BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value ($000): $9,361,492 (98.7% shares, 1.3% debt)

Holdings (95)

INCY Incyte Corporation 22.7%
Value ($000) $2,123,175 Shares 30,739,466 Est. Cost $72.80 Unrealized -2.1%
ONC BeiGene, Ltd. 18.8%
Value ($000) $1,760,634 Shares 9,531,880 Est. Cost $136.93 Unrealized
ACAD ACADIA Pharmaceuticals Inc. 8.4%
Value ($000) $786,810 Shares 42,877,916 Est. Cost $18.93 Unrealized -14.7%
MDGL Madrigal Pharmaceuticals, Inc. 6.5%
Value ($000) $609,299 Shares 1,974,590 Est. Cost $119.77 Unrealized +134.8%
SMMT Summit Therapeutics Inc. 4.7%
Value ($000) $435,862 Shares 24,424,865 Est. Cost $5.82 Unrealized +232.9%
RVMD Revolution Medicines, Inc. 3.7%
Value ($000) $347,163 Shares 7,936,972 Est. Cost $27.73 Unrealized +82.0%
INSM Insmed Incorporated 3.7%
Value ($000) $345,674 Shares 5,006,863 Est. Cost $47.27 Unrealized +52.4%
RYTM Rhythm Pharmaceuticals, Inc. 3.6%
Value ($000) $340,596 Shares 6,084,249 Est. Cost $23.49 Unrealized +135.2%
KYMR Kymera Therapeutics, Inc. 2.6%
Value ($000) $241,216 Shares 5,995,929 Est. Cost $28.14 Unrealized +60.5%
KOD Kodiak Sciences Inc. 1.8%
Value ($000) $172,239 Shares 17,310,490 Est. Cost $30.30 Unrealized -81.0%
EWTX Edgewise Therapeutics, Inc. 1.8%
Value ($000) $164,364 Shares 6,155,940 Est. Cost $14.27 Unrealized +123.1%
BCYC Bicycle Therapeutics plc 1.6%
Value ($000) $152,395 Shares 10,885,357 Est. Cost $20.78 Unrealized
REPL Replimune Group, Inc. 1.4%
Value ($000) $133,759 Shares 11,045,336 Est. Cost $14.45 Unrealized -15.9%
ALKS Alkermes plc 1.3%
Value ($000) $120,267 Shares 4,181,751 Est. Cost $24.53 Unrealized +17.2%
Insmed Incorporated 1.0%
Value ($000) $92,929 Shares 42,850,000 Est. Cost $2.11 Unrealized
TRDA Entrada Therapeutics, Inc. 0.9%
Value ($000) $84,130 Shares 4,865,819 Est. Cost $16.96 Unrealized
ABCL AbCellera Biologics Inc. 0.9%
Value ($000) $80,650 Shares 27,525,640 Est. Cost $21.02 Unrealized -86.8%
DNLI Denali Therapeutics Inc. 0.8%
Value ($000) $76,052 Shares 3,731,695 Est. Cost $23.78 Unrealized +7.7%
NRIX Nurix Therapeutics, Inc. 0.8%
Value ($000) $73,139 Shares 3,882,125 Est. Cost $22.27 Unrealized +2.9%
ARGX argenx SE 0.7%
Value ($000) $68,821 Shares 111,904 Est. Cost $79.01 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.7%
Value ($000) $66,307 Shares 1,576,114 Est. Cost $64.34 Unrealized -22.9%
KNSA Kiniksa Pharmaceuticals International, plc 0.6%
Value ($000) $55,746 Shares 2,818,323 Est. Cost $18.73 Unrealized +21.8%
IMTX Immatics N.V. 0.6%
Value ($000) $51,731 Shares 7,275,830 Est. Cost $10.61 Unrealized -19.0%
CRSP CRISPR Therapeutics AG 0.5%
Value ($000) $51,483 Shares 1,308,011 Est. Cost $50.03 Unrealized -5.6%
STOK Stoke Therapeutics, Inc. 0.5%
Value ($000) $51,111 Shares 4,633,838 Est. Cost $9.30 Unrealized +32.0%
IMCR Immunocore Holdings plc 0.5%
Value ($000) $44,702 Shares 1,515,318 Est. Cost $42.57 Unrealized
ROIV Roivant Sciences Ltd. 0.5%
Value ($000) $44,573 Shares 3,767,773 Est. Cost $9.71 Unrealized +21.7%
SERA Sera Prognostics, Inc. 0.5%
Value ($000) $44,236 Shares 5,434,399 Est. Cost $3.07 Unrealized +139.3%
IMVT Immunovant, Inc. 0.5%
Value ($000) $42,304 Shares 1,707,881 Est. Cost $27.44 Unrealized +3.4%
XENE Xenon Pharmaceuticals Inc. 0.4%
Value ($000) $38,952 Shares 993,679 Est. Cost $18.51 Unrealized +123.4%
CELC Celcuity Inc. 0.4%
Value ($000) $35,062 Shares 2,678,553 Est. Cost $14.28 Unrealized -1.2%
GLUE Monte Rosa Therapeutics, Inc. 0.4%
Value ($000) $34,118 Shares 4,916,095 Est. Cost $6.49 Unrealized +15.6%
Akero Therapeutics, Inc. 0.3%
Value ($000) $30,521 Shares 1,097,082 Est. Cost $32.79 Unrealized
CERS Cerus Corporation 0.3%
Value ($000) $29,995 Shares 19,477,339 Est. Cost $4.19 Unrealized -58.9%
Ionis Pharmaceuticals, Inc. 0.3%
Value ($000) $29,544 Shares 30,000,000 Est. Cost $0.98 Unrealized
GRAL GRAIL, Inc. 0.3%
Value ($000) $29,098 Shares 1,630,125 Est. Cost $16.26 Unrealized 0.0%
IDYA IDEAYA Biosciences, Inc. 0.3%
Value ($000) $27,297 Shares 1,062,123 Est. Cost $14.62 Unrealized +93.6%
KRYS Krystal Biotech, Inc. 0.3%
Value ($000) $26,622 Shares 169,934 Est. Cost $34.45 Unrealized +415.0%
CADL Candel Therapeutics, Inc. 0.3%
Value ($000) $25,884 Shares 2,981,983 Est. Cost $5.91 Unrealized 0.0%
PRAX Praxis Precision Medicines, Inc. 0.3%
Value ($000) $25,515 Shares 331,533 Est. Cost $50.85 Unrealized +42.3%
IGM Biosciences, Inc. 0.3%
Value ($000) $25,016 Shares 4,094,304 Est. Cost $15.73 Unrealized
CNTA Centessa Pharmaceuticals plc 0.2%
Value ($000) $20,555 Shares 1,227,178 Est. Cost $12.88 Unrealized
Merus N.V. 0.2%
Value ($000) $18,923 Shares 450,000 Est. Cost $53.46 Unrealized
DYN Dyne Therapeutics, Inc. 0.2%
Value ($000) $15,835 Shares 672,096 Est. Cost $26.33 Unrealized +12.4%
NGNE Neurogene Inc. 0.2%
Value ($000) $15,418 Shares 674,450 Est. Cost $21.73 Unrealized +71.2%
XNCR Xencor, Inc. 0.2%
Value ($000) $15,407 Shares 670,431 Est. Cost $21.77 Unrealized +5.5%
BCAX Bicara Therapeutics Inc. 0.2%
Value ($000) $14,517 Shares 833,333 Est. Cost $25.50 Unrealized -18.4%
PRLD Prelude Therapeutics Inc. 0.1%
Value ($000) $12,908 Shares 10,123,824 Est. Cost $28.24 Unrealized -95.3%
IONS Ionis Pharmaceuticals, Inc. 0.1%
Value ($000) $12,513 Shares 357,915 Est. Cost $43.09 Unrealized -13.3%
ALMS Alumis Inc. 0.1%
Value ($000) $12,281 Shares 1,562,500 Est. Cost $13.30 Unrealized -24.6%
NMRA Neumora Therapeutics, Inc. 0.1%
Value ($000) $10,967 Shares 1,034,600 Est. Cost $13.91 Unrealized -13.9%
DSGN Design Therapeutics, Inc. 0.1%
Value ($000) $10,759 Shares 1,743,725 Est. Cost $12.06 Unrealized -52.0%
GPCR Structure Therapeutics Inc. 0.1%
Value ($000) $9,806 Shares 361,565 Est. Cost $31.09 Unrealized
Verve Therapeutics, Inc. 0.1%
Value ($000) $9,540 Shares 1,691,530 Est. Cost $52.72 Unrealized
OPTEY Opthea Limited 0.1%
Value ($000) $8,537 Shares 2,173,622 Est. Cost $11.12 Unrealized
TCRX TScan Therapeutics, Inc. 0.1%
Value ($000) $8,466 Shares 2,784,792 Est. Cost $6.08 Unrealized -25.5%
KALA KALA BIO, Inc. 0.1%
Value ($000) $8,341 Shares 1,201,894 Est. Cost $7.72 Unrealized -18.3%
VIR Vir Biotechnology, Inc. 0.1%
Value ($000) $7,961 Shares 1,084,539 Est. Cost $7.89 Unrealized 0.0%
MIRM Mirum Pharmaceuticals, Inc. 0.1%
Value ($000) $7,876 Shares 190,476 Est. Cost $27.38 Unrealized +52.2%
ARVN Arvinas, Inc. 0.1%
Value ($000) $7,775 Shares 405,576 Est. Cost $26.11 Unrealized -7.0%
NTLA Intellia Therapeutics, Inc. 0.1%
Value ($000) $7,510 Shares 644,116 Est. Cost $15.61 Unrealized 0.0%
2seventy bio, Inc. 0.1%
Value ($000) $7,343 Shares 2,497,526 Est. Cost $18.72 Unrealized
TSHA Taysha Gene Therapies, Inc. 0.1%
Value ($000) $6,928 Shares 4,004,756 Est. Cost $1.91 Unrealized +8.3%
CLDX Celldex Therapeutics, Inc. 0.1%
Value ($000) $6,258 Shares 247,644 Est. Cost $29.41 Unrealized -7.6%
BMEA Biomea Fusion, Inc. 0.1%
Value ($000) $5,634 Shares 1,451,990 Est. Cost $8.56 Unrealized -7.0%
FATE Fate Therapeutics, Inc. 0.1%
Value ($000) $5,376 Shares 3,258,402 Est. Cost $5.24 Unrealized -51.9%
BNTX BioNTech SE 0.1%
Value ($000) $5,131 Shares 45,031 Est. Cost $113.95 Unrealized
IRON Disc Medicine, Inc. 0.1%
Value ($000) $4,885 Shares 77,050 Est. Cost $57.84 Unrealized 0.0%
RLAY Relay Therapeutics, Inc. 0.1%
Value ($000) $4,780 Shares 1,160,117 Est. Cost $13.78 Unrealized -60.5%
CTNM Contineum Therapeutics, Inc. 0.0%
Value ($000) $4,578 Shares 312,500 Est. Cost $16.10 Unrealized -1.7%
DBVT DBV Technologies S.A. 0.0%
Value ($000) $4,516 Shares 1,461,425 Est. Cost $3.09 Unrealized
SGMT Sagimet Biosciences Inc. 0.0%
Value ($000) $4,288 Shares 952,996 Est. Cost $9.53 Unrealized -46.8%
WVE Wave Life Sciences Ltd. 0.0%
Value ($000) $4,256 Shares 344,063 Est. Cost $5.98 Unrealized +123.3%
SKYE Skye Bioscience, Inc. 0.0%
Value ($000) $4,105 Shares 1,450,638 Est. Cost $7.74 Unrealized -46.0%
PCVX Vaxcyte, Inc. 0.0%
Value ($000) $4,002 Shares 48,885 Est. Cost $39.24 Unrealized +153.0%
SANA Sana Biotechnology, Inc. 0.0%
Value ($000) $3,881 Shares 2,380,949 Est. Cost $4.55 Unrealized -34.5%
CYPH Leap Therapeutics, Inc. 0.0%
Value ($000) $3,370 Shares 1,172,175 Est. Cost $5.02 Unrealized -40.8%
ALGS Aligos Therapeutics, Inc. 0.0%
Value ($000) $3,309 Shares 83,055 Est. Cost $12.44 Unrealized +55.4%
PRME Prime Medicine, Inc. 0.0%
Value ($000) $3,003 Shares 1,028,466 Est. Cost $18.06 Unrealized -80.6%
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $2,834 Shares 536,832 Est. Cost $13.35 Unrealized -75.8%
ELVN Enliven Therapeutics, Inc. 0.0%
Value ($000) $2,584 Shares 114,833 Est. Cost $15.34 Unrealized +69.0%
ARCT Arcturus Therapeutics Holdings Inc. 0.0%
Value ($000) $2,568 Shares 151,329 Est. Cost $30.32 Unrealized -37.9%
CMPX Compass Therapeutics, Inc. 0.0%
Value ($000) $2,259 Shares 1,557,630 Est. Cost $3.99 Unrealized -58.4%
Generation Bio Co. 0.0%
Value ($000) $2,062 Shares 1,944,945 Est. Cost $2.93 Unrealized
HOOK HOOKIPA Pharma Inc. 0.0%
Value ($000) $1,634 Shares 812,814 Est. Cost $7.93 Unrealized -61.0%
Mersana Therapeutics, Inc. 0.0%
Value ($000) $1,553 Shares 1,086,115 Est. Cost $4.11 Unrealized
VTVT vTv Therapeutics, Inc. 0.0%
Value ($000) $1,344 Shares 97,314 Est. Cost $12.72 Unrealized +16.2%
RCKT Rocket Pharmaceuticals, Inc. 0.0%
Value ($000) $1,220 Shares 97,079 Est. Cost $15.05 Unrealized 0.0%
PTCT PTC Therapeutics, Inc. 0.0%
Value ($000) $921 Shares 20,400 Est. Cost $42.80 Unrealized 0.0%
IPSC Century Therapeutics, Inc. 0.0%
Value ($000) $805 Shares 797,460 Est. Cost $9.79 Unrealized -86.1%
PMVP PMV Pharmaceuticals, Inc. 0.0%
Value ($000) $486 Shares 322,024 Est. Cost $14.45 Unrealized -89.0%
ACRV Acrivon Therapeutics, Inc. 0.0%
Value ($000) $318 Shares 52,885 Est. Cost $4.64 Unrealized +56.6%
FHTX Foghorn Therapeutics Inc. 0.0%
Value ($000) $213 Shares 45,027 Est. Cost $14.37 Unrealized -49.3%
TYRA Tyra Biosciences, Inc. 0.0%
Value ($000) $147 Shares 10,607 Est. Cost $12.95 Unrealized +40.2%
SRZNW Surrozen, Inc. 0.0%
Value ($000) $18 Shares 833,333 Est. Cost $1.14 Unrealized