Location: Luxembourg
CIK: 0001053906 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 11, 2021
Total Value: $4.658B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | WW INTL INC | 14,818,300 | $362M | 7.8% | $37.82 | — | COM | 98262P101 |
| SEER | SEER INC | 5,840,911 | $328M | 7.0% | $63.62 | 0.0% | COM CL A | 81578P106 |
| ONC | BEIGENE LTD | 1,000,000 | $258M | 5.5% | $152.23 | — | SPONSORED ADR | 07725L102 |
| LXRX | LEXICON PHARMACEUTICALS INC | 71,178,364 | $243M | 5.2% | $6.62 | -71.2% | COM NEW | 528872302 |
| — | ACCELERON PHARMA INC | 1,400,000 | $179M | 3.8% | $48.59 | — | COM | 00434H108 |
| FATE | FATE THERAPEUTICS INC | 1,400,000 | $127M | 2.7% | $13.37 | +364.5% | COM | 31189P102 |
| — | MIRATI THERAPEUTICS INC | 500,000 | $110M | 2.4% | $166.05 | — | COM | 60468T105 |
| — | IGM BIOSCIENCES INC | 1,200,000 | $106M | 2.3% | $79.98 | — | COM | 449585108 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 800,000 | $104M | 2.2% | $97.14 | +37.4% | COM | 02043Q107 |
| SRRK | SCHOLAR ROCK HLDG CORP | 2,100,000 | $102M | 2.2% | $18.13 | +100.3% | COM | 80706P103 |
| GDS | GDS HLDGS LTD | 1,000,000 | $93.64M | 2.0% | $79.66 | — | SPONSORED ADS | 36165L108 |
| — | ALLOVIR INC | 2,323,371 | $89.31M | 1.9% | $27.50 | — | COM | 019818103 |
| ARGX | ARGENX SE | 300,000 | $88.23M | 1.9% | $117.20 | — | SPONSORED ADR | 04016X101 |
| ABBV | ABBVIE INC | 800,000 | $85.72M | 1.8% | — | — | Call | 00287Y109 |
| BNTX | BIONTECH SE | 1,000,000 | $81.52M | 1.8% | $33.88 | — | SPONSORED ADS | 09075V102 |
| — | GENERATION BIO CO | 2,814,191 | $79.78M | 1.7% | $21.00 | — | COM | 37148K100 |
| TGTX | TG THERAPEUTICS INC | 1,500,000 | $78.03M | 1.7% | $12.64 | +167.3% | COM | 88322Q108 |
| Z | ZILLOW GROUP INC | 550,000 | $71.39M | 1.5% | $85.04 | +30.1% | CL C CAP STK | 98954M200 |
| SDGR | SCHRODINGER INC | 797,445 | $63.14M | 1.4% | $37.76 | +66.5% | COM | 80810D103 |
| BMY | BRISTOL-MYERS SQUIBB CO | 1,000,000 | $62.03M | 1.3% | — | — | Call | 110122108 |
| BEKE | KE HLDGS INC | 1,000,000 | $61.54M | 1.3% | $61.33 | — | SPONSORED ADS | 482497104 |
| FOLD | AMICUS THERAPEUTICS INC | 2,500,000 | $57.73M | 1.2% | $11.37 | +79.9% | COM | 03152W109 |
| — | MORPHIC HLDG INC | 1,651,686 | $55.41M | 1.2% | $18.58 | — | COM | 61775R105 |
| — | ATARA BIOTHERAPEUTICS INC | 2,800,000 | $54.96M | 1.2% | $17.77 | — | COM | 046513107 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 1,646,517 | $52.77M | 1.1% | $30.42 | +8.0% | COM | 09203E105 |
| SQZB | SQZ BIOTECHNOLOGIES CO | 1,606,308 | $46.55M | 1.0% | $28.98 | — | COM | 78472W104 |
| BABA | ALIBABA GROUP HLDG LTD | 200,000 | $46.55M | 1.0% | $162.35 | — | Call | 01609W102 |
| BABA | ALIBABA GROUP HLDG LTD | 200,000 | $46.55M | 1.0% | $162.35 | — | SPONSORED ADS | 01609W102 |
| — | TURNING POINT THERAPEUTICS I | 350,000 | $42.65M | 0.9% | $48.43 | — | COM | 90041T108 |
| — | PRAXIS PRECISION MEDICINES I | 750,000 | $41.27M | 0.9% | $55.02 | — | COM | 74006W108 |
| — | CHEMOCENTRYX INC | 650,000 | $40.25M | 0.9% | $61.92 | — | COM | 16383L106 |
| — | KRONOS BIO INC | 1,317,954 | $39.37M | 0.8% | $29.87 | — | COM | 50107A104 |
| — | CEREVEL THERAPEUTICS HLDNG I | 2,282,100 | $37.84M | 0.8% | $16.58 | — | COM | 15678U128 |
| — | ITEOS THERAPEUTICS INC | 1,094,047 | $37M | 0.8% | $24.67 | — | COM | 46565G104 |
| FHTX | FOGHORN THERAPEUTICS INC | 1,720,720 | $34.88M | 0.7% | $19.16 | 0.0% | COM | 344174107 |
| — | SAGE THERAPEUTICS INC | 400,000 | $34.6M | 0.7% | $74.04 | — | COM | 78667J108 |
| NBP | I MAB | 725,000 | $34.18M | 0.7% | $31.82 | — | SPONSORED ADS | 44975P103 |
| DNLI | DENALI THERAPEUTICS INC | 400,000 | $33.5M | 0.7% | $18.62 | +224.7% | COM | 24823R105 |
| — | SPRINGWORKS THERAPEUTICS INC | 450,000 | $32.63M | 0.7% | $41.58 | — | COM | 85205L107 |
| — | MERSANA THERAPEUTICS INC | 1,200,000 | $31.93M | 0.7% | $23.14 | — | COM | 59045L106 |
| — | TRILLIUM THERAPEUTICS INC | 2,100,000 | $30.89M | 0.7% | $9.74 | — | COM NEW | 89620X506 |
| — | RUBIUS THERAPEUTICS INC | 3,778,913 | $28.68M | 0.6% | $18.71 | — | COM | 78116T103 |
| — | DECIPHERA PHARMACEUTICALS IN | 500,000 | $28.54M | 0.6% | $38.91 | — | COM | 24344T101 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,040,882 | $27.63M | 0.6% | $23.52 | -8.4% | COM SHS | 877619106 |
| — | ADVERUM BIOTECHNOLOGIES INC | 2,500,000 | $27.1M | 0.6% | $11.59 | — | COM | 00773U108 |
| REPL | REPLIMUNE GROUP INC | 700,000 | $26.7M | 0.6% | $16.55 | +151.8% | COM | 76029N106 |
| — | ALBIREO PHARMA INC | 700,000 | $26.26M | 0.6% | $28.95 | — | COM | 01345P106 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 200,000 | $25.99M | 0.6% | $97.14 | +37.4% | Call | 02043Q107 |
| ALXO | ALX ONCOLOGY HLDGS INC | 300,000 | $25.86M | 0.6% | $53.20 | +13.1% | COM | 00166B105 |
| QURE | UNIQURE NV | 700,000 | $25.29M | 0.5% | $57.46 | -26.6% | SHS | N90064101 |
| NG | NOVAGOLD RES INC | 2,600,000 | $25.14M | 0.5% | $10.13 | +4.3% | COM NEW | 66987E206 |
| FOLD | AMICUS THERAPEUTICS INC | 1,000,000 | $23.09M | 0.5% | $11.37 | +79.9% | Call | 03152W109 |
| GOSS | GOSSAMER BIO INC | 2,358,968 | $22.81M | 0.5% | $17.62 | -44.1% | COM | 38341P102 |
| — | TRANSLATE BIO INC | 1,200,000 | $22.12M | 0.5% | $15.81 | — | COM | 89374L104 |
| — | AGENUS INC | 6,900,000 | $21.94M | 0.5% | $4.12 | — | COM NEW | 00847G705 |
| SLB | SCHLUMBERGER LTD | 1,000,000 | $21.83M | 0.5% | — | — | Call | 806857108 |
| BBIO | BRIDGEBIO PHARMA INC | 300,000 | $21.33M | 0.5% | $29.71 | +62.4% | COM | 10806X102 |
| KURA | KURA ONCOLOGY INC | 600,000 | $19.6M | 0.4% | $17.61 | +99.5% | COM | 50127T109 |
| — | REPARE THERAPEUTICS INC | 570,000 | $19.55M | 0.4% | $31.02 | — | COM | 760273102 |
| TECH | BIO-TECHNE CORP | 60,000 | $19.05M | 0.4% | $58.49 | +21.2% | COM | 09073M104 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 400,000 | $18.56M | 0.4% | $18.83 | +110.8% | COM | 462260100 |
| — | FORMA THERAPEUTICS HLDGS INC | 500,000 | $17.45M | 0.4% | $34.90 | — | SHS | 34633R104 |
| TCOM | TRIP COM GROUP LTD | 500,000 | $16.86M | 0.4% | $24.01 | — | ADS | 89677Q107 |
| RLAY | RELAY THERAPEUTICS INC | 400,000 | $16.62M | 0.4% | $38.13 | +18.6% | COM | 75943R102 |
| — | ZYMEWORKS INC | 350,000 | $16.54M | 0.4% | $47.26 | — | COM | 98985W102 |
| NBTX | NANOBIOTIX SA | 1,000,000 | $16.5M | 0.4% | $16.50 | — | SPONSORED ADS | 63009J107 |
| CRDF | CARDIFF ONCOLOGY INC | 900,000 | $16.19M | 0.3% | $6.60 | +166.2% | COM | 14147L108 |
| KYMR | KYMERA THERAPEUTICS INC | 250,000 | $15.5M | 0.3% | $30.53 | +59.8% | COM | 501575104 |
| STOK | STOKE THERAPEUTICS INC | 250,000 | $15.48M | 0.3% | $24.59 | +86.4% | COM | 86150R107 |
| — | TCR2 THERAPEUTICS INC | 500,000 | $15.46M | 0.3% | $18.30 | — | COM | 87808K106 |
| IQ | IQIYI INC | 850,000 | $14.86M | 0.3% | $17.48 | — | SPONSORED ADS | 46267X108 |
| — | FIBROGEN INC | 400,000 | $14.84M | 0.3% | $40.97 | — | COM | 31572Q808 |
| — | CURIS INC | 1,804,729 | $14.78M | 0.3% | $3.14 | — | COM NEW | 231269200 |
| — | BELLUS HEALTH INC NEW | 4,750,000 | $14.54M | 0.3% | $3.22 | — | COM NEW | 07987C204 |
| KRYS | KRYSTAL BIOTECH INC | 237,500 | $14.25M | 0.3% | $36.81 | +35.7% | COM | 501147102 |
| — | Y-MABS THERAPEUTICS INC | 285,028 | $14.11M | 0.3% | $22.87 | — | COM | 984241109 |
| AUPH | AURINIA PHARMACEUTICALS INC | 1,000,000 | $13.83M | 0.3% | $17.08 | -14.8% | COM | 05156V102 |
| — | SELECTA BIOSCIENCES INC | 4,500,000 | $13.63M | 0.3% | $3.52 | — | COM | 816212104 |
| NTLA | INTELLIA THERAPEUTICS INC | 250,000 | $13.6M | 0.3% | $21.63 | +67.9% | COM | 45826J105 |
| — | HARPOON THERAPEUTICS INC | 800,000 | $13.29M | 0.3% | $13.85 | — | COM | 41358P106 |
| — | SIGILON THERAPEUTICS INC | 276,000 | $13.26M | 0.3% | $48.03 | — | COM | 82657L107 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 150,000 | $13.15M | 0.3% | — | — | Call | 09061G101 |
| OLMA | OLEMA PHARMACEUTICALS INC | 260,500 | $12.53M | 0.3% | $46.89 | 0.0% | COM | 68062P106 |
| DHR | DANAHER CORPORATION | 50,000 | $11.11M | 0.2% | $173.71 | +12.8% | COM | 235851102 |
| IMUX | IMMUNIC INC | 700,000 | $10.7M | 0.2% | $10.33 | +73.8% | COM | 4525EP101 |
| — | HOOKIPA PHARMA INC | 949,616 | $10.53M | 0.2% | $8.34 | — | COM | 43906K100 |
| CYTK | CYTOKINETICS INC | 500,000 | $10.39M | 0.2% | $18.28 | 0.0% | COM NEW | 23282W605 |
| SPRO | SPERO THERAPEUTICS INC | 500,000 | $9.695M | 0.2% | $11.60 | +34.4% | COM | 84833T103 |
| BRKR | BRUKER CORP | 175,275 | $9.488M | 0.2% | $38.64 | +22.0% | COM | 116794108 |
| — | APTINYX INC | 2,502,035 | $8.657M | 0.2% | $2.68 | — | COM | 03836N103 |
| — | EVELO BIOSCIENCES INC | 700,000 | $8.463M | 0.2% | $7.21 | — | COM | 299734103 |
| — | APPLIED THERAPEUTICS INC | 380,000 | $8.364M | 0.2% | $20.76 | — | COM | 03828A101 |
| — | AEGLEA BIOTHERAPEUTICS INC | 1,045,000 | $8.224M | 0.2% | $8.28 | — | COM | 00773J103 |
| — | SYROS PHARMACEUTICALS INC | 750,000 | $8.138M | 0.2% | $7.80 | — | COM | 87184Q107 |
| AAL | AMERICAN AIRLS GROUP INC | 500,000 | $7.885M | 0.2% | — | — | Call | 02376R102 |
| — | ALPINE IMMUNE SCIENCES INC | 593,030 | $7.472M | 0.2% | $8.79 | — | COM | 02083G100 |
| — | ARAVIVE INC | 1,311,291 | $7.396M | 0.2% | $11.29 | — | COM | 03890D108 |
| — | METACRINE INC | 924,898 | $7.27M | 0.2% | $10.21 | — | COM | 59101E103 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 400,000 | $7.008M | 0.2% | $18.00 | 0.0% | COM NEW | 15117B202 |
| — | 111 INC | 1,000,000 | $6.95M | 0.1% | $9.49 | — | ADS | 68247Q102 |
| — | LEAP THERAPEUTICS INC | 3,000,000 | $6.75M | 0.1% | $2.06 | — | COM | 52187K101 |
| DYN | DYNE THERAPEUTICS INC | 300,000 | $6.3M | 0.1% | $21.96 | -9.9% | COM | 26818M108 |
| OVID | OVID THERAPEUTICS INC | 2,500,000 | $5.775M | 0.1% | $6.69 | -30.3% | COM | 690469101 |
| — | CYCLERION THERAPEUTICS INC | 1,817,584 | $5.561M | 0.1% | $9.09 | — | COM | 23255M105 |
| MRNA | MODERNA INC | 50,000 | $5.224M | 0.1% | $16.43 | +515.6% | COM | 60770K107 |
| ACIU | AC IMMUNE SA | 1,000,000 | $5.17M | 0.1% | $11.29 | -54.8% | SHS | H00263105 |
| — | CONTRAFECT CORP | 1,000,000 | $5.05M | 0.1% | $5.05 | — | COM NEW | 212326300 |
| PRQR | PROQR THERAPEUTICS N V | 1,196,218 | $5.024M | 0.1% | $5.65 | -25.4% | SHS EURO | N71542109 |
| — | KINNATE BIOPHARMA INC | 125,000 | $4.973M | 0.1% | $39.78 | — | COM | 49705R105 |
| — | SERES THERAPEUTICS INC | 200,000 | $4.9M | 0.1% | $28.31 | — | COM | 81750R102 |
| KLDO | KALEIDO BIOSCIENCES INC | 500,500 | $4.555M | 0.1% | $13.76 | -40.4% | COM | 483347100 |
| — | AXCELLA HEALTH INC | 712,500 | $3.698M | 0.1% | $6.82 | — | COM | 05454B105 |
| — | YUMANITY THERAPEUTICS INC | 217,391 | $3.696M | 0.1% | $17.00 | — | COM | 98872L102 |
| — | MARINUS PHARMACEUTICALS INC | 300,000 | $3.66M | 0.1% | $12.20 | — | COM NEW | 56854Q200 |
| RNAM | AVIDITY BIOSCIENCES INC | 142,500 | $3.637M | 0.1% | $28.83 | +1.1% | COM | 05370A108 |
| ORIC | ORIC PHARMACEUTICALS INC | 100,000 | $3.385M | 0.1% | $31.92 | -10.1% | COM | 68622P109 |
| ADCT | ADC THERAPEUTICS SA | 95,000 | $3.041M | 0.1% | $38.22 | -14.3% | SHS | H0036K147 |
| — | CHINOOK THERAPEUTICS INC | 180,500 | $2.863M | 0.1% | $15.86 | — | COM | 16961L106 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 133,000 | $2.681M | 0.1% | $12.55 | +71.6% | COM | 74366E102 |
| — | MEI PHARMA INC | 760,000 | $2.006M | 0.0% | $4.07 | — | COM NEW | 55279B202 |
| XLE | SELECT SECTOR SPDR TR | 50,000 | $1.895M | 0.0% | — | — | Call | 81369Y506 |
| — | IDERA PHARMACEUTICALS INC | 500,000 | $1.835M | 0.0% | $3.67 | — | COM PAR | 45168K405 |
| — | ADICET BIO INC | 129,335 | $1.817M | 0.0% | $11.89 | — | COM | 007002108 |
| — | CHIASMA INC | 380,000 | $1.653M | 0.0% | $4.30 | — | COM | 16706W102 |
| — | ORCHARD THERAPEUTICS PLC | 351,500 | $1.518M | 0.0% | $13.18 | — | ADS | 68570P101 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 110,532 | $1.258M | 0.0% | $13.01 | -15.9% | COM CL A | 46333X108 |
| — | RIGEL PHARMACEUTICALS INC | 321,100 | $1.124M | 0.0% | $1.56 | — | COM NEW | 766559603 |
| — | SURFACE ONCOLOGY INC | 100,000 | $924K | 0.0% | $9.24 | — | COM | 86877M209 |
| — | CEREVEL THERAPEUTICS HLDNG I | 79,600 | $450K | 0.0% | $5.65 | — | *W EXP 06/09/202 | 15678U102 |
| — | CIDARA THERAPEUTICS INC | 224,675 | $449K | 0.0% | $3.69 | — | COM | 171757107 |