Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2014 (← Previous) (Next →)

Filing Date: May 15, 2014

Total Value: $135M (100.0% shares, 0.0% debt)

Holdings (30)

— RETROPHIN INC 18.1%

Value $24.45M Shares 1,153,230 Est. Cost $21.20 Unrealized —

— ARIAD PHARMACEUTICALS INC 9.9%

Value $13.46M Shares 1,670,000 Est. Cost $7100.00 Unrealized —

— CHIMERIX INC 9.0%

Value $12.24M Shares 536,000 Est. Cost $22.84 Unrealized —

— PHARMACYCLICS INC 8.5%

Value $11.53M Shares 115,000 Est. Cost $108000.00 Unrealized —

— INSPIREMD INC 4.8%

Value $6.56M Shares 2,150,000 Est. Cost $1373.27 Unrealized —

OMER OMEROS CORP 4.5%

Value $6.036M Shares 500,100 Est. Cost $9.86 Unrealized +24.6%

— CEMPRA INC 4.1%

Value $5.544M Shares 480,000 Est. Cost $9888.18 Unrealized —

— BIND THERAPEUTICS INC 3.8%

Value $5.107M Shares 427,000 Est. Cost $4980.69 Unrealized —

— NPS PHARMACEUTICALS INC 3.3%

Value $4.49M Shares 150,000 Est. Cost $29000.00 Unrealized —

— GENMARK DIAGNOSTICS INC 3.2%

Value $4.324M Shares 435,000 Est. Cost $9.94 Unrealized —

— CARDIOVASCULAR SYS INC DEL 3.2%

Value $4.292M Shares 135,000 Est. Cost $33000.00 Unrealized —

— NOVADAQ TECHNOLOGIES INC 3.0%

Value $4.116M Shares 167,600 Est. Cost $17000.00 Unrealized —

LAB FLUIDIGM CORP DEL 2.9%

Value $3.966M Shares 90,000 Est. Cost $29.45 Unrealized +49.4%

— BIOLINERX LTD 2.4%

Value $3.236M Shares 1,451,000 Est. Cost $1426.15 Unrealized —

CPRX CATALYST PHARM PARTNERS INC 2.3%

Value $3.116M Shares 1,378,584 Est. Cost $2.02 Unrealized +3.4%

— EPIZYME INC 1.9%

Value $2.63M Shares 115,500 Est. Cost $22.77 Unrealized —

LGND LIGAND PHARMACEUTICALS INC 1.7%

Value $2.354M Shares 35,000 Est. Cost $32.58 Unrealized +27.9%

GERN GERON CORP 1.7%

Value $2.299M Shares 1,100,000 Est. Cost $4.29 Unrealized -7.1%

— FLEXION THERAPEUTICS INC 1.6%

Value $2.229M Shares 135,500 Est. Cost $16.45 Unrealized —

— EVOKE PHARMA INC 1.4%

Value $1.956M Shares 233,400 Est. Cost $8.38 Unrealized —

— CELGENE CORP 1.4%

Value $1.881M Shares 660,000 Est. Cost $2800.00 Unrealized —

— TETRAPHASE PHARMACEUTICALS I 1.3%

Value $1.757M Shares 160,000 Est. Cost $12472.32 Unrealized —

— KALOBIOS PHARMACEUTICALS INC 1.1%

Value $1.474M Shares 545,000 Est. Cost $2145.33 Unrealized —

— ARRAY BIOPHARMA INC 1.1%

Value $1.434M Shares 305,000 Est. Cost $4.70 Unrealized —

CDXS CODEXIS INC 1.1%

Value $1.425M Shares 698,300 Est. Cost $1.83 Unrealized 0.0%

— CELATOR PHARMACEUTICALS INC 0.8%

Value $1.031M Shares 325,000 Est. Cost $2957.07 Unrealized —

MGNX MACROGENICS INC 0.6%

Value $838K Shares 30,000 Est. Cost $35.31 Unrealized 0.0%

— AFFYMETRIX INC 0.5%

Value $713K Shares 100,000 Est. Cost $7.13 Unrealized —

— KIPS BAY MED INC 0.4%

Value $540K Shares 777,531 Est. Cost $0.69 Unrealized —

— SUNSHINE HEART INC 0.3%

Value $350K Shares 60,000 Est. Cost $9700.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	RETROPHIN INC	1,153,230	$24.45M	18.1%	$21.20	—	COM	761299106
—	ARIAD PHARMACEUTICALS INC	1,670,000	$13.46M	9.9%	$7100.00	—	COM	04033A100
—	CHIMERIX INC	536,000	$12.24M	9.0%	$22.84	—	COM	16934W106
—	PHARMACYCLICS INC	115,000	$11.53M	8.5%	$108000.00	—	COM	716933106
—	INSPIREMD INC	2,150,000	$6.56M	4.8%	$1373.27	—	COM NEW	45779A309
OMER	OMEROS CORP	500,100	$6.036M	4.5%	$9.86	+24.6%	COM	682143102
—	CEMPRA INC	480,000	$5.544M	4.1%	$9888.18	—	COM	15130J109
—	BIND THERAPEUTICS INC	427,000	$5.107M	3.8%	$4980.69	—	COM	05548N107
—	NPS PHARMACEUTICALS INC	150,000	$4.49M	3.3%	$29000.00	—	COM	62936P103
—	GENMARK DIAGNOSTICS INC	435,000	$4.324M	3.2%	$9.94	—	COM	372309104
—	CARDIOVASCULAR SYS INC DEL	135,000	$4.292M	3.2%	$33000.00	—	COM	141619106
—	NOVADAQ TECHNOLOGIES INC	167,600	$4.116M	3.0%	$17000.00	—	COM	66987G102
LAB	FLUIDIGM CORP DEL	90,000	$3.966M	2.9%	$29.45	+49.4%	COM	34385P108
—	BIOLINERX LTD	1,451,000	$3.236M	2.4%	$1426.15	—	SPONSORED ADR	09071M106
CPRX	CATALYST PHARM PARTNERS INC	1,378,584	$3.116M	2.3%	$2.02	+3.4%	COM	14888U101
—	EPIZYME INC	115,500	$2.63M	1.9%	$22.77	—	COM	29428V104
LGND	LIGAND PHARMACEUTICALS INC	35,000	$2.354M	1.7%	$32.58	+27.9%	COM NEW	53220K504
GERN	GERON CORP	1,100,000	$2.299M	1.7%	$4.29	-7.1%	COM	374163103
—	FLEXION THERAPEUTICS INC	135,500	$2.229M	1.6%	$16.45	—	COM	33938J106
—	EVOKE PHARMA INC	233,400	$1.956M	1.4%	$8.38	—	COM	30049G104
—	CELGENE CORP	660,000	$1.881M	1.4%	$2800.00	—	RIGHTS 12/31/2030	151020112
—	TETRAPHASE PHARMACEUTICALS I	160,000	$1.757M	1.3%	$12472.32	—	COM	88165N105
—	KALOBIOS PHARMACEUTICALS INC	545,000	$1.474M	1.1%	$2145.33	—	COM	48344T100
—	ARRAY BIOPHARMA INC	305,000	$1.434M	1.1%	$4.70	—	COM	04269X105
CDXS	CODEXIS INC	698,300	$1.425M	1.1%	$1.83	0.0%	COM	192005106
—	CELATOR PHARMACEUTICALS INC	325,000	$1.031M	0.8%	$2957.07	—	COM	15089R102
MGNX	MACROGENICS INC	30,000	$838K	0.6%	$35.31	0.0%	COM	556099109
—	AFFYMETRIX INC	100,000	$713K	0.5%	$7.13	—	COM	00826T108
—	KIPS BAY MED INC	777,531	$540K	0.4%	$0.69	—	COM	49726K105
—	SUNSHINE HEART INC	60,000	$350K	0.3%	$9700.00	—	COM	86782U106