| Nantahala Capital Management, LLC | 5,820,649 | $38,707 |
| BlackRock, Inc. | 4,095,300 | $27,234 |
| VANGUARD GROUP INC | 3,341,804 | $22,223 |
| BRAIDWELL LP | 3,105,209 | $20,650 |
| Frazier Life Sciences Management, L.P. | 2,630,665 | $17,494 |
| MILLENNIUM MANAGEMENT LLC | 2,093,037 | $13,919 |
| Stonepine Capital Management, LLC | 1,631,588 | $10,850 |
| STATE STREET CORP | 1,574,851 | $10,473 |
| D. E. Shaw & Co., Inc. | 1,541,096 | $10,248 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,386,248 | $9,221 |
| CITADEL ADVISORS LLC | 1,379,131 | $9,171 |
| TANG CAPITAL MANAGEMENT LLC | 1,245,692 | $8,284 |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,153,444 | $7,670 |
| Soleus Capital Management, L.P. | 1,070,000 | $7,116 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 986,466 | $6,580 |
| ARMISTICE CAPITAL, LLC | 976,000 | $6,490 |
| UBS Group AG | 881,369 | $5,861 |
| RENAISSANCE TECHNOLOGIES LLC | 799,900 | $5,319 |
| PINNACLE ASSOCIATES LTD | 782,365 | $5,203 |
| Buckley Capital Advisors, LLC | 744,242 | $4,949 |
| MORGAN STANLEY | 730,665 | $4,859 |
| EcoR1 Capital, LLC | 675,000 | $4,489 |
| Soviero Asset Management, LP | 655,000 | $4,356 |
| AWH Capital, L.P. | 625,000 | $4,156 |
| BNP PARIBAS ARBITRAGE, SA | 564,988 | $3,757 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 517,129 | $3,439 |
| NORTHERN TRUST CORP | 445,166 | $2,960 |
| DEUTSCHE BANK AG\ | 436,747 | $2,904 |
| HRT FINANCIAL LP | 428,647 | $3 |
| JANE STREET GROUP, LLC | 417,278 | $2,775 |
| BANK OF AMERICA CORP /DE/ | 358,046 | $2,381 |
| GOLDMAN SACHS GROUP INC | 350,742 | $2,332 |
| Eversept Partners, LP | 344,104 | $2,288 |
| Campbell & CO Investment Adviser LLC | 340,188 | $2,262 |
| Assenagon Asset Management S.A. | 270,219 | $1,797 |
| STIFEL FINANCIAL CORP | 263,129 | $1,750 |
| CM Management, LLC | 250,000 | $1,663 |
| JPMORGAN CHASE & CO | 225,602 | $1,500 |
| WELLINGTON MANAGEMENT GROUP LLP | 195,160 | $1,298 |
| Squarepoint Ops LLC | 174,346 | $1,159 |
| Potomac Capital Management, Inc. | 141,172 | $939 |
| Bank of New York Mellon Corp | 137,797 | $916 |
| Walleye Capital LLC | 132,970 | $884 |
| BARCLAYS PLC | 130,738 | $869 |
| AMERICAN ASSETS INC | 125,000 | $831 |
| GSA CAPITAL PARTNERS LLP | 118,139 | $1 |
| TWO SIGMA INVESTMENTS, LP | 102,094 | $679 |
| BOOTHBAY FUND MANAGEMENT, LLC | 101,812 | $677 |
| Krensavage Asset Management, LLC | 100,000 | $1 |
| Quantinno Capital Management LP | 88,988 | $592 |
| Nuveen, LLC | 88,369 | $588 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 85,364 | $1 |
| Seven Fleet Capital Management LP | 82,000 | $545 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,151 | $533 |
| Marex Group plc | 76,850 | $511 |
| WELLS FARGO & COMPANY/MN | 75,968 | $505 |
| RHUMBLINE ADVISERS | 70,049 | $466 |
| XTX Topco Ltd | 67,991 | $452 |
| Russell Investments Group, Ltd. | 65,571 | $436 |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,096 | $433 |
| ALLIANCEBERNSTEIN L.P. | 62,340 | $415 |
| Brooklyn Investment Group | 61,735 | $411 |
| LPL Financial LLC | 60,975 | $405 |
| AMERIPRISE FINANCIAL INC | 54,270 | $361 |
| GWN SECURITIES INC. | 48,913 | $325 |
| SEI INVESTMENTS CO | 45,501 | $303 |
| Man Group plc | 43,404 | $289 |
| Integrated Quantitative Investments LLC | 41,972 | $279 |
| Pathstone Holdings, LLC | 41,059 | $273 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 39,303 | $261 |
| ADAR1 Capital Management, LLC | 35,859 | $238 |
| CITIGROUP INC | 35,470 | $236 |
| Invesco Ltd. | 34,119 | $227 |
| INTECH INVESTMENT MANAGEMENT LLC | 32,689 | $217 |
| FOX RUN MANAGEMENT, L.L.C. | 32,664 | $217 |
| Atom Investors LP | 32,498 | $216 |
| MetLife Investment Management, LLC | 28,388 | $189 |
| Aquatic Capital Management LLC | 28,383 | $189 |
| SG Americas Securities, LLC | 27,827 | $0 |
| Versor Investments LP | 26,700 | $178 |
| ExodusPoint Capital Management, LP | 26,206 | $174 |
| Alpine Global Management, LLC | 26,085 | $173 |
| SIMPLEX TRADING, LLC | 24,684 | $164 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,126 | $160 |
| Creative Planning | 24,060 | $160 |
| AQR CAPITAL MANAGEMENT LLC | 22,977 | $153 |
| OXFORD ASSET MANAGEMENT LLP | 22,919 | $152 |
| Virtu Financial LLC | 22,701 | $0 |
| MERCER GLOBAL ADVISORS INC /ADV | 21,661 | $144 |
| PROFUND ADVISORS LLC | 20,418 | $136 |
| TWO SIGMA ADVISERS, LP | 19,400 | $129 |
| Trexquant Investment LP | 18,838 | $125 |
| Rafferty Asset Management, LLC | 18,181 | $121 |
| Quadrature Capital Ltd | 18,095 | $120 |
| Pure Financial Advisors, LLC | 17,800 | $118 |
| ENVESTNET ASSET MANAGEMENT INC | 16,705 | $111 |
| AlphaQuest LLC | 16,413 | $109 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,232 | $108 |
| Global Retirement Partners, LLC | 16,200 | $108 |
| Police & Firemen's Retirement System of New Jersey | 15,833 | $105 |
| 66 other institutions | 241,367 | $1,559 |