Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q1 2016 (← Previous) (Next →)
Filing Date: May 16, 2016
Total Value: $9.482B (85.5% shares, 14.5% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 23,498,460 | $1.703B | 18.0% | $48.57 | +53.4% | COM | 45337C102 |
| — | Seattle Genetics, Inc. | 43,235,267 | $1.517B | 16.0% | $34.70 | — | COM | 812578102 |
| — | Alexion Pharmaceuticals, Inc. | 6,542,599 | $911M | 9.6% | $180.77 | — | COM | 015351109 |
| ABBV | AbbVie Inc. | 14,373,538 | $821M | 8.7% | $42.33 | -12.3% | COM | 00287Y109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 24,213,838 | $677M | 7.1% | $15.27 | +43.0% | COM | 004225108 |
| — | Incyte Corporation Notes 1.25% 11/15/2020 144A | 274,500,000 | $432M | 4.6% | $1.21 | — | NOTE 1.25% 11/15/2020 | 45337CAL6 |
| — | Incyte Corporation Notes 0.375% 11/15/2018 144A | 259,000,000 | $398M | 4.2% | $1.20 | — | NOTE 0.375% 11/15/2018 | 45337CAK8 |
| BMRN | BioMarin Pharmaceutical Inc. | 4,806,483 | $396M | 4.2% | $76.68 | +6.1% | COM | 09061G101 |
| — | Genomic Health, Inc. | 13,659,832 | $338M | 3.6% | $31.71 | — | COM | 37244C101 |
| — | Anacor Pharmaceuticals, Inc. | 5,122,375 | $274M | 2.9% | $36.21 | — | COM | 032420101 |
| — | DBV Technologies S.A. | 5,509,560 | $179M | 1.9% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Acorda Therapeutics, Inc. | 3,661,082 | $96.84M | 1.0% | $39.85 | — | COM | 00484M106 |
| — | BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 | 22,379,000 | $89.83M | 0.9% | $2.76 | — | NOTE 1.875% 4/23/2017 | 09061GAD3 |
| — | Clovis Oncology Inc. 2.5% 9/15/2021 | 129,300,000 | $87.8M | 0.9% | $1.67 | — | NOTE 2.5% 9/15/2021 | 189464AB6 |
| — | Gilead Sciences, Inc. 1.625% 5/1/16 | 20,944,000 | $85.86M | 0.9% | $2.26 | — | NOTE 1.625% 5/1/2016 | 375558AP8 |
| CERS | Cerus Corporation | 13,553,275 | $80.37M | 0.8% | $4.68 | +18.2% | COM | 157085101 |
| — | Anacor Pharmaceuticals Inc. 2.0% 15 OCT 2021 | 42,000,000 | $75.34M | 0.8% | $3.63 | — | NOTE 2.0% 10/15/2021 | 032420AC5 |
| — | Xenoport, Inc. Notes 2.5% 2/1/2022 | 100,000,000 | $73.44M | 0.8% | $0.73 | — | NOTE 2.5% 2/1/2022 | 98411CAB6 |
| — | Mirati Therapeutics, Inc. | 3,268,556 | $69.95M | 0.7% | $18.66 | — | COM | 60468T105 |
| — | Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 | 77,083,000 | $68.46M | 0.7% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| — | Aquinox Pharmaceuticals, Inc. | 7,752,487 | $68.38M | 0.7% | $13.18 | — | COM | 03842B101 |
| — | Invitae Corporation | 6,554,967 | $67.06M | 0.7% | $16.76 | — | COM | 46185L103 |
| ONC | BeiGene, Ltd. | 1,912,680 | $56.06M | 0.6% | $29.31 | — | SPONSORED ADR | 07725L102 |
| HRTX | Heron Therapeutics, Inc. | 2,907,784 | $55.22M | 0.6% | $13.64 | +44.6% | COM | 427746102 |
| — | Bellicum Pharmaceuticals, Inc. | 4,865,647 | $45.49M | 0.5% | $22.66 | — | COM | 079481107 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 15,010,534 | $42.48M | 0.4% | $7.37 | -39.8% | COM | 09058V103 |
| — | ImmunoGen, Inc. | 4,452,445 | $37.94M | 0.4% | $11.68 | — | COM | 45253H101 |
| — | Spark Therapeutics, Inc. | 1,262,382 | $37.25M | 0.4% | $77.50 | — | COM | 84652J103 |
| NBIX | Neurocrine Biosciences, Inc. | 895,422 | $35.41M | 0.4% | $28.92 | +37.2% | COM | 64125C109 |
| — | Versartis, Inc. | 3,199,559 | $25.66M | 0.3% | $22.68 | — | COM | 92529L102 |
| SGMO | Sangamo BioSciences, Inc. | 4,055,876 | $24.54M | 0.3% | $12.13 | -50.5% | COM | 800677106 |
| — | Advanced Accelerator Applications S.A. | 615,033 | $21.54M | 0.2% | $31.56 | — | SPONSORED ADR | 00790T100 |
| — | Exelixis, Inc. Notes 4.25% 8/15/2019 | 20,000,000 | $19.77M | 0.2% | $1.20 | — | NOTE 4.25% 8/15/2019 | 30161QAC8 |
| — | Achillion Pharmaceuticals, Inc. | 2,475,515 | $19.11M | 0.2% | $8.21 | — | COM | 00448Q201 |
| INSM | Insmed Incorporated | 1,500,000 | $19M | 0.2% | $14.37 | -8.5% | COM PAR $.01 | 457669307 |
| — | Progenics Pharmaceuticals, Inc. | 4,350,808 | $18.97M | 0.2% | $4.44 | — | COM | 743187106 |
| HALO | Halozyme Therapeutics, Inc. | 1,931,057 | $18.29M | 0.2% | $6.50 | +44.8% | COM | 40637H109 |
| TGTX | TG Therapeutics, Inc. | 2,003,991 | $17.07M | 0.2% | $4.61 | +90.0% | COM | 88322Q108 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $16.93M | 0.2% | $37.28 | — | COM | 46116X101 |
| — | XenoPort, Inc. | 3,475,672 | $15.68M | 0.2% | $5.27 | — | COM | 98411C100 |
| — | Medivation, Inc. | 329,876 | $15.17M | 0.2% | $42.50 | — | COM | 58501N101 |
| — | bluebird bio, Inc. | 352,943 | $15M | 0.2% | $37.25 | — | COM | 09609G100 |
| — | Foamix Pharmaceuticals Ltd. | 2,241,702 | $14.62M | 0.2% | $7.38 | — | SHS | M46135105 |
| — | BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 | 12,228,000 | $14.13M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| — | Idera Pharmaceuticals, Inc. | 6,990,189 | $13.84M | 0.1% | $3.05 | — | COM NEW | 45168K306 |
| — | Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 | 26,517,000 | $13.53M | 0.1% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| — | Array BioPharma Inc. | 4,310,666 | $12.72M | 0.1% | $6.65 | — | COM | 04269X105 |
| GLPG | Galapagos NV | 303,394 | $12.69M | 0.1% | $51.50 | — | SPONSORED ADR | 36315X101 |
| AGIO | Agios Pharmaceuticals, Inc. | 307,915 | $12.5M | 0.1% | $37.79 | +13.1% | COM | 00847X104 |
| — | Novavax, Inc. | 2,379,254 | $12.28M | 0.1% | $5.27 | — | COM | 670002104 |
| — | Corsicanto Ltd. 3.5% 1/15/2032 | 15,000,000 | $12.1M | 0.1% | $0.84 | — | NOTE 3.5% 1/15/2032 | 220480AB3 |
| XNCR | Xencor, Inc. | 872,072 | $11.7M | 0.1% | $11.07 | +6.9% | COM | 98401F105 |
| — | Derma Sciences, Inc. | 3,752,390 | $11.63M | 0.1% | $12.19 | — | COM PAR $.01 | 249827502 |
| OMER | Omeros Corporation | 749,250 | $11.49M | 0.1% | $12.25 | -0.8% | COM | 682143102 |
| EXEL | Exelixis, Inc. | 2,580,000 | $10.32M | 0.1% | $4.23 | 0.0% | COM | 30161Q104 |
| — | Dimension Therapeutics, Inc. | 1,251,881 | $9.802M | 0.1% | $11.23 | — | COM | 25433V105 |
| — | Global Blood Therapeutics, Inc. | 600,000 | $9.516M | 0.1% | $30.12 | — | COM | 37890U108 |
| ASND | Ascendis Pharma A/S | 505,521 | $9.377M | 0.1% | $17.72 | — | SPONSORED ADR | 04351P101 |
| — | Zogenix, Inc. | 1,000,000 | $9.24M | 0.1% | $13.50 | — | COM NEW | 98978L204 |
| — | Alcobra Ltd. | 2,336,359 | $8.855M | 0.1% | $5.61 | — | SHS | M2239P109 |
| ALKS | Alkermes plc | 250,251 | $8.556M | 0.1% | $70.02 | -43.6% | SHS | G01767105 |
| — | aTyr Pharma, Inc. | 2,137,606 | $8.422M | 0.1% | $18.52 | — | COM | 002120103 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $7.859M | 0.1% | $41.68 | +45.8% | COM NEW | 53220K504 |
| RARE | Ultragenyx Pharmaceutical Inc. | 123,894 | $7.844M | 0.1% | $51.09 | +28.1% | COM | 90400D108 |
| — | Sage Therapeutics, Inc. | 224,048 | $7.183M | 0.1% | $37.36 | — | COM | 78667J108 |
| MGNX | MacroGenics, Inc. | 363,676 | $6.819M | 0.1% | $23.98 | -20.6% | COM | 556099109 |
| — | Concert Pharmaceuticals, Inc. | 495,908 | $6.774M | 0.1% | $10.71 | — | COM | 206022105 |
| PRQR | ProQR Therapeutics N.V. | 1,349,719 | $6.587M | 0.1% | $14.32 | -64.5% | SHS EURO | N71542109 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,498,459 | $6.433M | 0.1% | $2.61 | -40.6% | COM | 14888U101 |
| — | Dermira, Inc. | 275,000 | $5.687M | 0.1% | $21.44 | — | COM | 24983L104 |
| — | Akari Therapeutics plc | 395,882 | $5.542M | 0.1% | $23.99 | — | SPONSORED ADR | 00972G108 |
| — | Lion Biotechnologies, Inc. | 1,066,285 | $5.417M | 0.1% | $11.31 | — | COM | 53619R102 |
| — | Endocyte, Inc. | 1,695,865 | $5.257M | 0.1% | $4.47 | — | COM | 29269A102 |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 1,009,509 | $4.866M | 0.1% | $4.22 | 0.0% | COM NEW | 04280A100 |
| — | NeuroDerm Ltd. | 305,000 | $4.307M | 0.0% | $15.24 | — | ORD SHS | M74231107 |
| NTRA | Natera, Inc. | 450,000 | $4.284M | 0.0% | $13.15 | -35.6% | COM | 632307104 |
| — | Vitae Pharmaceuticals, Inc. | 637,597 | $4.227M | 0.0% | $8.12 | — | COM | 92847N103 |
| — | Ignyta, Inc. | 571,000 | $3.866M | 0.0% | $8.30 | — | COM | 451731103 |
| — | Loxo Oncology, Inc. | 137,735 | $3.766M | 0.0% | $17.33 | — | COM | 548862101 |
| — | Trevena, Inc. | 450,000 | $3.722M | 0.0% | $10.35 | — | COM | 89532E109 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $3.64M | 0.0% | $17.96 | — | COM | 00771V108 |
| — | Aimmune Therapeutics, Inc. | 250,000 | $3.39M | 0.0% | $25.32 | — | COM | 00900T107 |
| — | Medgenics Inc. | 765,000 | $3.366M | 0.0% | $6.02 | — | COM NEW | 58436Q203 |
| — | Seres Therapeutics, Inc. | 125,000 | $3.32M | 0.0% | $41.50 | — | COM | 81750R102 |
| — | Curis, Inc. | 1,999,303 | $3.219M | 0.0% | $2.72 | — | COM | 231269101 |
| — | Nabriva Therapeutics AG | 350,000 | $3.136M | 0.0% | $9.50 | — | SPONSORED ADR | 62957M104 |
| — | Juno Therapeutics, Inc. | 80,000 | $3.047M | 0.0% | $52.22 | — | COM | 48205A109 |
| — | Osiris Therapeutics, Inc. | 499,193 | $2.85M | 0.0% | $16.34 | — | COM | 68827R108 |
| — | Epizyme, Inc. | 232,481 | $2.818M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | InVivo Therapeutics Holdings Corp. | 400,000 | $2.792M | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| QURE | uniQure N.V. | 230,000 | $2.732M | 0.0% | $14.92 | -1.0% | SHS | N90064101 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $2.496M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Sunesis Pharmaceuticals, Inc. | 4,450,000 | $2.403M | 0.0% | $2.09 | — | COM NEW | 867328601 |
| — | Array BioPharma Inc. Notes 3.0% 6/1/2020 | 3,000,000 | $2.382M | 0.0% | $1.25 | — | NOTE 3.0% 6/1/2020 | 04269XAA3 |
| — | Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 | 3,423,000 | $2.334M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| IONS | Ionis Pharmaceuticals, Inc. | 57,140 | $2.314M | 0.0% | $53.96 | -24.7% | COM | 462222100 |
| — | Proteon Therapeutics Inc. | 298,591 | $2.311M | 0.0% | $12.06 | — | COM | 74371L109 |
| ENTA | Enanta Pharmaceuticals, Inc. | 75,357 | $2.213M | 0.0% | $19.50 | +42.8% | COM | 29251M106 |
| AUPH | Aurinia Pharmaceuticals Inc. | 711,499 | $2.082M | 0.0% | $3.55 | -31.9% | COM | 05156V102 |
| — | Trillium Therapeutics Inc. | 211,792 | $1.959M | 0.0% | $12.74 | — | COM NEW | 89620X506 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $1.936M | 0.0% | $31.09 | — | COM | 48576U106 |
| — | Immune Design Corp. | 148,937 | $1.936M | 0.0% | $20.65 | — | COM | 45252L103 |
| IRWD | Ironwood Pharmaceuticals, Inc. | 169,163 | $1.851M | 0.0% | $11.63 | -29.1% | COM CL A | 46333X108 |
| — | MediWound Ltd. | 226,000 | $1.824M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | CytRx Corporation | 659,995 | $1.769M | 0.0% | $3.49 | — | COM PAR $.001 | 232828509 |
| — | Stemline Therapeutics, Inc. | 333,497 | $1.554M | 0.0% | $23.84 | — | COM | 85858C107 |
| — | Ophthotech Corporation | 35,649 | $1.507M | 0.0% | $32.35 | — | COM | 683745103 |
| — | Affimed N.V. | 400,000 | $1.496M | 0.0% | $6.30 | — | COM | N01045108 |
| — | Dynavax Technologies Corporation | 75,000 | $1.443M | 0.0% | $24.55 | — | COM NEW | 268158201 |
| CLLS | Cellectis S.A. | 50,000 | $1.375M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | ProNai Therapeutics, Inc. | 200,000 | $1.348M | 0.0% | $20.52 | — | COM | 74346L101 |
| — | Mast Therapeutics, Inc. | 4,797,442 | $1.309M | 0.0% | $0.56 | — | COM | 576314108 |
| — | Assembly Biosciences, Inc. | 250,000 | $1.255M | 0.0% | $13.24 | — | COM | 045396108 |
| — | Amarin Corporation plc | 801,860 | $1.227M | 0.0% | $2.34 | — | SPONSORED ADR NEW | 023111206 |
| — | Palatin Technologies, Inc. | 2,050,000 | $1.107M | 0.0% | $0.73 | — | COM PAR $.01 | 696077403 |
| — | GW Pharmaceuticals plc | 15,000 | $1.082M | 0.0% | $72.13 | — | ADS | 36197T103 |
| — | Tenax Therapeutics, Inc. | 420,000 | $861K | 0.0% | $3.58 | — | COM | 88032L100 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $813K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $782K | 0.0% | $16.80 | — | COM | 33830X104 |
| — | Acceleron Pharma, Inc. | 28,765 | $759K | 0.0% | $39.60 | — | COM | 00434H108 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $746K | 0.0% | $8.87 | -59.7% | COM | 03879J100 |
| ALNY | Alnylam Pharmaceuticals, Inc. | 11,340 | $712K | 0.0% | $77.42 | -14.1% | COM | 02043Q107 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $678K | 0.0% | $5.21 | — | COM | 09060J106 |
| ALDX | Aldeyra Therapeutics, Inc. | 142,000 | $595K | 0.0% | $10.20 | -52.9% | COM | 01438T106 |
| — | Chimerix, Inc. | 115,216 | $589K | 0.0% | $40.26 | — | COM | 16934W106 |
| — | Ritter Pharmaceuticals, Inc. | 400,000 | $452K | 0.0% | $4.45 | — | COM | 767836109 |
| — | Discovery Laboratories, Inc. | 254,973 | $426K | 0.0% | $1.67 | — | COM PAR | 254668502 |
| — | Foundation Medicine, Inc. | 20,892 | $380K | 0.0% | $25.16 | — | COM | 350465100 |
| — | La Jolla Pharmaceutical Company | 13,746 | $287K | 0.0% | $10.24 | — | COM PAR $.0001 2 | 503459604 |
| — | Achaogen, Inc. | 100,000 | $276K | 0.0% | $15.46 | — | COM | 004449104 |
| — | ChemoCentryx, Inc. | 49,064 | $122K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | Aptose Biosciences Inc. | 33,397 | $100K | 0.0% | $5.91 | — | COM NEW | 03835T200 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $76,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $12,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |