Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q3 2019 (← Previous) (Next →)
Filing Date: Nov 14, 2019
Total Value: $14.7B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seattle Genetics, Inc. | 50,057,277 | $4.275B | 29.1% | $37.84 | — | COM | 812578102 |
| INCY | Incyte Corporation | 31,976,557 | $2.374B | 16.1% | $73.07 | +10.6% | COM | 45337C102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 40,854,586 | $1.47B | 10.0% | $18.28 | +65.9% | COM | 004225108 |
| ONC | BeiGene, Ltd. | 11,777,285 | $1.442B | 9.8% | $117.58 | — | SPONSORED ADR | 07725L102 |
| — | Alexion Pharmaceuticals, Inc. | 8,258,068 | $809M | 5.5% | $166.88 | — | COM | 015351109 |
| — | Amarin Corporation plc | 41,544,288 | $630M | 4.3% | $8.93 | — | SPONSORED ADR | 023111206 |
| — | Genomic Health, Inc. | 9,244,665 | $627M | 4.3% | $31.71 | — | COM | 37244C101 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,589,294 | $512M | 3.5% | $81.02 | -4.9% | COM | 09061G101 |
| ASND | Ascendis Pharma A/S | 3,390,270 | $327M | 2.2% | $44.21 | — | SPONSORED ADR | 04351P101 |
| — | Invitae Corporation | 8,792,678 | $169M | 1.2% | $17.11 | — | COM | 46185L103 |
| KOD | Kodiak Sciences Inc. | 9,145,116 | $132M | 0.9% | $8.85 | +47.5% | COM | 50015M109 |
| NBIX | Neurocrine Biosciences, Inc. | 1,415,283 | $128M | 0.9% | $62.87 | +48.6% | COM | 64125C109 |
| ARGX | argenx SE | 1,019,557 | $116M | 0.8% | $59.75 | — | SPONSORED ADR | 04016X101 |
| HRTX | Heron Therapeutics, Inc. | 6,018,104 | $111M | 0.8% | $17.78 | +3.5% | COM | 427746102 |
| — | Mirati Therapeutics, Inc. | 1,307,220 | $102M | 0.7% | $18.61 | — | COM | 60468T105 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,169,278 | $101M | 0.7% | $110.87 | -15.4% | COM | 558868105 |
| — | MyoKardia, Inc. | 1,517,237 | $79.12M | 0.5% | $49.57 | — | COM | 62857M105 |
| — | Spark Therapeutics, Inc. | 751,927 | $72.92M | 0.5% | $76.99 | — | COM | 84652J103 |
| — | Tricida, Inc. | 1,969,905 | $60.81M | 0.4% | $31.61 | — | COM | 89610F101 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 2,708,200 | $58.47M | 0.4% | $26.63 | -19.4% | COM | 76243J105 |
| — | IGM Biosciences, Inc. | 3,144,000 | $55.81M | 0.4% | $17.75 | — | COM | 449585108 |
| — | Ra Pharmaceuticals, Inc. | 2,345,496 | $55.47M | 0.4% | $24.19 | — | COM | 74933V108 |
| CERS | Cerus Corporation | 10,749,937 | $55.42M | 0.4% | $4.67 | +14.8% | COM | 157085101 |
| — | DBV Technologies S.A. | 5,509,560 | $47.38M | 0.3% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Principia Biopharma Inc. | 1,654,029 | $46.71M | 0.3% | $29.22 | — | COM | 74257L108 |
| — | Atreca, Inc. | 3,532,760 | $43.24M | 0.3% | $18.84 | — | CL A Common | 04965G109 |
| — | GW Pharmaceuticals plc | 370,845 | $42.66M | 0.3% | $132.99 | — | ADS | 36197T103 |
| — | Zymeworks Inc. | 1,708,472 | $42.37M | 0.3% | $14.76 | — | COM | 98985W102 |
| — | Audentes Therapeutics, Inc. | 1,506,438 | $42.32M | 0.3% | $31.63 | — | COM | 05070R104 |
| — | Neurocrine Biosciences, Inc. | 30,770,000 | $42.11M | 0.3% | $1.24 | — | NOTE 2.25% 5/15/2024 | 64125CAD1 |
| INSM | Insmed Incorporated | 2,229,760 | $39.33M | 0.3% | $21.96 | -12.1% | COM PAR $.01 | 457669307 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,725,472 | $36.46M | 0.2% | $6.96 | -55.3% | COM | 09058V103 |
| ADPT | Adaptive Biotechnologies Corporation | 1,165,411 | $36.01M | 0.2% | $44.30 | -7.9% | COM | 00650F109 |
| KRYS | Krystal Biotech, Inc. | 1,034,674 | $35.93M | 0.2% | $22.57 | +98.0% | COM | 501147102 |
| — | Neoleukin Therapeutics, Inc. | 11,305,679 | $32.22M | 0.2% | $2.85 | — | COM | 64049K104 |
| — | CymaBay Therapeutics, Inc. | 5,707,411 | $29.22M | 0.2% | $9.54 | — | COM | 23257D103 |
| — | Allakos Inc. | 339,690 | $26.71M | 0.2% | $78.63 | — | COM | 01671P100 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $23.82M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| — | Merus N.V. | 1,160,014 | $20.67M | 0.1% | $8.27 | — | COM | N5749R100 |
| QURE | uniQure N.V. | 517,700 | $20.38M | 0.1% | $18.33 | +214.7% | SHS | N90064101 |
| URGN | UroGen Pharma Ltd. | 747,751 | $17.82M | 0.1% | $32.69 | 0.0% | COM | M96088105 |
| AXSM | Axsome Therapeutics, Inc. | 772,286 | $15.63M | 0.1% | $9.29 | +176.7% | COM | 05464T104 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $14.72M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 | 09061GAH4 |
| XNCR | Xencor, Inc. | 428,120 | $14.44M | 0.1% | $11.07 | +260.8% | COM | 98401F105 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $14.11M | 0.1% | $16.20 | — | COM | 00900T107 |
| PTGX | Protagonist Therapeutics, Inc. | 1,174,282 | $14.1M | 0.1% | $10.52 | +19.7% | COM | 74366E102 |
| — | La Jolla Pharmaceutical Company | 1,559,231 | $13.72M | 0.1% | $10.60 | — | COM PAR $.0001 2 | 503459604 |
| — | Idera Pharmaceuticals, Inc. | 4,608,786 | $13.32M | 0.1% | $1.32 | — | COM PAR | 45168K405 |
| — | Aeglea BioTherapeutics, Inc. | 1,713,604 | $13.18M | 0.1% | $5.64 | — | COM | 00773J103 |
| ALKS | Alkermes plc | 625,030 | $12.19M | 0.1% | $29.95 | -27.3% | SHS | G01767105 |
| — | Syros Pharmaceuticals, Inc. | 974,835 | $10.12M | 0.1% | $13.72 | — | COM | 87184Q107 |
| SGMO | Sangamo Therapeutics, Inc. | 999,823 | $9.048M | 0.1% | $11.28 | -0.6% | COM | 800677106 |
| — | Assembly Biosciences, Inc. | 803,246 | $7.896M | 0.1% | $14.78 | — | COM | 045396108 |
| — | Marker Therapeutics, Inc. | 1,500,000 | $7.665M | 0.1% | $5.55 | — | COM | 57055L107 |
| APLS | Apellis Pharmaceuticals, Inc. | 313,725 | $7.558M | 0.1% | $20.26 | +35.9% | COM | 03753U106 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 1,341,902 | $7.125M | 0.0% | $2.70 | +97.2% | COM | 14888U101 |
| — | HOOKIPA Pharma Inc. | 892,857 | $6.696M | 0.0% | $6.73 | — | COM | 43906K100 |
| — | Acorda Therapeutics, Inc. | 2,232,589 | $6.408M | 0.0% | $7.93 | — | COM | 00484M106 |
| — | Dermira, Inc. | 906,943 | $5.795M | 0.0% | $13.55 | — | COM | 24983L104 |
| XBIT | Xbiotech Inc. | 521,327 | $5.453M | 0.0% | $7.37 | -4.7% | COM | 98400H102 |
| — | Albireo Pharma, Inc. | 250,000 | $5M | 0.0% | $22.99 | — | COM | 01345P106 |
| — | Aravive, Inc. | 664,088 | $4.981M | 0.0% | $4.94 | — | COM | 03890D108 |
| MIST | Milestone Pharmaceuticals Inc. | 266,667 | $4.973M | 0.0% | $20.62 | -4.4% | COM | 59935V107 |
| — | Orchard Therapeutics plc | 405,702 | $4.82M | 0.0% | $14.53 | — | ADS | 68570P101 |
| HALO | Halozyme Therapeutics, Inc. | 299,969 | $4.653M | 0.0% | $7.32 | +124.9% | COM | 40637H109 |
| — | NextCure, Inc. | 150,000 | $4.628M | 0.0% | $14.98 | — | COM | 65343E108 |
| IFRX | Inflarx N.V. | 1,778,415 | $4.393M | 0.0% | $2.91 | 0.0% | COM | N44821101 |
| ANAB | AnaptysBio, Inc. | 113,086 | $3.957M | 0.0% | $56.96 | -16.5% | COM | 032724106 |
| — | Achillion Pharmaceuticals, Inc. | 1,095,359 | $3.943M | 0.0% | $6.34 | — | COM | 00448Q201 |
| GLPG | Galapagos NV | 25,072 | $3.827M | 0.0% | $51.50 | — | SPONSORED ADR | 36315X101 |
| — | bluebird bio, Inc. | 40,000 | $3.673M | 0.0% | $41.25 | — | COM | 09609G100 |
| — | NGM Biopharmaceuticals, Inc. | 250,000 | $3.463M | 0.0% | $14.64 | — | COM | 62921N105 |
| MIRM | Mirum Pharmaceuticals, Inc. | 333,333 | $3.353M | 0.0% | $12.27 | 0.0% | COM | 604749101 |
| — | Acceleron Pharma Inc. | 83,900 | $3.315M | 0.0% | $37.72 | — | COM | 00434H108 |
| — | Menlo Therapeutics Inc. | 700,000 | $3.136M | 0.0% | $37.58 | — | COM | 586858102 |
| — | Harpoon Therapeutics, Inc. | 214,285 | $2.927M | 0.0% | $9.47 | — | COM | 41358P106 |
| VKTX | Viking Therapeutics, Inc. | 425,000 | $2.924M | 0.0% | $11.90 | -37.6% | COM | 92686J106 |
| — | Abeona Therapeutics Inc. | 1,288,235 | $2.911M | 0.0% | $7.28 | — | COM | 00289Y107 |
| — | G1 Therapeutics, Inc. | 127,236 | $2.898M | 0.0% | $37.05 | — | COM | 3621LQ109 |
| — | Dova Pharmaceuticals, Inc. | 102,205 | $2.857M | 0.0% | $14.48 | — | COM | 25985T102 |
| — | Bellicum Pharmaceuticals, Inc. | 2,677,818 | $2.812M | 0.0% | $22.31 | — | COM | 079481107 |
| — | Y-mAbs Therapeutics, Inc. | 102,800 | $2.679M | 0.0% | $26.56 | — | COM | 984241109 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 175,000 | $2.632M | 0.0% | $27.18 | -28.5% | COM | 22663K107 |
| — | Cyclerion Therapeutics, Inc. | 202,581 | $2.455M | 0.0% | $11.45 | — | COM | 23255M105 |
| — | Spring Bank Pharmaceuticals, Inc. | 613,144 | $2.109M | 0.0% | $10.97 | — | COM | 849431101 |
| AUTL | Autolus Therapeutics plc | 156,773 | $1.947M | 0.0% | $26.79 | — | SPON ADS | 05280R100 |
| IDYA | IDEAYA Biosciences, Inc. | 200,000 | $1.8M | 0.0% | $10.88 | -29.8% | COM | 45166A102 |
| NTLA | Intellia Therapeutics, Inc. | 128,538 | $1.716M | 0.0% | $26.35 | -39.5% | COM | 45826J105 |
| — | Molecular Templates, Inc. | 254,230 | $1.675M | 0.0% | $5.84 | — | COM | 608550109 |
| — | Forty Seven, Inc. | 250,000 | $1.605M | 0.0% | $16.00 | — | COM | 34983P104 |
| — | Foamix Pharmaceuticals Ltd. | 498,189 | $1.514M | 0.0% | $7.55 | — | SHS | M46135105 |
| CTMX | CytomX Therapeutics, Inc. | 194,377 | $1.435M | 0.0% | $14.78 | -33.3% | COM | 23284F105 |
| — | ChemoCentryx, Inc. | 207,029 | $1.404M | 0.0% | $13.66 | — | COM | 16383L106 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $1.299M | 0.0% | $9.20 | +2.6% | COM | 359664109 |
| — | Matinas BioPharma Holdings, Inc. | 1,984,965 | $1.252M | 0.0% | $0.63 | — | COM | 576810105 |
| — | Leap Therapeutics, Inc. | 978,454 | $1.145M | 0.0% | $1.17 | — | COM | 52187K101 |
| RCUS | Arcus Biosciences, Inc. | 121,534 | $1.106M | 0.0% | $15.69 | -48.8% | COM | 03969F109 |
| — | Galmed Pharmaceuticals Ltd. | 215,594 | $1.031M | 0.0% | $11.90 | — | SHS | M47238106 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $883K | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Constellation Pharmaceuticals, Inc. | 133,333 | $861K | 0.0% | $6.73 | — | COM | 210373106 |
| — | Sierra Oncology, Inc. | 2,000,000 | $781K | 0.0% | $1.32 | — | COM | 82640U107 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $598K | 0.0% | $1.54 | -11.3% | COM | 45665G303 |
| — | Affimed N.V. | 200,000 | $588K | 0.0% | $6.30 | — | COM | N01045108 |
| — | Evofem Biosciences, Inc. | 102,048 | $514K | 0.0% | $5.04 | — | COM | 30048L104 |
| — | Sunesis Pharmaceuticals, Inc. | 556,665 | $401K | 0.0% | $4.37 | — | COM | 867328700 |
| AQST | Aquestive Therapeutics, Inc. | 99,600 | $317K | 0.0% | $16.48 | -77.3% | COM | 03843E104 |
| — | Dynavax Technologies Corporation | 75,000 | $268K | 0.0% | $24.55 | — | COM | 268158201 |
| — | Trillium Therapeutics Inc. | 505,262 | $155K | 0.0% | $12.19 | — | COM | 89620X506 |
| — | Ritter Pharmaceuticals, Inc. | 279,999 | $87,000 | 0.0% | $2.72 | — | COM | 767836307 |