| JANUS HENDERSON GROUP PLC | 32,543,142 | $80,870 |
| PERCEPTIVE ADVISORS LLC | 21,785,166 | $53,809 |
| BVF INC/IL | 19,525,000 | $48,227 |
| MAVERICK CAPITAL LTD | 18,970,913 | $46,858 |
| RA CAPITAL MANAGEMENT, L.P. | 17,119,096 | $42,284 |
| Point72 Asset Management, L.P. | 16,653,036 | $41,133 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 13,062,945 | $32,265 |
| VANGUARD GROUP INC | 10,703,977 | $26,439 |
| M28 Capital Management LP | 9,248,250 | $22,843 |
| Saturn V Capital Management LP | 7,735,386 | $19,106 |
| Soleus Capital Management, L.P. | 7,708,727 | $19,041 |
| EVENTIDE ASSET MANAGEMENT, LLC | 5,809,256 | $14,349 |
| STATE STREET CORP | 5,637,593 | $13,925 |
| Siren, L.L.C. | 4,000,000 | $9,880 |
| ADAR1 Capital Management, LLC | 3,899,397 | $9,632 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,806,976 | $9,403 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | $9,044 |
| BlackRock, Inc. | 3,546,947 | $8,761 |
| 683 Capital Management, LLC | 2,900,000 | $7,163 |
| Redmile Group, LLC | 2,681,159 | $6,622 |
| Ikarian Capital, LLC | 2,656,570 | $6,562 |
| TWO SIGMA INVESTMENTS, LP | 2,191,900 | $5,414 |
| GOLDMAN SACHS GROUP INC | 2,173,747 | $5,369 |
| Eversept Partners, LP | 2,140,130 | $5,286 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,056,472 | $5,082 |
| MORGAN STANLEY | 1,638,367 | $4,047 |
| Boxer Capital Management, LLC | 1,500,000 | $3,705 |
| MILLENNIUM MANAGEMENT LLC | 1,286,455 | $3,178 |
| UBS Group AG | 1,050,923 | $2,596 |
| RENAISSANCE TECHNOLOGIES LLC | 1,026,620 | $2,536 |
| STEMPOINT CAPITAL LP | 989,822 | $2,445 |
| AMERIPRISE FINANCIAL INC | 985,216 | $2,433 |
| TWO SIGMA ADVISERS, LP | 916,600 | $2,264 |
| BOOTHBAY FUND MANAGEMENT, LLC | 774,635 | $1,913 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 625,783 | $1,546 |
| DEUTSCHE BANK AG\ | 585,385 | $1,446 |
| JANE STREET GROUP, LLC | 513,863 | $1,269 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 428,847 | $1,059 |
| NORTHERN TRUST CORP | 392,416 | $969 |
| BANK OF AMERICA CORP /DE/ | 380,604 | $940 |
| GSA CAPITAL PARTNERS LLP | 376,612 | $1 |
| CITADEL ADVISORS LLC | 331,083 | $818 |
| BARCLAYS PLC | 295,120 | $729 |
| Invesco Ltd. | 293,580 | $725 |
| Rafferty Asset Management, LLC | 284,564 | $703 |
| Qube Research & Technologies Ltd | 210,648 | $520 |
| Scientech Research LLC | 209,331 | $517 |
| Squarepoint Ops LLC | 204,591 | $505 |
| Virtu Financial LLC | 202,310 | $1 |
| XTX Topco Ltd | 147,634 | $365 |
| FMR LLC | 141,939 | $351 |
| CITIGROUP INC | 137,984 | $341 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,920 | $291 |
| Virtus Investment Advisers, LLC | 114,668 | $283 |
| PROFUND ADVISORS LLC | 102,591 | $253 |
| Knott David M Jr | 100,000 | $247 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | $245 |
| OMERS ADMINISTRATION Corp | 98,100 | $242 |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC | 96,507 | $238 |
| Quadrature Capital Ltd | 91,241 | $225 |
| EMERALD ADVISERS, LLC | 89,938 | $222 |
| Jefferies Financial Group Inc. | 87,685 | $217 |
| Hudson Bay Capital Management LP | 87,030 | $215 |
| a16z Perennial Management, L.P. | 79,869 | $197 |
| Persistent Asset Partners Ltd | 68,843 | $170 |
| Lighthouse Investment Partners, LLC | 63,000 | $156 |
| Miller Financial Services LLC | 51,000 | $126 |
| GILDER GAGNON HOWE & CO LLC | 49,906 | $123 |
| Jain Global LLC | 49,251 | $122 |
| China Universal Asset Management Co., Ltd. | 45,157 | $112 |
| MANGROVE PARTNERS IM, LLC | 42,127 | $104 |
| AMERICAN CENTURY COMPANIES INC | 39,930 | $99 |
| Tower Research Capital LLC (TRC) | 39,798 | $98 |
| Vanguard Personalized Indexing Management, LLC | 38,805 | $96 |
| VICTORY CAPITAL MANAGEMENT INC | 25,976 | $64 |
| FORTRESS PRIVATE LEDGER, LLC | 25,000 | $62 |
| SG Americas Securities, LLC | 24,146 | $0 |
| OXFORD FINANCIAL GROUP LTD | 23,094 | $57 |
| JPMORGAN CHASE & CO | 22,161 | $55 |
| LAZARD ASSET MANAGEMENT LLC | 20,933 | $52 |
| Bank of New York Mellon Corp | 17,616 | $44 |
| BNP PARIBAS ARBITRAGE, SA | 16,797 | $41 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,600 | $40 |
| CIBC Asset Management Inc | 15,180 | $37 |
| Schonfeld Strategic Advisors LLC | 14,460 | $36 |
| Mirae Asset Global Investments Co., Ltd. | 13,466 | $33 |
| Gotham Asset Management, LLC | 13,139 | $32 |
| State of Wyoming | 12,322 | $30 |
| ProShare Advisors LLC | 12,240 | $30 |
| Ethic Inc. | 11,686 | $29 |
| DGS Capital Management, LLC | 11,300 | $28 |
| DRW Securities, LLC | 11,124 | $27 |
| Bronte Capital Management Pty Ltd. | 11,012 | $27 |
| COURIER CAPITAL LLC | 10,000 | $25 |
| NAPLES GLOBAL ADVISORS, LLC | 10,000 | $25 |
| Sunbelt Securities, Inc. | 7,500 | $19 |
| GF FUND MANAGEMENT CO. LTD. | 5,446 | $13 |
| Global Retirement Partners, LLC | 2,000 | $5 |
| SBI Securities Co., Ltd. | 1,070 | $3 |
| JONES FINANCIAL COMPANIES LLLP | 950 | $2 |
| 15 other institutions | 5,277 | $10 |