DESIGN THERAPEUTICS INC

Institution	Shares	Value ($000)
Vivo Capital, LLC	1,612,903	$15,129
ACUTA CAPITAL PARTNERS, LLC	150,906	$1,415
DIADEMA PARTNERS LP	100,320	$941
AlphaCentric Advisors LLC	20,262	$190
Persistent Asset Partners Ltd	34,989	$328
EAM Investors, LLC	78,949	$741
AXQ CAPITAL, LP	11,728	$110
TWO SIGMA SECURITIES, LLC	11,396	$107
Trexquant Investment LP	99,967	$938
JACOBS LEVY EQUITY MANAGEMENT, INC	194,611	$1,825
Baader Bank Aktiengesellschaft	20,000	$188
ALGERT GLOBAL LLC	187,769	$2
MARSHALL WACE, LLP	225,528	$2,115
ALPS ADVISORS INC	46,771	$439
AMERIPRISE FINANCIAL INC	158,383	$1,486
RAYMOND JAMES FINANCIAL INC	109,763	$1,030
SEI INVESTMENTS CO	52,730	$495
CANADA PENSION PLAN INVESTMENT BOARD	54,600	$512
Squarepoint Ops LLC	46,142	$433
Engineers Gate Manager LP	14,012	$131

Increased Positions (38)

RA CAPITAL MANAGEMENT, L.P.

Value ($000) $13,708 (+282.7%) Shares 1,461,381 (+207.2%)

BAKER BROS. ADVISORS LP

Value ($000) $20,946 (+62.4%) Shares 2,233,099 (+30.4%)

Point72 Asset Management, L.P.

Value ($000) $50,389 (+100.3%) Shares 5,372,004 (+60.8%)

Palumbo Wealth Management LLC

Value ($000) $651 (+65.9%) Shares 69,377 (+33.2%)

Woodline Partners LP

Value ($000) $8,855 (+91.9%) Shares 944,039 (+54.1%)

DRIEHAUS CAPITAL MANAGEMENT LLC

Value ($000) $11,067 (+36.6%) Shares 1,179,817 (+9.6%)

XTX Topco Ltd

Value ($000) $331 (+270.3%) Shares 35,284 (+197.3%)

Lynx1 Capital Management LP

Value ($000) $652 (+31.3%) Shares 69,516 (+5.4%)

MORGAN STANLEY

Value ($000) $6,588 (+397.1%) Shares 702,306 (+299.1%)

Invesco Ltd.

Value ($000) $2,868 (+2510.7%) Shares 305,757 (+1995.8%)

KENNEDY CAPITAL MANAGEMENT LLC

Value ($000) $469 (+111.9%) Shares 50,023 (+70.1%)

VANGUARD GROUP INC

Value ($000) $15,298 (+40.7%) Shares 1,630,910 (+13.0%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $1,697 (+227.4%) Shares 180,866 (+162.8%)

JANE STREET GROUP, LLC

Value ($000) $2,125 (+139.5%) Shares 226,512 (+92.2%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $889 (+2201.3%) Shares 94,828 (+1747.4%)

D. E. Shaw & Co., Inc.

Value ($000) $4,117 (+46.5%) Shares 438,894 (+17.6%)

BlackRock, Inc.

Value ($000) $19,859 (+29.0%) Shares 2,117,156 (+3.6%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $580 (+449.4%) Shares 61,852 (+341.1%)

STATE OF WISCONSIN INVESTMENT BOARD

Value ($000) $475 (+133.2%) Shares 50,657 (+87.2%)

FMR LLC

Value ($000) $7,234 (+29.7%) Shares 771,268 (+4.1%)

Institution	Prev Shares	Curr Shares	Change
RA CAPITAL MANAGEMENT, L.P.	475,699	1,461,381	+985,682 (+207.2%)
BAKER BROS. ADVISORS LP	1,712,882	2,233,099	+520,217 (+30.4%)
Point72 Asset Management, L.P.	3,340,552	5,372,004	+2,031,452 (+60.8%)
Palumbo Wealth Management LLC	52,081	69,377	+17,296 (+33.2%)
Woodline Partners LP	612,712	944,039	+331,327 (+54.1%)
DRIEHAUS CAPITAL MANAGEMENT LLC	1,076,236	1,179,817	+103,581 (+9.6%)
XTX Topco Ltd	11,868	35,284	+23,416 (+197.3%)
Lynx1 Capital Management LP	65,954	69,516	+3,562 (+5.4%)
MORGAN STANLEY	175,991	702,306	+526,315 (+299.1%)
Invesco Ltd.	14,589	305,757	+291,168 (+1995.8%)
KENNEDY CAPITAL MANAGEMENT LLC	29,411	50,023	+20,612 (+70.1%)
VANGUARD GROUP INC	1,443,701	1,630,910	+187,209 (+13.0%)
MILLENNIUM MANAGEMENT LLC	68,823	180,866	+112,043 (+162.8%)
JANE STREET GROUP, LLC	117,833	226,512	+108,679 (+92.2%)
BNP PARIBAS ARBITRAGE, SA	5,133	94,828	+89,695 (+1747.4%)
D. E. Shaw & Co., Inc.	373,276	438,894	+65,618 (+17.6%)
BlackRock, Inc.	2,044,388	2,117,156	+72,768 (+3.6%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	14,023	61,852	+47,829 (+341.1%)
STATE OF WISCONSIN INVESTMENT BOARD	27,062	50,657	+23,595 (+87.2%)
FMR LLC	740,849	771,268	+30,419 (+4.1%)

Decreased Positions (26)

Logos Global Management LP

Value ($000) $23,450 (-14.8%) Shares 2,500,000 (-31.6%)

Frazier Life Sciences Management, L.P.

Value ($000) $4,887 (-66.8%) Shares 521,000 (-73.3%)

Kynam Capital Management, LP

Value ($000) $7,360 (-5.1%) Shares 784,606 (-23.8%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $736 (-48.0%) Shares 78,500 (-58.3%)

CAZ INVESTMENTS LP

Value ($000) $33 (-12.8%) Shares 3,500 (-30.0%)

CITADEL ADVISORS LLC

Value ($000) $4,314 (+3.4%) Shares 459,874 (-17.0%)

TWO SIGMA ADVISERS, LP

Value ($000) $237 (-22.2%) Shares 25,300 (-37.5%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $6,376 (+21.7%) Shares 679,590 (-2.3%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $434 (-2.8%) Shares 46,237 (-21.9%)

RHUMBLINE ADVISERS

Value ($000) $326 (-6.5%) Shares 34,778 (-24.9%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $2,222 (+19.0%) Shares 236,863 (-4.5%)

NORTHERN TRUST CORP

Value ($000) $2,688 (+20.4%) Shares 286,572 (-3.4%)

JPMORGAN CHASE & CO

Value ($000) $136 (-22.5%) Shares 14,451 (-37.8%)

BARCLAYS PLC

Value ($000) $817 (+57.1%) Shares 87,060 (-9.9%)

Nuveen, LLC

Value ($000) $1,175 (+17.3%) Shares 125,260 (-5.8%)

Mariner, LLC

Value ($000) $120 (-0.9%) Shares 12,822 (-20.3%)

Bank of New York Mellon Corp

Value ($000) $797 (+21.0%) Shares 84,975 (-2.9%)

PRUDENTIAL FINANCIAL INC

Value ($000) $401 (+18.7%) Shares 42,710 (-4.7%)

China Universal Asset Management Co., Ltd.

Value ($000) $322 (+22.1%) Shares 34,282 (-2.0%)

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

Value ($000) $14 (-6.9%) Shares 1,471 (-25.3%)

Institution	Prev Shares	Curr Shares	Change
Logos Global Management LP	3,655,000	2,500,000	-1,155,000 (-31.6%)
Frazier Life Sciences Management, L.P.	1,953,547	521,000	-1,432,547 (-73.3%)
Kynam Capital Management, LP	1,029,579	784,606	-244,973 (-23.8%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	188,200	78,500	-109,700 (-58.3%)
CAZ INVESTMENTS LP	5,000	3,500	-1,500 (-30.0%)
CITADEL ADVISORS LLC	554,020	459,874	-94,146 (-17.0%)
TWO SIGMA ADVISERS, LP	40,500	25,300	-15,200 (-37.5%)
GEODE CAPITAL MANAGEMENT, LLC	695,613	679,590	-16,023 (-2.3%)
TWO SIGMA INVESTMENTS, LP	59,237	46,237	-13,000 (-21.9%)
RHUMBLINE ADVISERS	46,334	34,778	-11,556 (-24.9%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	247,934	236,863	-11,071 (-4.5%)
NORTHERN TRUST CORP	296,529	286,572	-9,957 (-3.4%)
JPMORGAN CHASE & CO	23,221	14,451	-8,770 (-37.8%)
BARCLAYS PLC	96,635	87,060	-9,575 (-9.9%)
Nuveen, LLC	133,028	125,260	-7,768 (-5.8%)
Mariner, LLC	16,081	12,822	-3,259 (-20.3%)
Bank of New York Mellon Corp	87,475	84,975	-2,500 (-2.9%)
PRUDENTIAL FINANCIAL INC	44,825	42,710	-2,115 (-4.7%)
China Universal Asset Management Co., Ltd.	34,982	34,282	-700 (-2.0%)
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	1,969	1,471	-498 (-25.3%)

Exited Positions (8)

MPM BioImpact LLC

Value ($000) $4,181 Shares 555,187

TANG CAPITAL MANAGEMENT LLC

Value ($000) $13,411 Shares 1,780,975

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $165 Shares 21,918

DLD Asset Management, LP

Value ($000) $377 Shares 50,000

INTECH INVESTMENT MANAGEMENT LLC

Value ($000) $107 Shares 14,155

Rise Advisors, LLC

Value ($000) $1 Shares 130

Versant Capital Management, Inc

Value ($000) $1 Shares 71

HRT FINANCIAL LP

Value ($000) $0 Shares 31,903

Institution	Prev Shares	Prev Value ($000)
MPM BioImpact LLC	555,187	$4,181
TANG CAPITAL MANAGEMENT LLC	1,780,975	$13,411
SPHERA FUNDS MANAGEMENT LTD.	21,918	$165
DLD Asset Management, LP	50,000	$377
INTECH INVESTMENT MANAGEMENT LLC	14,155	$107
Rise Advisors, LLC	130	$1
Versant Capital Management, Inc	71	$1
HRT FINANCIAL LP	31,903	$0