BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q4 2015 (← Previous) (Next →)

Filing Date: Feb 16, 2016

Total Value: $12.07B (85.5% shares, 14.5% debt)

Holdings (133)

INCY Incyte Corporation 17.5%
Value $2.112B Shares 19,475,316 Est. Cost $43.21 Unrealized +158.1%
Seattle Genetics, Inc. 13.9%
Value $1.674B Shares 37,293,728 Est. Cost $34.64 Unrealized
Alexion Pharmaceuticals, Inc. 10.3%
Value $1.248B Shares 6,542,599 Est. Cost $180.77 Unrealized
ABBV AbbVie Inc. 7.1%
Value $851M Shares 14,373,538 Est. Cost $42.33 Unrealized -10.3%
ACAD ACADIA Pharmaceuticals Inc. 6.0%
Value $730M Shares 20,481,442 Est. Cost $14.07 Unrealized +150.4%
Incyte Corporation 4.9%
Value $597M Shares 274,500,000 Est. Cost $1.21 Unrealized
Incyte Corporation 4.6%
Value $557M Shares 259,000,000 Est. Cost $1.20 Unrealized
Genomic Health, Inc. 4.0%
Value $481M Shares 13,659,264 Est. Cost $31.71 Unrealized
Anacor Pharmaceuticals, Inc. 3.9%
Value $474M Shares 4,198,520 Est. Cost $32.42 Unrealized
BMRN BioMarin Pharmaceutical Inc. 3.6%
Value $431M Shares 4,115,083 Est. Cost $75.89 Unrealized +37.5%
Dyax Corp. 2.6%
Value $313M Shares 8,310,017 Est. Cost $15.34 Unrealized
DBV Technologies S.A. 1.6%
Value $198M Shares 5,462,019 Est. Cost $32.87 Unrealized
Acorda Therapeutics, Inc. 1.3%
Value $153M Shares 3,580,112 Est. Cost $40.15 Unrealized
Anacor Pharmaceuticals Inc. 1.3%
Value $152M Shares 42,000,000 Est. Cost $3.63 Unrealized
BCRX BioCryst Pharmaceuticals, Inc. 1.2%
Value $147M Shares 14,217,779 Est. Cost $7.53 Unrealized +32.0%
BioMarin Pharmaceutical Inc. 1.0%
Value $115M Shares 22,379,000 Est. Cost $2.76 Unrealized
Clovis Oncology Inc. 0.9%
Value $111M Shares 129,300,000 Est. Cost $1.67 Unrealized
Bellicum Pharmaceuticals, Inc. 0.8%
Value $98.63M Shares 4,865,647 Est. Cost $22.66 Unrealized
Gilead Sciences Inc. 0.8%
Value $93.47M Shares 20,944,000 Est. Cost $2.26 Unrealized
Mirati Therapeutics, Inc. 0.8%
Value $93.38M Shares 2,955,074 Est. Cost $18.37 Unrealized
CERS Cerus Corporation 0.7%
Value $85.66M Shares 13,553,275 Est. Cost $4.68 Unrealized +13.6%
Aquinox Pharmaceuticals, Inc. 0.7%
Value $84.21M Shares 6,747,332 Est. Cost $13.83 Unrealized
HRTX Heron Therapeutics, Inc. 0.6%
Value $77.64M Shares 2,907,784 Est. Cost $13.64 Unrealized +96.0%
ImmunoGen, Inc. 0.5%
Value $60.42M Shares 4,452,445 Est. Cost $11.68 Unrealized
Acorda Therapeutics, Inc. 0.5%
Value $59.3M Shares 51,583,000 Est. Cost $1.04 Unrealized
Spark Therapeutics, Inc. 0.5%
Value $57.2M Shares 1,262,382 Est. Cost $77.50 Unrealized
Invitae Corporation 0.4%
Value $53.82M Shares 6,554,967 Est. Cost $16.76 Unrealized
NBIX Neurocrine Biosciences, Inc. 0.4%
Value $48.13M Shares 850,739 Est. Cost $28.36 Unrealized +79.2%
Versartis, Inc. 0.3%
Value $40.17M Shares 3,241,783 Est. Cost $22.68 Unrealized
SGMO Sangamo BioSciences, Inc. 0.3%
Value $37.03M Shares 4,055,876 Est. Cost $12.13 Unrealized -36.5%
HALO Halozyme Therapeutics, Inc. 0.3%
Value $33.47M Shares 1,931,057 Est. Cost $6.50 Unrealized +145.3%
Intra-Cellular Therapies, Inc. 0.3%
Value $32.77M Shares 609,166 Est. Cost $37.28 Unrealized
Medivation, Inc. 0.3%
Value $31.89M Shares 659,752 Est. Cost $42.50 Unrealized
Progenics Pharmaceuticals, Inc. 0.2%
Value $26.67M Shares 4,350,808 Est. Cost $4.44 Unrealized
GILD Gilead Sciences, Inc. 0.2%
Value $25.3M Shares 249,995 Est. Cost $36.21 Unrealized +101.3%
TGTX TG Therapeutics, Inc. 0.2%
Value $23.91M Shares 2,003,991 Est. Cost $4.61 Unrealized +174.2%
Exelixis, Inc. 0.2%
Value $23.26M Shares 20,000,000 Est. Cost $1.20 Unrealized
GLPG Galapagos NV 0.2%
Value $23.22M Shares 369,276 Est. Cost $51.50 Unrealized
aTyr Pharma Inc. 0.2%
Value $22.95M Shares 2,335,125 Est. Cost $18.52 Unrealized
Achillion Pharmaceuticals, Inc. 0.2%
Value $21.58M Shares 2,000,000 Est. Cost $8.32 Unrealized
Idera Pharmaceuticals, Inc. 0.2%
Value $21.58M Shares 6,983,107 Est. Cost $3.05 Unrealized
CPRX Catalyst Pharmaceuticals, Inc. 0.2%
Value $20.27M Shares 8,275,630 Est. Cost $2.61 Unrealized +9.6%
ALKS Alkermes PLC 0.2%
Value $19.86M Shares 250,251 Est. Cost $70.02 Unrealized 0.0%
XenoPort, Inc. 0.2%
Value $19.08M Shares 3,475,672 Est. Cost $5.27 Unrealized
Novavax, Inc. 0.2%
Value $18.42M Shares 2,195,687 Est. Cost $5.28 Unrealized
Array BioPharma Inc. 0.2%
Value $18.19M Shares 4,310,666 Est. Cost $6.65 Unrealized
INSM Insmed, Inc. 0.2%
Value $18.15M Shares 1,000,000 Est. Cost $14.99 Unrealized +17.6%
Advanced Accelerator Applications SA 0.1%
Value $17.74M Shares 567,454 Est. Cost $31.27 Unrealized
Aegerion Pharmaceuticals, Inc. 0.1%
Value $17.55M Shares 26,517,000 Est. Cost $0.75 Unrealized
Derma Sciences, Inc. 0.1%
Value $17.15M Shares 3,752,390 Est. Cost $12.19 Unrealized
Foamix Pharmaceuticals Ltd. 0.1%
Value $16.6M Shares 2,046,967 Est. Cost $7.46 Unrealized
BioMarin Pharmaceutical Inc. 0.1%
Value $15.7M Shares 12,228,000 Est. Cost $1.06 Unrealized
Zogenix, Inc. 0.1%
Value $14.74M Shares 1,000,000 Est. Cost $13.50 Unrealized
Alcobra Ltd. 0.1%
Value $14.67M Shares 2,336,359 Est. Cost $5.61 Unrealized
Lion Biotechnologies, Inc. 0.1%
Value $14.03M Shares 1,817,429 Est. Cost $11.31 Unrealized
Dimension Therapeutics, Inc. 0.1%
Value $13.93M Shares 1,234,481 Est. Cost $11.28 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.1%
Value $13.9M Shares 123,894 Est. Cost $51.09 Unrealized +95.7%
Global Blood Therapeutics, Inc. 0.1%
Value $12.93M Shares 400,000 Est. Cost $37.24 Unrealized
XNCR Xencor, Inc. 0.1%
Value $12.75M Shares 872,072 Est. Cost $11.07 Unrealized +21.5%
MGNX MacroGenics, Inc. 0.1%
Value $11.26M Shares 363,676 Est. Cost $23.98 Unrealized +26.7%
Dermira, Inc. 0.1%
Value $9.518M Shares 275,000 Est. Cost $21.44 Unrealized
Concert Pharmaceuticals, Inc. 0.1%
Value $9.407M Shares 495,908 Est. Cost $10.71 Unrealized
ASND Ascendis Pharma A/S 0.1%
Value $9.261M Shares 505,521 Est. Cost $17.72 Unrealized
bluebird bio, Inc. 0.1%
Value $9.062M Shares 141,105 Est. Cost $29.38 Unrealized
PRQR ProQR Therapeutics N.V. 0.1%
Value $8.578M Shares 988,299 Est. Cost $17.70 Unrealized -35.0%
LGND Ligand Pharmaceuticals Incorporated 0.1%
Value $7.957M Shares 73,386 Est. Cost $41.68 Unrealized +48.1%
Ignyta, Inc. 0.1%
Value $7.651M Shares 571,000 Est. Cost $8.30 Unrealized
Aerie Pharmaceuticals, Inc. 0.1%
Value $7.289M Shares 299,356 Est. Cost $17.96 Unrealized
Endocyte, Inc. 0.1%
Value $6.8M Shares 1,695,865 Est. Cost $4.47 Unrealized
AGIO Agios Pharmaceuticals, Inc. 0.1%
Value $6.492M Shares 100,000 Est. Cost $27.47 Unrealized +138.7%
Arrowhead Research Corp. 0.1%
Value $6.208M Shares 1,009,509 Est. Cost $9.76 Unrealized
Sage Therapeutics, Inc. 0.1%
Value $6.122M Shares 105,000 Est. Cost $43.36 Unrealized
Curis, Inc. 0.0%
Value $5.818M Shares 1,999,303 Est. Cost $2.72 Unrealized
Akari Therapeutics PLC 0.0%
Value $5.74M Shares 395,882 Est. Cost $23.99 Unrealized
OMER Omeros Corporation 0.0%
Value $5.289M Shares 336,226 Est. Cost $12.37 Unrealized +11.7%
NeuroDerm Ltd. 0.0%
Value $5.2M Shares 305,000 Est. Cost $15.24 Unrealized
Osiris Therapeutics, Inc. 0.0%
Value $5.182M Shares 499,193 Est. Cost $16.34 Unrealized
Trevena, Inc. 0.0%
Value $4.725M Shares 450,000 Est. Cost $10.35 Unrealized
Proteon Therapeutics, Inc. 0.0%
Value $4.631M Shares 298,591 Est. Cost $12.06 Unrealized
Aimmune Therapeutics, Inc. 0.0%
Value $4.613M Shares 250,000 Est. Cost $25.32 Unrealized
Medgenics Inc. 0.0%
Value $4.605M Shares 765,000 Est. Cost $6.02 Unrealized
Corsicanto Ltd. 0.0%
Value $4.48M Shares 5,000,000 Est. Cost $0.90 Unrealized
Seres Therapeutics, Inc. 0.0%
Value $4.386M Shares 125,000 Est. Cost $41.50 Unrealized
Amarin Corporation plc 0.0%
Value $4.169M Shares 2,205,710 Est. Cost $2.34 Unrealized
Sunesis Pharmaceuticals, Inc. 0.0%
Value $3.994M Shares 4,450,000 Est. Cost $2.09 Unrealized
Loxo Oncology, Inc. 0.0%
Value $3.919M Shares 137,735 Est. Cost $17.33 Unrealized
Epizyme, Inc. 0.0%
Value $3.724M Shares 232,481 Est. Cost $21.12 Unrealized
IONS Ionis Pharmaceuticals, Inc. 0.0%
Value $3.539M Shares 57,140 Est. Cost $53.96 Unrealized 0.0%
Juno Therapeutics, Inc. 0.0%
Value $3.518M Shares 80,000 Est. Cost $52.22 Unrealized
Vitae Pharmaceuticals, Inc. 0.0%
Value $3.396M Shares 187,597 Est. Cost $11.71 Unrealized
Nabriva Therapeutics AG 0.0%
Value $3.367M Shares 350,000 Est. Cost $9.50 Unrealized
Pronai Therapeutics, Inc. 0.0%
Value $3.008M Shares 200,000 Est. Cost $20.52 Unrealized
Immune Design Corp. 0.0%
Value $2.991M Shares 148,937 Est. Cost $20.65 Unrealized
Karyopharm Therapeutics Inc. 0.0%
Value $2.875M Shares 216,990 Est. Cost $31.09 Unrealized
Affimed N.V. 0.0%
Value $2.848M Shares 400,000 Est. Cost $6.30 Unrealized
Flexion Therapeutics, Inc. 0.0%
Value $2.826M Shares 146,642 Est. Cost $19.27 Unrealized
Array BioPharma Inc. 0.0%
Value $2.816M Shares 3,000,000 Est. Cost $1.25 Unrealized
Ophthotech Corporation 0.0%
Value $2.8M Shares 35,649 Est. Cost $32.35 Unrealized
NTRA Natera, Inc. 0.0%
Value $2.7M Shares 250,000 Est. Cost $16.90 Unrealized -43.7%
Trillium Therapeutics, Inc. 0.0%
Value $2.671M Shares 211,792 Est. Cost $12.74 Unrealized
ENTA Enanta Pharmaceuticals, Inc. 0.0%
Value $2.488M Shares 75,357 Est. Cost $19.50 Unrealized +67.1%
Protalix BioTherapeutics, Inc. 0.0%
Value $2.375M Shares 3,423,000 Est. Cost $0.76 Unrealized
Ohr Pharmaceuticals, Inc. 0.0%
Value $2.274M Shares 370,370 Est. Cost $2.54 Unrealized
Stemline Therapeutics, Inc. 0.0%
Value $2.104M Shares 333,497 Est. Cost $23.84 Unrealized
Mast Therapeutics, Inc. 0.0%
Value $2.016M Shares 4,797,442 Est. Cost $0.56 Unrealized
IRWD Ironwood Pharmaceuticals, Inc. 0.0%
Value $1.961M Shares 169,163 Est. Cost $11.63 Unrealized -16.9%
MediWound Ltd. 0.0%
Value $1.922M Shares 225,000 Est. Cost $11.38 Unrealized
Assembly Biosciences, Inc. 0.0%
Value $1.878M Shares 250,000 Est. Cost $13.24 Unrealized
Dynavax Technologies Corporation 0.0%
Value $1.812M Shares 75,000 Est. Cost $24.55 Unrealized
AUPH Aurinia Pharmaceuticals Inc. 0.0%
Value $1.789M Shares 711,499 Est. Cost $3.55 Unrealized -23.5%
CytRx Corporation 0.0%
Value $1.749M Shares 659,995 Est. Cost $3.49 Unrealized
CLLS Cellectis S.A. 0.0%
Value $1.552M Shares 50,000 Est. Cost $34.58 Unrealized
Marinus Pharmaceuticals, Inc. 0.0%
Value $1.528M Shares 200,000 Est. Cost $6.47 Unrealized
Acceleron Pharma, Inc. 0.0%
Value $1.403M Shares 28,765 Est. Cost $39.60 Unrealized
Tenax Therapeutics Inc. 0.0%
Value $1.378M Shares 420,000 Est. Cost $3.58 Unrealized
Palatin Technologies, Inc. 0.0%
Value $1.361M Shares 2,050,000 Est. Cost $0.73 Unrealized
ADAPY Adaptimmune Therapeutics plc 0.0%
Value $1.206M Shares 100,000 Est. Cost $18.33 Unrealized
ALNY Alnylam Pharmaceuticals, Inc. 0.0%
Value $1.068M Shares 11,340 Est. Cost $77.42 Unrealized +19.8%
Chimerix, Inc. 0.0%
Value $1.031M Shares 115,216 Est. Cost $40.26 Unrealized
BioDelivery Sciences International, Inc. 0.0%
Value $1.006M Shares 210,021 Est. Cost $5.21 Unrealized
ALDX Aldeyra Therapeutics, Inc. 0.0%
Value $963K Shares 142,000 Est. Cost $10.20 Unrealized -34.2%
ABUS Arbutus Biopharma Corporation 0.0%
Value $804K Shares 180,582 Est. Cost $8.87 Unrealized -38.2%
Five Prime Therapeutics, Inc. 0.0%
Value $799K Shares 19,247 Est. Cost $16.80 Unrealized
Discovery Laboratories, Inc. 0.0%
Value $764K Shares 3,569,643 Est. Cost $1.95 Unrealized
Ritter Pharmaceuticals, Inc. 0.0%
Value $680K Shares 400,000 Est. Cost $4.45 Unrealized
Achaogen, Inc. 0.0%
Value $574K Shares 100,000 Est. Cost $15.46 Unrealized
QURE UniQure N.V. 0.0%
Value $496K Shares 30,000 Est. Cost $15.95 Unrealized +16.2%
Foundation Medicine, Inc. 0.0%
Value $440K Shares 20,892 Est. Cost $25.16 Unrealized
ChemoCentryx, Inc. 0.0%
Value $397K Shares 49,064 Est. Cost $14.14 Unrealized
La Jolla Pharmaceutical Company 0.0%
Value $371K Shares 13,746 Est. Cost $10.24 Unrealized
Aptose Biosciences, Inc. 0.0%
Value $84,000 Shares 33,397 Est. Cost $5.91 Unrealized
Cyclacel Pharmaceuticals, Inc. 0.0%
Value $52,000 Shares 13,253 Est. Cost $7.20 Unrealized
BioTime, Inc. 0.0%
Value $24,000 Shares 20,084 Est. Cost $1.07 Unrealized