Location: Luxembourg
CIK: 0001053906 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: Feb 11, 2022
Total Value: $3.685B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| LXRX | LEXICON PHARMACEUTICALS INC | 71,178,364 | $280M | 7.6% | $6.62 | -26.6% | COM NEW | 528872302 |
| — | WW INTL INC | 14,818,300 | $239M | 6.5% | $37.82 | — | COM | 98262P101 |
| — | MIRATI THERAPEUTICS INC | 1,400,000 | $205M | 5.6% | $166.44 | — | COM | 60468T105 |
| ONC | BEIGENE LTD | 675,000 | $183M | 5.0% | $156.62 | — | SPONSORED ADR | 07725L102 |
| ARGX | ARGENX SE | 500,000 | $175M | 4.8% | $198.97 | — | SPONSORED ADR | 04016X101 |
| XBI | SPDR SER TR | 1,000,000 | $112M | 3.0% | — | — | Call | 78464A870 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 650,000 | $110M | 3.0% | $97.14 | +91.3% | COM | 02043Q107 |
| SEER | SEER INC | 4,750,000 | $108M | 2.9% | $63.62 | -54.7% | COM CL A | 81578P106 |
| FATE | FATE THERAPEUTICS INC | 1,800,000 | $105M | 2.9% | $27.27 | +107.8% | COM | 31189P102 |
| — | SEAGEN INC | 500,000 | $77.3M | 2.1% | $166.00 | — | COM | 81181C104 |
| — | MORPHIC HLDG INC | 1,585,049 | $75.1M | 2.0% | $22.70 | — | COM | 61775R105 |
| FOLD | AMICUS THERAPEUTICS INC | 6,000,000 | $69.3M | 1.9% | $11.63 | -4.2% | COM | 03152W109 |
| — | BELLUS HEALTH INC NEW | 8,500,000 | $68.42M | 1.9% | $5.24 | — | COM NEW | 07987C204 |
| KYMR | KYMERA THERAPEUTICS INC | 1,000,000 | $63.49M | 1.7% | $51.28 | +13.6% | COM | 501575104 |
| BMY | BRISTOL-MYERS SQUIBB CO | 1,000,000 | $62.35M | 1.7% | — | — | Call | 110122108 |
| SRRK | SCHOLAR ROCK HLDG CORP | 2,450,000 | $60.86M | 1.7% | $20.06 | +37.6% | COM | 80706P103 |
| C | CITIGROUP INC | 1,000,000 | $60.39M | 1.6% | — | — | Call | 172967424 |
| — | SPRINGWORKS THERAPEUTICS INC | 850,000 | $52.68M | 1.4% | $54.96 | — | COM | 85205L107 |
| ERAS | ERASCA INC | 3,172,221 | $49.42M | 1.3% | $20.63 | -17.0% | COM | 29479A108 |
| KRYS | KRYSTAL BIOTECH INC | 700,000 | $48.97M | 1.3% | $56.38 | +3.2% | COM | 501147102 |
| — | CEREVEL THERAPEUTICS HLDNG I | 1,500,000 | $48.63M | 1.3% | $16.33 | — | COM | 15678U128 |
| CYTK | CYTOKINETICS INC | 1,000,000 | $45.58M | 1.2% | $27.15 | +42.1% | COM NEW | 23282W605 |
| — | IGM BIOSCIENCES INC | 1,500,000 | $43.99M | 1.2% | $72.54 | — | COM | 449585108 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,250,000 | $42.75M | 1.2% | $42.63 | -25.9% | COM | 74366E102 |
| — | SAGE THERAPEUTICS INC | 1,000,000 | $42.54M | 1.2% | $68.21 | — | COM | 78667J108 |
| NBP | I MAB | 850,000 | $40.28M | 1.1% | $36.36 | — | SPONSORED ADS | 44975P103 |
| FHTX | FOGHORN THERAPEUTICS INC | 1,720,720 | $39.35M | 1.1% | $19.16 | -25.0% | COM | 344174107 |
| — | RUBIUS THERAPEUTICS INC | 3,701,580 | $35.83M | 1.0% | $20.48 | — | COM | 78116T103 |
| NTLA | INTELLIA THERAPEUTICS INC | 275,000 | $32.52M | 0.9% | $33.42 | +274.8% | COM | 45826J105 |
| — | TALARIS THERAPEUTICS INC | 2,064,262 | $31.56M | 0.9% | $14.69 | — | COM | 87410C104 |
| — | ALLOVIR INC | 2,323,371 | $30.06M | 0.8% | $27.50 | — | COM | 019818103 |
| EVO | EVOTEC AG | 1,149,425 | $27.3M | 0.7% | $23.75 | — | SPONSORED ADS | 30050E105 |
| — | EQRX INC | 4,000,000 | $27.28M | 0.7% | $6.82 | — | COM | 26886C107 |
| DNLI | DENALI THERAPEUTICS INC | 600,000 | $26.76M | 0.7% | $31.47 | +50.6% | COM | 24823R105 |
| GOSS | GOSSAMER BIO INC | 2,358,968 | $26.68M | 0.7% | $17.62 | -32.6% | COM | 38341P102 |
| — | OMEGA THERAPEUTICS INC | 2,273,530 | $25.76M | 0.7% | $18.85 | — | COMMON STOCK | 68217N105 |
| — | ITEOS THERAPEUTICS INC | 544,047 | $25.33M | 0.7% | $24.67 | — | COM | 46565G104 |
| REPL | REPLIMUNE GROUP INC | 900,000 | $24.39M | 0.7% | $20.83 | +43.6% | COM | 76029N106 |
| SDGR | SCHRODINGER INC | 700,000 | $24.38M | 0.7% | $37.76 | +20.9% | COM | 80810D103 |
| — | PRAXIS PRECISION MEDICINES I | 1,200,000 | $23.64M | 0.6% | $41.24 | — | COM | 74006W108 |
| — | ATARA BIOTHERAPEUTICS INC | 1,500,000 | $23.64M | 0.6% | $17.77 | — | COM | 046513107 |
| RLAY | RELAY THERAPEUTICS INC | 750,000 | $23.03M | 0.6% | $35.08 | -9.9% | COM | 75943R102 |
| AUPH | AURINIA PHARMACEUTICALS INC | 1,000,000 | $22.87M | 0.6% | $17.08 | +38.7% | COM | 05156V102 |
| VRTX | VERTEX PHARMACEUTICALS INC | 100,000 | $21.96M | 0.6% | — | — | Call | 92532F100 |
| — | KRONOS BIO INC | 1,542,954 | $20.97M | 0.6% | $27.50 | — | COM | 50107A104 |
| — | AGENUS INC | 6,500,000 | $20.93M | 0.6% | $3.98 | — | COM NEW | 00847G705 |
| — | GENERATION BIO CO | 2,814,191 | $19.92M | 0.5% | $21.00 | — | COM | 37148K100 |
| — | AMBRX BIOPHARMA INC | 2,152,291 | $19.43M | 0.5% | $13.20 | — | SPONSORED ADS | 02290A102 |
| — | IKENA ONCOLOGY INC | 1,549,513 | $19.43M | 0.5% | $28.25 | — | COM | 45175G108 |
| NG | NOVAGOLD RES INC | 2,600,000 | $17.84M | 0.5% | $10.13 | -27.9% | COM NEW | 66987E206 |
| — | APTINYX INC | 6,116,493 | $16.33M | 0.4% | $2.87 | — | COM | 03836N103 |
| INTC | INTEL CORP | 300,000 | $15.45M | 0.4% | — | — | Call | 458140100 |
| TGTX | TG THERAPEUTICS INC | 800,000 | $15.2M | 0.4% | $12.64 | +105.4% | COM | 88322Q108 |
| — | REPARE THERAPEUTICS INC | 700,000 | $14.76M | 0.4% | $28.89 | — | COM | 760273102 |
| — | VERVE THERAPEUTICS INC | 400,000 | $14.75M | 0.4% | $60.25 | — | COM | 92539P101 |
| KURA | KURA ONCOLOGY INC | 1,050,000 | $14.7M | 0.4% | $18.14 | -10.7% | COM | 50127T109 |
| SQZB | SQZ BIOTECHNOLOGIES CO | 1,606,309 | $14.34M | 0.4% | $28.98 | — | COM | 78472W104 |
| — | FORMA THERAPEUTICS HLDGS INC | 1,000,000 | $14.22M | 0.4% | $31.46 | — | SHS | 34633R104 |
| — | ALBIREO PHARMA INC | 600,000 | $13.97M | 0.4% | $28.95 | — | COM | 01345P106 |
| — | SELECTA BIOSCIENCES INC | 4,000,000 | $13.04M | 0.4% | $3.52 | — | COM | 816212104 |
| — | LEAP THERAPEUTICS INC | 4,000,000 | $12.96M | 0.4% | $2.55 | — | COM | 52187K101 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,040,882 | $12.13M | 0.3% | $23.52 | -35.9% | COM SHS | 877619106 |
| — | OATLY GROUP AB | 1,500,000 | $11.94M | 0.3% | $24.46 | — | SPONSORED ADS | 67421J108 |
| — | TURNING POINT THERAPEUTICS I | 250,000 | $11.93M | 0.3% | $51.59 | — | COM | 90041T108 |
| — | MARINUS PHARMACEUTICALS INC | 1,000,000 | $11.88M | 0.3% | $14.99 | — | COM NEW | 56854Q200 |
| — | ACHILLES THERAPEUTICS PLC | 2,255,375 | $11.3M | 0.3% | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | EXSCIENTIA PLC | 550,000 | $10.87M | 0.3% | $19.76 | — | ADS | 30223G102 |
| ALXO | ALX ONCOLOGY HLDGS INC | 500,000 | $10.74M | 0.3% | $64.13 | -32.7% | COM | 00166B105 |
| — | SAGE THERAPEUTICS INC | 250,000 | $10.63M | 0.3% | $68.21 | — | Call | 78667J108 |
| — | SYROS PHARMACEUTICALS INC | 3,000,000 | $9.78M | 0.3% | $5.39 | — | COM | 87184Q107 |
| — | GRITSTONE BIO INC | 750,000 | $9.645M | 0.3% | $12.86 | — | COM | 39868T105 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 1,646,517 | $8.776M | 0.2% | $30.42 | -77.0% | COM | 09203E105 |
| — | GRAPHITE BIO INC | 700,000 | $8.701M | 0.2% | $30.73 | — | COM | 38870X104 |
| DSGN | DESIGN THERAPEUTICS INC | 400,000 | $8.564M | 0.2% | $31.14 | -44.9% | COM | 25056L103 |
| — | ALPINE IMMUNE SCIENCES INC | 593,030 | $8.213M | 0.2% | $8.79 | — | COM | 02083G100 |
| NBTX | NANOBIOTIX SA | 1,000,000 | $8.1M | 0.2% | $16.50 | — | SPONSORED ADS | 63009J107 |
| ADAG | ADAGENE INC | 1,000,000 | $8.068M | 0.2% | $17.07 | — | ADS | 005329107 |
| OVID | OVID THERAPEUTICS INC | 2,500,000 | $8.025M | 0.2% | $6.69 | -48.8% | COM | 690469101 |
| SPRO | SPERO THERAPEUTICS INC | 500,000 | $8.005M | 0.2% | $11.60 | +36.9% | COM | 84833T103 |
| — | INSTIL BIO INC | 450,000 | $7.7M | 0.2% | $25.08 | — | COM | 45783C101 |
| — | HARPOON THERAPEUTICS INC | 1,000,000 | $7.55M | 0.2% | $15.27 | — | COM | 41358P106 |
| — | MERSANA THERAPEUTICS INC | 1,200,000 | $7.464M | 0.2% | $23.14 | — | COM | 59045L106 |
| — | ZYMEWORKS INC | 450,000 | $7.376M | 0.2% | $43.78 | — | COM | 98985W102 |
| — | OMEGA ALPHA SPAC | 750,000 | $7.328M | 0.2% | $9.90 | — | CL A | G6749V107 |
| XLO | XILIO THERAPEUTICS INC | 450,000 | $7.2M | 0.2% | $17.03 | 0.0% | COM | 98422T100 |
| IMCR | IMMUNOCORE HLDGS PLC | 200,000 | $6.848M | 0.2% | $42.57 | — | ADS | 45258D105 |
| IMUX | IMMUNIC INC | 700,000 | $6.699M | 0.2% | $10.33 | -12.8% | COM | 4525EP101 |
| — | Y-MABS THERAPEUTICS INC | 400,000 | $6.484M | 0.2% | $24.99 | — | COM | 984241109 |
| — | VOR BIOPHARMA INC | 550,000 | $6.391M | 0.2% | $43.10 | — | COM | 929033108 |
| DYN | DYNE THERAPEUTICS INC | 525,000 | $6.242M | 0.2% | $20.85 | -32.6% | COM | 26818M108 |
| SANA | SANA BIOTECHNOLOGY INC | 400,000 | $6.192M | 0.2% | $32.56 | -40.8% | COM | 799566104 |
| — | CURIS INC | 1,300,000 | $6.188M | 0.2% | $3.14 | — | COM NEW | 231269200 |
| CRBU | CARIBOU BIOSCIENCES INC | 405,347 | $6.117M | 0.2% | $24.45 | -20.4% | COM | 142038108 |
| — | EVELO BIOSCIENCES INC | 1,000,000 | $6.07M | 0.2% | $8.26 | — | COM | 299734103 |
| STOK | STOKE THERAPEUTICS INC | 250,000 | $5.998M | 0.2% | $24.59 | -3.0% | COM | 86150R107 |
| RNAM | AVIDITY BIOSCIENCES INC | 250,000 | $5.943M | 0.2% | $26.70 | -10.6% | COM | 05370A108 |
| ORIC | ORIC PHARMACEUTICALS INC | 400,000 | $5.88M | 0.2% | $24.42 | -36.1% | COM | 68622P109 |
| — | NEXIMMUNE INC | 1,200,000 | $5.532M | 0.2% | $19.08 | — | COM | 65344D109 |
| — | LYELL IMMUNOPHARMA INC | 700,000 | $5.418M | 0.1% | $16.24 | — | COM | 55083R104 |
| — | ADVERUM BIOTECHNOLOGIES INC | 3,000,000 | $5.28M | 0.1% | $9.97 | — | COM | 00773U108 |
| — | SOLID BIOSCIENCES INC | 3,000,000 | $5.25M | 0.1% | $4.75 | — | COM | 83422E105 |
| MIR | MIRION TECHNOLOGIES INC | 500,000 | $5.235M | 0.1% | $10.74 | 0.0% | COM CL A | 60471A101 |
| — | AEGLEA BIOTHERAPEUTICS INC | 1,045,000 | $4.964M | 0.1% | $8.28 | — | COM | 00773J103 |
| ACIU | AC IMMUNE SA | 1,000,000 | $4.95M | 0.1% | $11.29 | -48.5% | SHS | H00263105 |
| — | DYNAMICS SPECIAL PURPOSE COR | 500,000 | $4.93M | 0.1% | $9.94 | — | CLASS A COM | 268010105 |
| — | CYCLERION THERAPEUTICS INC | 2,779,122 | $4.78M | 0.1% | $7.29 | — | COM | 23255M105 |
| GDS | GDS HLDGS LTD | 100,000 | $4.716M | 0.1% | $56.61 | — | SPONSORED ADS | 36165L108 |
| IQ | IQIYI INC | 1,000,000 | $4.56M | 0.1% | $17.33 | — | SPONSORED ADS | 46267X108 |
| CRDF | CARDIFF ONCOLOGY INC | 750,000 | $4.508M | 0.1% | $6.60 | -9.7% | COM | 14147L108 |
| — | 23ANDME HOLDING CO | 661,009 | $4.402M | 0.1% | $6.66 | — | CLASS A COM | 90138Q108 |
| BBIO | BRIDGEBIO PHARMA INC | 250,000 | $4.17M | 0.1% | $32.20 | +31.4% | COM | 10806X102 |
| — | CONTRAFECT CORP | 1,500,000 | $3.945M | 0.1% | $4.97 | — | COM NEW | 212326300 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 200,000 | $3.934M | 0.1% | $23.53 | 0.0% | COM | 71722W107 |
| CGEM | CULLINAN ONCOLOGY INC | 250,000 | $3.858M | 0.1% | $28.21 | -29.3% | COM | 230031106 |
| PFTA | PORTAGE FINTECH ACQUISITN CO | 380,000 | $3.781M | 0.1% | $10.00 | — | CLASS A ORD SHS | G7185D106 |
| — | APPLIED THERAPEUTICS INC | 400,000 | $3.58M | 0.1% | $20.66 | — | COM | 03828A101 |
| — | TCR2 THERAPEUTICS INC | 750,000 | $3.495M | 0.1% | $19.56 | — | COM | 87808K106 |
| RXRX | RECURSION PHARMACEUTICALS IN | 200,000 | $3.426M | 0.1% | $29.60 | -36.4% | CL A | 75629V104 |
| — | 111 INC | 966,349 | $3.382M | 0.1% | $9.49 | — | ADS | 68247Q102 |
| IMMP | IMMUTEP LTD | 1,000,000 | $3.28M | 0.1% | $3.87 | — | SPONSORED ADS | 45257L108 |
| WVE | WAVE LIFE SCIENCES LTD | 1,000,000 | $3.14M | 0.1% | $6.06 | -31.5% | SHS | Y95308105 |
| — | FUSION PHARMACEUTICALS INC | 750,000 | $3.128M | 0.1% | $9.98 | — | COM | 36118A100 |
| — | CHINOOK THERAPEUTICS INC | 180,500 | $2.944M | 0.1% | $15.86 | — | COM | 16961L106 |
| — | ARAVIVE INC | 1,311,291 | $2.872M | 0.1% | $11.29 | — | COM | 03890D108 |
| — | MEI PHARMA INC | 1,000,000 | $2.67M | 0.1% | $3.78 | — | COM NEW | 55279B202 |
| OLMA | OLEMA PHARMACEUTICALS INC | 260,500 | $2.438M | 0.1% | $46.89 | -55.8% | COM | 68062P106 |
| MREO | MEREO BIOPHARMA GROUP PLC | 1,500,000 | $2.4M | 0.1% | $3.37 | — | ADS | 589492107 |
| — | ORCHARD THERAPEUTICS PLC | 1,803,858 | $2.381M | 0.1% | $8.41 | — | ADS | 68570P101 |
| — | CODIAK BIOSCIENCES INC | 200,000 | $2.228M | 0.1% | $15.08 | — | COM | 192010106 |
| — | KINNATE BIOPHARMA INC | 125,000 | $2.215M | 0.1% | $39.78 | — | COM | 49705R105 |
| — | HIPPO HLDGS INC | 600,000 | $1.698M | 0.0% | $4.68 | — | COMMON STOCK | 433539103 |
| — | AMRYT PHARMA PLC | 150,480 | $1.625M | 0.0% | $12.05 | — | SPONSORED ADS | 03217L106 |
| — | AXCELLA HEALTH INC | 712,500 | $1.489M | 0.0% | $6.82 | — | COM | 05454B105 |
| — | HOOKIPA PHARMA INC | 599,616 | $1.397M | 0.0% | $8.34 | — | COM | 43906K100 |
| — | MINK THERAPEUTICS INC | 289,588 | $1.292M | 0.0% | $4.46 | — | COM | 603693102 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 110,532 | $1.289M | 0.0% | $13.01 | -5.7% | COM CL A | 46333X108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 500,000 | $1.205M | 0.0% | $2.96 | +31.0% | COM | 221015100 |
| KLDO | KALEIDO BIOSCIENCES INC | 500,500 | $1.196M | 0.0% | $13.76 | -70.4% | COM | 483347100 |
| — | LAVA THERAPEUTICS NV | 200,000 | $1.1M | 0.0% | $15.19 | — | SHS | N51517105 |
| — | DECIPHERA PHARMACEUTICALS IN | 100,000 | $977K | 0.0% | $38.91 | — | COM | 24344T101 |
| — | RIGEL PHARMACEUTICALS INC | 321,100 | $851K | 0.0% | $1.56 | — | COM NEW | 766559603 |
| — | SIGILON THERAPEUTICS INC | 276,000 | $762K | 0.0% | $48.03 | — | COM | 82657L107 |
| — | MARRONE BIO INNOVATIONS INC | 1,048,679 | $755K | 0.0% | $0.72 | — | COM | 57165B106 |
| RIVN | RIVIAN AUTOMOTIVE INC | 7,000 | $726K | 0.0% | $115.22 | 0.0% | COM CL A | 76954A103 |
| DLO | DLOCAL LTD | 20,000 | $714K | 0.0% | $41.22 | 0.0% | CLASS A COM | G29018101 |
| — | YUMANITY THERAPEUTICS INC | 217,391 | $643K | 0.0% | $17.00 | — | COM | 98872L102 |
| — | METACRINE INC | 924,898 | $624K | 0.0% | $10.21 | — | COM | 59101E103 |
| — | SURFACE ONCOLOGY INC | 100,000 | $478K | 0.0% | $9.24 | — | COM | 86877M209 |
| — | CIDARA THERAPEUTICS INC | 224,675 | $285K | 0.0% | $3.69 | — | COM | 171757107 |
| — | ASTRIA THERAPEUTICS INC | 33,333 | $180K | 0.0% | $8.85 | — | COM | 04635X102 |