| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | $66,861 |
| FMR LLC | 3,702,718 | $59,243 |
| Alpha Wave Global, LP | 3,612,211 | $57,795 |
| Versant Venture Management, LLC | 2,656,888 | $42,510 |
| BlackRock, Inc. | 1,692,006 | $27,072 |
| UBS Group AG | 1,571,738 | $25,148 |
| VANGUARD GROUP INC | 1,321,202 | $21,139 |
| FRANKLIN RESOURCES INC | 1,096,334 | $17,541 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,023,542 | $16 |
| 72 Investment Holdings, LLC | 1,017,751 | $16,284 |
| TANG CAPITAL MANAGEMENT LLC | 865,169 | $13,843 |
| Intrinsic Edge Capital Management LLC | 569,705 | $9,115 |
| MILLENNIUM MANAGEMENT LLC | 539,348 | $8,630 |
| STATE STREET CORP | 510,749 | $8,172 |
| C WorldWide Group Holding A/S | 500,000 | $8 |
| Squarepoint Ops LLC | 491,898 | $7,870 |
| abrdn plc | 489,432 | $7,831 |
| Alyeska Investment Group, L.P. | 463,495 | $7,416 |
| GEODE CAPITAL MANAGEMENT, LLC | 461,075 | $7,379 |
| Granahan Investment Management, LLC | 431,100 | $6,898 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 398,566 | $6,377 |
| Candriam S.C.A. | 374,932 | $5,999 |
| PRIMECAP MANAGEMENT CO/CA/ | 372,200 | $5,955 |
| TWO SIGMA INVESTMENTS, LP | 293,446 | $4,695 |
| Vestal Point Capital, LP | 275,000 | $4,400 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 270,919 | $4,335 |
| GOLDMAN SACHS GROUP INC | 257,942 | $4,127 |
| Rock Springs Capital Management LP | 257,460 | $4,119 |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 241,300 | $3,861 |
| MORGAN STANLEY | 233,382 | $3,734 |
| PLUSTICK MANAGEMENT LLC | 200,000 | $3,200 |
| Skandinaviska Enskilda Banken AB (publ) | 185,642 | $2,970 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 174,692 | $2,795 |
| Trexquant Investment LP | 173,183 | $2,771 |
| HRT FINANCIAL LP | 171,283 | $3 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 170,224 | $2,724 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,122 | $2,706 |
| NORTHERN TRUST CORP | 161,911 | $2,591 |
| Sovran Advisors, LLC | 160,134 | $2,905 |
| AWM Investment Company, Inc. | 150,000 | $2,400 |
| Blue Owl Capital Holdings LP | 150,000 | $2,400 |
| AMERIPRISE FINANCIAL INC | 136,896 | $2,190 |
| SCOGGIN MANAGEMENT LP | 125,000 | $2,000 |
| BANK OF AMERICA CORP /DE/ | 114,688 | $1,835 |
| DIMENSIONAL FUND ADVISORS LP | 113,094 | $1,810 |
| Woodline Partners LP | 100,000 | $1,600 |
| NOMURA ASSET MANAGEMENT CO LTD | 96,780 | $1,548 |
| XTX Topco Ltd | 85,782 | $1,373 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,243 | $1,403 |
| CITADEL ADVISORS LLC | 80,574 | $1,289 |
| VARCOV Co. | 78,831 | $1,261 |
| TWO SIGMA ADVISERS, LP | 77,426 | $1,239 |
| Ensign Peak Advisors, Inc | 77,275 | $1,236 |
| ALGERT GLOBAL LLC | 76,025 | $1 |
| BARCLAYS PLC | 72,432 | $1,159 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,722 | $1,084 |
| Vivaldi Capital Management LP | 64,052 | $1,025 |
| FEDERATED HERMES, INC. | 62,636 | $1,002 |
| Propel Bio Management, LLC | 59,085 | $945 |
| WELLINGTON MANAGEMENT GROUP LLP | 54,402 | $870 |
| Knott David M Jr | 53,732 | $860 |
| PERCEPTIVE ADVISORS LLC | 50,000 | $800 |
| Rockefeller Capital Management L.P. | 48,071 | $769 |
| JANE STREET GROUP, LLC | 46,847 | $750 |
| Verition Fund Management LLC | 46,268 | $740 |
| Qube Research & Technologies Ltd | 44,290 | $709 |
| Bank of New York Mellon Corp | 44,055 | $705 |
| ROYAL BANK OF CANADA | 43,172 | $691 |
| Aquatic Capital Management LLC | 42,729 | $684 |
| SECTORAL ASSET MANAGEMENT INC | 42,500 | $680 |
| Jump Financial, LLC | 40,851 | $654 |
| Y-Intercept (Hong Kong) Ltd | 40,615 | $650 |
| Nuveen, LLC | 39,905 | $638 |
| Virtus Investment Advisers, LLC | 37,674 | $603 |
| MARSHALL WACE, LLP | 35,252 | $564 |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,235 | $516 |
| Engineers Gate Manager LP | 31,058 | $497 |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 27,304 | $437 |
| TD Asset Management Inc | 26,978 | $432 |
| HARBOR CAPITAL ADVISORS, INC. | 23,921 | $0 |
| ExodusPoint Capital Management, LP | 23,147 | $370 |
| Freestone Grove Partners LP | 22,971 | $368 |
| WELLS FARGO & COMPANY/MN | 22,916 | $367 |
| Swiss National Bank | 21,800 | $349 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,816 | $335 |
| RHUMBLINE ADVISERS | 20,250 | $324 |
| AXQ CAPITAL, LP | 19,839 | $317 |
| AlphaQuest LLC | 19,613 | $314 |
| DnB Asset Management AS | 19,163 | $307 |
| State of Alaska, Department of Revenue | 19,159 | $0 |
| UBS ASSET MANAGEMENT AMERICAS INC | 18,851 | $302 |
| Simplify Asset Management Inc. | 17,481 | $280 |
| KELLEHER FINANCIAL ADVISORS | 17,023 | $272 |
| Quantbot Technologies LP | 16,879 | $270 |
| GSA CAPITAL PARTNERS LLP | 16,455 | $0 |
| Marex Group plc | 16,000 | $256 |
| FOX RUN MANAGEMENT, L.L.C. | 15,739 | $252 |
| Russell Investments Group, Ltd. | 15,461 | $247 |
| Brevan Howard Capital Management LP | 15,408 | $247 |
| Rinkey Investments | 15,186 | $243 |
| 60 other institutions | 236,733 | $3,631 |