BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value ($000): $10,307,840 (100.0% shares, 0.0% debt)

Holdings (89)

ONC BeOne Medicines Ltd. 20.7%
Value ($000) $2,129,987 Shares 8,799,053 Est. Cost $136.93 Unrealized
INCY Incyte Corporation 20.3%
Value ($000) $2,093,617 Shares 30,743,275 Est. Cost $72.80 Unrealized -13.0%
ACAD ACADIA Pharmaceuticals Inc. 9.0%
Value ($000) $925,282 Shares 42,896,690 Est. Cost $18.93 Unrealized -1.8%
INSM Insmed Incorporated 7.5%
Value ($000) $776,226 Shares 7,712,900 Est. Cost $57.51 Unrealized +33.0%
SMMT Summit Therapeutics Inc. 7.0%
Value ($000) $717,625 Shares 33,722,974 Est. Cost $10.51 Unrealized +117.1%
MDGL Madrigal Pharmaceuticals, Inc. 5.8%
Value ($000) $598,022 Shares 1,976,018 Est. Cost $119.77 Unrealized +148.8%
RYTM Rhythm Pharmaceuticals, Inc. 3.4%
Value ($000) $354,147 Shares 5,604,483 Est. Cost $23.49 Unrealized +160.7%
RVMD Revolution Medicines, Inc. 3.3%
Value ($000) $344,537 Shares 9,364,972 Est. Cost $29.36 Unrealized +30.9%
KYMR Kymera Therapeutics, Inc. 2.8%
Value ($000) $290,268 Shares 6,651,429 Est. Cost $28.76 Unrealized +19.7%
ALKS Alkermes plc 1.8%
Value ($000) $183,407 Shares 6,410,603 Est. Cost $26.48 Unrealized +12.4%
REPL Replimune Group, Inc. 1.0%
Value ($000) $102,611 Shares 11,045,336 Est. Cost $14.45 Unrealized -39.6%
RARE Ultragenyx Pharmaceutical Inc. 1.0%
Value ($000) $100,815 Shares 2,772,692 Est. Cost $52.13 Unrealized -30.8%
EWTX Edgewise Therapeutics, Inc. 0.9%
Value ($000) $95,781 Shares 7,305,940 Est. Cost $14.29 Unrealized +0.9%
ABCL AbCellera Biologics Inc. 0.9%
Value ($000) $94,413 Shares 27,525,640 Est. Cost $21.02 Unrealized -88.2%
IMVT Immunovant, Inc. 0.8%
Value ($000) $87,326 Shares 5,457,881 Est. Cost $22.96 Unrealized -34.1%
GRAL GRAIL, Inc. 0.8%
Value ($000) $83,821 Shares 1,630,125 Est. Cost $16.26 Unrealized +122.6%
KNSA Kiniksa Pharmaceuticals International, plc 0.8%
Value ($000) $78,159 Shares 2,824,669 Est. Cost $18.73 Unrealized +35.9%
BCYC Bicycle Therapeutics plc 0.7%
Value ($000) $75,653 Shares 10,885,357 Est. Cost $20.78 Unrealized
IMCR Immunocore Holdings plc 0.7%
Value ($000) $72,885 Shares 2,322,656 Est. Cost $38.09 Unrealized
CELC Celcuity Inc. 0.7%
Value ($000) $72,763 Shares 5,450,445 Est. Cost $12.68 Unrealized -14.1%
KOD Kodiak Sciences Inc. 0.6%
Value ($000) $64,568 Shares 17,310,490 Est. Cost $30.30 Unrealized -88.3%
IMTX Immatics N.V. 0.5%
Value ($000) $54,709 Shares 10,168,901 Est. Cost $9.00 Unrealized -44.9%
STOK Stoke Therapeutics, Inc. 0.5%
Value ($000) $52,594 Shares 4,633,838 Est. Cost $9.30 Unrealized +2.1%
DNLI Denali Therapeutics Inc. 0.5%
Value ($000) $52,206 Shares 3,731,695 Est. Cost $23.78 Unrealized -40.8%
GPCR Structure Therapeutics Inc. 0.5%
Value ($000) $52,032 Shares 2,508,767 Est. Cost $22.23 Unrealized
IDYA IDEAYA Biosciences, Inc. 0.4%
Value ($000) $44,536 Shares 2,118,728 Est. Cost $16.90 Unrealized +13.5%
NRIX Nurix Therapeutics, Inc. 0.4%
Value ($000) $44,217 Shares 3,882,125 Est. Cost $22.27 Unrealized -51.5%
ROIV Roivant Sciences Ltd. 0.4%
Value ($000) $42,463 Shares 3,767,773 Est. Cost $9.71 Unrealized +11.6%
BNTX BioNTech SE 0.4%
Value ($000) $39,279 Shares 368,923 Est. Cost $107.38 Unrealized
TRDA Entrada Therapeutics, Inc. 0.3%
Value ($000) $32,698 Shares 4,865,819 Est. Cost $16.96 Unrealized
Merus N.V. 0.3%
Value ($000) $30,212 Shares 574,377 Est. Cost $52.94 Unrealized
PRAX Praxis Precision Medicines, Inc. 0.3%
Value ($000) $28,993 Shares 689,488 Est. Cost $44.22 Unrealized -13.9%
NTLA Intellia Therapeutics, Inc. 0.2%
Value ($000) $25,098 Shares 2,675,674 Est. Cost $9.99 Unrealized -17.8%
VRDN Viridian Therapeutics, Inc. 0.2%
Value ($000) $24,387 Shares 1,744,406 Est. Cost $13.57 Unrealized 0.0%
GLUE Monte Rosa Therapeutics, Inc. 0.2%
Value ($000) $22,172 Shares 4,916,095 Est. Cost $6.49 Unrealized -31.3%
Verona Pharma plc 0.2%
Value ($000) $21,171 Shares 223,843 Est. Cost $63.49 Unrealized
PCVX Vaxcyte, Inc. 0.2%
Value ($000) $20,835 Shares 640,885 Est. Cost $76.85 Unrealized -57.3%
ARGX argenx SE 0.2%
Value ($000) $20,814 Shares 37,760 Est. Cost $79.01 Unrealized
Verve Therapeutics, Inc. 0.2%
Value ($000) $18,996 Shares 1,691,530 Est. Cost $52.72 Unrealized
CERS Cerus Corporation 0.2%
Value ($000) $18,166 Shares 12,883,844 Est. Cost $4.19 Unrealized -68.1%
IRON Disc Medicine, Inc. 0.2%
Value ($000) $17,850 Shares 337,050 Est. Cost $49.46 Unrealized -5.0%
Akero Therapeutics, Inc. 0.2%
Value ($000) $17,322 Shares 324,630 Est. Cost $32.79 Unrealized
Blueprint Medicines Corporation 0.2%
Value ($000) $16,091 Shares 125,538 Est. Cost $128.18 Unrealized
SERA Sera Prognostics, Inc. 0.1%
Value ($000) $15,230 Shares 5,498,170 Est. Cost $3.09 Unrealized -20.0%
ARWR Arrowhead Pharmaceuticals, Inc. 0.1%
Value ($000) $14,839 Shares 939,174 Est. Cost $14.35 Unrealized 0.0%
NGNE Neurogene Inc. 0.1%
Value ($000) $14,826 Shares 991,691 Est. Cost $19.35 Unrealized -18.9%
DNTH Dianthus Therapeutics, Inc. 0.1%
Value ($000) $14,713 Shares 789,759 Est. Cost $18.76 Unrealized 0.0%
CLDX Celldex Therapeutics, Inc. 0.1%
Value ($000) $13,540 Shares 665,370 Est. Cost $23.17 Unrealized -16.0%
DBVT DBV Technologies S.A. 0.1%
Value ($000) $13,387 Shares 1,461,425 Est. Cost $3.09 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.1%
Value ($000) $11,588 Shares 370,208 Est. Cost $19.37 Unrealized +68.4%
Cidara Therapeutics, Inc. 0.1%
Value ($000) $11,070 Shares 227,272 Est. Cost $48.71 Unrealized
ACLX Arcellx, Inc. 0.1%
Value ($000) $10,985 Shares 166,825 Est. Cost $62.26 Unrealized 0.0%
NUVL Nuvalent, Inc. 0.1%
Value ($000) $10,982 Shares 143,937 Est. Cost $73.17 Unrealized 0.0%
SYRE Spyre Therapeutics, Inc. 0.1%
Value ($000) $9,382 Shares 626,703 Est. Cost $14.80 Unrealized 0.0%
TSHA Taysha Gene Therapies, Inc. 0.1%
Value ($000) $9,251 Shares 4,004,756 Est. Cost $1.91 Unrealized +13.4%
PRLD Prelude Therapeutics Inc. 0.1%
Value ($000) $8,194 Shares 10,123,824 Est. Cost $28.24 Unrealized -96.9%
CRNX Crinetics Pharmaceuticals, Inc. 0.1%
Value ($000) $8,053 Shares 280,000 Est. Cost $30.88 Unrealized 0.0%
CTMX CytomX Therapeutics, Inc. 0.1%
Value ($000) $7,909 Shares 3,484,226 Est. Cost $1.61 Unrealized 0.0%
SGMT Sagimet Biosciences Inc. 0.1%
Value ($000) $7,262 Shares 952,996 Est. Cost $9.53 Unrealized -55.7%
SION Sionna Therapeutics, Inc. 0.1%
Value ($000) $6,940 Shares 400,000 Est. Cost $16.34 Unrealized -19.8%
AGIO Agios Pharmaceuticals, Inc. 0.1%
Value ($000) $6,315 Shares 189,866 Est. Cost $30.31 Unrealized 0.0%
RAPP Rapport Therapeutics, Inc. 0.1%
Value ($000) $6,255 Shares 550,090 Est. Cost $10.61 Unrealized 0.0%
SKYE Skye Bioscience, Inc. 0.1%
Value ($000) $6,064 Shares 1,450,638 Est. Cost $7.74 Unrealized -73.3%
DSGN Design Therapeutics, Inc. 0.1%
Value ($000) $5,772 Shares 1,712,882 Est. Cost $12.06 Unrealized -69.0%
KALA KALA BIO, Inc. 0.1%
Value ($000) $5,721 Shares 1,201,894 Est. Cost $7.72 Unrealized -49.5%
SANA Sana Biotechnology, Inc. 0.1%
Value ($000) $5,544 Shares 2,030,949 Est. Cost $4.55 Unrealized -54.7%
XNCR Xencor, Inc. 0.1%
Value ($000) $5,270 Shares 670,431 Est. Cost $21.77 Unrealized -58.8%
ALMS Alumis Inc. 0.0%
Value ($000) $4,688 Shares 1,562,500 Est. Cost $13.30 Unrealized -64.5%
IGM Biosciences, Inc. 0.0%
Value ($000) $4,588 Shares 4,096,210 Est. Cost $15.73 Unrealized
TCRX TScan Therapeutics, Inc. 0.0%
Value ($000) $4,038 Shares 2,784,792 Est. Cost $6.08 Unrealized -76.2%
RLAY Relay Therapeutics, Inc. 0.0%
Value ($000) $4,014 Shares 1,160,117 Est. Cost $13.78 Unrealized -78.4%
FATE Fate Therapeutics, Inc. 0.0%
Value ($000) $2,783 Shares 2,485,018 Est. Cost $5.24 Unrealized -77.8%
VIR Vir Biotechnology, Inc. 0.0%
Value ($000) $2,734 Shares 542,539 Est. Cost $7.89 Unrealized -32.0%
ELVN Enliven Therapeutics, Inc. 0.0%
Value ($000) $2,304 Shares 114,833 Est. Cost $15.34 Unrealized +23.4%
WVE Wave Life Sciences Ltd. 0.0%
Value ($000) $2,236 Shares 344,063 Est. Cost $5.98 Unrealized +10.5%
TECX Tectonic Therapeutic, Inc. 0.0%
Value ($000) $1,987 Shares 100,000 Est. Cost $32.59 Unrealized -37.8%
CADL Candel Therapeutics, Inc. 0.0%
Value ($000) $1,797 Shares 355,112 Est. Cost $5.91 Unrealized -12.9%
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $1,627 Shares 536,832 Est. Cost $13.35 Unrealized -74.2%
VTVT vTv Therapeutics, Inc. 0.0%
Value ($000) $1,460 Shares 97,314 Est. Cost $12.72 Unrealized +44.1%
RCKT Rocket Pharmaceuticals, Inc. 0.0%
Value ($000) $1,353 Shares 552,079 Est. Cost $10.34 Unrealized -51.0%
CTNM Contineum Therapeutics, Inc. 0.0%
Value ($000) $1,241 Shares 312,500 Est. Cost $16.10 Unrealized -73.0%
HOOK HOOKIPA Pharma Inc. 0.0%
Value ($000) $1,020 Shares 812,814 Est. Cost $7.93 Unrealized -84.4%
NMRA Neumora Therapeutics, Inc. 0.0%
Value ($000) $759 Shares 1,034,600 Est. Cost $13.91 Unrealized -94.6%
Generation Bio Co. 0.0%
Value ($000) $623 Shares 1,944,945 Est. Cost $2.93 Unrealized
ALGS Aligos Therapeutics, Inc. 0.0%
Value ($000) $599 Shares 83,055 Est. Cost $12.44 Unrealized -51.9%
TYRA Tyra Biosciences, Inc. 0.0%
Value ($000) $102 Shares 10,607 Est. Cost $12.95 Unrealized -26.6%
ACRV Acrivon Therapeutics, Inc. 0.0%
Value ($000) $27 Shares 22,809 Est. Cost $4.64 Unrealized -70.4%
SRZNW Surrozen, Inc. 0.0%
Value ($000) $15 Shares 833,333 Est. Cost $1.14 Unrealized
OPTEY Opthea Limited 0.0%
Value ($000) $0 Shares 2,087,320 Est. Cost $11.12 Unrealized