Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 9, 2018

Total Value ($000): $312,298 (100.0% shares, 0.0% debt)

Holdings (35)

AXGN AXOGEN INC 17.9%

Value ($000) $55,751 Shares 1,970,000 Est. Cost $3.33 Unrealized +609.5%

— BLUEPRINT MEDICINES 17.7%

Value ($000) $55,426 Shares 735,000 Est. Cost $27.77 Unrealized —

— FIBROGEN INC 5.5%

Value ($000) $17,064 Shares 360,000 Est. Cost $26.18 Unrealized —

— LOXO ONCOLOGY 4.8%

Value ($000) $14,841 Shares 176,300 Est. Cost $42.37 Unrealized —

— IMMUNOMEDICS INC 4.7%

Value ($000) $14,524 Shares 898,800 Est. Cost $6.47 Unrealized —

CDXS CODEXIS INC 4.5%

Value ($000) $14,200 Shares 1,700,600 Est. Cost $2.93 Unrealized +136.6%

XOMA XOMA CORP DEL 3.7%

Value ($000) $11,399 Shares 320,200 Est. Cost $6.46 Unrealized +319.7%

— ABLYNX NV 3.4%

Value ($000) $10,495 Shares 420,000 Est. Cost $24.99 Unrealized —

— CORIUM INTERNATIONAL INC 3.3%

Value ($000) $10,186 Shares 1,060,000 Est. Cost $8.50 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 3.0%

Value ($000) $9,512 Shares 580,000 Est. Cost $3.76 Unrealized +296.0%

— STRONGBRIDGE BIOPHARMA PLC 2.9%

Value ($000) $9,062 Shares 1,250,000 Est. Cost $2.71 Unrealized —

FENC FENNEC PHARMACEUTICALS INC 2.7%

Value ($000) $8,486 Shares 846,900 Est. Cost $9.98 Unrealized 0.0%

AGIO AGIOS PHARMACEUTICALS 2.4%

Value ($000) $7,432 Shares 130,000 Est. Cost $43.03 Unrealized +46.2%

— AUDENTES THERAPEUTICS INC 2.1%

Value ($000) $6,652 Shares 210,000 Est. Cost $22.19 Unrealized —

CRSP CRISPR THERAPEUTICS AG 2.1%

Value ($000) $6,597 Shares 281,000 Est. Cost $19.00 Unrealized 0.0%

— CYMABAY THERAPEUTICS INC 2.0%

Value ($000) $6,118 Shares 665,000 Est. Cost $8.05 Unrealized —

ARDX ARDELYX 1.9%

Value ($000) $5,940 Shares 900,000 Est. Cost $7.37 Unrealized -19.6%

— FOAMIX PHARMACEUTICALS LTD 1.8%

Value ($000) $5,769 Shares 960,000 Est. Cost $5.96 Unrealized —

ARGX ARGENX 1.8%

Value ($000) $5,587 Shares 88,500 Est. Cost $63.13 Unrealized —

— NEKTAR THERAPEUTICS 1.5%

Value ($000) $4,777 Shares 80,000 Est. Cost $59.71 Unrealized —

— INOTEK PHARMACEUTICALS CORP 1.5%

Value ($000) $4,703 Shares 1,802,000 Est. Cost $1.78 Unrealized —

— ACCELERON PHARMA INC 1.4%

Value ($000) $4,307 Shares 101,500 Est. Cost $30.49 Unrealized —

RARE ULTRAGENYX PHARMACEUTICALS INC 1.3%

Value ($000) $4,174 Shares 90,000 Est. Cost $49.03 Unrealized 0.0%

— AMARIN CORP PLC 1.1%

Value ($000) $3,448 Shares 860,000 Est. Cost $4.01 Unrealized —

— DERMIRA INC 0.9%

Value ($000) $2,781 Shares 100,000 Est. Cost $27.81 Unrealized —

— CHIMERIX INC 0.9%

Value ($000) $2,778 Shares 600,000 Est. Cost $5.07 Unrealized —

VKTX VIKING THERAPEUTICS INC 0.6%

Value ($000) $1,951 Shares 480,558 Est. Cost $2.90 Unrealized 0.0%

QURE UNIQURE NV 0.6%

Value ($000) $1,778 Shares 90,801 Est. Cost $15.23 Unrealized 0.0%

QTRX QUANTERIX CORP 0.4%

Value ($000) $1,395 Shares 65,000 Est. Cost $19.52 Unrealized 0.0%

— ACHILLION PHARMACEUTICALS INC 0.4%

Value ($000) $1,267 Shares 440,000 Est. Cost $2.88 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 0.4%

Value ($000) $1,206 Shares 1,825,000 Est. Cost $0.66 Unrealized —

RYTM RHYTHM PHARMACEUTICALS INC 0.4%

Value ($000) $1,113 Shares 38,300 Est. Cost $26.40 Unrealized 0.0%

— SYROS PHARMACEUTICALS INC 0.2%

Value ($000) $720 Shares 74,074 Est. Cost $15.97 Unrealized —

— SPECTRUM PHARMACEUTICALS INC 0.2%

Value ($000) $587 Shares 31,000 Est. Cost $18.94 Unrealized —

— BIOLINERX LTD 0.1%

Value ($000) $272 Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
AXGN	AXOGEN INC	1,970,000	$55,751	17.9%	$3.33	+609.5%	COM	05463X106
—	BLUEPRINT MEDICINES	735,000	$55,426	17.7%	$27.77	—	COM	09627Y109
—	FIBROGEN INC	360,000	$17,064	5.5%	$26.18	—	COM	31572Q808
—	LOXO ONCOLOGY	176,300	$14,841	4.8%	$42.37	—	COM	548862101
—	IMMUNOMEDICS INC	898,800	$14,524	4.7%	$6.47	—	COM	452907108
CDXS	CODEXIS INC	1,700,600	$14,200	4.5%	$2.93	+136.6%	COM	192005106
XOMA	XOMA CORP DEL	320,200	$11,399	3.7%	$6.46	+319.7%	COM NEW	98419J206
—	ABLYNX NV	420,000	$10,495	3.4%	$24.99	—	SPONSORED ADR	00372Y905
—	CORIUM INTERNATIONAL INC	1,060,000	$10,186	3.3%	$8.50	—	COM	21887L107
SGMO	SANGAMO BIOSCIENCES INC	580,000	$9,512	3.0%	$3.76	+296.0%	COM	800677106
—	STRONGBRIDGE BIOPHARMA PLC	1,250,000	$9,062	2.9%	$2.71	—	COM	G85347105
FENC	FENNEC PHARMACEUTICALS INC	846,900	$8,486	2.7%	$9.98	0.0%	COM	31447P100
AGIO	AGIOS PHARMACEUTICALS	130,000	$7,432	2.4%	$43.03	+46.2%	COM	00847X104
—	AUDENTES THERAPEUTICS INC	210,000	$6,652	2.1%	$22.19	—	COM	05070R104
CRSP	CRISPR THERAPEUTICS AG	281,000	$6,597	2.1%	$19.00	0.0%	NAMEN AKT	H17182108
—	CYMABAY THERAPEUTICS INC	665,000	$6,118	2.0%	$8.05	—	COM	23257D103
ARDX	ARDELYX	900,000	$5,940	1.9%	$7.37	-19.6%	COM	039697107
—	FOAMIX PHARMACEUTICALS LTD	960,000	$5,769	1.8%	$5.96	—	SHS	M46135105
ARGX	ARGENX	88,500	$5,587	1.8%	$63.13	—	SPONSORED ADR	04016X101
—	NEKTAR THERAPEUTICS	80,000	$4,777	1.5%	$59.71	—	COM	640268108
—	INOTEK PHARMACEUTICALS CORP	1,802,000	$4,703	1.5%	$1.78	—	COM	45780V102
—	ACCELERON PHARMA INC	101,500	$4,307	1.4%	$30.49	—	COM	00434H108
RARE	ULTRAGENYX PHARMACEUTICALS INC	90,000	$4,174	1.3%	$49.03	0.0%	COM	90400D108
—	AMARIN CORP PLC	860,000	$3,448	1.1%	$4.01	—	SPONSORED ADR	023111206
—	DERMIRA INC	100,000	$2,781	0.9%	$27.81	—	COM	24983L104
—	CHIMERIX INC	600,000	$2,778	0.9%	$5.07	—	COM	16934W106
VKTX	VIKING THERAPEUTICS INC	480,558	$1,951	0.6%	$2.90	0.0%	COM	92686J106
QURE	UNIQURE NV	90,801	$1,778	0.6%	$15.23	0.0%	SHS	N90064101
QTRX	QUANTERIX CORP	65,000	$1,395	0.4%	$19.52	0.0%	COM	74766Q101
—	ACHILLION PHARMACEUTICALS INC	440,000	$1,267	0.4%	$2.88	—	COM	00448Q201
—	PROTALIX BIOTHERAPEUTICS INC	1,825,000	$1,206	0.4%	$0.66	—	COM	74365A101
RYTM	RHYTHM PHARMACEUTICALS INC	38,300	$1,113	0.4%	$26.40	0.0%	COM	76243J105
—	SYROS PHARMACEUTICALS INC	74,074	$720	0.2%	$15.97	—	COM	87184Q107
—	SPECTRUM PHARMACEUTICALS INC	31,000	$587	0.2%	$18.94	—	COM	84763A108
—	BIOLINERX LTD	250,000	$272	0.1%	$1426.15	—	SPONSORED ADR	09071M106