| BAKER BROS. ADVISORS LP | 30,744,412 | $2.894B |
| BlackRock, Inc. | 18,978,198 | $1.786B |
| DODGE & COX | 12,252,356 | $1.153B |
| VANGUARD CAPITAL MANAGEMENT LLC | 10,930,066 | $1.029B |
| STATE STREET CORP | 9,641,384 | $907M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,759,183 | $730M |
| AQR CAPITAL MANAGEMENT LLC | 5,807,930 | $536M |
| GEODE CAPITAL MANAGEMENT, LLC | 4,703,184 | $441M |
| LSV ASSET MANAGEMENT | 3,920,056 | $369K |
| Invesco Ltd. | 3,870,764 | $364M |
| RENAISSANCE TECHNOLOGIES LLC | 3,651,532 | $344M |
| WELLINGTON MANAGEMENT GROUP LLP | 3,266,136 | $307M |
| MORGAN STANLEY | 2,850,328 | $268M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,830,799 | $266M |
| GOLDMAN SACHS GROUP INC | 2,351,221 | $221M |
| ACADIAN ASSET MANAGEMENT LLC | 1,900,824 | $179K |
| NORTHERN TRUST CORP | 1,849,726 | $174M |
| VICTORY CAPITAL MANAGEMENT INC | 1,742,870 | $164M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,729,102 | $163M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,717,978 | $162M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME | 1,540,913 | $145M |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 1,520,486 | $143M |
| FIRST TRUST ADVISORS LP | 1,500,792 | $141M |
| MARSHALL WACE, LLP | 1,253,138 | $118M |
| PANAGORA ASSET MANAGEMENT INC | 1,210,909 | $114M |
| FMR LLC | 1,172,890 | $110M |
| ROYAL BANK OF CANADA | 1,054,123 | $99.21M |
| Amundi | 1,003,969 | $94.49M |
| VANGUARD FIDUCIARY TRUST CO | 948,295 | $89.25M |
| BNP Paribas Asset Management Holding S.A. | 938,848 | $88.45M |
| Man Group plc | 930,171 | $87.55M |
| BANK OF AMERICA CORP /DE/ | 915,527 | $86.17M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 751,856 | $70,765 |
| SEI INVESTMENTS CO | 714,558 | $67.25M |
| FRANKLIN RESOURCES INC | 693,785 | $65.3M |
| RHUMBLINE ADVISERS | 693,665 | $65.29M |
| Gotham Asset Management, LLC | 676,670 | $63.69M |
| ARMISTICE CAPITAL, LLC | 656,817 | $61.82M |
| CANADA PENSION PLAN INVESTMENT BOARD | 607,944 | $57.22M |
| Woodline Partners LP | 605,717 | $57.01M |
| AMERIPRISE FINANCIAL INC | 605,474 | $56.99M |
| HSBC HOLDINGS PLC | 582,368 | $54.78M |
| MACKENZIE FINANCIAL CORP | 549,633 | $51.73M |
| GLENMEDE TRUST CO NA | 523,291 | $49.25M |
| FEDERATED HERMES, INC. | 499,864 | $47.05M |
| IEQ CAPITAL, LLC | 498,835 | $46.95M |
| JPMORGAN CHASE & CO | 497,042 | $44.9M |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 493,713 | $46.47M |
| CITIGROUP INC | 489,649 | $46.09M |
| JUPITER ASSET MANAGEMENT LTD | 482,642 | $45.43M |
| TWO SIGMA INVESTMENTS, LP | 415,914 | $39.15M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 410,729 | $39.12M |
| BNP PARIBAS FINANCIAL MARKETS | 405,530 | $38.17M |
| Vanguard Global Advisers, LLC | 387,895 | $36.51M |
| PRUDENTIAL FINANCIAL INC | 374,280 | $35.23M |
| BARCLAYS PLC | 367,095 | $34.55M |
| Mitsubishi UFJ Asset Management Co., Ltd. | 366,912 | $34.53M |
| Grantham, Mayo, Van Otterloo & Co. LLC | 364,657 | $34.32M |
| Swedbank AB | 362,456 | $34.11M |
| Mitsubishi UFJ Trust & Banking Corp | 359,761 | $33.86M |
| Empowered Funds, LLC | 353,386 | $33.26M |
| AMERICAN CENTURY COMPANIES INC | 336,785 | $31.7M |
| CAPITAL FUND MANAGEMENT S.A. | 312,021 | $29.37M |
| Vinva Investment Management Ltd | 300,405 | $27.14M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 297,504 | $28M |
| VANGUARD ASSET MANAGEMENT, Ltd | 289,697 | $27.27M |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 263,340 | $24,785 |
| WELLS FARGO & COMPANY/MN | 255,022 | $24M |
| TODD ASSET MANAGEMENT LLC | 251,893 | $23.71M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 241,287 | $22.71M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 235,852 | $22.16M |
| Ensign Peak Advisors, Inc | 227,612 | $21.42M |
| Cerity Partners LLC | 226,501 | $21.32M |
| PRINCIPAL FINANCIAL GROUP INC | 225,492 | $21.22M |
| Korea Investment CORP | 220,926 | $20.79M |
| LAZARD ASSET MANAGEMENT LLC | 219,881 | $20.7M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 210,788 | $19.84M |
| CWM, LLC | 202,772 | $19.08M |
| ROYAL LONDON ASSET MANAGEMENT LTD | 192,049 | $18.08M |
| Baird Financial Group, Inc. | 186,860 | $17.59M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 185,081 | $17.42M |
| ALLIANCEBERNSTEIN L.P. | 184,755 | $18.25M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 183,834 | $17.3M |
| Catalio Capital Management, LP | 182,101 | $17.14M |
| Distillate Capital Partners LLC | 180,044 | $16.95M |
| APG Asset Management N.V. | 176,330 | $14.4M |
| WINTON GROUP Ltd | 173,032 | $16.29M |
| MILLENNIUM MANAGEMENT LLC | 172,915 | $16.27M |
| BANK OF MONTREAL /CAN/ | 171,790 | $16.17M |
| Point72 Asset Management, L.P. | 168,763 | $15.88M |
| ASHFORD CAPITAL MANAGEMENT INC | 165,247 | $15.55M |
| MARTINGALE ASSET MANAGEMENT L P | 164,646 | $15.5M |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 160,295 | $15,087 |
| Quantinno Capital Management LP | 158,226 | $14.89M |
| Edgestream Partners, L.P. | 157,472 | $14.82M |
| AVIVA PLC | 148,088 | $13.94M |
| TD ASSET MANAGEMENT INC | 142,983 | $13.46M |
| Treasurer of the State of North Carolina | 136,241 | $12,823 |
| Allianz Asset Management GmbH | 135,105 | $12.72M |
| SAWGRASS ASSET MANAGEMENT LLC | 133,532 | $12.57M |
| 352 other institutions | 7,746,297 | $677M |