Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q2 2018 (← Previous) (Next →)

Filing Date: Aug 14, 2018

Total Value: $386M (100.0% shares, 0.0% debt)

Holdings (36)

AXGN AXOGEN INC 18.7%

Value $72.36M Shares 1,440,000 Est. Cost $3.33 Unrealized +1224.8%

— LOXO ONCOLOGY 7.9%

Value $30.36M Shares 175,000 Est. Cost $43.63 Unrealized —

CDXS CODEXIS INC 6.5%

Value $25.2M Shares 1,750,000 Est. Cost $3.21 Unrealized +306.2%

— FIBROGEN INC 5.8%

Value $22.54M Shares 360,000 Est. Cost $26.18 Unrealized —

— BLUEPRINT MEDICINES 5.8%

Value $22.22M Shares 350,000 Est. Cost $27.77 Unrealized —

— POLARITYTE INC 4.9%

Value $18.83M Shares 800,000 Est. Cost $23.54 Unrealized —

— DECIPHERA PHARMACEUTICALS IN 4.3%

Value $16.53M Shares 420,000 Est. Cost $22.57 Unrealized —

VKTX VIKING THERAPEUTICS INC 2.9%

Value $11.39M Shares 1,200,000 Est. Cost $4.57 Unrealized +45.5%

— STRONGBRIDGE BIOPHARMA PLC 2.8%

Value $10.98M Shares 1,830,000 Est. Cost $4.28 Unrealized —

AGIO AGIOS PHARMACEUTICALS 2.8%

Value $10.95M Shares 130,000 Est. Cost $43.03 Unrealized +102.7%

FENC FENNEC PHARMACEUTICALS INC 2.6%

Value $9.865M Shares 945,000 Est. Cost $10.11 Unrealized +17.3%

— CYMABAY THERAPEUTICS INC 2.4%

Value $9.36M Shares 697,500 Est. Cost $8.30 Unrealized —

TGTX TG THERAPEUTICS INC 2.1%

Value $8.218M Shares 625,000 Est. Cost $13.33 Unrealized +3.2%

— AMAG PHARMACEUTICALS INC 2.1%

Value $8.19M Shares 420,000 Est. Cost $19.50 Unrealized —

— MIRAGEN THERAPEUTICS INC 2.0%

Value $7.692M Shares 1,200,000 Est. Cost $6.41 Unrealized —

OCUL OCULAR THERAPEUTIX INC 1.9%

Value $7.499M Shares 1,111,000 Est. Cost $6.87 Unrealized 0.0%

— MAGENTA THERAPEUTICS INC 1.9%

Value $7.425M Shares 550,000 Est. Cost $13.50 Unrealized —

— AUDENTES THERAPEUTICS INC 1.9%

Value $7.259M Shares 190,000 Est. Cost $22.19 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 1.9%

Value $7.171M Shares 505,000 Est. Cost $3.76 Unrealized +342.2%

XOMA XOMA CORP DEL 1.7%

Value $6.685M Shares 320,200 Est. Cost $6.46 Unrealized +252.3%

XNCR XENCOR INC 1.7%

Value $6.661M Shares 180,000 Est. Cost $34.46 Unrealized 0.0%

— CORIUM INTERNATIONAL INC 1.7%

Value $6.408M Shares 800,000 Est. Cost $8.50 Unrealized —

— CIDARA THERAPEUTICS INC 1.6%

Value $6.24M Shares 1,200,000 Est. Cost $5.20 Unrealized —

RARE ULTRAGENYX PHARMACEUTICALS INC 1.6%

Value $6.149M Shares 80,000 Est. Cost $49.03 Unrealized +31.7%

PTCT PTC THERAPEUTICS INC 1.6%

Value $6.071M Shares 180,000 Est. Cost $26.47 Unrealized +17.8%

APLS APELLIS PHARMACEUTICALS INC 1.5%

Value $5.83M Shares 265,000 Est. Cost $22.98 Unrealized 0.0%

— CHIMERIX INC 1.4%

Value $5.474M Shares 1,150,000 Est. Cost $4.92 Unrealized —

— AMARIN CORP PLC 1.4%

Value $5.407M Shares 1,750,000 Est. Cost $3.50 Unrealized —

— BIOFRONTERA AG 1.2%

Value $4.755M Shares 391,400 Est. Cost $12.15 Unrealized —

— GTX INC 1.0%

Value $3.827M Shares 250,000 Est. Cost $5.96 Unrealized —

— EPIZYME INC 1.0%

Value $3.726M Shares 275,000 Est. Cost $14.62 Unrealized —

— ARQULE INC 0.6%

Value $2.322M Shares 420,000 Est. Cost $5.53 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 0.3%

Value $1.333M Shares 3,100,000 Est. Cost $0.61 Unrealized —

— CTI BIOPHARMA CORP 0.2%

Value $803K Shares 161,400 Est. Cost $4.98 Unrealized —

— AZURRX BIOPHARMA INC 0.1%

Value $417K Shares 130,000 Est. Cost $3.21 Unrealized —

— BIOLINERX LTD 0.1%

Value $222K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AXGN	AXOGEN INC	1,440,000	$72.36M	18.7%	$3.33	+1224.8%	COM	05463X106
—	LOXO ONCOLOGY	175,000	$30.36M	7.9%	$43.63	—	COM	548862101
CDXS	CODEXIS INC	1,750,000	$25.2M	6.5%	$3.21	+306.2%	COM	192005106
—	FIBROGEN INC	360,000	$22.54M	5.8%	$26.18	—	COM	31572Q808
—	BLUEPRINT MEDICINES	350,000	$22.22M	5.8%	$27.77	—	COM	09627Y109
—	POLARITYTE INC	800,000	$18.83M	4.9%	$23.54	—	COM	731094108
—	DECIPHERA PHARMACEUTICALS IN	420,000	$16.53M	4.3%	$22.57	—	COM	24344T101
VKTX	VIKING THERAPEUTICS INC	1,200,000	$11.39M	2.9%	$4.57	+45.5%	COM	92686J106
—	STRONGBRIDGE BIOPHARMA PLC	1,830,000	$10.98M	2.8%	$4.28	—	COM	G85347105
AGIO	AGIOS PHARMACEUTICALS	130,000	$10.95M	2.8%	$43.03	+102.7%	COM	00847X104
FENC	FENNEC PHARMACEUTICALS INC	945,000	$9.865M	2.6%	$10.11	+17.3%	COM	31447P100
—	CYMABAY THERAPEUTICS INC	697,500	$9.36M	2.4%	$8.30	—	COM	23257D103
TGTX	TG THERAPEUTICS INC	625,000	$8.218M	2.1%	$13.33	+3.2%	COM	88322Q108
—	AMAG PHARMACEUTICALS INC	420,000	$8.19M	2.1%	$19.50	—	COM	00163U106
—	MIRAGEN THERAPEUTICS INC	1,200,000	$7.692M	2.0%	$6.41	—	COM	60463E103
OCUL	OCULAR THERAPEUTIX INC	1,111,000	$7.499M	1.9%	$6.87	0.0%	COM	67576A100
—	MAGENTA THERAPEUTICS INC	550,000	$7.425M	1.9%	$13.50	—	COM	55910K108
—	AUDENTES THERAPEUTICS INC	190,000	$7.259M	1.9%	$22.19	—	COM	05070R104
SGMO	SANGAMO BIOSCIENCES INC	505,000	$7.171M	1.9%	$3.76	+342.2%	COM	800677106
XOMA	XOMA CORP DEL	320,200	$6.685M	1.7%	$6.46	+252.3%	COM NEW	98419J206
XNCR	XENCOR INC	180,000	$6.661M	1.7%	$34.46	0.0%	COM	98401F105
—	CORIUM INTERNATIONAL INC	800,000	$6.408M	1.7%	$8.50	—	COM	21887L107
—	CIDARA THERAPEUTICS INC	1,200,000	$6.24M	1.6%	$5.20	—	COM	171757107
RARE	ULTRAGENYX PHARMACEUTICALS INC	80,000	$6.149M	1.6%	$49.03	+31.7%	COM	90400D108
PTCT	PTC THERAPEUTICS INC	180,000	$6.071M	1.6%	$26.47	+17.8%	COM	69366J200
APLS	APELLIS PHARMACEUTICALS INC	265,000	$5.83M	1.5%	$22.98	0.0%	COM	03753U106
—	CHIMERIX INC	1,150,000	$5.474M	1.4%	$4.92	—	COM	16934W106
—	AMARIN CORP PLC	1,750,000	$5.407M	1.4%	$3.50	—	SPONSORED ADR	023111206
—	BIOFRONTERA AG	391,400	$4.755M	1.2%	$12.15	—	SPONSORED ADR	09075G105
—	GTX INC	250,000	$3.827M	1.0%	$5.96	—	SHS	M46135105
—	EPIZYME INC	275,000	$3.726M	1.0%	$14.62	—	COM	29428V104
—	ARQULE INC	420,000	$2.322M	0.6%	$5.53	—	COM	04269E107
—	PROTALIX BIOTHERAPEUTICS INC	3,100,000	$1.333M	0.3%	$0.61	—	COM	74365A101
—	CTI BIOPHARMA CORP	161,400	$803K	0.2%	$4.98	—	COM	12648L601
—	AZURRX BIOPHARMA INC	130,000	$417K	0.1%	$3.21	—	COM	05502L105
—	BIOLINERX LTD	250,000	$222K	0.1%	$1426.15	—	SPONSORED ADR	09071M106