Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q1 2021 (← Previous) (Next →)
Filing Date: May 17, 2021
Total Value: $6.632B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 6,412,228 | $826M | 12.5% | $128.88 | $60.10 | — | SPONSORED ADR | 04351P101 |
| NVAX | NOVAVAX INC | 3,002,087 | $544M | 8.2% | $181.31 * | $84.76 | +135.1% | COM NEW | 670002401 |
| — | VOR BIOPHARMA INC | 11,120,973 | $479M | 7.2% | $43.10 | $43.10 | — | COM | 929033108 |
| AVIR | ATEA PHARMACEUTICALS INC | 5,368,451 | $332M | 5.0% | $61.75 * | $32.23 | +109.6% | COM | 04683R106 |
| — | FORMA THERAPEUTICS HLDGS INC | 9,011,651 | $253M | 3.8% | $28.02 | $46.49 | — | SHS | 34633R104 |
| TGTX | TG THERAPEUTICS INC | 4,636,146 | $223M | 3.4% | $48.20 | $11.95 | +302.0% | COM | 88322Q108 |
| NKTX | NKARTA INC | 5,605,129 | $184M | 2.8% | $32.90 * | $29.47 | +62.1% | COM | 65487U108 |
| — | CHEMOCENTRYX INC | 3,556,810 | $182M | 2.7% | $51.24 | $42.10 | — | COM | 16383L106 |
| MGNX | MACROGENICS INC | 4,933,594 | $157M | 2.4% | $31.85 * | $18.15 | +33.8% | COM | 556099109 |
| — | ITEOS THERAPEUTICS INC | 4,417,258 | $151M | 2.3% | $34.18 | $24.67 | — | COM | 46565G104 |
| — | IMMUNOGEN INC | 18,417,458 | $149M | 2.2% | $8.10 | $5.36 | — | COM | 45253H101 |
| TVTX | TRAVERE THERAPEUTICS INC | 5,614,428 | $140M | 2.1% | $24.97 * | $24.15 | +14.4% | COM | 89422G107 |
| — | INSTIL BIO INC | 4,870,793 | $122M | 1.8% | $25.08 | $25.08 | — | COM | 45783C101 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 3,115,008 | $117M | 1.8% | $37.56 * | $25.67 | +63.0% | COM | 71722W107 |
| — | 89BIO INC | 4,736,214 | $112M | 1.7% | $23.68 | $26.08 | — | COM | 282559103 |
| — | KINNATE BIOPHARMA INC | 3,593,052 | $112M | 1.7% | $31.16 | $39.78 | — | COM | 49705R105 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 4,871,067 | $104M | 1.6% | $21.27 * | $24.79 | +17.0% | COM | 76243J105 |
| — | ZOGENIX INC | 5,283,976 | $103M | 1.6% | $19.52 | $26.04 | — | COM NEW | 98978L204 |
| AXSM | AXSOME THERAPEUTICS INC | 1,655,447 | $93.73M | 1.4% | $56.62 * | $68.14 | +3.2% | COM | 05464T104 |
| RCKT | ROCKET PHARMACEUTICALS INC COM | 2,107,149 | $93.49M | 1.4% | $44.37 * | $36.45 | +50.6% | COM | 77313F106 |
| — | ADVERUM BIOTECHNOLOGIES INC | 9,365,833 | $92.35M | 1.4% | $9.86 | $10.49 | — | COM | 00773U108 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,613,623 | $84.94M | 1.3% | $32.50 | $32.43 | 0.0% | COM | 28036F105 |
| — | CURIS INC | 7,140,091 | $80.83M | 1.2% | $11.32 | $8.19 | — | COM NEW | 231269200 |
| — | BOLT BIOTHERAPEUTICS INC | 2,378,325 | $78.27M | 1.2% | $32.91 | $32.91 | — | COM | 097702104 |
| PCVX | VAXCYTE INC | 3,865,808 | $76.35M | 1.2% | $19.75 * | $31.88 | -21.1% | COM | 92243G108 |
| — | SERES THERAPEUTICS INC | 3,694,193 | $76.06M | 1.1% | $20.59 | $20.59 | — | COM | 81750R102 |
| SPRY | SILVERBACK THERAPEUTICS INC | 1,742,186 | $76.01M | 1.1% | $43.63 * | $33.40 | +41.7% | COM | 82835W108 |
| — | IGM BIOSCIENCES INC | 982,723 | $75.36M | 1.1% | $76.69 | $28.47 | — | COM | 449585108 |
| — | KALA PHARMACEUTICALS INC | 10,874,613 | $73.3M | 1.1% | $6.74 | $10.65 | — | COM | 483119103 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,150,404 | $71.35M | 1.1% | $33.18 * | $46.89 | -8.6% | COM | 68062P106 |
| — | ORCHARD THERAPEUTICS PLC | 12,315,213 | $69.16M | 1.0% | $5.62 | $10.43 | — | ADS | 68570P101 |
| — | SOLID BIOSCIENCES INC | 12,367,873 | $68.39M | 1.0% | $5.53 | $7.59 | — | COM | 83422E105 |
| DSGN | DESIGN THERAPEUTICS INC | 2,186,636 | $65.38M | 1.0% | $29.90 * | $31.14 | 0.0% | COM | 25056L103 |
| BDTX | BLACK DIAMOND THERAPEUTICS INC | 2,589,904 | $62.83M | 0.9% | $24.26 * | $30.22 | -10.7% | COM | 09203E105 |
| — | TRILLIUM THERAPEUTICS INC | 5,290,481 | $56.82M | 0.9% | $10.74 | $4.04 | — | COM NEW | 89620X506 |
| PMVP | PMV PHARMACEUTICALS INC | 1,710,265 | $56.25M | 0.8% | $32.89 * | $36.80 | +7.1% | COM | 69353Y103 |
| — | CONNECT BIOPHARMA HLDGS LTD | 2,991,208 | $55.34M | 0.8% | $18.50 | $18.50 | — | ADS | 207523101 |
| — | CONSTELLATION PHARMCETICLS INC | 2,238,536 | $52.36M | 0.8% | $23.39 | $27.87 | — | COM | 210373106 |
| CCCC | C4 THERAPEUTICS INC | 1,377,569 | $50.96M | 0.8% | $36.99 * | $29.00 | +37.2% | COM STK | 12529R107 |
| — | SUTRO BIOPHARMA INC | 2,118,212 | $48.21M | 0.7% | $22.76 | $7.97 | — | COM | 869367102 |
| GERN | GERON CORP | 30,126,299 | $47.6M | 0.7% | $1.58 * | $1.49 | +19.5% | COM | 374163103 |
| WVE | WAVE LIFE SCIENCES LTD | 7,775,207 | $43.62M | 0.7% | $5.61 * | $17.26 | -44.3% | SHS | Y95308105 |
| DYN | DYNE THERAPEUTICS INC | 2,805,045 | $43.56M | 0.7% | $15.53 * | $21.96 | -11.9% | COM | 26818M108 |
| — | VERONA PHARMA PLC | 5,100,000 | $42.64M | 0.6% | $8.36 | $6.24 | — | SPONSORED ADS | 925050106 |
| ARDX | ARDELYX INC | 6,077,294 | $40.23M | 0.6% | $6.62 * | $6.19 | +10.8% | COM | 039697107 |
| — | INOZYME PHARMA INC | 2,003,653 | $39.67M | 0.6% | $19.80 | $26.29 | — | COM | 45790W108 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $34.95M | 0.5% | $5.91 | $13.11 | — | COM | 80405P107 |
| RLAY | RELAY THERAPEUTICS INC | 1,000,000 | $34.57M | 0.5% | $34.57 * | $38.13 | +13.8% | COM | 75943R102 |
| — | AKOUOS INC | 2,281,249 | $31.64M | 0.5% | $13.87 | $22.50 | — | COM | 00973J101 |
| — | CEREVEL THERAPEUTICS HLDNG INC | 2,200,000 | $30.21M | 0.5% | $13.73 | $16.58 | — | COM | 15678U128 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,500,000 | $27.05M | 0.4% | $7.73 * | $7.92 | 0.0% | COM | 23284F105 |
| — | ACHILLES THERAPEUTICS PLC | 1,388,888 | $22.99M | 0.3% | $16.55 | $16.55 | — | SPONSORED ADS | 00449L102 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 1,023,067 | $22.88M | 0.3% | $22.36 | $15.23 | +48.3% | COM | 87164F105 |
| LRMR | LARIMAR THERAPEUTICS INC | 1,515,151 | $22.14M | 0.3% | $14.61 * | $11.65 | +56.0% | COM | 517125100 |
| — | IKENA ONCOLOGY INC | 750,000 | $21.19M | 0.3% | $28.25 | $28.25 | — | COM | 45175G108 |
| — | SCPHARMACEUTICALS INC | 2,731,170 | $18.16M | 0.3% | $6.65 | $10.74 | — | COM | 810648105 |
| — | CONCERT PHARMACEUTICALS INC | 3,033,603 | $15.14M | 0.2% | $4.99 | $7.30 | — | COM | 206022105 |
| CGEM | CULLINAN ONCOLOGY INC COM | 350,000 | $14.59M | 0.2% | $41.67 * | $40.60 | 0.0% | COM | 230031106 |
| ORIC | ORIC PHARMACEUTICALS INC | 584,000 | $14.31M | 0.2% | $24.50 * | $28.69 | +10.1% | COM | 68622P109 |
| PRQR | PROQR THERAPEUTICS N V | 2,117,669 | $14M | 0.2% | $6.61 * | $5.11 | 0.0% | SHS EURO | N71542109 |
| — | BCTG ACQUISITION CORP | 1,250,000 | $13.9M | 0.2% | $11.12 | $10.36 | — | COM | 05492W103 |
| — | ARYA SCIENCES ACQUISITION CO | 971,430 | $13.39M | 0.2% | $13.78 | $10.81 | — | COM CL A | G3166W106 |
| — | BCLS ACQUISITION CORP | 1,250,000 | $13.21M | 0.2% | $10.57 | $11.14 | — | COM CL A | G0904B105 |
| MIST | MILESTONE PHARMACEUTICALS INC | 2,246,503 | $13.01M | 0.2% | $5.79 * | $7.17 | +2.1% | COM | 59935V107 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 1,250,000 | $12.7M | 0.2% | $10.16 * | $11.25 | 0.0% | COM NEW | 30233G209 |
| — | REPARE THERAPEUTICS INC | 409,000 | $12.55M | 0.2% | $30.69 | $31.02 | — | COM | 760273102 |
| OCUL | OCULAR THERAPEUTIX INC | 750,000 | $12.31M | 0.2% | $16.41 * | $6.63 | +190.6% | COM | 67576A100 |
| — | ARYA SCIENCES ACQU CORP IV | 1,000,000 | $10.47M | 0.2% | $10.47 | $10.47 | — | CL A | G31659108 |
| — | THERAPEUTICSMD INC | 7,812,500 | $10.47M | 0.2% | $1.34 | $1.21 | — | COM | 88338N107 |
| — | FRAZIER LIFESCIENCES ACQUISITION CO | 1,000,000 | $10.16M | 0.2% | $10.16 | $10.38 | — | UNIT 12/09/2025 | G3710A121 |
| — | FS DEVELOPMENT CORP II | 1,000,000 | $9.96M | 0.2% | $9.96 | $9.96 | — | COM CL A | 30318F100 |
| — | PHASEBIO PHARMACEUTICALS INC | 2,850,000 | $9.861M | 0.1% | $3.46 | $3.46 | — | COM | 717224109 |
| COGT | COGENT BIOSCIENCES INC | 1,025,641 | $9.005M | 0.1% | $8.78 * | $10.99 | -12.4% | COM | 19240Q201 |
| KALV | KALVISTA PHARMACEUTICALS INC | 350,000 | $8.992M | 0.1% | $25.69 * | $26.28 | 0.0% | COM | 483497103 |
| — | 5 01 ACQUISITION CORP | 750,000 | $7.463M | 0.1% | $9.95 | $10.17 | — | COM CL A | 33836P105 |
| MLTX | HELIX ACQUISITION CORP | 700,000 | $7.147M | 0.1% | $10.21 | $11.37 | — | COM CL A | G4444C102 |
| — | HEALTH SCIENCES ACQ CORP 2 | 625,000 | $6.994M | 0.1% | $11.19 | $11.00 | — | ORD SHS | G4411D109 |
| — | SYROS PHARMACEUTICALS INC | 900,000 | $6.732M | 0.1% | $7.48 | $7.48 | — | COM | 87184Q107 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 312,328 | $5.219M | 0.1% | $16.71 * | $18.72 | 0.0% | COM | 92790C104 |
| — | X4 PHARMACEUTICALS INC | 536,962 | $4.623M | 0.1% | $8.61 | $12.24 | — | COM | 98420X103 |
| — | IMARA INC | 248,804 | $2.1M | 0.0% | $8.44 | $16.03 | — | COM | 45249V107 |
| — | CEREVEL THERAPEUTICS HLDNG INC | 233,333 | $1.006M | 0.0% | $4.31 | $5.65 | — | *W EXP 06/09/2027 | 15678U102 |