| FMR LLC | 23,086,967 | $820,049 |
| BlackRock, Inc. | 12,974,591 | $460,857 |
| VANGUARD GROUP INC | 11,514,326 | $408,989 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,043,903 | $321,239 |
| Fairmount Funds Management LLC | 9,003,418 | $319,801 |
| RTW INVESTMENTS, LP | 7,592,241 | $269,676 |
| Kynam Capital Management, LP | 6,165,223 | $218,989 |
| TCG Crossover Management, LLC | 5,868,162 | $208,437 |
| STATE STREET CORP | 4,940,300 | $175,479 |
| JANUS HENDERSON GROUP PLC | 4,537,408 | $161,115 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,514,562 | $124,862 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,712,336 | $96,342 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,564,062 | $91 |
| Vivo Capital, LLC | 2,398,993 | $85,212 |
| Octagon Capital Advisors LP | 2,350,000 | $83,472 |
| D. E. Shaw & Co., Inc. | 2,247,804 | $79,842 |
| Duquesne Family Office LLC | 2,214,470 | $79 |
| Commodore Capital LP | 2,196,845 | $78,032 |
| VR Adviser, LLC | 2,000,000 | $71,040 |
| Sofinnova Investments, Inc. | 1,973,625 | $70,103 |
| LORD, ABBETT & CO. LLC | 1,870,537 | $66 |
| GOLDMAN SACHS GROUP INC | 1,705,144 | $60,567 |
| MARSHALL WACE, LLP | 1,660,735 | $58,989 |
| Siren, L.L.C. | 1,629,279 | $57,872 |
| EMERALD ADVISERS, LLC | 1,583,346 | $56,240 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,440,318 | $51,160 |
| CITADEL ADVISORS LLC | 1,438,994 | $51,113 |
| Redmile Group, LLC | 1,437,918 | $51,075 |
| Candriam S.C.A. | 1,296,475 | $46,053 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,280,779 | $45,493 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,245,254 | $44,231 |
| Saturn V Capital Management LP | 1,217,064 | $43,230 |
| MILLENNIUM MANAGEMENT LLC | 1,208,228 | $42,916 |
| NORTHERN TRUST CORP | 1,199,300 | $42,599 |
| BANK OF AMERICA CORP /DE/ | 1,191,930 | $42,337 |
| Holocene Advisors, LP | 1,178,208 | $41,850 |
| Elmind Capital, LP | 1,170,740 | $41,585 |
| FRED ALGER MANAGEMENT, LLC | 1,102,181 | $39,149 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,038,494 | $36,887 |
| Nuveen, LLC | 932,621 | $33,127 |
| AMERICAN CENTURY COMPANIES INC | 892,920 | $31,717 |
| Rock Springs Capital Management LP | 849,030 | $30,158 |
| Point72 Asset Management, L.P. | 827,525 | $29,394 |
| First Turn Management, LLC | 824,283 | $29,279 |
| Woodline Partners LP | 818,782 | $29,083 |
| Squadron Capital Management LLC | 780,000 | $27,706 |
| MORGAN STANLEY | 726,777 | $25,815 |
| RENAISSANCE TECHNOLOGIES LLC | 689,068 | $24,476 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 668,970 | $23,762 |
| Invesco Ltd. | 585,765 | $20,806 |
| Defilade Capital Management, L.P. | 568,619 | $20,197 |
| Atika Capital Management LLC | 506,000 | $17,973 |
| Alyeska Investment Group, L.P. | 493,934 | $17,545 |
| Deep Track Capital, LP | 453,102 | $16,094 |
| J. Goldman & Co LP | 439,269 | $15,603 |
| FEDERATED HERMES, INC. | 426,782 | $15,159 |
| Ensign Peak Advisors, Inc | 421,540 | $14,973 |
| JPMORGAN CHASE & CO | 400,931 | $14,241 |
| Russell Investments Group, Ltd. | 385,457 | $13,691 |
| SPHERA FUNDS MANAGEMENT LTD. | 378,500 | $13,444 |
| Bank of New York Mellon Corp | 376,296 | $13,366 |
| RAYMOND JAMES FINANCIAL INC | 375,919 | $13,353 |
| Assenagon Asset Management S.A. | 375,626 | $13,342 |
| ORBIMED ADVISORS LLC | 371,000 | $13,178 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 366,238 | $13,009 |
| KENNEDY CAPITAL MANAGEMENT LLC | 352,387 | $12,517 |
| Affinity Asset Advisors, LLC | 350,000 | $12,432 |
| Hennion & Walsh Asset Management, Inc. | 338,065 | $12,008 |
| HighVista Strategies LLC | 336,667 | $11,958 |
| Burkehill Global Management, LP | 325,000 | $11,544 |
| BARCLAYS PLC | 321,606 | $11,423 |
| Patient Square Capital LP | 317,372 | $11,273 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 305,940 | $10,867 |
| Exome Asset Management LLC | 305,568 | $10,854 |
| Man Group plc | 292,082 | $10,375 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,497 | $10,070 |
| Qube Research & Technologies Ltd | 276,728 | $9,829 |
| UBS Group AG | 264,047 | $9,379 |
| SummitTX Capital, L.P. | 257,171 | $9,135 |
| Nantahala Capital Management, LLC | 250,000 | $8,880 |
| Evergreen Quality Fund GP, Ltd. | 250,000 | $8,880 |
| NWI MANAGEMENT LP | 241,671 | $9 |
| F/M Investments LLC | 235,804 | $8,376 |
| Susquehanna Portfolio Strategies, LLC | 229,755 | $8,161 |
| ALGERT GLOBAL LLC | 227,862 | $8 |
| Cormorant Asset Management, LP | 225,000 | $7,992 |
| Boxer Capital Management, LLC | 225,000 | $7,992 |
| BNP PARIBAS ARBITRAGE, SA | 198,969 | $7,067 |
| AMERIPRISE FINANCIAL INC | 188,349 | $6,690 |
| RHUMBLINE ADVISERS | 180,176 | $6,400 |
| SEI INVESTMENTS CO | 179,414 | $6,373 |
| Connor, Clark & Lunn Investment Management Ltd. | 175,889 | $6,248 |
| Swiss National Bank | 165,400 | $5,875 |
| Skandinaviska Enskilda Banken AB (publ) | 164,437 | $5,840 |
| UBS ASSET MANAGEMENT AMERICAS INC | 164,140 | $5,830 |
| TUDOR INVESTMENT CORP ET AL | 159,942 | $5,681 |
| Squarepoint Ops LLC | 155,984 | $5,541 |
| ALLIANCEBERNSTEIN L.P. | 155,510 | $5,524 |
| WELLS FARGO & COMPANY/MN | 153,625 | $5,457 |
| Nicholas Investment Partners, LP | 151,066 | $5,366 |
| 165 other institutions | 5,757,335 | $193,916 |