Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q3 2023 (← Previous) (Next →)
Filing Date: Nov 15, 2023
Total Value: $5.08B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,719,555 | $1.004B | 19.8% | $93.64 | $79.32 | — | COM | 04351P101 |
| LEGN | LEGEND BIOTECH CORP-ADR | 6,264,707 | $421M | 8.3% | $67.17 | $58.19 | — | COM | 52490G102 |
| PCVX | VAXCYTE INC | 7,891,254 | $402M | 7.9% | $50.98 * | $35.36 | +39.5% | SPONSORED ADS | 92243G108 |
| — | IMMUNOGEN INC | 13,322,288 | $211M | 4.2% | $15.87 | $14.05 | — | COM | 45253H101 |
| — | 89BIO INC | 11,416,948 | $176M | 3.5% | $15.44 | $16.58 | — | COM | 282559103 |
| BIIB | BIOGEN INC | 532,892 | $137M | 2.7% | $257.01 * | $216.32 | +23.6% | SPONSORED ADR | 09062X103 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,676,067 | $130M | 2.6% | $22.93 * | $23.94 | -6.5% | COM | 76243J105 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $112M | 2.2% | $13.57 | $22.83 | — | COM | 008064107 |
| — | CYMABAY THERAPEUTICS INC | 6,940,000 | $103M | 2.0% | $14.91 | $14.91 | — | COM | 23257D103 |
| — | VERONA PHARMA PLC - ADR | 6,317,990 | $103M | 2.0% | $16.30 | $7.68 | — | COM | 925050106 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $99.65M | 2.0% | $13.77 * | $19.11 | -22.4% | COM | 90240B106 |
| WVE | WAVE LIFE SCIENCES LTD | 17,202,009 | $98.91M | 1.9% | $5.75 * | $8.85 | -48.4% | COM | Y95308105 |
| GERN | GERON CORP | 46,202,425 | $97.95M | 1.9% | $2.12 * | $2.42 | +12.0% | COM | 374163103 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,809,852 | $95.83M | 1.9% | $12.27 * | $17.63 | -26.0% | COM | 23954D109 |
| JANX | JANUX THERAPEUTICS INC | 9,165,652 | $92.39M | 1.8% | $10.08 * | $21.69 | -46.8% | COM | 47103J105 |
| ANTX | AN2 THERAPEUTICS INC | 5,551,295 | $89.26M | 1.8% | $16.08 * | $13.91 | -18.6% | COM | 037326105 |
| — | INHIBRX INC | 4,724,207 | $86.69M | 1.7% | $18.35 | $23.48 | — | SH | 45720L107 |
| RXST | RXSIGHT INC | 3,052,796 | $85.14M | 1.7% | $27.89 * | $13.76 | +116.6% | COM | 78349D107 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 9,000,000 | $83.25M | 1.6% | $9.25 * | $11.79 | -8.2% | ORD SHS | N62509109 |
| EVH | EVOLENT HEALTH INC - A | 2,736,680 | $74.52M | 1.5% | $27.23 * | $27.80 | 0.0% | COM | 30050B101 |
| — | CUREVAC NV | 10,604,344 | $72.43M | 1.4% | $6.83 | $6.97 | — | COM | N2451R105 |
| AXSM | AXSOME THERAPEUTICS INC | 1,000,000 | $69.89M | 1.4% | $69.89 * | $73.77 | +1.3% | CLASS A ORD SHS | 05464T104 |
| COGT | COGENT BIOSCIENCES INC | 6,416,147 | $62.56M | 1.2% | $9.75 * | $13.15 | -9.8% | COM | 19240Q201 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $61.97M | 1.2% | $4.15 * | $13.02 | -52.6% | COMMON STOCK | 00509G209 |
| TSHA | TAYSHA GENE THERAPIES INC | 18,472,503 | $58.37M | 1.1% | $3.16 * | $1.87 | 0.0% | COM | 877619106 |
| GHRS | GH RESEARCH PLC | 5,587,333 | $56.15M | 1.1% | $10.05 * | $17.97 | -35.7% | SPONSORED ADR | G3855L106 |
| — | ALPINE IMMUNE SCIENCES INC | 4,691,178 | $53.71M | 1.1% | $11.45 | $7.23 | — | COM | 02083G100 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,163,211 | $53M | 1.0% | $12.73 * | $17.97 | -6.9% | COM | 35104E100 |
| FULC | FULCRUM THERAPEUTICS INC | 11,609,704 | $51.55M | 1.0% | $4.44 | $7.35 | -40.5% | COM | 359616109 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $48.37M | 1.0% | $10.95 | $24.67 | — | COM | 46565G104 |
| — | VOR BIOPHARMA INC | 22,748,880 | $48.23M | 0.9% | $2.12 | $24.47 | — | COM | 929033108 |
| — | ICOSAVAX INC | 5,963,565 | $46.22M | 0.9% | $7.75 | $28.89 | — | COM | 45114M109 |
| ACRV | ACRIVON THERAPEUTICS INC | 4,810,508 | $45.99M | 0.9% | $9.56 * | $12.69 | -9.0% | COM | 004890109 |
| APGE | APOGEE THERAPEUTICS INC | 1,977,901 | $42.13M | 0.8% | $21.30 * | $22.03 | 0.0% | COM | 03770N101 |
| PEPG | PEPGEN INC | 8,131,952 | $41.31M | 0.8% | $5.08 * | $11.15 | -42.8% | COM | 713317105 |
| RNAM | AVIDITY BIOSCIENCES INC | 6,416,998 | $40.94M | 0.8% | $6.38 * | $16.99 | -49.3% | COM | 05370A108 |
| CTKB | CYTEK BIOSCIENCES INC | 6,809,404 | $37.59M | 0.7% | $5.52 * | $20.70 | -61.2% | COM | 23285D109 |
| SLNO | SOLENO THERAPEUTICS INC | 1,239,000 | $36.56M | 0.7% | $29.51 * | $6.05 | 0.0% | COM | 834203309 |
| SPRY | ARS PHARMACEUTICALS INC | 9,459,678 | $35.76M | 0.7% | $3.78 * | $6.54 | +0.4% | COM | 82835W108 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $34.59M | 0.7% | $2.63 * | $20.66 | -86.8% | ADS | 28658R106 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 2,007,946 | $30.8M | 0.6% | $15.34 * | $25.89 | -26.3% | COM | 92790C104 |
| PLRX | PLIANT THERAPEUTICS INC | 1,762,000 | $30.55M | 0.6% | $17.34 | $28.47 | -39.1% | COM | 729139105 |
| MLYS | MINERALYS THERAPEUTICS INC | 3,178,476 | $30.23M | 0.6% | $9.51 * | $16.83 | -22.5% | COM | 603170101 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,398,453 | $30.13M | 0.6% | $6.85 * | $13.86 | -38.3% | SPONSORED ADS | 00461U105 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 204,500 | $29.87M | 0.6% | $146.04 * | $188.22 | 0.0% | COM | 558868105 |
| ELVN | ENLIVEN THERAPEUTICS INC | 2,122,465 | $28.99M | 0.6% | $13.66 * | $20.34 | -17.2% | COM | 29337E102 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,370,506 | $26.93M | 0.5% | $7.99 * | $11.52 | -4.8% | COM | 30233G209 |
| URGN | UROGEN PHARMA LTD | 1,483,697 | $20.79M | 0.4% | $14.01 * | $16.05 | 0.0% | COM | M96088105 |
| TNYA | TENAYA THERAPEUTICS INC | 6,718,483 | $17.13M | 0.3% | $2.55 * | $7.15 | -41.5% | COM | 87990A106 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 800,000 | $16.07M | 0.3% | $20.09 | $20.09 | — | SPONSORED ADR | 088786108 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $13.15M | 0.3% | $2.14 * | $10.47 | -73.7% | COM | 95075A107 |
| CELC | CELCUITY INC | 1,400,001 | $12.8M | 0.3% | $9.14 * | $10.24 | -3.9% | COM | 15102K100 |
| — | NEKTAR THERAPEUTICS | 18,700,000 | $11.14M | 0.2% | $0.60 | $0.60 | — | COM | 640268108 |
| NKTX | NKARTA INC | 7,805,129 | $10.85M | 0.2% | $1.39 * | $24.86 | -92.4% | COM | 65487U108 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 3,525,754 | $10.12M | 0.2% | $2.87 * | $22.74 | -83.8% | COM | 09203E105 |
| CMPS | COMPASS PATHWAYS PLC | 1,286,000 | $9.516M | 0.2% | $7.40 | $7.40 | — | COM | 20451W101 |
| SLDB | SOLID BIOSCIENCES INC | 3,426,286 | $8.634M | 0.2% | $2.52 * | $6.55 | -40.8% | COM | 83422E204 |
| — | IGM BIOSCIENCES INC | 937,500 | $7.828M | 0.2% | $8.35 | $9.23 | — | COM | 449585108 |
| — | TALARIS THERAPEUTICS INC | 2,403,238 | $6.753M | 0.1% | $2.81 | $3.03 | — | COM | 87410C104 |
| — | CHIMERIX INC | 6,501,624 | $6.24M | 0.1% | $0.96 | $0.96 | — | COM | 16934W106 |
| — | THIRD HARMONIC BIO INC | 961,863 | $6.146M | 0.1% | $6.39 | $6.39 | — | COM | 88427A107 |
| — | CONNECT BIOPHARMA HOLDINGS L | 6,991,003 | $5.726M | 0.1% | $0.82 | $19.09 | — | COM | 207523101 |
| — | UNICYCIVE THERAPEUTICS INC | 3,470,688 | $2.985M | 0.1% | $0.86 | $0.86 | — | COM | 90466Y103 |
| — | NANOSTRING TECHNOLOGIES INC | 1,723,373 | $2.964M | 0.1% | $1.72 | $10.06 | — | ORDINARY SHARES | 63009R109 |
| MGNX | MACROGENICS INC | 342,000 | $1.594M | 0.0% | $4.66 * | $4.98 | 0.0% | COM | 556099109 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $633K | 0.0% | $1.90 | $0.87 | — | ORD SHS | N62509117 |