BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q4 2020 (← Previous) (Next →)

Filing Date: Feb 16, 2021

Total Value ($000): $26,543,637 (99.9% shares, 0.1% debt)

Holdings (126)

Seagen Inc. 31.2%
Value ($000) $8,278,767 Shares 47,269,424 Est. Cost $195.69 Unrealized
ONC BeiGene, Ltd. 11.4%
Value ($000) $3,015,126 Shares 11,668,897 Est. Cost $136.93 Unrealized
INCY Incyte Corporation 10.5%
Value ($000) $2,783,337 Shares 31,999,741 Est. Cost $73.07 Unrealized +18.4%
ACAD ACADIA Pharmaceuticals Inc. 8.4%
Value ($000) $2,240,219 Shares 41,904,586 Est. Cost $18.86 Unrealized +163.3%
KOD Kodiak Sciences Inc. 7.7%
Value ($000) $2,039,104 Shares 13,879,952 Est. Cost $28.18 Unrealized +295.6%
Alexion Pharmaceuticals, Inc. 5.2%
Value ($000) $1,368,786 Shares 8,760,794 Est. Cost $162.46 Unrealized
PRLD Prelude Therapeutics Incorporated 2.7%
Value ($000) $723,988 Shares 10,118,636 Est. Cost $28.24 Unrealized +76.1%
BMRN BioMarin Pharmaceutical Inc. 2.5%
Value ($000) $665,505 Shares 7,589,294 Est. Cost $81.02 Unrealized -2.2%
Invitae Corporation 2.5%
Value ($000) $654,292 Shares 15,649,182 Est. Cost $25.40 Unrealized
ASND Ascendis Pharma A/S 2.2%
Value ($000) $590,446 Shares 3,540,270 Est. Cost $48.88 Unrealized
ABCL AbCellera Biologics Inc. 1.6%
Value ($000) $420,515 Shares 10,450,180 Est. Cost $45.73 Unrealized 0.0%
Mirati Therapeutics, Inc. 1.2%
Value ($000) $309,645 Shares 1,409,784 Est. Cost $22.85 Unrealized
ARGX argenx SE 1.1%
Value ($000) $299,842 Shares 1,019,557 Est. Cost $59.75 Unrealized
IGM Biosciences, Inc. 1.0%
Value ($000) $277,663 Shares 3,144,892 Est. Cost $17.75 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 0.6%
Value ($000) $166,668 Shares 1,499,213 Est. Cost $104.81 Unrealized +16.6%
Amarin Corporation plc 0.5%
Value ($000) $136,880 Shares 27,991,761 Est. Cost $8.93 Unrealized
HRTX Heron Therapeutics, Inc. 0.5%
Value ($000) $126,878 Shares 5,994,704 Est. Cost $17.78 Unrealized -2.2%
KYMR Kymera Therapeutics, Inc. 0.5%
Value ($000) $121,471 Shares 1,959,211 Est. Cost $30.53 Unrealized +59.8%
Allakos Inc. 0.4%
Value ($000) $99,995 Shares 714,250 Est. Cost $62.02 Unrealized
CERS Cerus Corporation 0.4%
Value ($000) $94,895 Shares 13,713,195 Est. Cost $4.64 Unrealized +41.3%
BCRX BioCryst Pharmaceuticals, Inc. 0.4%
Value ($000) $94,584 Shares 12,695,818 Est. Cost $6.35 Unrealized -18.8%
PACB Pacific Biosciences of California, Inc. 0.3%
Value ($000) $83,059 Shares 3,201,972 Est. Cost $5.76 Unrealized +195.2%
Zymeworks Inc. 0.3%
Value ($000) $80,742 Shares 1,708,472 Est. Cost $14.76 Unrealized
INSM Insmed Incorporated 0.3%
Value ($000) $71,773 Shares 2,156,001 Est. Cost $22.18 Unrealized +64.7%
Forma Therapeutics Holdings, Inc. 0.3%
Value ($000) $70,668 Shares 2,024,876 Est. Cost $45.04 Unrealized
RYTM Rhythm Pharmaceuticals, Inc. 0.3%
Value ($000) $68,821 Shares 2,314,873 Est. Cost $26.63 Unrealized -4.6%
NBIX Neurocrine Biosciences, Inc. 0.2%
Value ($000) $64,888 Shares 676,975 Est. Cost $62.87 Unrealized +53.6%
AXSM Axsome Therapeutics, Inc. 0.2%
Value ($000) $63,452 Shares 778,834 Est. Cost $23.39 Unrealized +219.7%
RARE Ultragenyx Pharmaceutical Inc. 0.2%
Value ($000) $61,524 Shares 444,444 Est. Cost $118.63 Unrealized 0.0%
NRIX Nurix Therapeutics, Inc. 0.2%
Value ($000) $58,820 Shares 1,788,921 Est. Cost $25.20 Unrealized +31.5%
Atreca, Inc. 0.2%
Value ($000) $57,054 Shares 3,532,760 Est. Cost $18.84 Unrealized
Neoleukin Therapeutics, Inc. 0.2%
Value ($000) $53,887 Shares 3,821,740 Est. Cost $3.87 Unrealized
ADAPY Adaptimmune Therapeutics plc 0.2%
Value ($000) $52,988 Shares 9,830,877 Est. Cost $5.77 Unrealized
APLS Apellis Pharmaceuticals, Inc. 0.2%
Value ($000) $51,283 Shares 896,551 Est. Cost $28.57 Unrealized +48.1%
Kiniksa Pharmaceuticals, Ltd. 0.2%
Value ($000) $49,469 Shares 2,799,577 Est. Cost $17.35 Unrealized
ADCT ADC Therapeutics SA 0.2%
Value ($000) $45,394 Shares 1,418,107 Est. Cost $38.22 Unrealized -14.3%
Aligos Therapeutics, Inc. 0.2%
Value ($000) $44,517 Shares 1,610,000 Est. Cost $27.65 Unrealized
Horizon Therapeutics Public Ltd Co 0.2%
Value ($000) $43,825 Shares 599,110 Est. Cost $63.26 Unrealized
KRYS Krystal Biotech, Inc. 0.2%
Value ($000) $41,932 Shares 698,874 Est. Cost $22.57 Unrealized +121.2%
ChemoCentryx, Inc. 0.2%
Value ($000) $40,663 Shares 656,710 Est. Cost $35.60 Unrealized
Global Blood Therapeutics, Inc. 0.2%
Value ($000) $39,861 Shares 920,375 Est. Cost $54.93 Unrealized
DBV Technologies S.A. 0.1%
Value ($000) $38,289 Shares 14,614,264 Est. Cost $19.06 Unrealized
OPTEY Opthea Limited 0.1%
Value ($000) $37,107 Shares 3,308,705 Est. Cost $11.21 Unrealized
Merus N.V. 0.1%
Value ($000) $35,717 Shares 2,037,469 Est. Cost $10.77 Unrealized
ALKS Alkermes plc 0.1%
Value ($000) $30,626 Shares 1,535,149 Est. Cost $23.07 Unrealized -20.8%
Frequency Therapeutics, Inc. 0.1%
Value ($000) $30,200 Shares 856,507 Est. Cost $17.53 Unrealized
PTGX Protagonist Therapeutics, Inc. 0.1%
Value ($000) $28,954 Shares 1,436,192 Est. Cost $9.97 Unrealized +115.9%
BCAB BioAtla, Inc. 0.1%
Value ($000) $28,058 Shares 825,000 Est. Cost $33.43 Unrealized 0.0%
Reata Pharmaceuticals, Inc. 0.1%
Value ($000) $27,688 Shares 223,976 Est. Cost $138.99 Unrealized
Athira Pharma, Inc. 0.1%
Value ($000) $27,618 Shares 806,367 Est. Cost $18.46 Unrealized
Aeglea BioTherapeutics, Inc. 0.1%
Value ($000) $26,838 Shares 3,410,106 Est. Cost $7.84 Unrealized
FLGT Fulgent Genetics, Inc. 0.1%
Value ($000) $25,819 Shares 495,573 Est. Cost $11.30 Unrealized +269.9%
ADPT Adaptive Biotechnologies Corporation 0.1%
Value ($000) $22,451 Shares 379,682 Est. Cost $44.30 Unrealized +16.4%
Verastem, Inc. 0.1%
Value ($000) $21,607 Shares 10,144,039 Est. Cost $2.13 Unrealized
MREO Mereo BioPharma Group plc 0.1%
Value ($000) $21,588 Shares 6,030,293 Est. Cost $3.58 Unrealized
ALT Altimmune, Inc. 0.1%
Value ($000) $21,257 Shares 1,884,451 Est. Cost $6.15 Unrealized +91.7%
AUPH Aurinia Pharmaceuticals Inc. 0.1%
Value ($000) $19,501 Shares 1,410,064 Est. Cost $9.21 Unrealized +58.0%
IMTX Immatics N.V. 0.1%
Value ($000) $19,476 Shares 1,805,025 Est. Cost $10.54 Unrealized +0.1%
NVAX Novavax, Inc. 0.1%
Value ($000) $18,924 Shares 169,706 Est. Cost $38.25 Unrealized +177.9%
Idera Pharmaceuticals, Inc. 0.1%
Value ($000) $16,914 Shares 4,608,786 Est. Cost $1.32 Unrealized
Cymabay Therapeutics, Inc. 0.1%
Value ($000) $16,607 Shares 2,893,276 Est. Cost $5.48 Unrealized
Invitae Corporation 0.1%
Value ($000) $16,446 Shares 10,300,000 Est. Cost $1.64 Unrealized
XNCR Xencor, Inc. 0.1%
Value ($000) $16,116 Shares 369,370 Est. Cost $11.07 Unrealized +273.7%
BioMarin Pharmaceutical Inc. 0.1%
Value ($000) $16,033 Shares 15,000,000 Est. Cost $1.01 Unrealized
Albireo Pharma, Inc. 0.1%
Value ($000) $15,472 Shares 412,466 Est. Cost $24.96 Unrealized
SGMO Sangamo Therapeutics, Inc. 0.1%
Value ($000) $13,379 Shares 857,339 Est. Cost $11.28 Unrealized +3.8%
GW Pharmaceuticals plc 0.0%
Value ($000) $13,029 Shares 112,897 Est. Cost $132.99 Unrealized
Gamida Cell Ltd. 0.0%
Value ($000) $12,990 Shares 1,548,314 Est. Cost $6.83 Unrealized
Chinook Therapeutics, Inc. 0.0%
Value ($000) $11,874 Shares 748,693 Est. Cost $15.86 Unrealized
Five Prime Therapeutics, Inc. 0.0%
Value ($000) $11,363 Shares 668,000 Est. Cost $17.01 Unrealized
MIRM Mirum Pharmaceuticals, Inc. 0.0%
Value ($000) $11,302 Shares 647,313 Est. Cost $14.86 Unrealized +32.3%
SPRY Silverback Therapeutics, Inc. 0.0%
Value ($000) $11,033 Shares 238,095 Est. Cost $33.40 Unrealized 0.0%
XENE Xenon Pharmaceuticals Inc. 0.0%
Value ($000) $10,572 Shares 687,386 Est. Cost $12.73 Unrealized -8.1%
bluebird bio, Inc. 0.0%
Value ($000) $9,822 Shares 226,988 Est. Cost $58.05 Unrealized
IVERIC bio, Inc. 0.0%
Value ($000) $9,716 Shares 1,406,037 Est. Cost $3.89 Unrealized
Assembly Biosciences, Inc. 0.0%
Value ($000) $9,326 Shares 1,541,418 Est. Cost $17.50 Unrealized
ANAB AnaptysBio, Inc. 0.0%
Value ($000) $9,184 Shares 427,179 Est. Cost $26.06 Unrealized -6.8%
CRNX Crinetics Pharmaceuticals, Inc. 0.0%
Value ($000) $8,699 Shares 616,520 Est. Cost $18.19 Unrealized -23.4%
VXRT Vaxart, Inc. 0.0%
Value ($000) $7,987 Shares 1,398,795 Est. Cost $2.87 Unrealized +121.4%
CABA Cabaletta Bio, Inc. 0.0%
Value ($000) $7,942 Shares 636,363 Est. Cost $11.85 Unrealized +9.5%
HOOKIPA Pharma Inc. 0.0%
Value ($000) $7,768 Shares 700,481 Est. Cost $6.73 Unrealized
Syros Pharmaceuticals, Inc. 0.0%
Value ($000) $7,488 Shares 690,167 Est. Cost $13.72 Unrealized
DNLI Denali Therapeutics Inc. 0.0%
Value ($000) $7,433 Shares 88,738 Est. Cost $20.86 Unrealized +189.8%
Karuna Therapeutics, Inc. 0.0%
Value ($000) $7,108 Shares 69,966 Est. Cost $91.25 Unrealized
AUTL Autolus Therapeutics plc 0.0%
Value ($000) $6,993 Shares 782,183 Est. Cost $15.17 Unrealized
HRMY Harmony Biosciences Holdings, Inc. 0.0%
Value ($000) $6,507 Shares 180,000 Est. Cost $36.46 Unrealized +10.7%
Genetron Holdings Limited 0.0%
Value ($000) $6,374 Shares 455,306 Est. Cost $13.55 Unrealized
NTLA Intellia Therapeutics, Inc. 0.0%
Value ($000) $6,055 Shares 111,296 Est. Cost $26.35 Unrealized +37.8%
Passage Bio, Inc. 0.0%
Value ($000) $6,018 Shares 235,362 Est. Cost $15.75 Unrealized
REPL Replimune Group, Inc. 0.0%
Value ($000) $5,856 Shares 153,512 Est. Cost $22.66 Unrealized +83.9%
Iteos Therapeutics, Inc. 0.0%
Value ($000) $5,085 Shares 150,346 Est. Cost $24.67 Unrealized
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $4,834 Shares 199,671 Est. Cost $30.96 Unrealized -30.4%
Burning Rock Biotech Limited 0.0%
Value ($000) $4,831 Shares 209,131 Est. Cost $27.01 Unrealized
GOSS Gossamer Bio, Inc. 0.0%
Value ($000) $4,649 Shares 480,729 Est. Cost $9.85 Unrealized 0.0%
MGNX MacroGenics, Inc. 0.0%
Value ($000) $4,588 Shares 200,679 Est. Cost $23.02 Unrealized 0.0%
Tricida, Inc. 0.0%
Value ($000) $4,437 Shares 629,300 Est. Cost $7.05 Unrealized
IFRX Inflarx N.V. 0.0%
Value ($000) $4,307 Shares 856,228 Est. Cost $2.91 Unrealized +54.8%
ALEC Alector, Inc. 0.0%
Value ($000) $3,620 Shares 239,228 Est. Cost $25.49 Unrealized -51.2%
LogicBio Therapeutics, Inc. 0.0%
Value ($000) $3,445 Shares 451,478 Est. Cost $7.63 Unrealized
TCR2 Therapeutics Inc. 0.0%
Value ($000) $3,430 Shares 110,888 Est. Cost $20.32 Unrealized
Constellation Pharmaceuticals, Inc. 0.0%
Value ($000) $3,304 Shares 114,735 Est. Cost $6.73 Unrealized
LEGN Legend Biotech Corporation 0.0%
Value ($000) $3,256 Shares 115,626 Est. Cost $42.56 Unrealized
NGM Biopharmaceuticals, Inc. 0.0%
Value ($000) $3,230 Shares 106,616 Est. Cost $14.64 Unrealized
Chiasma, Inc. 0.0%
Value ($000) $3,228 Shares 742,133 Est. Cost $5.38 Unrealized
Akero Therapeutics, Inc. 0.0%
Value ($000) $3,054 Shares 118,378 Est. Cost $30.79 Unrealized
Acceleron Pharma Inc. 0.0%
Value ($000) $2,870 Shares 22,430 Est. Cost $89.85 Unrealized
Dicerna Pharmaceuticals, Inc. 0.0%
Value ($000) $2,250 Shares 102,121 Est. Cost $20.57 Unrealized
Inozyme Pharma, Inc. 0.0%
Value ($000) $2,208 Shares 106,999 Est. Cost $26.29 Unrealized
OVID Ovid Therapeutics Inc. 0.0%
Value ($000) $2,208 Shares 955,690 Est. Cost $4.86 Unrealized -4.0%
VKTX Viking Therapeutics, Inc. 0.0%
Value ($000) $2,049 Shares 363,980 Est. Cost $11.90 Unrealized -49.1%
RCUS Arcus Biosciences, Inc. 0.0%
Value ($000) $1,888 Shares 72,709 Est. Cost $15.69 Unrealized +54.3%
Orchard Therapeutics plc 0.0%
Value ($000) $1,436 Shares 332,502 Est. Cost $14.53 Unrealized
Leap Therapeutics, Inc. 0.0%
Value ($000) $1,259 Shares 559,705 Est. Cost $1.17 Unrealized
Molecular Templates, Inc. 0.0%
Value ($000) $1,257 Shares 133,833 Est. Cost $7.45 Unrealized
Oyster Point Pharma, Inc. 0.0%
Value ($000) $1,156 Shares 61,424 Est. Cost $28.88 Unrealized
INFIQ Infinity Pharmaceuticals, Inc. 0.0%
Value ($000) $1,107 Shares 522,360 Est. Cost $1.54 Unrealized +7.3%
GLPG Galapagos NV 0.0%
Value ($000) $1,107 Shares 11,180 Est. Cost $51.50 Unrealized
Evofem Biosciences, Inc. 0.0%
Value ($000) $991 Shares 411,396 Est. Cost $4.22 Unrealized
Affimed N.V. 0.0%
Value ($000) $958 Shares 164,605 Est. Cost $6.30 Unrealized
Bellicum Pharmaceuticals, Inc. 0.0%
Value ($000) $879 Shares 249,123 Est. Cost $4.71 Unrealized
Kezar Life Sciences, Inc. 0.0%
Value ($000) $729 Shares 139,676 Est. Cost $5.18 Unrealized
Adamas Pharmaceuticals, Inc. 0.0%
Value ($000) $641 Shares 147,996 Est. Cost $14.46 Unrealized
Galmed Pharmaceuticals Ltd. 0.0%
Value ($000) $575 Shares 184,927 Est. Cost $11.90 Unrealized
QURE uniQure N.V. 0.0%
Value ($000) $244 Shares 6,740 Est. Cost $18.33 Unrealized +130.1%
Sunesis Pharmaceuticals, Inc. 0.0%
Value ($000) $106 Shares 53,066 Est. Cost $2.00 Unrealized
GNFTY Genfit SA 0.0%
Value ($000) $71 Shares 14,720 Est. Cost $14.24 Unrealized