. Cost $2.83 Unrealized 0.0%
AVIR ATEA PHARMACEUTICALS INC 0.1%
Value $642K Shares 179,815 Est. Cost $3.18 Unrealized 0.0%
SLN SILENCE THERAPEUTICS PLC 0.1%
Value $480K Shares 78,926 Est. Cost $6.08 Unrealized
RAPT RAPT THERAPEUTICS INC 0.0%
Value $213K Shares 150,000 Est. Cost $31.06 Unrealized 0.0%
ADGM ADAGIO MED HLDGS INC 0.0%
Value $19,182 Shares 18,444 Est. Cost $4.76 Unrealized -75.1%