Location: Luxembourg
CIK: 0001053906 · Show all filings
Period: Q1 2022 (← Previous) (Next →)
Filing Date: May 12, 2022
Total Value: $2.388B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ARGX | ARGENX SE | 587,500 | $185M | 7.8% | $216.30 | — | SPONSORED ADR | 04016X101 |
| — | WW INTL INC | 14,818,300 | $152M | 6.3% | $37.82 | — | COM | 98262P101 |
| LXRX | LEXICON PHARMACEUTICALS INC | 71,178,364 | $149M | 6.2% | $6.62 | -58.1% | COM NEW | 528872302 |
| ONC | BEIGENE LTD | 665,000 | $125M | 5.3% | $156.62 | — | SPONSORED ADR | 07725L102 |
| — | MIRATI THERAPEUTICS INC | 1,350,000 | $111M | 4.6% | $166.44 | — | COM | 60468T105 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 650,000 | $106M | 4.4% | $97.14 | +56.8% | COM | 02043Q107 |
| — | SEAGEN INC | 650,000 | $93.63M | 3.9% | $160.93 | — | COM | 81181C104 |
| FATE | FATE THERAPEUTICS INC | 2,000,000 | $77.54M | 3.2% | $28.42 | +36.3% | COM | 31189P102 |
| SEER | SEER INC | 4,750,000 | $72.39M | 3.0% | $63.62 | -75.7% | COM CL A | 81578P106 |
| — | MORPHIC HLDG INC | 1,650,000 | $66.25M | 2.8% | $23.38 | — | COM | 61775R105 |
| — | BELLUS HEALTH INC NEW | 8,500,000 | $58.48M | 2.4% | $5.24 | — | COM NEW | 07987C204 |
| — | IGM BIOSCIENCES INC | 2,000,000 | $53.46M | 2.2% | $61.09 | — | COM | 449585108 |
| — | CEREVEL THERAPEUTICS HLDNG I | 1,500,000 | $52.52M | 2.2% | $16.33 | — | COM | 15678U128 |
| — | SPRINGWORKS THERAPEUTICS INC | 850,000 | $47.97M | 2.0% | $54.96 | — | COM | 85205L107 |
| KYMR | KYMERA THERAPEUTICS INC | 1,000,000 | $42.32M | 1.8% | $51.28 | -17.6% | COM | 501575104 |
| FOLD | AMICUS THERAPEUTICS INC | 4,000,000 | $37.88M | 1.6% | $11.63 | -19.4% | COM | 03152W109 |
| CYTK | CYTOKINETICS INC | 1,000,000 | $36.81M | 1.5% | $27.15 | +30.9% | COM NEW | 23282W605 |
| KRYS | KRYSTAL BIOTECH INC | 500,000 | $33.27M | 1.4% | $56.38 | +10.7% | COM | 501147102 |
| SRRK | SCHOLAR ROCK HLDG CORP | 2,450,000 | $31.58M | 1.3% | $20.06 | -14.8% | COM | 80706P103 |
| ERAS | ERASCA INC | 3,172,221 | $27.28M | 1.1% | $20.63 | -43.8% | COM | 29479A108 |
| FHTX | FOGHORN THERAPEUTICS INC | 1,720,720 | $26.21M | 1.1% | $19.16 | -28.4% | COM | 344174107 |
| — | SAGE THERAPEUTICS INC | 750,000 | $24.82M | 1.0% | $68.21 | — | COM | 78667J108 |
| SDGR | SCHRODINGER INC | 700,000 | $23.88M | 1.0% | $37.76 | -19.6% | COM | 80810D103 |
| RLAY | RELAY THERAPEUTICS INC | 700,000 | $20.95M | 0.9% | $35.08 | -30.8% | COM | 75943R102 |
| — | GENERATION BIO CO | 2,814,191 | $20.66M | 0.9% | $21.00 | — | COM | 37148K100 |
| GOSS | GOSSAMER BIO INC | 2,358,968 | $20.48M | 0.9% | $17.62 | -45.3% | COM | 38341P102 |
| — | RUBIUS THERAPEUTICS INC | 3,701,580 | $20.4M | 0.9% | $20.48 | — | COM | 78116T103 |
| — | TALARIS THERAPEUTICS INC | 2,064,262 | $20.31M | 0.9% | $14.69 | — | COM | 87410C104 |
| NTLA | INTELLIA THERAPEUTICS INC | 275,000 | $19.98M | 0.8% | $33.42 | +153.5% | COM | 45826J105 |
| DNLI | DENALI THERAPEUTICS INC | 600,000 | $19.3M | 0.8% | $31.47 | +9.4% | COM | 24823R105 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 800,100 | $18.95M | 0.8% | $42.63 | -33.9% | COM | 74366E102 |
| EVO | EVOTEC AG | 1,149,425 | $17.39M | 0.7% | $23.75 | — | SPONSORED ADS | 30050E105 |
| KURA | KURA ONCOLOGY INC | 1,050,000 | $16.88M | 0.7% | $18.14 | -20.4% | COM | 50127T109 |
| — | EQRX INC | 4,000,000 | $16.52M | 0.7% | $6.82 | — | COM | 26886C107 |
| — | ALLOVIR INC | 2,323,371 | $15.68M | 0.7% | $27.50 | — | COM | 019818103 |
| REPL | REPLIMUNE GROUP INC | 900,000 | $15.28M | 0.6% | $20.83 | -9.4% | COM | 76029N106 |
| INTC | INTEL CORP | 300,000 | $14.86M | 0.6% | — | — | Call | 458140100 |
| — | OMEGA THERAPEUTICS INC | 2,273,530 | $14.19M | 0.6% | $18.85 | — | COMMON STOCK | 68217N105 |
| — | APTINYX INC | 6,116,493 | $13.88M | 0.6% | $2.87 | — | COM | 03836N103 |
| NBP | I MAB | 850,000 | $13.8M | 0.6% | $36.36 | — | SPONSORED ADS | 44975P103 |
| — | AGENUS INC | 5,500,000 | $13.53M | 0.6% | $3.98 | — | COM NEW | 00847G705 |
| — | ITEOS THERAPEUTICS INC | 400,000 | $12.87M | 0.5% | $24.67 | — | COM | 46565G104 |
| AUPH | AURINIA PHARMACEUTICALS INC | 1,000,000 | $12.38M | 0.5% | $17.08 | -9.5% | COM | 05156V102 |
| — | PRAXIS PRECISION MEDICINES I | 1,200,000 | $12.25M | 0.5% | $41.24 | — | COM | 74006W108 |
| — | KRONOS BIO INC | 1,542,954 | $11.16M | 0.5% | $27.50 | — | COM | 50107A104 |
| APLS | APELLIS PHARMACEUTICALS INC | 200,000 | $10.16M | 0.4% | $44.15 | 0.0% | COM | 03753U106 |
| — | REPARE THERAPEUTICS INC | 700,000 | $9.968M | 0.4% | $28.89 | — | COM | 760273102 |
| — | IKENA ONCOLOGY INC | 1,549,513 | $9.452M | 0.4% | $28.25 | — | COM | 45175G108 |
| — | MARINUS PHARMACEUTICALS INC | 1,000,000 | $9.35M | 0.4% | $14.99 | — | COM NEW | 56854Q200 |
| — | FORMA THERAPEUTICS HLDGS INC | 1,000,000 | $9.3M | 0.4% | $31.46 | — | SHS | 34633R104 |
| — | ATARA BIOTHERAPEUTICS INC | 1,000,000 | $9.29M | 0.4% | $17.77 | — | COM | 046513107 |
| — | VERVE THERAPEUTICS INC | 400,000 | $9.128M | 0.4% | $60.25 | — | COM | 92539P101 |
| — | AMBRX BIOPHARMA INC | 2,152,291 | $8.867M | 0.4% | $13.20 | — | SPONSORED ADS | 02290A102 |
| — | MERSANA THERAPEUTICS INC | 2,200,000 | $8.778M | 0.4% | $14.43 | — | COM | 59045L106 |
| ALXO | ALX ONCOLOGY HLDGS INC | 500,000 | $8.45M | 0.4% | $64.13 | -73.4% | COM | 00166B105 |
| — | SAGE THERAPEUTICS INC | 250,000 | $8.275M | 0.3% | $68.21 | — | Call | 78667J108 |
| — | EXSCIENTIA PLC | 550,000 | $7.92M | 0.3% | $19.76 | — | ADS | 30223G102 |
| IMUX | IMMUNIC INC | 700,000 | $7.91M | 0.3% | $10.33 | +12.0% | COM | 4525EP101 |
| — | VIGIL NEUROSCIENCE INC | 1,121,191 | $7.882M | 0.3% | $7.03 | — | COM | 92673K108 |
| OVID | OVID THERAPEUTICS INC | 2,500,000 | $7.85M | 0.3% | $6.69 | -53.0% | COM | 690469101 |
| SQZB | SQZ BIOTECHNOLOGIES CO | 1,606,309 | $7.726M | 0.3% | $28.98 | — | COM | 78472W104 |
| TGTX | TG THERAPEUTICS INC | 800,000 | $7.608M | 0.3% | $12.64 | -8.4% | COM | 88322Q108 |
| — | OATLY GROUP AB | 1,500,000 | $7.515M | 0.3% | $24.46 | — | SPONSORED ADS | 67421J108 |
| NBTX | NANOBIOTIX SA | 1,000,000 | $7.44M | 0.3% | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | OMEGA ALPHA SPAC | 750,000 | $7.365M | 0.3% | $9.90 | — | CL A | G6749V107 |
| — | LEAP THERAPEUTICS INC | 4,000,000 | $7M | 0.3% | $2.55 | — | COM | 52187K101 |
| SE | SEA LTD | 57,500 | $6.888M | 0.3% | $119.79 | — | SPONSORED ADS | 81141R100 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,040,882 | $6.787M | 0.3% | $23.52 | -68.2% | COM SHS | 877619106 |
| — | ACHILLES THERAPEUTICS PLC | 2,255,375 | $6.631M | 0.3% | $16.55 | — | SPONSORED ADS | 00449L102 |
| DSGN | DESIGN THERAPEUTICS INC | 400,000 | $6.46M | 0.3% | $31.14 | -50.8% | COM | 25056L103 |
| IMCR | IMMUNOCORE HLDGS PLC | 200,000 | $5.98M | 0.3% | $42.57 | — | ADS | 45258D105 |
| — | FUSION PHARMACEUTICALS INC | 750,000 | $5.828M | 0.2% | $9.98 | — | COM | 36118A100 |
| — | CONTRAFECT CORP | 1,500,000 | $5.475M | 0.2% | $4.97 | — | COM NEW | 212326300 |
| — | ALPINE IMMUNE SCIENCES INC | 593,030 | $5.319M | 0.2% | $8.79 | — | COM | 02083G100 |
| STOK | STOKE THERAPEUTICS INC | 250,000 | $5.263M | 0.2% | $24.59 | -18.6% | COM | 86150R107 |
| DYN | DYNE THERAPEUTICS INC | 525,000 | $5.061M | 0.2% | $20.85 | -59.2% | COM | 26818M108 |
| — | NEXIMMUNE INC | 1,200,000 | $5.052M | 0.2% | $19.08 | — | COM | 65344D109 |
| — | HARPOON THERAPEUTICS INC | 1,000,000 | $4.97M | 0.2% | $15.27 | — | COM | 41358P106 |
| — | DYNAMICS SPECIAL PURPOSE COR | 500,000 | $4.935M | 0.2% | $9.94 | — | CLASS A COM | 268010105 |
| — | SELECTA BIOSCIENCES INC | 4,000,000 | $4.92M | 0.2% | $3.52 | — | COM | 816212104 |
| — | INSTIL BIO INC | 450,000 | $4.838M | 0.2% | $25.08 | — | COM | 45783C101 |
| — | Y-MABS THERAPEUTICS INC | 400,000 | $4.752M | 0.2% | $24.99 | — | COM | 984241109 |
| RNAM | AVIDITY BIOSCIENCES INC | 250,000 | $4.618M | 0.2% | $26.70 | -36.4% | COM | 05370A108 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 1,646,517 | $4.561M | 0.2% | $30.42 | -88.0% | COM | 09203E105 |
| IVVD | ADAGIO THERAPEUTICS INC | 1,000,000 | $4.56M | 0.2% | $6.12 | 0.0% | COM | 00534A102 |
| SPRO | SPERO THERAPEUTICS INC | 500,000 | $4.35M | 0.2% | $11.60 | -11.7% | COM | 84833T103 |
| — | HOOKIPA PHARMA INC | 1,849,616 | $4.217M | 0.2% | $4.24 | — | COM | 43906K100 |
| — | SYROS PHARMACEUTICALS INC | 3,500,000 | $4.165M | 0.2% | $4.79 | — | COM | 87184Q107 |
| MIR | MIRION TECHNOLOGIES INC | 500,000 | $4.035M | 0.2% | $10.74 | -19.8% | COM CL A | 60471A101 |
| ACIU | AC IMMUNE SA | 1,000,000 | $4M | 0.2% | $11.29 | -61.7% | SHS | H00263105 |
| — | ADVERUM BIOTECHNOLOGIES INC | 3,000,000 | $3.93M | 0.2% | $9.97 | — | COM | 00773U108 |
| PFTA | PORTAGE FINTECH ACQUISITN CO | 380,000 | $3.773M | 0.2% | $10.00 | — | CLASS A ORD SHS | G7185D106 |
| — | SOLID BIOSCIENCES INC | 3,000,000 | $3.6M | 0.2% | $4.75 | — | COM | 83422E105 |
| — | GRAPHITE BIO INC | 700,000 | $3.57M | 0.1% | $30.73 | — | COM | 38870X104 |
| — | LYELL IMMUNOPHARMA INC | 700,000 | $3.535M | 0.1% | $16.24 | — | COM | 55083R104 |
| ADAG | ADAGENE INC | 1,000,000 | $3.5M | 0.1% | $17.07 | — | ADS | 005329107 |
| — | VOR BIOPHARMA INC | 550,000 | $3.322M | 0.1% | $43.10 | — | COM | 929033108 |
| SANA | SANA BIOTECHNOLOGY INC | 400,000 | $3.304M | 0.1% | $32.56 | -75.2% | COM | 799566104 |
| RXRX | RECURSION PHARMACEUTICALS IN | 450,000 | $3.222M | 0.1% | $19.06 | -44.2% | CL A | 75629V104 |
| XLO | XILIO THERAPEUTICS INC | 450,000 | $3.182M | 0.1% | $17.03 | -33.7% | COM | 98422T100 |
| — | CURIS INC | 1,300,000 | $3.094M | 0.1% | $3.14 | — | COM NEW | 231269200 |
| — | GRITSTONE BIO INC | 750,000 | $3.09M | 0.1% | $12.86 | — | COM | 39868T105 |
| — | CYCLERION THERAPEUTICS INC | 2,779,122 | $3.085M | 0.1% | $7.29 | — | COM | 23255M105 |
| — | ZYMEWORKS INC | 450,000 | $2.948M | 0.1% | $43.78 | — | COM | 98985W102 |
| IMMP | IMMUTEP LTD | 1,000,000 | $2.74M | 0.1% | $3.87 | — | SPONSORED ADS | 45257L108 |
| CGEM | CULLINAN ONCOLOGY INC | 250,000 | $2.618M | 0.1% | $28.21 | -52.1% | COM | 230031106 |
| — | 111 INC | 966,349 | $2.57M | 0.1% | $9.49 | — | ADS | 68247Q102 |
| BBIO | BRIDGEBIO PHARMA INC | 250,000 | $2.538M | 0.1% | $32.20 | -68.1% | COM | 10806X102 |
| — | 23ANDME HOLDING CO | 661,009 | $2.532M | 0.1% | $6.66 | — | CLASS A COM | 90138Q108 |
| — | ARAVIVE INC | 1,311,291 | $2.531M | 0.1% | $11.29 | — | COM | 03890D108 |
| ORIC | ORIC PHARMACEUTICALS INC | 400,000 | $2.136M | 0.1% | $24.42 | -63.1% | COM | 68622P109 |
| — | TCR2 THERAPEUTICS INC | 750,000 | $2.07M | 0.1% | $19.56 | — | COM | 87808K106 |
| WVE | WAVE LIFE SCIENCES LTD | 1,000,000 | $2M | 0.1% | $6.06 | -59.6% | SHS | Y95308105 |
| CRDF | CARDIFF ONCOLOGY INC | 750,000 | $1.86M | 0.1% | $6.60 | -46.4% | COM | 14147L108 |
| — | AXCELLA HEALTH INC | 712,500 | $1.831M | 0.1% | $6.82 | — | COM | 05454B105 |
| MREO | MEREO BIOPHARMA GROUP PLC | 1,500,000 | $1.68M | 0.1% | $3.37 | — | ADS | 589492107 |
| — | KINNATE BIOPHARMA INC | 125,000 | $1.408M | 0.1% | $39.78 | — | COM | 49705R105 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 110,532 | $1.39M | 0.1% | $13.01 | -11.9% | COM CL A | 46333X108 |
| — | ORCHARD THERAPEUTICS PLC | 1,803,858 | $1.284M | 0.1% | $8.41 | — | ADS | 68570P101 |
| — | CODIAK BIOSCIENCES INC | 200,000 | $1.254M | 0.1% | $15.08 | — | COM | 192010106 |
| — | HIPPO HLDGS INC | 600,000 | $1.194M | 0.0% | $4.68 | — | COMMON STOCK | 433539103 |
| OLMA | OLEMA PHARMACEUTICALS INC | 260,500 | $1.11M | 0.0% | $46.89 | -88.2% | COM | 68062P106 |
| XP | XP INC | 35,000 | $1.054M | 0.0% | $31.19 | 0.0% | CL A | G98239109 |
| CRBU | CARIBOU BIOSCIENCES INC | 105,347 | $967K | 0.0% | $24.45 | -56.9% | COM | 142038108 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 75,000 | $964K | 0.0% | $22.45 | 0.0% | COM | 03237H101 |
| — | LAVA THERAPEUTICS NV | 200,000 | $880K | 0.0% | $15.19 | — | SHS | N51517105 |
| — | APPLIED THERAPEUTICS INC | 400,000 | $844K | 0.0% | $20.66 | — | COM | 03828A101 |
| KLDO | KALEIDO BIOSCIENCES INC | 500,500 | $826K | 0.0% | $13.76 | -87.0% | COM | 483347100 |
| CRVS | CORVUS PHARMACEUTICALS INC | 500,000 | $820K | 0.0% | $2.96 | -38.2% | COM | 221015100 |
| — | MINK THERAPEUTICS INC | 289,588 | $652K | 0.0% | $4.46 | — | COM | 603693102 |
| — | MEI PHARMA INC | 1,000,000 | $603K | 0.0% | $3.78 | — | COM NEW | 55279B202 |
| — | METACRINE INC | 924,898 | $564K | 0.0% | $10.21 | — | COM | 59101E103 |
| — | SIGILON THERAPEUTICS INC | 276,000 | $406K | 0.0% | $48.03 | — | COM | 82657L107 |
| — | YUMANITY THERAPEUTICS INC | 217,391 | $326K | 0.0% | $17.00 | — | COM | 98872L102 |
| — | ASTRIA THERAPEUTICS INC | 33,333 | $224K | 0.0% | $8.85 | — | COM | 04635X102 |
| — | GINKGO BIOWORKS HOLDINGS INC | 50,000 | $202K | 0.0% | $4.04 | — | CL A SHS | 37611X100 |
| — | CIDARA THERAPEUTICS INC | 224,675 | $187K | 0.0% | $3.69 | — | COM | 171757107 |