| Bain Capital Life Sciences Investors, LLC | 8,508,641 | $212,716 |
| Paradigm Biocapital Advisors LP | 7,544,172 | $188,604 |
| JANUS HENDERSON GROUP PLC | 6,710,194 | $167,901 |
| BlackRock, Inc. | 5,563,260 | $139,082 |
| BVF INC/IL | 5,295,893 | $132,397 |
| FMR LLC | 5,023,092 | $125,577 |
| VANGUARD GROUP INC | 3,561,355 | $89,034 |
| Siren, L.L.C. | 3,300,700 | $82,518 |
| Logos Global Management LP | 3,208,875 | $80,222 |
| Cormorant Asset Management, LP | 2,750,000 | $68,750 |
| RA CAPITAL MANAGEMENT, L.P. | 2,600,000 | $65,000 |
| FRANKLIN RESOURCES INC | 2,476,665 | $61,917 |
| Lightspeed Management Company, L.L.C. | 1,930,894 | $48,272 |
| STATE STREET CORP | 1,884,399 | $47,110 |
| Vestal Point Capital, LP | 1,650,000 | $41,250 |
| Woodline Partners LP | 1,481,930 | $37,048 |
| Polar Capital Holdings Plc | 1,380,450 | $34,511 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,441 | $31,442 |
| Defilade Capital Management, L.P. | 1,234,634 | $30,866 |
| CITADEL ADVISORS LLC | 1,200,307 | $30,008 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,096,035 | $27 |
| SAMLYN CAPITAL, LLC | 1,069,543 | $26,739 |
| JENNISON ASSOCIATES LLC | 963,997 | $24,100 |
| DIMENSIONAL FUND ADVISORS LP | 958,644 | $23,966 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 953,600 | $23,840 |
| GOLDMAN SACHS GROUP INC | 817,889 | $20,447 |
| Ikarian Capital, LLC | 758,654 | $18,966 |
| Candriam S.C.A. | 679,484 | $16,988 |
| Vivo Capital, LLC | 671,843 | $16,796 |
| MORGAN STANLEY | 665,803 | $16,645 |
| First Turn Management, LLC | 617,714 | $15,443 |
| EVENTIDE ASSET MANAGEMENT, LLC | 569,000 | $14,225 |
| Holocene Advisors, LP | 506,001 | $12,650 |
| Pictet Asset Management Holding SA | 502,568 | $12,596 |
| MILLENNIUM MANAGEMENT LLC | 498,490 | $12,462 |
| Hennion & Walsh Asset Management, Inc. | 447,046 | $11,176 |
| NORTHERN TRUST CORP | 445,327 | $11,133 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 407,141 | $10,179 |
| TWO SIGMA INVESTMENTS, LP | 393,658 | $9,841 |
| MARSHALL WACE, LLP | 360,394 | $9,010 |
| Squarepoint Ops LLC | 328,680 | $8,217 |
| Point72 Asset Management, L.P. | 307,890 | $7,697 |
| UBS Group AG | 293,560 | $7,339 |
| Skandinaviska Enskilda Banken AB (publ) | 281,687 | $7,042 |
| Birchview Capital, LP | 269,000 | $6,725 |
| JPMORGAN CHASE & CO | 268,471 | $6,712 |
| Catalio Capital Management, LP | 267,058 | $6,676 |
| HighVista Strategies LLC | 241,489 | $6,037 |
| BANK OF AMERICA CORP /DE/ | 238,914 | $5,973 |
| Nuveen, LLC | 229,469 | $5,737 |
| WELLINGTON MANAGEMENT GROUP LLP | 220,971 | $5,524 |
| BOOTHBAY FUND MANAGEMENT, LLC | 219,086 | $5,477 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 210,000 | $5,250 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 206,280 | $5,157 |
| AMERIPRISE FINANCIAL INC | 204,629 | $5,116 |
| Bank of New York Mellon Corp | 176,201 | $4,405 |
| BALYASNY ASSET MANAGEMENT L.P. | 167,308 | $4,183 |
| PERCEPTIVE ADVISORS LLC | 165,713 | $4,143 |
| Invesco Ltd. | 155,732 | $3,893 |
| ExodusPoint Capital Management, LP | 150,670 | $3,767 |
| CITIGROUP INC | 147,363 | $3,684 |
| Pier Capital, LLC | 140,101 | $3,503 |
| TD Asset Management Inc | 136,400 | $3,410 |
| BARCLAYS PLC | 133,125 | $3,328 |
| Burkehill Global Management, LP | 125,000 | $3,125 |
| Susquehanna Portfolio Strategies, LLC | 121,342 | $3,034 |
| Schonfeld Strategic Advisors LLC | 113,978 | $2,849 |
| Brevan Howard Capital Management LP | 107,950 | $2,699 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 102,322 | $2,564 |
| Jump Financial, LLC | 100,274 | $2,507 |
| Rock Springs Capital Management LP | 98,240 | $2,456 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 94,883 | $2,372 |
| AMERICAN CENTURY COMPANIES INC | 93,900 | $2,348 |
| VICTORY CAPITAL MANAGEMENT INC | 86,100 | $2,153 |
| WELLS FARGO & COMPANY/MN | 84,130 | $2,103 |
| ADAR1 Capital Management, LLC | 81,399 | $2,035 |
| AQR CAPITAL MANAGEMENT LLC | 81,167 | $2,029 |
| RHUMBLINE ADVISERS | 74,379 | $1,859 |
| Soleus Capital Management, L.P. | 69,874 | $1,747 |
| SG Americas Securities, LLC | 69,382 | $2 |
| Harvest Investment Services, LLC | 68,723 | $1,718 |
| Nicholas Investment Partners, LP | 64,757 | $1,619 |
| Creative Planning | 64,654 | $1,616 |
| ALPS ADVISORS INC | 64,592 | $1,615 |
| FRED ALGER MANAGEMENT, LLC | 64,484 | $1,612 |
| DEUTSCHE BANK AG\ | 63,067 | $1,577 |
| ALLIANCEBERNSTEIN L.P. | 62,610 | $1,565 |
| Quantinno Capital Management LP | 61,306 | $1,533 |
| LPL Financial LLC | 56,195 | $1,405 |
| Swedbank AB | 55,100 | $1,378 |
| ACT CAPITAL MANAGEMENT, LLC | 53,500 | $1,338 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 50,000 | $1,250 |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | $1,250 |
| Trexquant Investment LP | 49,754 | $1,244 |
| NEOS Investment Management LLC | 45,170 | $1,129 |
| Rafferty Asset Management, LLC | 45,005 | $1,125 |
| TEMA ETFS LLC | 44,505 | $1,113 |
| Virtu Financial LLC | 42,437 | $1 |
| RAYMOND JAMES FINANCIAL INC | 40,647 | $1,016 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,500 | $1,013 |
| 99 other institutions | 1,024,959 | $23,313 |