Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2024 (← Previous) (Next →)
Filing Date: Feb 14, 2025
Total Value: $9.361B (98.7% shares, 1.3% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 30,739,466 | $2.123B | 22.7% | $72.80 | -2.1% | COM | 45337C102 |
| ONC | BeiGene, Ltd. | 9,531,880 | $1.761B | 18.8% | $136.93 | — | SPONSORED ADR | 07725L102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 42,877,916 | $787M | 8.4% | $18.93 | -14.7% | COM | 004225108 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,974,590 | $609M | 6.5% | $119.77 | +134.8% | COM | 558868105 |
| SMMT | Summit Therapeutics Inc. | 24,424,865 | $436M | 4.7% | $5.82 | +232.9% | COM | 86627T108 |
| RVMD | Revolution Medicines, Inc. | 7,936,972 | $347M | 3.7% | $27.73 | +82.0% | COM | 76155X100 |
| INSM | Insmed Incorporated | 5,006,863 | $346M | 3.7% | $47.27 | +52.4% | COM PAR $.01 | 457669307 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 6,084,249 | $341M | 3.6% | $23.49 | +135.2% | COM | 76243J105 |
| KYMR | Kymera Therapeutics, Inc. | 5,995,929 | $241M | 2.6% | $28.14 | +60.5% | COM | 501575104 |
| KOD | Kodiak Sciences Inc. | 17,310,490 | $172M | 1.8% | $30.30 | -81.0% | COM | 50015M109 |
| EWTX | Edgewise Therapeutics, Inc. | 6,155,940 | $164M | 1.8% | $14.27 | +123.1% | COM | 28036F105 |
| BCYC | Bicycle Therapeutics plc | 10,885,357 | $152M | 1.6% | $20.78 | — | SPONSORED ADS | 088786108 |
| REPL | Replimune Group, Inc. | 11,045,336 | $134M | 1.4% | $14.45 | -15.9% | COM | 76029N106 |
| ALKS | Alkermes plc | 4,181,751 | $120M | 1.3% | $24.53 | +17.2% | SHS | G01767105 |
| — | Insmed Incorporated | 42,850,000 | $92.93M | 1.0% | $2.11 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| TRDA | Entrada Therapeutics, Inc. | 4,865,819 | $84.13M | 0.9% | $16.96 | — | COM | 29384C108 |
| ABCL | AbCellera Biologics Inc. | 27,525,640 | $80.65M | 0.9% | $21.02 | -86.8% | COM | 00288U106 |
| DNLI | Denali Therapeutics Inc. | 3,731,695 | $76.05M | 0.8% | $23.78 | +7.7% | COM | 24823R105 |
| NRIX | Nurix Therapeutics, Inc. | 3,882,125 | $73.14M | 0.8% | $22.27 | +2.9% | COM | 67080M103 |
| ARGX | argenx SE | 111,904 | $68.82M | 0.7% | $79.01 | — | SPONSORED ADR | 04016X101 |
| RARE | Ultragenyx Pharmaceutical Inc. | 1,576,114 | $66.31M | 0.7% | $64.34 | -22.9% | COM | 90400D108 |
| KNSA | Kiniksa Pharmaceuticals International, plc | 2,818,323 | $55.75M | 0.6% | $18.73 | +21.8% | ORD SHS CL A | G52694109 |
| IMTX | Immatics N.V. | 7,275,830 | $51.73M | 0.6% | $10.61 | -19.0% | SHS | N44445109 |
| CRSP | CRISPR Therapeutics AG | 1,308,011 | $51.48M | 0.5% | $50.03 | -5.6% | NAMEN AKT | H17182108 |
| STOK | Stoke Therapeutics, Inc. | 4,633,838 | $51.11M | 0.5% | $9.30 | +32.0% | COM | 86150R107 |
| IMCR | Immunocore Holdings plc | 1,515,318 | $44.7M | 0.5% | $42.57 | — | ADS | 45258D105 |
| ROIV | Roivant Sciences Ltd. | 3,767,773 | $44.57M | 0.5% | $9.71 | +21.7% | SHS | G76279101 |
| SERA | Sera Prognostics, Inc. | 5,434,399 | $44.24M | 0.5% | $3.07 | +139.3% | CLASS A COM | 81749D107 |
| IMVT | Immunovant, Inc. | 1,707,881 | $42.3M | 0.5% | $27.44 | +3.4% | COM | 45258J102 |
| XENE | Xenon Pharmaceuticals Inc. | 993,679 | $38.95M | 0.4% | $18.51 | +123.4% | COM | 98420N105 |
| CELC | Celcuity Inc. | 2,678,553 | $35.06M | 0.4% | $14.28 | -1.2% | COM | 15102K100 |
| GLUE | Monte Rosa Therapeutics, Inc. | 4,916,095 | $34.12M | 0.4% | $6.49 | +15.6% | COM | 61225M102 |
| — | Akero Therapeutics, Inc. | 1,097,082 | $30.52M | 0.3% | $32.79 | — | COM | 00973Y108 |
| CERS | Cerus Corporation | 19,477,339 | $30M | 0.3% | $4.19 | -58.9% | COM | 157085101 |
| — | Ionis Pharmaceuticals, Inc. | 30,000,000 | $29.54M | 0.3% | $0.98 | — | Note 1.75% 6/15/2028 | 462222AF7 |
| GRAL | GRAIL, Inc. | 1,630,125 | $29.1M | 0.3% | $16.26 | 0.0% | COM | 384747101 |
| IDYA | IDEAYA Biosciences, Inc. | 1,062,123 | $27.3M | 0.3% | $14.62 | +93.6% | COM | 45166A102 |
| KRYS | Krystal Biotech, Inc. | 169,934 | $26.62M | 0.3% | $34.45 | +415.0% | COM | 501147102 |
| CADL | Candel Therapeutics, Inc. | 2,981,983 | $25.88M | 0.3% | $5.91 | 0.0% | COM | 137404109 |
| PRAX | Praxis Precision Medicines, Inc. | 331,533 | $25.51M | 0.3% | $50.85 | +42.3% | COM | 74006W207 |
| — | IGM Biosciences, Inc. | 4,094,304 | $25.02M | 0.3% | $15.73 | — | COM | 449585108 |
| CNTA | Centessa Pharmaceuticals plc | 1,227,178 | $20.56M | 0.2% | $12.88 | — | SPONSORED ADS | 152309100 |
| — | Merus N.V. | 450,000 | $18.92M | 0.2% | $53.46 | — | COM | N5749R100 |
| DYN | Dyne Therapeutics, Inc. | 672,096 | $15.83M | 0.2% | $26.33 | +12.4% | COM | 26818M108 |
| NGNE | Neurogene Inc. | 674,450 | $15.42M | 0.2% | $21.73 | +71.2% | COM | 64135M105 |
| XNCR | Xencor, Inc. | 670,431 | $15.41M | 0.2% | $21.77 | +5.5% | COM | 98401F105 |
| BCAX | Bicara Therapeutics Inc. | 833,333 | $14.52M | 0.2% | $25.50 | -18.4% | COM | 055477103 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $12.91M | 0.1% | $28.24 | -95.3% | COM | 74065P101 |
| IONS | Ionis Pharmaceuticals, Inc. | 357,915 | $12.51M | 0.1% | $43.09 | -13.3% | COM | 462222100 |
| ALMS | Alumis Inc. | 1,562,500 | $12.28M | 0.1% | $13.30 | -24.6% | COM | 022307102 |
| NMRA | Neumora Therapeutics, Inc. | 1,034,600 | $10.97M | 0.1% | $13.91 | -13.9% | COM | 640979100 |
| DSGN | Design Therapeutics, Inc. | 1,743,725 | $10.76M | 0.1% | $12.06 | -52.0% | COM | 25056L103 |
| GPCR | Structure Therapeutics Inc. | 361,565 | $9.806M | 0.1% | $31.09 | — | SPONSORED ADS | 86366E106 |
| — | Verve Therapeutics, Inc. | 1,691,530 | $9.54M | 0.1% | $52.72 | — | COM | 92539P101 |
| OPTEY | Opthea Limited | 2,173,622 | $8.537M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| TCRX | TScan Therapeutics, Inc. | 2,784,792 | $8.466M | 0.1% | $6.08 | -25.5% | COM | 89854M101 |
| KALA | KALA BIO, Inc. | 1,201,894 | $8.341M | 0.1% | $7.72 | -18.3% | COM | 483119202 |
| VIR | Vir Biotechnology, Inc. | 1,084,539 | $7.961M | 0.1% | $7.89 | 0.0% | COM | 92764N102 |
| MIRM | Mirum Pharmaceuticals, Inc. | 190,476 | $7.876M | 0.1% | $27.38 | +52.2% | COM | 604749101 |
| ARVN | Arvinas, Inc. | 405,576 | $7.775M | 0.1% | $26.11 | -7.0% | COM | 04335A105 |
| NTLA | Intellia Therapeutics, Inc. | 644,116 | $7.51M | 0.1% | $15.61 | 0.0% | COM | 45826J105 |
| — | 2seventy bio, Inc. | 2,497,526 | $7.343M | 0.1% | $18.72 | — | COMMON STOCK | 901384107 |
| TSHA | Taysha Gene Therapies, Inc. | 4,004,756 | $6.928M | 0.1% | $1.91 | +8.3% | COM SHS | 877619106 |
| CLDX | Celldex Therapeutics, Inc. | 247,644 | $6.258M | 0.1% | $29.41 | -7.6% | COM | 15117B202 |
| BMEA | Biomea Fusion, Inc. | 1,451,990 | $5.634M | 0.1% | $8.56 | -7.0% | COM | 09077A106 |
| FATE | Fate Therapeutics, Inc. | 3,258,402 | $5.376M | 0.1% | $5.24 | -51.9% | COM | 31189P102 |
| BNTX | BioNTech SE | 45,031 | $5.131M | 0.1% | $113.95 | — | SPONSORED ADS | 09075V102 |
| IRON | Disc Medicine, Inc. | 77,050 | $4.885M | 0.1% | $57.84 | 0.0% | COM | 254604101 |
| RLAY | Relay Therapeutics, Inc. | 1,160,117 | $4.78M | 0.1% | $13.78 | -60.5% | COM | 75943R102 |
| CTNM | Contineum Therapeutics, Inc. | 312,500 | $4.578M | 0.0% | $16.10 | -1.7% | CL A | 21217B100 |
| DBVT | DBV Technologies S.A. | 1,461,425 | $4.516M | 0.0% | $3.09 | — | SPONSORED ADS | 23306J309 |
| SGMT | Sagimet Biosciences Inc. | 952,996 | $4.288M | 0.0% | $9.53 | -46.8% | COM SER A | 786700104 |
| WVE | Wave Life Sciences Ltd. | 344,063 | $4.256M | 0.0% | $5.98 | +123.3% | SHS | Y95308105 |
| SKYE | Skye Bioscience, Inc. | 1,450,638 | $4.105M | 0.0% | $7.74 | -46.0% | COM | 83086J200 |
| PCVX | Vaxcyte, Inc. | 48,885 | $4.002M | 0.0% | $39.24 | +153.0% | COM | 92243G108 |
| SANA | Sana Biotechnology, Inc. | 2,380,949 | $3.881M | 0.0% | $4.55 | -34.5% | COM | 799566104 |
| CYPH | Leap Therapeutics, Inc. | 1,172,175 | $3.37M | 0.0% | $5.02 | -40.8% | COM | 52187K200 |
| ALGS | Aligos Therapeutics, Inc. | 83,055 | $3.309M | 0.0% | $12.44 | +55.4% | COM | 01626L204 |
| PRME | Prime Medicine, Inc. | 1,028,466 | $3.003M | 0.0% | $18.06 | -80.6% | COM | 74168J101 |
| TARA | Protara Therapeutics, Inc. | 536,832 | $2.834M | 0.0% | $13.35 | -75.8% | COM STK | 74365U107 |
| ELVN | Enliven Therapeutics, Inc. | 114,833 | $2.584M | 0.0% | $15.34 | +69.0% | COM | 29337E102 |
| ARCT | Arcturus Therapeutics Holdings Inc. | 151,329 | $2.568M | 0.0% | $30.32 | -37.9% | COM | 03969T109 |
| CMPX | Compass Therapeutics, Inc. | 1,557,630 | $2.259M | 0.0% | $3.99 | -58.4% | COM | 20454B104 |
| — | Generation Bio Co. | 1,944,945 | $2.062M | 0.0% | $2.93 | — | COM | 37148K100 |
| HOOK | HOOKIPA Pharma Inc. | 812,814 | $1.634M | 0.0% | $7.93 | -61.0% | COM | 43906K209 |
| — | Mersana Therapeutics, Inc. | 1,086,115 | $1.553M | 0.0% | $4.11 | — | COM | 59045L106 |
| VTVT | vTv Therapeutics, Inc. | 97,314 | $1.344M | 0.0% | $12.72 | +16.2% | CL A | 918385204 |
| RCKT | Rocket Pharmaceuticals, Inc. | 97,079 | $1.22M | 0.0% | $15.05 | 0.0% | COM | 77313F106 |
| PTCT | PTC Therapeutics, Inc. | 20,400 | $921K | 0.0% | $42.80 | 0.0% | COM | 69366J200 |
| IPSC | Century Therapeutics, Inc. | 797,460 | $805K | 0.0% | $9.79 | -86.1% | COM | 15673T100 |
| PMVP | PMV Pharmaceuticals, Inc. | 322,024 | $486K | 0.0% | $14.45 | -89.0% | COM | 69353Y103 |
| ACRV | Acrivon Therapeutics, Inc. | 52,885 | $318K | 0.0% | $4.64 | +56.6% | COMMON STOCK | 004890109 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $213K | 0.0% | $14.37 | -49.3% | COM | 344174107 |
| TYRA | Tyra Biosciences, Inc. | 10,607 | $147K | 0.0% | $12.95 | +40.2% | COM | 90240B106 |
| SRZNW | Surrozen, Inc. | 833,333 | $17,833 | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |