Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 16, 2021
Total Value: $26.54B (99.9% shares, 0.1% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 47,269,424 | $8.279B | 31.2% | $195.69 | — | COM | 81181C104 |
| ONC | BeiGene, Ltd. | 11,668,897 | $3.015B | 11.4% | $136.93 | — | SPONSORED ADR | 07725L102 |
| INCY | Incyte Corporation | 31,999,741 | $2.783B | 10.5% | $73.07 | +18.4% | COM | 45337C102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,904,586 | $2.24B | 8.4% | $18.86 | +163.3% | COM | 004225108 |
| KOD | Kodiak Sciences Inc. | 13,879,952 | $2.039B | 7.7% | $28.18 | +295.6% | COM | 50015M109 |
| — | Alexion Pharmaceuticals, Inc. | 8,760,794 | $1.369B | 5.2% | $162.46 | — | COM | 015351109 |
| PRLD | Prelude Therapeutics Incorporated | 10,118,636 | $724M | 2.7% | $28.24 | +76.1% | COM | 74065P101 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,589,294 | $666M | 2.5% | $81.02 | -2.2% | COM | 09061G101 |
| — | Invitae Corporation | 15,649,182 | $654M | 2.5% | $25.40 | — | COM | 46185L103 |
| ASND | Ascendis Pharma A/S | 3,540,270 | $590M | 2.2% | $48.88 | — | SPONSORED ADR | 04351P101 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $421M | 1.6% | $45.73 | 0.0% | COM | 00288U106 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $310M | 1.2% | $22.85 | — | COM | 60468T105 |
| ARGX | argenx SE | 1,019,557 | $300M | 1.1% | $59.75 | — | SPONSORED ADR | 04016X101 |
| — | IGM Biosciences, Inc. | 3,144,892 | $278M | 1.0% | $17.75 | — | COM | 449585108 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,499,213 | $167M | 0.6% | $104.81 | +16.6% | COM | 558868105 |
| — | Amarin Corporation plc | 27,991,761 | $137M | 0.5% | $8.93 | — | SPONSORED ADR | 023111206 |
| HRTX | Heron Therapeutics, Inc. | 5,994,704 | $127M | 0.5% | $17.78 | -2.2% | COM | 427746102 |
| KYMR | Kymera Therapeutics, Inc. | 1,959,211 | $121M | 0.5% | $30.53 | +59.8% | COM | 501575104 |
| — | Allakos Inc. | 714,250 | $100M | 0.4% | $62.02 | — | COM | 01671P100 |
| CERS | Cerus Corporation | 13,713,195 | $94.89M | 0.4% | $4.64 | +41.3% | COM | 157085101 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,695,818 | $94.58M | 0.4% | $6.35 | -18.8% | COM | 09058V103 |
| PACB | Pacific Biosciences of California, Inc. | 3,201,972 | $83.06M | 0.3% | $5.76 | +195.2% | COM | 69404D108 |
| — | Zymeworks Inc. | 1,708,472 | $80.74M | 0.3% | $14.76 | — | COM | 98985W102 |
| INSM | Insmed Incorporated | 2,156,001 | $71.77M | 0.3% | $22.18 | +64.7% | COM PAR $.01 | 457669307 |
| — | Forma Therapeutics Holdings, Inc. | 2,024,876 | $70.67M | 0.3% | $45.04 | — | SHS | 34633R104 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 2,314,873 | $68.82M | 0.3% | $26.63 | -4.6% | COM | 76243J105 |
| NBIX | Neurocrine Biosciences, Inc. | 676,975 | $64.89M | 0.2% | $62.87 | +53.6% | COM | 64125C109 |
| AXSM | Axsome Therapeutics, Inc. | 778,834 | $63.45M | 0.2% | $23.39 | +219.7% | COM | 05464T104 |
| RARE | Ultragenyx Pharmaceutical Inc. | 444,444 | $61.52M | 0.2% | $118.63 | 0.0% | COM | 90400D108 |
| NRIX | Nurix Therapeutics, Inc. | 1,788,921 | $58.82M | 0.2% | $25.20 | +31.5% | COM | 67080M103 |
| — | Atreca, Inc. | 3,532,760 | $57.05M | 0.2% | $18.84 | — | CL A COM | 04965G109 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $53.89M | 0.2% | $3.87 | — | COM | 64049K104 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $52.99M | 0.2% | $5.77 | — | SPONSORED ADR | 00653A107 |
| APLS | Apellis Pharmaceuticals, Inc. | 896,551 | $51.28M | 0.2% | $28.57 | +48.1% | COM | 03753U106 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $49.47M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| ADCT | ADC Therapeutics SA | 1,418,107 | $45.39M | 0.2% | $38.22 | -14.3% | SHS | H0036K147 |
| — | Aligos Therapeutics, Inc. | 1,610,000 | $44.52M | 0.2% | $27.65 | — | COM | 01626L105 |
| — | Horizon Therapeutics Public Ltd Co | 599,110 | $43.83M | 0.2% | $63.26 | — | SHS | G46188101 |
| KRYS | Krystal Biotech, Inc. | 698,874 | $41.93M | 0.2% | $22.57 | +121.2% | COM | 501147102 |
| — | ChemoCentryx, Inc. | 656,710 | $40.66M | 0.2% | $35.60 | — | COM | 16383L106 |
| — | Global Blood Therapeutics, Inc. | 920,375 | $39.86M | 0.2% | $54.93 | — | COM | 37890U108 |
| — | DBV Technologies S.A. | 14,614,264 | $38.29M | 0.1% | $19.06 | — | SPONSORED ADR | 23306J101 |
| OPTEY | Opthea Limited | 3,308,705 | $37.11M | 0.1% | $11.21 | — | SPONSORED ADS | 68386J208 |
| — | Merus N.V. | 2,037,469 | $35.72M | 0.1% | $10.77 | — | COM | N5749R100 |
| ALKS | Alkermes plc | 1,535,149 | $30.63M | 0.1% | $23.07 | -20.8% | SHS | G01767105 |
| — | Frequency Therapeutics, Inc. | 856,507 | $30.2M | 0.1% | $17.53 | — | COM | 35803L108 |
| PTGX | Protagonist Therapeutics, Inc. | 1,436,192 | $28.95M | 0.1% | $9.97 | +115.9% | COM | 74366E102 |
| BCAB | BioAtla, Inc. | 825,000 | $28.06M | 0.1% | $33.43 | 0.0% | COM | 09077B104 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $27.69M | 0.1% | $138.99 | — | CL A | 75615P103 |
| — | Athira Pharma, Inc. | 806,367 | $27.62M | 0.1% | $18.46 | — | COM | 04746L104 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $26.84M | 0.1% | $7.84 | — | COM | 00773J103 |
| FLGT | Fulgent Genetics, Inc. | 495,573 | $25.82M | 0.1% | $11.30 | +269.9% | COM | 359664109 |
| ADPT | Adaptive Biotechnologies Corporation | 379,682 | $22.45M | 0.1% | $44.30 | +16.4% | COM | 00650F109 |
| — | Verastem, Inc. | 10,144,039 | $21.61M | 0.1% | $2.13 | — | COM | 92337C104 |
| MREO | Mereo BioPharma Group plc | 6,030,293 | $21.59M | 0.1% | $3.58 | — | ADS | 589492107 |
| ALT | Altimmune, Inc. | 1,884,451 | $21.26M | 0.1% | $6.15 | +91.7% | COM | 02155H200 |
| AUPH | Aurinia Pharmaceuticals Inc. | 1,410,064 | $19.5M | 0.1% | $9.21 | +58.0% | COM | 05156V102 |
| IMTX | Immatics N.V. | 1,805,025 | $19.48M | 0.1% | $10.54 | +0.1% | SHS | N44445109 |
| NVAX | Novavax, Inc. | 169,706 | $18.92M | 0.1% | $38.25 | +177.9% | COM | 670002401 |
| — | Idera Pharmaceuticals, Inc. | 4,608,786 | $16.91M | 0.1% | $1.32 | — | COM PAR | 45168K405 |
| — | Cymabay Therapeutics, Inc. | 2,893,276 | $16.61M | 0.1% | $5.48 | — | COM | 23257D103 |
| — | Invitae Corporation | 10,300,000 | $16.45M | 0.1% | $1.64 | — | NOTE 2.0% 9/1/2024 | 46185LAB9 |
| XNCR | Xencor, Inc. | 369,370 | $16.12M | 0.1% | $11.07 | +273.7% | COM | 98401F105 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $16.03M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 | 09061GAH4 |
| — | Albireo Pharma, Inc. | 412,466 | $15.47M | 0.1% | $24.96 | — | COM | 01345P106 |
| SGMO | Sangamo Therapeutics, Inc. | 857,339 | $13.38M | 0.1% | $11.28 | +3.8% | COM | 800677106 |
| — | GW Pharmaceuticals plc | 112,897 | $13.03M | 0.0% | $132.99 | — | ADS | 36197T103 |
| — | Gamida Cell Ltd. | 1,548,314 | $12.99M | 0.0% | $6.83 | — | SHS | M47364100 |
| — | Chinook Therapeutics, Inc. | 748,693 | $11.87M | 0.0% | $15.86 | — | COM | 16961L106 |
| — | Five Prime Therapeutics, Inc. | 668,000 | $11.36M | 0.0% | $17.01 | — | COM | 33830X104 |
| MIRM | Mirum Pharmaceuticals, Inc. | 647,313 | $11.3M | 0.0% | $14.86 | +32.3% | COM | 604749101 |
| SPRY | Silverback Therapeutics, Inc. | 238,095 | $11.03M | 0.0% | $33.40 | 0.0% | COM | 82835W108 |
| XENE | Xenon Pharmaceuticals Inc. | 687,386 | $10.57M | 0.0% | $12.73 | -8.1% | COM | 98420N105 |
| — | bluebird bio, Inc. | 226,988 | $9.822M | 0.0% | $58.05 | — | COM | 09609G100 |
| — | IVERIC bio, Inc. | 1,406,037 | $9.716M | 0.0% | $3.89 | — | COM | 46583P102 |
| — | Assembly Biosciences, Inc. | 1,541,418 | $9.326M | 0.0% | $17.50 | — | COM | 045396108 |
| ANAB | AnaptysBio, Inc. | 427,179 | $9.184M | 0.0% | $26.06 | -6.8% | COM | 032724106 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 616,520 | $8.699M | 0.0% | $18.19 | -23.4% | COM | 22663K107 |
| VXRT | Vaxart, Inc. | 1,398,795 | $7.987M | 0.0% | $2.87 | +121.4% | COM | 92243A200 |
| CABA | Cabaletta Bio, Inc. | 636,363 | $7.942M | 0.0% | $11.85 | +9.5% | COM | 12674W109 |
| — | HOOKIPA Pharma Inc. | 700,481 | $7.768M | 0.0% | $6.73 | — | COM | 43906K100 |
| — | Syros Pharmaceuticals, Inc. | 690,167 | $7.488M | 0.0% | $13.72 | — | COM | 87184Q107 |
| DNLI | Denali Therapeutics Inc. | 88,738 | $7.433M | 0.0% | $20.86 | +189.8% | COM | 24823R105 |
| — | Karuna Therapeutics, Inc. | 69,966 | $7.108M | 0.0% | $91.25 | — | COM | 48576A100 |
| AUTL | Autolus Therapeutics plc | 782,183 | $6.993M | 0.0% | $15.17 | — | SPONSORED ADS | 05280R100 |
| HRMY | Harmony Biosciences Holdings, Inc. | 180,000 | $6.507M | 0.0% | $36.46 | +10.7% | COM | 413197104 |
| — | Genetron Holdings Limited | 455,306 | $6.374M | 0.0% | $13.55 | — | ADS | 37186H100 |
| NTLA | Intellia Therapeutics, Inc. | 111,296 | $6.055M | 0.0% | $26.35 | +37.8% | COM | 45826J105 |
| — | Passage Bio, Inc. | 235,362 | $6.018M | 0.0% | $15.75 | — | COM | 702712100 |
| REPL | Replimune Group, Inc. | 153,512 | $5.856M | 0.0% | $22.66 | +83.9% | COM | 76029N106 |
| — | Iteos Therapeutics, Inc. | 150,346 | $5.085M | 0.0% | $24.67 | — | COM | 46565G104 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $4.834M | 0.0% | $30.96 | -30.4% | COM STK | 74365U107 |
| — | Burning Rock Biotech Limited | 209,131 | $4.831M | 0.0% | $27.01 | — | SPONSORED ADS | 12233L107 |
| GOSS | Gossamer Bio, Inc. | 480,729 | $4.649M | 0.0% | $9.85 | 0.0% | COM | 38341P102 |
| MGNX | MacroGenics, Inc. | 200,679 | $4.588M | 0.0% | $23.02 | 0.0% | COM | 556099109 |
| — | Tricida, Inc. | 629,300 | $4.437M | 0.0% | $7.05 | — | COM | 89610F101 |
| IFRX | Inflarx N.V. | 856,228 | $4.307M | 0.0% | $2.91 | +54.8% | COM | N44821101 |
| ALEC | Alector, Inc. | 239,228 | $3.62M | 0.0% | $25.49 | -51.2% | COM | 014442107 |
| — | LogicBio Therapeutics, Inc. | 451,478 | $3.445M | 0.0% | $7.63 | — | COM | 54142F102 |
| — | TCR2 Therapeutics Inc. | 110,888 | $3.43M | 0.0% | $20.32 | — | COM | 87808K106 |
| — | Constellation Pharmaceuticals, Inc. | 114,735 | $3.304M | 0.0% | $6.73 | — | COM | 210373106 |
| LEGN | Legend Biotech Corporation | 115,626 | $3.256M | 0.0% | $42.56 | — | SPONSORED ADS | 52490G102 |
| — | NGM Biopharmaceuticals, Inc. | 106,616 | $3.23M | 0.0% | $14.64 | — | COM | 62921N105 |
| — | Chiasma, Inc. | 742,133 | $3.228M | 0.0% | $5.38 | — | COM | 16706W102 |
| — | Akero Therapeutics, Inc. | 118,378 | $3.054M | 0.0% | $30.79 | — | COM | 00973Y108 |
| — | Acceleron Pharma Inc. | 22,430 | $2.87M | 0.0% | $89.85 | — | COM | 00434H108 |
| — | Dicerna Pharmaceuticals, Inc. | 102,121 | $2.25M | 0.0% | $20.57 | — | COM | 253031108 |
| — | Inozyme Pharma, Inc. | 106,999 | $2.208M | 0.0% | $26.29 | — | COM | 45790W108 |
| OVID | Ovid Therapeutics Inc. | 955,690 | $2.208M | 0.0% | $4.86 | -4.0% | COM | 690469101 |
| VKTX | Viking Therapeutics, Inc. | 363,980 | $2.049M | 0.0% | $11.90 | -49.1% | COM | 92686J106 |
| RCUS | Arcus Biosciences, Inc. | 72,709 | $1.888M | 0.0% | $15.69 | +54.3% | COM | 03969F109 |
| — | Orchard Therapeutics plc | 332,502 | $1.436M | 0.0% | $14.53 | — | ADS | 68570P101 |
| — | Leap Therapeutics, Inc. | 559,705 | $1.259M | 0.0% | $1.17 | — | COM | 52187K101 |
| — | Molecular Templates, Inc. | 133,833 | $1.257M | 0.0% | $7.45 | — | COM | 608550109 |
| — | Oyster Point Pharma, Inc. | 61,424 | $1.156M | 0.0% | $28.88 | — | COM | 69242L106 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 522,360 | $1.107M | 0.0% | $1.54 | +7.3% | COM | 45665G303 |
| GLPG | Galapagos NV | 11,180 | $1.107M | 0.0% | $51.50 | — | SPONSORED ADR | 36315X101 |
| — | Evofem Biosciences, Inc. | 411,396 | $991K | 0.0% | $4.22 | — | COM | 30048L104 |
| — | Affimed N.V. | 164,605 | $958K | 0.0% | $6.30 | — | COM | N01045108 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $879K | 0.0% | $4.71 | — | COM | 079481404 |
| — | Kezar Life Sciences, Inc. | 139,676 | $729K | 0.0% | $5.18 | — | COM | 49372L100 |
| — | Adamas Pharmaceuticals, Inc. | 147,996 | $641K | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Galmed Pharmaceuticals Ltd. | 184,927 | $575K | 0.0% | $11.90 | — | SHS | M47238106 |
| QURE | uniQure N.V. | 6,740 | $244K | 0.0% | $18.33 | +130.1% | SHS | N90064101 |
| — | Sunesis Pharmaceuticals, Inc. | 53,066 | $106K | 0.0% | $2.00 | — | COM | 867328874 |
| GNFTY | Genfit SA | 14,720 | $71,000 | 0.0% | $14.24 | — | ADS | 372279109 |