| BAKER BROS. ADVISORS LP | 30,762,330 | $3.487B |
| BlackRock, Inc. | 18,032,718 | $2.044B |
| DODGE & COX | 11,957,326 | $1.355B |
| VANGUARD CAPITAL MANAGEMENT LLC | 11,024,289 | $1.25B |
| STATE STREET CORP | 9,722,336 | $1.102B |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,791,091 | $883M |
| AQR CAPITAL MANAGEMENT LLC | 5,320,901 | $603M |
| GEODE CAPITAL MANAGEMENT, LLC | 4,750,735 | $537M |
| LSV ASSET MANAGEMENT | 4,123,759 | $467M |
| Invesco Ltd. | 4,080,461 | $463M |
| WELLINGTON MANAGEMENT GROUP LLP | 3,575,521 | $405M |
| RENAISSANCE TECHNOLOGIES LLC | 3,512,132 | $398M |
| MORGAN STANLEY | 2,948,364 | $334M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,744,958 | $311M |
| Robeco Institutional Asset Management B.V. | 2,441,735 | $277M |
| GOLDMAN SACHS GROUP INC | 2,305,782 | $261M |
| DIMENSIONAL FUND ADVISORS LP | 2,280,803 | $259M |
| TWO SIGMA INVESTMENTS, LP | 2,003,559 | $227M |
| NORTHERN TRUST CORP | 1,761,966 | $200M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,692,439 | $192M |
| ACADIAN ASSET MANAGEMENT LLC | 1,664,999 | $189M |
| Legal & General Group Plc | 1,605,980 | $182M |
| FIRST TRUST ADVISORS LP | 1,587,996 | $180M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME | 1,508,720 | $171M |
| VICTORY CAPITAL MANAGEMENT INC | 1,480,342 | $168M |
| Pacer Advisors, Inc. | 1,431,426 | $162M |
| FMR LLC | 1,381,773 | $157M |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 1,370,503 | $155M |
| MARSHALL WACE, LLP | 1,310,154 | $149M |
| HSBC HOLDINGS PLC | 1,307,743 | $148M |
| DEUTSCHE BANK AG\ | 1,262,988 | $143M |
| AustralianSuper Pty Ltd | 1,196,491 | $136M |
| Amundi | 1,181,498 | $134M |
| ROYAL BANK OF CANADA | 1,132,050 | $128M |
| NORGES BANK | 1,119,107 | $127M |
| Bank of New York Mellon Corp | 972,825 | $110M |
| Man Group plc | 952,941 | $108M |
| VANGUARD FIDUCIARY TRUST CO | 943,540 | $107M |
| BNP Paribas Asset Management Holding S.A. | 937,763 | $106M |
| ARMISTICE CAPITAL, LLC | 900,005 | $102M |
| PANAGORA ASSET MANAGEMENT INC | 881,889 | $99.97M |
| UBS Group AG | 767,924 | $87.05M |
| JPMORGAN CHASE & CO | 761,690 | $87.34M |
| SOUND SHORE MANAGEMENT INC /CT/ | 757,723 | $85.9M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 731,774 | $82.95M |
| Gotham Asset Management, LLC | 719,545 | $81.57M |
| Pictet Asset Management Holding SA | 713,354 | $81.32M |
| BANK OF AMERICA CORP /DE/ | 676,191 | $76.65M |
| MACKENZIE FINANCIAL CORP | 634,862 | $71.97M |
| CITIGROUP INC | 586,431 | $66.48M |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 578,986 | $65.63M |
| FRANKLIN RESOURCES INC | 558,663 | $63.33M |
| SEB Asset Management AB | 558,467 | $63.31M |
| GLENMEDE TRUST CO NA | 538,822 | $61.08M |
| AMERIPRISE FINANCIAL INC | 532,397 | $60.38M |
| Woodline Partners LP | 512,690 | $58.12M |
| JUPITER ASSET MANAGEMENT LTD | 511,050 | $57.93M |
| BNP PARIBAS FINANCIAL MARKETS | 500,881 | $56.78M |
| SEI INVESTMENTS CO | 498,013 | $56.45M |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 486,810 | $55.18M |
| Swiss National Bank | 476,874 | $54.06M |
| Vinva Investment Management Ltd | 462,843 | $53.07M |
| CANADA PENSION PLAN INVESTMENT BOARD | 442,500 | $50.16M |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 429,872 | $48.73M |
| RHUMBLINE ADVISERS | 428,533 | $48.58M |
| IEQ CAPITAL, LLC | 424,682 | $48.14M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 414,666 | $47.65M |
| Mitsubishi UFJ Asset Management Co., Ltd. | 412,258 | $46.73M |
| Russell Investments Group, Ltd. | 411,163 | $46.7M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 409,514 | $46.42M |
| Nuveen, LLC | 407,291 | $46.17M |
| Sumitomo Mitsui Trust Group, Inc. | 393,738 | $44.63M |
| Vanguard Global Advisers, LLC | 380,037 | $43.08M |
| Swedbank AB | 371,387 | $42.1M |
| BARCLAYS PLC | 351,221 | $39.81M |
| AMERICAN CENTURY COMPANIES INC | 345,602 | $39.18M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 339,892 | $38.53M |
| CAPITAL FUND MANAGEMENT S.A. | 336,318 | $38.13M |
| VANGUARD ASSET MANAGEMENT, Ltd | 335,081 | $37.98M |
| Grantham, Mayo, Van Otterloo & Co. LLC | 318,584 | $36.11M |
| Aware Super Pty Ltd as trustee of Aware Super | 306,810 | $34.78M |
| Arbejdsmarkedets Tillaegspension | 298,400 | $33.83M |
| KBC Group NV | 270,882 | $30.71M |
| Ensign Peak Advisors, Inc | 269,956 | $30.6M |
| JANE STREET GROUP, LLC | 268,804 | $30.47M |
| Illinois Municipal Retirement Fund | 260,338 | $29.51M |
| FEDERATED HERMES, INC. | 257,039 | $29.14M |
| WELLS FARGO & COMPANY/MN | 255,064 | $28.91M |
| WINTON GROUP Ltd | 254,408 | $28.84M |
| PFA Pension, Forsikringsaktieselskab | 252,509 | $28.62M |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 245,750 | $27.86M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 236,172 | $26.72M |
| TODD ASSET MANAGEMENT LLC | 234,375 | $26.57M |
| Baird Financial Group, Inc. | 224,855 | $25.49M |
| PRINCIPAL FINANCIAL GROUP INC | 221,978 | $25.16M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 218,950 | $24.82M |
| Quantinno Capital Management LP | 214,446 | $24.31M |
| Fideuram Asset Management (Ireland) dac | 213,883 | $20.93M |
| BANK OF MONTREAL /CAN/ | 208,134 | $23.59M |
| Cerity Partners LLC | 205,071 | $23.25M |
| 752 other institutions | 18,402,989 | $2.076B |