Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2018 (← Previous) (Next →)

Filing Date: May 14, 2018

Total Value: $350M (100.0% shares, 0.0% debt)

Holdings (38)

AXGN AXOGEN INC 17.9%

Value $62.6M Shares 1,715,000 Est. Cost $3.33 Unrealized +822.2%

— BLUEPRINT MEDICINES 15.7%

Value $55.02M Shares 600,000 Est. Cost $27.77 Unrealized —

— LOXO ONCOLOGY 5.9%

Value $20.7M Shares 179,400 Est. Cost $43.63 Unrealized —

CDXS CODEXIS INC 5.3%

Value $18.71M Shares 1,700,600 Est. Cost $2.93 Unrealized +227.3%

— FIBROGEN INC 4.8%

Value $16.63M Shares 360,000 Est. Cost $26.18 Unrealized —

— STRONGBRIDGE BIOPHARMA PLC 4.0%

Value $14.07M Shares 1,590,000 Est. Cost $4.02 Unrealized —

— CORIUM INTERNATIONAL INC 3.5%

Value $12.21M Shares 1,065,000 Est. Cost $8.50 Unrealized —

AGIO AGIOS PHARMACEUTICALS 3.0%

Value $10.63M Shares 130,000 Est. Cost $43.03 Unrealized +79.6%

FENC FENNEC PHARMACEUTICALS INC 3.0%

Value $10.56M Shares 873,000 Est. Cost $9.96 Unrealized -5.2%

SGMO SANGAMO BIOSCIENCES INC 2.9%

Value $10.16M Shares 535,000 Est. Cost $3.76 Unrealized +469.1%

— CYMABAY THERAPEUTICS INC 2.5%

Value $8.638M Shares 665,000 Est. Cost $8.05 Unrealized —

— AMAG PHARMACEUTICALS INC 2.4%

Value $8.463M Shares 420,000 Est. Cost $20.15 Unrealized —

— MIRAGEN THERAPEUTICS INC 2.1%

Value $7.43M Shares 1,060,000 Est. Cost $7.01 Unrealized —

— DECIPHERA PHARMACEUTICALS INC 2.1%

Value $7.314M Shares 365,000 Est. Cost $20.04 Unrealized —

— OCULAR THERAPEUTIX INC 2.1%

Value $7.232M Shares 1,111,000 Est. Cost $6.51 Unrealized —

XOMA XOMA CORP DEL 1.9%

Value $6.477M Shares 320,200 Est. Cost $6.46 Unrealized +333.2%

— BIOFRONTERA AG 1.8%

Value $6.462M Shares 391,200 Est. Cost $16.52 Unrealized —

ARDX ARDELYX 1.6%

Value $5.734M Shares 1,135,600 Est. Cost $7.13 Unrealized -12.5%

— AUDENTES THERAPEUTICS INC 1.6%

Value $5.709M Shares 190,000 Est. Cost $22.19 Unrealized —

— AMARIN CORP PLC 1.5%

Value $5.252M Shares 1,745,000 Est. Cost $3.50 Unrealized —

— ABLYNX NV 1.4%

Value $4.91M Shares 90,000 Est. Cost $24.99 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 1.4%

Value $4.873M Shares 950,000 Est. Cost $5.96 Unrealized —

VKTX VIKING THERAPEUTICS INC 1.4%

Value $4.81M Shares 1,100,800 Est. Cost $4.39 Unrealized +26.2%

RARE ULTRAGENYX PHARMACEUTICALS INC 1.2%

Value $4.079M Shares 80,000 Est. Cost $49.03 Unrealized +2.7%

— ACHILLION PHARMACEUTICALS INC 1.2%

Value $4.063M Shares 1,095,100 Est. Cost $3.38 Unrealized —

— DEPOMED INC 1.1%

Value $3.954M Shares 600,000 Est. Cost $6.59 Unrealized —

PTCT PTC THERAPEUTICS INC 1.1%

Value $3.923M Shares 145,000 Est. Cost $25.34 Unrealized 0.0%

TGTX TG THERAPEUTICS INC 1.1%

Value $3.893M Shares 274,200 Est. Cost $12.78 Unrealized 0.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.9%

Value $3.166M Shares 222,500 Est. Cost $10.61 Unrealized 0.0%

— CHIMERIX INC 0.9%

Value $3.12M Shares 600,000 Est. Cost $5.07 Unrealized —

QTRX QUANTERIX CORP 0.7%

Value $2.556M Shares 150,000 Est. Cost $19.82 Unrealized +1.1%

— PROTALIX BIOTHERAPEUTICS INC 0.5%

Value $1.76M Shares 3,260,000 Est. Cost $0.61 Unrealized —

— FORTRESS BIOTECH INC 0.4%

Value $1.433M Shares 315,000 Est. Cost $4.55 Unrealized —

— EPIZYME INC 0.4%

Value $1.242M Shares 70,000 Est. Cost $17.74 Unrealized —

— SYROS PHARMACEUTICALS INC 0.3%

Value $961K Shares 74,074 Est. Cost $15.97 Unrealized —

— ZOSANO PHARMA CORP 0.1%

Value $504K Shares 100,000 Est. Cost $5.04 Unrealized —

— QUOTIENT LTD 0.1%

Value $282K Shares 60,000 Est. Cost $4.70 Unrealized —

— BIOLINERX LTD 0.1%

Value $214K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AXGN	AXOGEN INC	1,715,000	$62.6M	17.9%	$3.33	+822.2%	COM	05463X106
—	BLUEPRINT MEDICINES	600,000	$55.02M	15.7%	$27.77	—	COM	09627Y109
—	LOXO ONCOLOGY	179,400	$20.7M	5.9%	$43.63	—	COM	548862101
CDXS	CODEXIS INC	1,700,600	$18.71M	5.3%	$2.93	+227.3%	COM	192005106
—	FIBROGEN INC	360,000	$16.63M	4.8%	$26.18	—	COM	31572Q808
—	STRONGBRIDGE BIOPHARMA PLC	1,590,000	$14.07M	4.0%	$4.02	—	COM	G85347105
—	CORIUM INTERNATIONAL INC	1,065,000	$12.21M	3.5%	$8.50	—	COM	21887L107
AGIO	AGIOS PHARMACEUTICALS	130,000	$10.63M	3.0%	$43.03	+79.6%	COM	00847X104
FENC	FENNEC PHARMACEUTICALS INC	873,000	$10.56M	3.0%	$9.96	-5.2%	COM	31447P100
SGMO	SANGAMO BIOSCIENCES INC	535,000	$10.16M	2.9%	$3.76	+469.1%	COM	800677106
—	CYMABAY THERAPEUTICS INC	665,000	$8.638M	2.5%	$8.05	—	COM	23257D103
—	AMAG PHARMACEUTICALS INC	420,000	$8.463M	2.4%	$20.15	—	COM	00163UAA4
—	MIRAGEN THERAPEUTICS INC	1,060,000	$7.43M	2.1%	$7.01	—	COM	60463E10E
—	DECIPHERA PHARMACEUTICALS INC	365,000	$7.314M	2.1%	$20.04	—	COM	24344T101
—	OCULAR THERAPEUTIX INC	1,111,000	$7.232M	2.1%	$6.51	—	COM	67576A900
XOMA	XOMA CORP DEL	320,200	$6.477M	1.9%	$6.46	+333.2%	COM NEW	98419J206
—	BIOFRONTERA AG	391,200	$6.462M	1.8%	$16.52	—	SPONSORED ADS	090758105
ARDX	ARDELYX	1,135,600	$5.734M	1.6%	$7.13	-12.5%	COM	039697107
—	AUDENTES THERAPEUTICS INC	190,000	$5.709M	1.6%	$22.19	—	COM	05070R104
—	AMARIN CORP PLC	1,745,000	$5.252M	1.5%	$3.50	—	SPONSORED ADR	023111206
—	ABLYNX NV	90,000	$4.91M	1.4%	$24.99	—	SPONSORED ADR	00372Y905
—	FOAMIX PHARMACEUTICALS LTD	950,000	$4.873M	1.4%	$5.96	—	SHS	M46135105
VKTX	VIKING THERAPEUTICS INC	1,100,800	$4.81M	1.4%	$4.39	+26.2%	COM	92686J106
RARE	ULTRAGENYX PHARMACEUTICALS INC	80,000	$4.079M	1.2%	$49.03	+2.7%	COM	90400D108
—	ACHILLION PHARMACEUTICALS INC	1,095,100	$4.063M	1.2%	$3.38	—	COM	00448Q201
—	DEPOMED INC	600,000	$3.954M	1.1%	$6.59	—	COM	249908104
PTCT	PTC THERAPEUTICS INC	145,000	$3.923M	1.1%	$25.34	0.0%	COM	69366J200
TGTX	TG THERAPEUTICS INC	274,200	$3.893M	1.1%	$12.78	0.0%	COM	88322Q108
SNDX	SYNDAX PHARMACEUTICALS INC	222,500	$3.166M	0.9%	$10.61	0.0%	COM	87164F105
—	CHIMERIX INC	600,000	$3.12M	0.9%	$5.07	—	COM	16934W106
QTRX	QUANTERIX CORP	150,000	$2.556M	0.7%	$19.82	+1.1%	COM	74766Q101
—	PROTALIX BIOTHERAPEUTICS INC	3,260,000	$1.76M	0.5%	$0.61	—	COM	74365A101
—	FORTRESS BIOTECH INC	315,000	$1.433M	0.4%	$4.55	—	COM	34960Q109
—	EPIZYME INC	70,000	$1.242M	0.4%	$17.74	—	COM	29428V104
—	SYROS PHARMACEUTICALS INC	74,074	$961K	0.3%	$15.97	—	COM	87184Q107
—	ZOSANO PHARMA CORP	100,000	$504K	0.1%	$5.04	—	COM	98979H103
—	QUOTIENT LTD	60,000	$282K	0.1%	$4.70	—	SHS	G73268107
—	BIOLINERX LTD	250,000	$214K	0.1%	$1426.15	—	SPONSORED ADR	09071M106