BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value ($000): $9,036,702 (98.9% shares, 1.1% debt)

Holdings (89)

ONC BeiGene, Ltd. 26.5%
Value ($000) $2,394,838 Shares 8,799,053 Est. Cost $136.93 Unrealized
INCY Incyte Corporation 20.6%
Value ($000) $1,861,304 Shares 30,739,953 Est. Cost $72.80 Unrealized -4.2%
ACAD ACADIA Pharmaceuticals Inc. 7.9%
Value ($000) $712,202 Shares 42,877,916 Est. Cost $18.93 Unrealized -4.0%
MDGL Madrigal Pharmaceuticals, Inc. 7.2%
Value ($000) $654,043 Shares 1,974,590 Est. Cost $119.77 Unrealized +174.3%
SMMT Summit Therapeutics Inc. 5.2%
Value ($000) $471,156 Shares 24,424,865 Est. Cost $5.82 Unrealized +244.5%
INSM Insmed Incorporated 4.5%
Value ($000) $410,488 Shares 5,380,626 Est. Cost $49.30 Unrealized +55.2%
RYTM Rhythm Pharmaceuticals, Inc. 3.3%
Value ($000) $296,869 Shares 5,604,483 Est. Cost $23.49 Unrealized +136.2%
RVMD Revolution Medicines, Inc. 3.1%
Value ($000) $280,651 Shares 7,936,972 Est. Cost $27.73 Unrealized +46.4%
KYMR Kymera Therapeutics, Inc. 1.8%
Value ($000) $164,109 Shares 5,995,929 Est. Cost $28.14 Unrealized +29.6%
ALKS Alkermes plc 1.6%
Value ($000) $148,038 Shares 4,483,285 Est. Cost $25.07 Unrealized +30.1%
EWTX Edgewise Therapeutics, Inc. 1.5%
Value ($000) $135,431 Shares 6,155,940 Est. Cost $14.27 Unrealized +83.8%
REPL Replimune Group, Inc. 1.2%
Value ($000) $107,692 Shares 11,045,336 Est. Cost $14.45 Unrealized -14.4%
Insmed Incorporated 1.1%
Value ($000) $101,588 Shares 42,850,000 Est. Cost $2.11 Unrealized
IMVT Immunovant, Inc. 1.0%
Value ($000) $93,275 Shares 5,457,881 Est. Cost $22.96 Unrealized -8.9%
BCYC Bicycle Therapeutics plc 1.0%
Value ($000) $92,417 Shares 10,885,357 Est. Cost $20.78 Unrealized
IMCR Immunocore Holdings plc 0.8%
Value ($000) $68,913 Shares 2,322,656 Est. Cost $38.09 Unrealized
KNSA Kiniksa Pharmaceuticals International, plc 0.7%
Value ($000) $62,595 Shares 2,818,323 Est. Cost $18.73 Unrealized +9.9%
ABCL AbCellera Biologics Inc. 0.7%
Value ($000) $61,382 Shares 27,525,640 Est. Cost $21.02 Unrealized -86.4%
RARE Ultragenyx Pharmaceutical Inc. 0.6%
Value ($000) $57,071 Shares 1,576,114 Est. Cost $64.34 Unrealized -35.3%
DNLI Denali Therapeutics Inc. 0.6%
Value ($000) $50,732 Shares 3,731,695 Est. Cost $23.78 Unrealized -19.4%
KOD Kodiak Sciences Inc. 0.5%
Value ($000) $48,556 Shares 17,310,490 Est. Cost $30.30 Unrealized -82.1%
NRIX Nurix Therapeutics, Inc. 0.5%
Value ($000) $46,120 Shares 3,882,125 Est. Cost $22.27 Unrealized -24.9%
ARGX argenx SE 0.5%
Value ($000) $46,023 Shares 77,760 Est. Cost $79.01 Unrealized
TRDA Entrada Therapeutics, Inc. 0.5%
Value ($000) $43,987 Shares 4,865,819 Est. Cost $16.96 Unrealized
CELC Celcuity Inc. 0.5%
Value ($000) $43,046 Shares 4,257,735 Est. Cost $13.18 Unrealized -14.1%
GRAL GRAIL, Inc. 0.5%
Value ($000) $41,633 Shares 1,630,125 Est. Cost $16.26 Unrealized +90.0%
ROIV Roivant Sciences Ltd. 0.4%
Value ($000) $38,017 Shares 3,767,773 Est. Cost $9.71 Unrealized +11.3%
IMTX Immatics N.V. 0.4%
Value ($000) $32,814 Shares 7,275,830 Est. Cost $10.61 Unrealized -50.8%
STOK Stoke Therapeutics, Inc. 0.3%
Value ($000) $30,815 Shares 4,633,838 Est. Cost $9.30 Unrealized +0.2%
CERS Cerus Corporation 0.3%
Value ($000) $26,898 Shares 19,351,087 Est. Cost $4.19 Unrealized -60.0%
PCVX Vaxcyte, Inc. 0.3%
Value ($000) $24,200 Shares 640,885 Est. Cost $76.85 Unrealized +4.0%
GLUE Monte Rosa Therapeutics, Inc. 0.3%
Value ($000) $22,811 Shares 4,916,095 Est. Cost $6.49 Unrealized -5.6%
CRSP CRISPR Therapeutics AG 0.2%
Value ($000) $22,259 Shares 654,099 Est. Cost $50.03 Unrealized -15.3%
Akero Therapeutics, Inc. 0.2%
Value ($000) $22,212 Shares 548,713 Est. Cost $32.79 Unrealized
SERA Sera Prognostics, Inc. 0.2%
Value ($000) $20,233 Shares 5,498,170 Est. Cost $3.09 Unrealized +64.6%
CNTA Centessa Pharmaceuticals plc 0.2%
Value ($000) $17,647 Shares 1,227,178 Est. Cost $12.88 Unrealized
NGNE Neurogene Inc. 0.2%
Value ($000) $17,403 Shares 1,486,200 Est. Cost $19.35 Unrealized -10.2%
IDYA IDEAYA Biosciences, Inc. 0.2%
Value ($000) $17,398 Shares 1,062,123 Est. Cost $14.62 Unrealized +45.7%
Verona Pharma plc 0.2%
Value ($000) $14,212 Shares 223,843 Est. Cost $63.49 Unrealized
CADL Candel Therapeutics, Inc. 0.2%
Value ($000) $13,770 Shares 2,437,189 Est. Cost $5.91 Unrealized +38.3%
PRAX Praxis Precision Medicines, Inc. 0.1%
Value ($000) $12,555 Shares 331,533 Est. Cost $50.85 Unrealized +22.8%
2seventy bio, Inc. 0.1%
Value ($000) $12,338 Shares 2,497,526 Est. Cost $18.72 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.1%
Value ($000) $11,656 Shares 347,408 Est. Cost $18.51 Unrealized +105.2%
BCAX Bicara Therapeutics Inc. 0.1%
Value ($000) $10,858 Shares 833,333 Est. Cost $25.50 Unrealized -47.9%
IONS Ionis Pharmaceuticals, Inc. 0.1%
Value ($000) $10,798 Shares 357,915 Est. Cost $43.09 Unrealized -24.0%
DBVT DBV Technologies S.A. 0.1%
Value ($000) $9,967 Shares 1,461,425 Est. Cost $3.09 Unrealized
ALMS Alumis Inc. 0.1%
Value ($000) $9,594 Shares 1,562,500 Est. Cost $13.30 Unrealized -56.3%
Merus N.V. 0.1%
Value ($000) $9,407 Shares 223,500 Est. Cost $53.46 Unrealized
PRLD Prelude Therapeutics Inc. 0.1%
Value ($000) $7,775 Shares 10,123,824 Est. Cost $28.24 Unrealized -96.7%
Verve Therapeutics, Inc. 0.1%
Value ($000) $7,730 Shares 1,691,530 Est. Cost $52.72 Unrealized
RCKT Rocket Pharmaceuticals, Inc. 0.1%
Value ($000) $7,318 Shares 1,097,079 Est. Cost $10.34 Unrealized -4.4%
XNCR Xencor, Inc. 0.1%
Value ($000) $7,133 Shares 670,431 Est. Cost $21.77 Unrealized -24.1%
DYN Dyne Therapeutics, Inc. 0.1%
Value ($000) $7,030 Shares 672,096 Est. Cost $26.33 Unrealized -45.7%
KALA KALA BIO, Inc. 0.1%
Value ($000) $6,887 Shares 1,201,894 Est. Cost $7.72 Unrealized -2.0%
DSGN Design Therapeutics, Inc. 0.1%
Value ($000) $6,731 Shares 1,743,725 Est. Cost $12.06 Unrealized -60.4%
GPCR Structure Therapeutics Inc. 0.1%
Value ($000) $6,259 Shares 361,565 Est. Cost $31.09 Unrealized
TSHA Taysha Gene Therapies, Inc. 0.1%
Value ($000) $5,567 Shares 4,004,756 Est. Cost $1.91 Unrealized -12.6%
Regulus Therapeutics Inc. 0.1%
Value ($000) $4,715 Shares 2,694,044 Est. Cost $1.75 Unrealized
IGM Biosciences, Inc. 0.1%
Value ($000) $4,710 Shares 4,095,257 Est. Cost $15.73 Unrealized
NTLA Intellia Therapeutics, Inc. 0.1%
Value ($000) $4,580 Shares 644,116 Est. Cost $15.61 Unrealized -35.3%
CLDX Celldex Therapeutics, Inc. 0.0%
Value ($000) $4,495 Shares 247,644 Est. Cost $29.41 Unrealized -24.0%
SION Sionna Therapeutics, Inc. 0.0%
Value ($000) $4,184 Shares 400,000 Est. Cost $16.34 Unrealized 0.0%
BNTX BioNTech SE 0.0%
Value ($000) $4,101 Shares 45,031 Est. Cost $113.95 Unrealized
TCRX TScan Therapeutics, Inc. 0.0%
Value ($000) $3,843 Shares 2,784,792 Est. Cost $6.08 Unrealized -64.4%
IRON Disc Medicine, Inc. 0.0%
Value ($000) $3,825 Shares 77,050 Est. Cost $57.84 Unrealized -3.9%
VIR Vir Biotechnology, Inc. 0.0%
Value ($000) $3,516 Shares 542,539 Est. Cost $7.89 Unrealized +12.7%
SANA Sana Biotechnology, Inc. 0.0%
Value ($000) $3,412 Shares 2,030,949 Est. Cost $4.55 Unrealized -38.6%
SGMT Sagimet Biosciences Inc. 0.0%
Value ($000) $3,107 Shares 952,996 Est. Cost $9.53 Unrealized -56.0%
RLAY Relay Therapeutics, Inc. 0.0%
Value ($000) $3,040 Shares 1,160,117 Est. Cost $13.78 Unrealized -71.6%
WVE Wave Life Sciences Ltd. 0.0%
Value ($000) $2,780 Shares 344,063 Est. Cost $5.98 Unrealized +83.0%
FATE Fate Therapeutics, Inc. 0.0%
Value ($000) $2,574 Shares 3,258,402 Est. Cost $5.24 Unrealized -76.6%
SKYE Skye Bioscience, Inc. 0.0%
Value ($000) $2,307 Shares 1,450,638 Est. Cost $7.74 Unrealized -64.7%
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $2,287 Shares 536,832 Est. Cost $13.35 Unrealized -66.5%
ELVN Enliven Therapeutics, Inc. 0.0%
Value ($000) $2,260 Shares 114,833 Est. Cost $15.34 Unrealized +40.3%
CTNM Contineum Therapeutics, Inc. 0.0%
Value ($000) $2,181 Shares 312,500 Est. Cost $16.10 Unrealized -43.5%
PRME Prime Medicine, Inc. 0.0%
Value ($000) $2,047 Shares 1,028,466 Est. Cost $18.06 Unrealized -85.9%
TECX Tectonic Therapeutic, Inc. 0.0%
Value ($000) $1,771 Shares 100,000 Est. Cost $32.59 Unrealized 0.0%
VTVT vTv Therapeutics, Inc. 0.0%
Value ($000) $1,685 Shares 97,314 Est. Cost $12.72 Unrealized +31.3%
CMPX Compass Therapeutics, Inc. 0.0%
Value ($000) $1,040 Shares 547,498 Est. Cost $3.99 Unrealized -33.3%
NMRA Neumora Therapeutics, Inc. 0.0%
Value ($000) $1,035 Shares 1,034,600 Est. Cost $13.91 Unrealized -87.7%
HOOK HOOKIPA Pharma Inc. 0.0%
Value ($000) $878 Shares 812,814 Est. Cost $7.93 Unrealized -79.2%
Generation Bio Co. 0.0%
Value ($000) $788 Shares 1,944,945 Est. Cost $2.93 Unrealized
ALGS Aligos Therapeutics, Inc. 0.0%
Value ($000) $685 Shares 83,055 Est. Cost $12.44 Unrealized +76.2%
CYPH Leap Therapeutics, Inc. 0.0%
Value ($000) $123 Shares 404,744 Est. Cost $5.02 Unrealized -78.1%
IPSC Century Therapeutics, Inc. 0.0%
Value ($000) $115 Shares 241,684 Est. Cost $9.79 Unrealized -92.3%
TYRA Tyra Biosciences, Inc. 0.0%
Value ($000) $99 Shares 10,607 Est. Cost $12.95 Unrealized -0.0%
ACRV Acrivon Therapeutics, Inc. 0.0%
Value ($000) $46 Shares 22,809 Est. Cost $4.64 Unrealized +16.0%
SRZNW Surrozen, Inc. 0.0%
Value ($000) $25 Shares 833,333 Est. Cost $1.14 Unrealized
OPTEY Opthea Limited 0.0%
Value ($000) $0 Shares 2,087,320 Est. Cost $11.12 Unrealized