Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q4 2023 (← Previous) (Next →)
Filing Date: Feb 14, 2024
Total Value: $6.402B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,107,400 | $1.273B | 19.9% | $125.95 | $79.32 | — | SH | 04351P101 |
| — | IMMUNOGEN INC | 23,750,601 | $704M | 11.0% | $29.65 | $20.90 | — | SH | 45253H101 |
| PCVX | VAXCYTE INC | 7,891,254 | $496M | 7.7% | $62.80 * | $35.36 | +46.9% | SH | 92243G108 |
| LEGN | LEGEND BIOTECH CORP-ADR | 6,264,707 | $377M | 5.9% | $60.17 | $58.19 | — | SH | 52490G102 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,330,412 | $245M | 3.8% | $45.97 * | $23.94 | +31.8% | SH | 76243J105 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $187M | 2.9% | $22.63 | $22.83 | — | SH | 008064107 |
| — | INHIBRX INC | 4,724,207 | $180M | 2.8% | $38.00 | $23.48 | — | SH | 45720L107 |
| — | CYMABAY THERAPEUTICS INC | 6,940,000 | $164M | 2.6% | $23.62 | $14.91 | — | SH | 23257D103 |
| BIIB | BIOGEN INC | 532,892 | $138M | 2.2% | $258.77 * | $216.32 | +13.5% | SH | 09062X103 |
| RXST | RXSIGHT INC | 3,404,285 | $137M | 2.1% | $40.32 * | $15.37 | +90.8% | SH | 78349D107 |
| — | 89BIO INC | 11,416,948 | $128M | 2.0% | $11.17 | $16.58 | — | SH | 282559103 |
| — | VERONA PHARMA PLC - ADR | 6,317,990 | $126M | 2.0% | $19.88 | $7.68 | — | SH | 925050106 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,809,852 | $114M | 1.8% | $14.60 * | $17.63 | -31.3% | SH | 23954D109 |
| ANTX | AN2 THERAPEUTICS INC | 5,551,295 | $114M | 1.8% | $20.49 * | $13.91 | +20.3% | SH | 037326105 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $100M | 1.6% | $13.85 * | $19.11 | -32.3% | SH | 90240B106 |
| JANX | JANUX THERAPEUTICS INC | 9,165,652 | $98.35M | 1.5% | $10.73 * | $21.69 | -60.1% | SH | 47103J105 |
| GERN | GERON CORP | 46,202,425 | $97.49M | 1.5% | $2.11 * | $2.42 | -19.8% | SH | 374163103 |
| — | ICOSAVAX INC | 5,963,565 | $93.99M | 1.5% | $15.76 | $28.89 | — | SH | 45114M109 |
| — | ALPINE IMMUNE SCIENCES INC | 4,909,763 | $93.58M | 1.5% | $19.06 | $7.76 | — | SH | 02083G100 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $91.92M | 1.4% | $5.05 * | $8.66 | -38.3% | SH | Y95308105 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 7,864,000 | $87.84M | 1.4% | $11.17 * | $11.79 | -22.3% | SH | N62509109 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,163,211 | $84.35M | 1.3% | $20.26 * | $17.97 | -26.8% | SH | 35104E100 |
| EVH | EVOLENT HEALTH INC - A | 2,549,132 | $84.2M | 1.3% | $33.03 * | $27.80 | +1.8% | SH | 30050B101 |
| AXSM | AXSOME THERAPEUTICS INC | 1,000,000 | $79.59M | 1.2% | $79.59 * | $73.77 | -9.4% | SH | 05464T104 |
| FULC | FULCRUM THERAPEUTICS INC | 11,609,704 | $78.37M | 1.2% | $6.75 * | $7.35 | -39.6% | SH | 359616109 |
| CTKB | CYTEK BIOSCIENCES INC | 6,809,404 | $62.1M | 1.0% | $9.12 * | $20.70 | -69.6% | SH | 23285D109 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $57.34M | 0.9% | $3.84 * | $13.02 | -77.2% | SH | 00509G209 |
| PEPG | PEPGEN INC | 8,131,952 | $55.3M | 0.9% | $6.80 * | $11.15 | -50.8% | SH | 713317105 |
| APGE | APOGEE THERAPEUTICS INC | 1,977,901 | $55.26M | 0.9% | $27.94 * | $22.03 | -9.0% | SH | 03770N101 |
| SPRY | ARS PHARMACEUTICALS INC | 9,459,678 | $51.84M | 0.8% | $5.48 * | $6.54 | -33.0% | SH | 82835W108 |
| NKTX | NKARTA INC | 7,805,129 | $51.51M | 0.8% | $6.60 * | $24.86 | -89.6% | SH | 65487U108 |
| — | VOR BIOPHARMA INC | 22,748,880 | $51.18M | 0.8% | $2.25 | $24.47 | — | SH | 929033108 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $48.37M | 0.8% | $10.95 | $24.67 | — | SH | 46565G104 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 204,500 | $47.32M | 0.7% | $231.38 * | $188.22 | -7.0% | SH | 558868105 |
| URGN | UROGEN PHARMA LTD | 3,083,430 | $46.25M | 0.7% | $15.00 * | $14.46 | -10.2% | SH | M96088105 |
| MGNX | MACROGENICS INC | 4,053,077 | $38.99M | 0.6% | $9.62 * | $6.75 | +2.4% | SH | 556099109 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $35.51M | 0.6% | $2.70 * | $20.66 | -87.4% | SH | 28658R106 |
| TSHA | TAYSHA GENE THERAPIES INC | 18,472,503 | $32.7M | 0.5% | $1.77 * | $1.87 | +6.7% | SH | 877619106 |
| GHRS | GH RESEARCH PLC | 5,587,333 | $32.41M | 0.5% | $5.80 * | $17.97 | -60.7% | SH | G3855L106 |
| ELVN | ENLIVEN THERAPEUTICS INC | 2,122,465 | $29.37M | 0.5% | $13.84 * | $20.34 | -39.8% | SH | 29337E102 |
| CCCC | C4 THERAPEUTICS INC | 4,878,000 | $27.56M | 0.4% | $5.65 * | $2.28 | 0.0% | SH | 12529R107 |
| MLYS | MINERALYS THERAPEUTICS INC | 3,178,476 | $27.33M | 0.4% | $8.60 * | $16.83 | -53.4% | SH | 603170101 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $23.72M | 0.4% | $3.86 * | $10.47 | -75.6% | SH | 95075A107 |
| ACRV | ACRIVON THERAPEUTICS INC | 4,810,508 | $23.67M | 0.4% | $4.92 * | $12.69 | -58.4% | SH | 004890109 |
| PLRX | PLIANT THERAPEUTICS INC | 1,281,000 | $23.2M | 0.4% | $18.11 * | $28.47 | -46.6% | SH | 729139105 |
| — | THIRD HARMONIC BIO INC | 2,033,056 | $22.3M | 0.3% | $10.97 | $8.80 | — | SH | 88427A107 |
| RNAM | AVIDITY BIOSCIENCES INC | 2,454,533 | $22.21M | 0.3% | $9.05 * | $16.99 | -60.7% | SH | 05370A108 |
| SLDB | SOLID BIOSCIENCES INC | 3,426,286 | $21.04M | 0.3% | $6.14 * | $6.55 | -51.2% | SH | 83422E204 |
| GPCR | STRUCTURE THERAPEUTICS INC | 486,832 | $19.84M | 0.3% | $40.76 | $40.76 | — | SH | 86366E106 |
| TNYA | TENAYA THERAPEUTICS INC | 5,507,347 | $17.84M | 0.3% | $3.24 * | $7.15 | -69.8% | SH | 87990A106 |
| ARVN | ARVINAS INC | 421,348 | $17.34M | 0.3% | $41.16 * | $23.38 | 0.0% | SH | 04335A105 |
| — | HARPOON THERAPEUTICS INC | 1,500,000 | $17.05M | 0.3% | $11.37 | $11.37 | — | SH | 41358P205 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 800,000 | $14.46M | 0.2% | $18.08 | $20.09 | — | SH | 088786108 |
| — | CUREVAC NV | 2,744,270 | $11.55M | 0.2% | $4.21 | $6.97 | — | SH | N2451R105 |
| CMPS | COMPASS PATHWAYS PLC | 1,286,000 | $11.25M | 0.2% | $8.75 | $7.40 | — | SH | 20451W101 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 3,525,754 | $9.907M | 0.2% | $2.81 * | $22.74 | -89.7% | SH | 09203E105 |
| — | CHIMERIX INC | 8,800,000 | $8.47M | 0.1% | $0.96 | $0.96 | — | SH | 16934W106 |
| — | IGM BIOSCIENCES INC | 937,500 | $7.791M | 0.1% | $8.31 | $9.23 | — | SH | 449585108 |
| — | CONNECT BIOPHARMA HOLDINGS L | 3,062,871 | $3.614M | 0.1% | $1.18 | $19.09 | — | SH | 207523101 |
| — | UNICYCIVE THERAPEUTICS INC | 3,470,688 | $3.012M | 0.0% | $0.87 | $0.86 | — | SH | 90466Y103 |
| SABS | SAB BIOTHERAPEUTICS INC | 2,374,081 | $1.632M | 0.0% | $0.69 * | $8.38 | 0.0% | SH | 78397T202 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $1.043M | 0.0% | $3.13 | $0.87 | — | SH | N62509117 |