| BAKER BROS. ADVISORS LP | 7,915,792 | $789,521 |
| NEA Management Company, LLC | 3,535,561 | $352,637 |
| PERCEPTIVE ADVISORS LLC | 3,160,200 | $315,198 |
| Avoro Capital Advisors LLC | 3,111,111 | $310,302 |
| BlackRock, Inc. | 2,540,377 | $253,377 |
| VANGUARD GROUP INC | 2,279,433 | $227,351 |
| Soleus Capital Management, L.P. | 1,808,258 | $180,356 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,714,000 | $170,954 |
| STATE STREET CORP | 1,637,687 | $163,343 |
| MORGAN STANLEY | 1,398,970 | $139,533 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,240,281 | $124 |
| TANG CAPITAL MANAGEMENT LLC | 1,050,000 | $104,727 |
| BANK OF AMERICA CORP /DE/ | 977,118 | $97,458 |
| GEODE CAPITAL MANAGEMENT, LLC | 830,684 | $82,872 |
| Holocene Advisors, LP | 695,340 | $69,353 |
| GOLDMAN SACHS GROUP INC | 652,827 | $65,113 |
| APIS CAPITAL ADVISORS, LLC | 602,000 | $60,043 |
| RTW INVESTMENTS, LP | 550,160 | $54,873 |
| Artisan Partners Limited Partnership | 546,641 | $54,522 |
| Nearwater Capital Markets, Ltd | 520,200 | $51,885 |
| Sio Capital Management, LLC | 477,067 | $47,583 |
| Candriam S.C.A. | 476,370 | $47,515 |
| ALLIANCEBERNSTEIN L.P. | 472,938 | $47,171 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 375,132 | $37,416 |
| WELLINGTON MANAGEMENT GROUP LLP | 371,139 | $37,017 |
| Capitolis Liquid Global Markets LLC | 355,200 | $35,428 |
| Pfizer Inc | 349,406 | $34,850 |
| Saturn V Capital Management LP | 317,095 | $31,627 |
| EVENTIDE ASSET MANAGEMENT, LLC | 313,679 | $31,287 |
| Sofinnova Investments, Inc. | 299,417 | $29,864 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 292,315 | $29,155 |
| NORTHERN TRUST CORP | 287,746 | $28,700 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 250,055 | $24,940 |
| Focus Partners Wealth | 234,807 | $23,420 |
| JENNISON ASSOCIATES LLC | 229,704 | $22,911 |
| Public Sector Pension Investment Board | 226,469 | $22,588 |
| Boxer Capital Management, LLC | 225,000 | $22,442 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 221,595 | $22,102 |
| Qube Research & Technologies Ltd | 208,505 | $20,796 |
| Hennion & Walsh Asset Management, Inc. | 190,933 | $19,044 |
| LORD, ABBETT & CO. LLC | 181,485 | $18 |
| Walleye Capital LLC | 153,289 | $15,289 |
| Ensign Peak Advisors, Inc | 148,994 | $14,861 |
| Invesco Ltd. | 147,938 | $14,755 |
| BNP PARIBAS ARBITRAGE, SA | 142,203 | $14,183 |
| WELLS FARGO & COMPANY/MN | 138,435 | $13,807 |
| Woodline Partners LP | 130,943 | $13,060 |
| AMERIPRISE FINANCIAL INC | 123,251 | $12,293 |
| BARCLAYS PLC | 122,854 | $12,253 |
| Patient Square Capital LP | 120,000 | $11,969 |
| RAYMOND JAMES FINANCIAL INC | 119,561 | $11,945 |
| STEMPOINT CAPITAL LP | 118,333 | $11,803 |
| Clearbridge Investments, LLC | 106,931 | $10,665 |
| Ikarian Capital, LLC | 105,545 | $10,527 |
| Voya Investment Management LLC | 104,986 | $10,471 |
| TD Asset Management Inc | 97,526 | $9,727 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,895 | $9,166 |
| Bank of New York Mellon Corp | 88,623 | $8,839 |
| Granahan Investment Management, LLC | 87,032 | $8,681 |
| Russell Investments Group, Ltd. | 85,773 | $8,555 |
| ORBIMED ADVISORS LLC | 85,664 | $8,544 |
| Atom Investors LP | 85,583 | $8,536 |
| Nuveen, LLC | 85,298 | $8,508 |
| MILLENNIUM MANAGEMENT LLC | 82,243 | $8,203 |
| UBS Group AG | 81,571 | $8,136 |
| NAN FUNG TRINITY (HK) LTD | 80,775 | $8,056 |
| Integral Health Asset Management, LLC | 80,000 | $7,979 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,653 | $7,156 |
| ACT CAPITAL MANAGEMENT, LLC | 63,415 | $6,325 |
| Man Group plc | 62,507 | $6,234 |
| CAPTRUST FINANCIAL ADVISORS | 61,530 | $6,137 |
| D. E. Shaw & Co., Inc. | 57,654 | $5,750 |
| Rafferty Asset Management, LLC | 57,128 | $5,698 |
| Squarepoint Ops LLC | 57,053 | $5,690 |
| GAGNON SECURITIES LLC | 53,401 | $5,326 |
| BI Asset Management Fondsmaeglerselskab A/S | 51,155 | $5 |
| JPMORGAN CHASE & CO | 51,059 | $5,093 |
| NEW YORK STATE COMMON RETIREMENT FUND | 48,704 | $4,858 |
| EAM Investors, LLC | 48,034 | $4,791 |
| CITADEL ADVISORS LLC | 47,037 | $4,691 |
| Aquatic Capital Management LLC | 45,705 | $4,559 |
| Harvest Investment Services, LLC | 42,485 | $4,237 |
| HealthInvest Partners AB | 41,831 | $4,172 |
| VICTORY CAPITAL MANAGEMENT INC | 41,507 | $4,140 |
| ExodusPoint Capital Management, LP | 39,959 | $3,986 |
| PRUDENTIAL FINANCIAL INC | 38,690 | $3,859 |
| RHUMBLINE ADVISERS | 38,104 | $3,800 |
| ALPS ADVISORS INC | 37,894 | $3,780 |
| JNBA Financial Advisors | 36,753 | $3,666 |
| Exome Asset Management LLC | 34,289 | $3,420 |
| BOOTHBAY FUND MANAGEMENT, LLC | 30,335 | $3,026 |
| NEOS Investment Management LLC | 28,233 | $2,816 |
| TEMA ETFS LLC | 27,818 | $2,775 |
| Accredited Investors Inc. | 27,115 | $2,704 |
| FMR LLC | 26,651 | $2,658 |
| Swiss National Bank | 25,100 | $2,503 |
| DEUTSCHE BANK AG\ | 23,525 | $2,346 |
| PROFUND ADVISORS LLC | 21,220 | $2,116 |
| SEI INVESTMENTS CO | 21,181 | $2,113 |
| Creative Planning | 20,972 | $2,092 |
| 137 other institutions | 764,114 | $72,168 |