Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 9, 2018

Total Value: $312M (100.0% shares, 0.0% debt)

Holdings (35)

AXGN AXOGEN INC 17.9%

Value $55.75M Shares 1,970,000 Est. Cost $3.33 Unrealized +609.5%

— BLUEPRINT MEDICINES 17.7%

Value $55.43M Shares 735,000 Est. Cost $27.77 Unrealized —

— FIBROGEN INC 5.5%

Value $17.06M Shares 360,000 Est. Cost $26.18 Unrealized —

— LOXO ONCOLOGY 4.8%

Value $14.84M Shares 176,300 Est. Cost $42.37 Unrealized —

— IMMUNOMEDICS INC 4.7%

Value $14.52M Shares 898,800 Est. Cost $6.47 Unrealized —

CDXS CODEXIS INC 4.5%

Value $14.2M Shares 1,700,600 Est. Cost $2.93 Unrealized +136.6%

XOMA XOMA CORP DEL 3.7%

Value $11.4M Shares 320,200 Est. Cost $6.46 Unrealized +319.7%

— ABLYNX NV 3.4%

Value $10.49M Shares 420,000 Est. Cost $24.99 Unrealized —

— CORIUM INTERNATIONAL INC 3.3%

Value $10.19M Shares 1,060,000 Est. Cost $8.50 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 3.0%

Value $9.512M Shares 580,000 Est. Cost $3.76 Unrealized +296.0%

— STRONGBRIDGE BIOPHARMA PLC 2.9%

Value $9.062M Shares 1,250,000 Est. Cost $2.71 Unrealized —

FENC FENNEC PHARMACEUTICALS INC 2.7%

Value $8.486M Shares 846,900 Est. Cost $9.98 Unrealized 0.0%

AGIO AGIOS PHARMACEUTICALS 2.4%

Value $7.432M Shares 130,000 Est. Cost $43.03 Unrealized +46.2%

— AUDENTES THERAPEUTICS INC 2.1%

Value $6.652M Shares 210,000 Est. Cost $22.19 Unrealized —

CRSP CRISPR THERAPEUTICS AG 2.1%

Value $6.597M Shares 281,000 Est. Cost $19.00 Unrealized 0.0%

— CYMABAY THERAPEUTICS INC 2.0%

Value $6.118M Shares 665,000 Est. Cost $8.05 Unrealized —

ARDX ARDELYX 1.9%

Value $5.94M Shares 900,000 Est. Cost $7.37 Unrealized -19.6%

— FOAMIX PHARMACEUTICALS LTD 1.8%

Value $5.769M Shares 960,000 Est. Cost $5.96 Unrealized —

ARGX ARGENX 1.8%

Value $5.587M Shares 88,500 Est. Cost $63.13 Unrealized —

— NEKTAR THERAPEUTICS 1.5%

Value $4.777M Shares 80,000 Est. Cost $59.71 Unrealized —

— INOTEK PHARMACEUTICALS CORP 1.5%

Value $4.703M Shares 1,802,000 Est. Cost $1.78 Unrealized —

— ACCELERON PHARMA INC 1.4%

Value $4.307M Shares 101,500 Est. Cost $30.49 Unrealized —

RARE ULTRAGENYX PHARMACEUTICALS INC 1.3%

Value $4.174M Shares 90,000 Est. Cost $49.03 Unrealized 0.0%

— AMARIN CORP PLC 1.1%

Value $3.448M Shares 860,000 Est. Cost $4.01 Unrealized —

— DERMIRA INC 0.9%

Value $2.781M Shares 100,000 Est. Cost $27.81 Unrealized —

— CHIMERIX INC 0.9%

Value $2.778M Shares 600,000 Est. Cost $5.07 Unrealized —

VKTX VIKING THERAPEUTICS INC 0.6%

Value $1.951M Shares 480,558 Est. Cost $2.90 Unrealized 0.0%

QURE UNIQURE NV 0.6%

Value $1.778M Shares 90,801 Est. Cost $15.23 Unrealized 0.0%

QTRX QUANTERIX CORP 0.4%

Value $1.395M Shares 65,000 Est. Cost $19.52 Unrealized 0.0%

— ACHILLION PHARMACEUTICALS INC 0.4%

Value $1.267M Shares 440,000 Est. Cost $2.88 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 0.4%

Value $1.206M Shares 1,825,000 Est. Cost $0.66 Unrealized —

RYTM RHYTHM PHARMACEUTICALS INC 0.4%

Value $1.113M Shares 38,300 Est. Cost $26.40 Unrealized 0.0%

— SYROS PHARMACEUTICALS INC 0.2%

Value $720K Shares 74,074 Est. Cost $15.97 Unrealized —

— SPECTRUM PHARMACEUTICALS INC 0.2%

Value $587K Shares 31,000 Est. Cost $18.94 Unrealized —

— BIOLINERX LTD 0.1%

Value $272K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AXGN	AXOGEN INC	1,970,000	$55.75M	17.9%	$3.33	+609.5%	COM	05463X106
—	BLUEPRINT MEDICINES	735,000	$55.43M	17.7%	$27.77	—	COM	09627Y109
—	FIBROGEN INC	360,000	$17.06M	5.5%	$26.18	—	COM	31572Q808
—	LOXO ONCOLOGY	176,300	$14.84M	4.8%	$42.37	—	COM	548862101
—	IMMUNOMEDICS INC	898,800	$14.52M	4.7%	$6.47	—	COM	452907108
CDXS	CODEXIS INC	1,700,600	$14.2M	4.5%	$2.93	+136.6%	COM	192005106
XOMA	XOMA CORP DEL	320,200	$11.4M	3.7%	$6.46	+319.7%	COM NEW	98419J206
—	ABLYNX NV	420,000	$10.49M	3.4%	$24.99	—	SPONSORED ADR	00372Y905
—	CORIUM INTERNATIONAL INC	1,060,000	$10.19M	3.3%	$8.50	—	COM	21887L107
SGMO	SANGAMO BIOSCIENCES INC	580,000	$9.512M	3.0%	$3.76	+296.0%	COM	800677106
—	STRONGBRIDGE BIOPHARMA PLC	1,250,000	$9.062M	2.9%	$2.71	—	COM	G85347105
FENC	FENNEC PHARMACEUTICALS INC	846,900	$8.486M	2.7%	$9.98	0.0%	COM	31447P100
AGIO	AGIOS PHARMACEUTICALS	130,000	$7.432M	2.4%	$43.03	+46.2%	COM	00847X104
—	AUDENTES THERAPEUTICS INC	210,000	$6.652M	2.1%	$22.19	—	COM	05070R104
CRSP	CRISPR THERAPEUTICS AG	281,000	$6.597M	2.1%	$19.00	0.0%	NAMEN AKT	H17182108
—	CYMABAY THERAPEUTICS INC	665,000	$6.118M	2.0%	$8.05	—	COM	23257D103
ARDX	ARDELYX	900,000	$5.94M	1.9%	$7.37	-19.6%	COM	039697107
—	FOAMIX PHARMACEUTICALS LTD	960,000	$5.769M	1.8%	$5.96	—	SHS	M46135105
ARGX	ARGENX	88,500	$5.587M	1.8%	$63.13	—	SPONSORED ADR	04016X101
—	NEKTAR THERAPEUTICS	80,000	$4.777M	1.5%	$59.71	—	COM	640268108
—	INOTEK PHARMACEUTICALS CORP	1,802,000	$4.703M	1.5%	$1.78	—	COM	45780V102
—	ACCELERON PHARMA INC	101,500	$4.307M	1.4%	$30.49	—	COM	00434H108
RARE	ULTRAGENYX PHARMACEUTICALS INC	90,000	$4.174M	1.3%	$49.03	0.0%	COM	90400D108
—	AMARIN CORP PLC	860,000	$3.448M	1.1%	$4.01	—	SPONSORED ADR	023111206
—	DERMIRA INC	100,000	$2.781M	0.9%	$27.81	—	COM	24983L104
—	CHIMERIX INC	600,000	$2.778M	0.9%	$5.07	—	COM	16934W106
VKTX	VIKING THERAPEUTICS INC	480,558	$1.951M	0.6%	$2.90	0.0%	COM	92686J106
QURE	UNIQURE NV	90,801	$1.778M	0.6%	$15.23	0.0%	SHS	N90064101
QTRX	QUANTERIX CORP	65,000	$1.395M	0.4%	$19.52	0.0%	COM	74766Q101
—	ACHILLION PHARMACEUTICALS INC	440,000	$1.267M	0.4%	$2.88	—	COM	00448Q201
—	PROTALIX BIOTHERAPEUTICS INC	1,825,000	$1.206M	0.4%	$0.66	—	COM	74365A101
RYTM	RHYTHM PHARMACEUTICALS INC	38,300	$1.113M	0.4%	$26.40	0.0%	COM	76243J105
—	SYROS PHARMACEUTICALS INC	74,074	$720K	0.2%	$15.97	—	COM	87184Q107
—	SPECTRUM PHARMACEUTICALS INC	31,000	$587K	0.2%	$18.94	—	COM	84763A108
—	BIOLINERX LTD	250,000	$272K	0.1%	$1426.15	—	SPONSORED ADR	09071M106