| GSK plc | 18,245,691 | $310,177 |
| RA CAPITAL MANAGEMENT, L.P. | 18,203,009 | $309,451 |
| FMR LLC | 15,135,983 | $257,312 |
| BlackRock, Inc. | 12,648,907 | $215,031 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,786,061 | $166,363 |
| MAVERICK CAPITAL LTD | 9,280,237 | $157,764 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,407,372 | $126 |
| Darwin Global Management, Ltd. | 7,298,421 | $125,168 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,581,067 | $111,878 |
| M28 Capital Management LP | 5,664,548 | $96,297 |
| FEDERATED HERMES, INC. | 4,744,520 | $80,657 |
| PRIMECAP MANAGEMENT CO/CA/ | 4,095,282 | $69,620 |
| 683 Capital Management, LLC | 4,015,000 | $68,255 |
| VANGUARD GROUP INC | 3,573,746 | $60,754 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,170,110 | $53,902 |
| STATE STREET CORP | 2,996,084 | $50,933 |
| GOLDMAN SACHS GROUP INC | 2,854,082 | $48,519 |
| Affinity Asset Advisors, LLC | 2,700,000 | $45,900 |
| EMERALD ADVISERS, LLC | 2,455,089 | $41,737 |
| Siren, L.L.C. | 2,450,000 | $41,650 |
| Kynam Capital Management, LP | 2,169,105 | $36,875 |
| LOOMIS SAYLES & CO L P | 2,040,223 | $34,684 |
| Pfizer Inc | 1,875,000 | $31,875 |
| First Light Asset Management, LLC | 1,853,851 | $31,515 |
| Bellevue Group AG | 1,490,518 | $25,339 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,414,665 | $24,049 |
| RTW INVESTMENTS, LP | 1,350,000 | $22,950 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,191,361 | $20,253 |
| NORTHERN TRUST CORP | 1,033,068 | $17,562 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,005,984 | $17,253 |
| JPMORGAN CHASE & CO | 892,886 | $15,179 |
| Squarepoint Ops LLC | 883,586 | $15,021 |
| Pictet Asset Management Holding SA | 805,901 | $13,830 |
| CITADEL ADVISORS LLC | 789,964 | $13,429 |
| TWO SIGMA INVESTMENTS, LP | 749,448 | $12,741 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 722,237 | $12,278 |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | $10,200 |
| MILLENNIUM MANAGEMENT LLC | 584,633 | $9,939 |
| EVENTIDE ASSET MANAGEMENT, LLC | 500,000 | $8,500 |
| KENNEDY CAPITAL MANAGEMENT LLC | 492,437 | $8,371 |
| Elmind Capital, LP | 447,846 | $7,613 |
| Exome Asset Management LLC | 421,488 | $7,165 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 411,494 | $6,995 |
| MORGAN STANLEY | 409,663 | $6,964 |
| SPHERA FUNDS MANAGEMENT LTD. | 408,166 | $6,939 |
| AMERIPRISE FINANCIAL INC | 398,416 | $6,773 |
| F/M Investments LLC | 395,894 | $6,730 |
| Trexquant Investment LP | 391,111 | $6,649 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 378,987 | $6,443 |
| Walleye Capital LLC | 378,823 | $6,440 |
| WELLINGTON MANAGEMENT GROUP LLP | 365,235 | $6,209 |
| BOONE CAPITAL MANAGEMENT LLC | 352,144 | $5,986 |
| Woodline Partners LP | 350,531 | $5,959 |
| BAKER BROS. ADVISORS LP | 344,063 | $5,849 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 338,546 | $5,755 |
| Nuveen, LLC | 332,735 | $5,656 |
| Jain Global LLC | 328,145 | $5,578 |
| Bank of New York Mellon Corp | 321,445 | $5,465 |
| Jump Financial, LLC | 313,509 | $5,330 |
| Newtyn Management, LLC | 300,000 | $5,100 |
| HRT FINANCIAL LP | 299,718 | $5 |
| BARCLAYS PLC | 276,781 | $4,705 |
| Moody Aldrich Partners LLC | 274,425 | $4,665 |
| UBS Group AG | 268,723 | $4,568 |
| D. E. Shaw & Co., Inc. | 266,132 | $4,524 |
| TD Asset Management Inc | 252,160 | $4,287 |
| EAM Investors, LLC | 248,815 | $4,230 |
| RENAISSANCE TECHNOLOGIES LLC | 236,420 | $4,019 |
| BOOTHBAY FUND MANAGEMENT, LLC | 234,799 | $3,992 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 230,687 | $3,922 |
| Susquehanna Portfolio Strategies, LLC | 230,512 | $3,919 |
| Swiss National Bank | 219,700 | $3,735 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 203,744 | $3,464 |
| AQR CAPITAL MANAGEMENT LLC | 202,721 | $3,446 |
| WELLS FARGO & COMPANY/MN | 200,890 | $3,415 |
| Privium Fund Management B.V. | 193,010 | $3,281 |
| BANK OF AMERICA CORP /DE/ | 182,855 | $3,109 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 182,728 | $3,129 |
| Invesco Ltd. | 179,932 | $3,059 |
| Squadron Capital Management LLC | 175,000 | $2,975 |
| Duquesne Family Office LLC | 173,000 | $3 |
| PRINCIPAL FINANCIAL GROUP INC | 170,170 | $2,893 |
| UBS ASSET MANAGEMENT AMERICAS INC | 164,985 | $2,805 |
| Sofinnova Investments, Inc. | 158,182 | $2,689 |
| Burkehill Global Management, LP | 150,000 | $2,550 |
| RHUMBLINE ADVISERS | 141,895 | $2,412 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 134,558 | $2,287 |
| ALGERT GLOBAL LLC | 122,470 | $2 |
| Voya Investment Management LLC | 112,875 | $1,919 |
| ALLIANCEBERNSTEIN L.P. | 112,030 | $1,905 |
| RAYMOND JAMES FINANCIAL INC | 111,170 | $1,890 |
| JANE STREET GROUP, LLC | 110,924 | $1,886 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,680 | $1,831 |
| James J. Burns & Company, LLC | 105,802 | $1,799 |
| Itau Unibanco Holding S.A. | 102,000 | $1,749 |
| LMR Partners LLP | 100,000 | $1,700 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $1,700 |
| DEUTSCHE BANK AG\ | 95,706 | $1,627 |
| DARK FOREST CAPITAL MANAGEMENT LP | 95,068 | $1,616 |
| Legal & General Group Plc | 93,985 | $1,598 |
| 115 other institutions | 2,584,572 | $41,006 |