Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q1 2022 (← Previous) (Next →)
Filing Date: May 16, 2022
Total Value: $4.583B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 7,567,900 | $888M | 19.4% | $73.22 | — | SPONSORED ADR | 04351P101 |
| BIIB | BIOGEN INC | 727,024 | $153M | 3.3% | $217.46 | 0.0% | COM | 09062X103 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $151M | 3.3% | $22.83 | — | COM | 008064107 |
| CTKB | CYTEK BIOSCIENCES INC | 13,381,054 | $144M | 3.1% | $20.70 | -34.8% | COM | 23285D109 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $142M | 3.1% | $24.67 | — | COM | 46565G104 |
| TVTX | TRAVERE THERAPEUTICS INC | 4,922,941 | $127M | 2.8% | $24.15 | +9.9% | COM | 89422G107 |
| JANX | JANUX THERAPEUTICS INC | 8,670,644 | $124M | 2.7% | $22.27 | -26.5% | COM | 47103J105 |
| PCVX | VAXCYTE INC | 4,581,203 | $111M | 2.4% | $30.49 | -28.3% | COM | 92243G108 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $110M | 2.4% | $20.66 | -54.8% | COM | 28658R106 |
| — | IMMUNOGEN INC | 21,741,458 | $103M | 2.3% | $5.49 | — | COM | 45253H101 |
| — | DICE THERAPEUTICS INC | 5,208,911 | $99.65M | 2.2% | $32.75 | — | COM | 23345J104 |
| GHRS | GH RESEARCH PLC | 4,827,330 | $88.29M | 1.9% | $19.29 | -8.4% | ORDINARY SHARES | G3855L106 |
| — | FORMA THERAPEUTICS HLDGS INC | 9,011,651 | $83.81M | 1.8% | $46.49 | — | SHS | 34633R104 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $77.43M | 1.7% | $19.11 | -37.9% | COM | 90240B106 |
| — | POINT BIOPHARMA GLOBAL INC | 9,003,018 | $71.75M | 1.6% | $7.66 | — | COM | 730541109 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 2,075,000 | $70.67M | 1.5% | $44.65 | -28.4% | COM NEW | 15117B202 |
| — | BELLUS HEALTH INC NEW | 10,230,274 | $70.38M | 1.5% | $8.05 | — | COM NEW | 07987C204 |
| ENTA | ENANTA PHARMACEUTICALS INC | 964,212 | $68.63M | 1.5% | $65.07 | 0.0% | COM | 29251M106 |
| — | VOR BIOPHARMA INC | 11,120,973 | $67.17M | 1.5% | $43.10 | — | COM | 929033108 |
| NKTX | NKARTA INC | 5,605,129 | $63.79M | 1.4% | $29.47 | -63.7% | COM | 65487U108 |
| — | MIRATI THERAPEUTICS INC | 734,343 | $60.38M | 1.3% | $115.67 | — | COM | 60468T105 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 6,060,090 | $60.12M | 1.3% | $19.40 | -31.9% | COM | 23954D109 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 4,871,067 | $56.12M | 1.2% | $24.79 | -64.6% | COM | 76243J105 |
| ANTX | AN2 THERAPEUTICS INC | 3,666,663 | $55.26M | 1.2% | $15.17 | 0.0% | COM | 037326105 |
| RLMD | RELMADA THERAPEUTICS INC | 2,000,000 | $53.98M | 1.2% | $22.24 | -7.0% | COM | 75955J402 |
| MGNX | MACROGENICS INC | 6,103,594 | $53.77M | 1.2% | $20.01 | -44.8% | COM | 556099109 |
| NTRA | NATERA INC | 1,310,289 | $53.3M | 1.2% | $60.09 | 0.0% | COM | 632307104 |
| — | INSTIL BIO INC | 4,870,793 | $52.36M | 1.1% | $25.08 | — | COM | 45783C101 |
| NVAX | NOVAVAX INC | 692,794 | $51.02M | 1.1% | $84.76 | +5.2% | COM NEW | 670002401 |
| — | KINNATE BIOPHARMA INC | 4,264,144 | $48.01M | 1.0% | $35.29 | — | COM | 49705R105 |
| VERA | VERA THERAPEUTICS INC | 1,966,084 | $46.18M | 1.0% | $21.52 | 0.0% | CL A | 92337R101 |
| — | PARDES BIOSCIENCES INC | 6,175,038 | $44.58M | 1.0% | $11.85 | — | COM | 69945Q105 |
| — | ICOSAVAX INC | 5,963,565 | $41.98M | 0.9% | $28.89 | — | COM | 45114M109 |
| TNYA | TENAYA THERAPEUTICS INC | 3,551,508 | $41.84M | 0.9% | $21.49 | -43.7% | COM | 87990A106 |
| GERN | GERON CORP | 30,126,299 | $40.97M | 0.9% | $1.49 | -25.4% | COM | 374163103 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,370,506 | $40.95M | 0.9% | $11.52 | -4.9% | COM NEW | 30233G209 |
| RNAM | AVIDITY BIOSCIENCES INC | 2,167,391 | $40.03M | 0.9% | $17.92 | -5.2% | COM | 05370A108 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 9,770,773 | $38.2M | 0.8% | $16.64 | -67.3% | COM | 00509G209 |
| RXST | RXSIGHT INC | 3,052,796 | $37.79M | 0.8% | $13.76 | -12.8% | COM | 78349D107 |
| PMVP | PMV PHARMACEUTICALS INC | 1,710,265 | $35.61M | 0.8% | $36.80 | -52.1% | COM | 69353Y103 |
| DSGN | DESIGN THERAPEUTICS INC | 2,186,636 | $35.31M | 0.8% | $31.14 | -50.8% | COM | 25056L103 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,107,149 | $33.42M | 0.7% | $36.45 | -52.6% | COM | 77313F106 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,577,094 | $32.09M | 0.7% | $18.67 | — | SPONSORED ADS | 152309100 |
| GH | GUARDANT HEALTH INC | 476,380 | $31.55M | 0.7% | $68.43 | 0.0% | COM | 40131M109 |
| ACRS | ACLARIS THERAPEUTICS INC | 1,817,808 | $31.34M | 0.7% | $13.64 | 0.0% | COM | 00461U105 |
| — | CHEMOCENTRYX INC | 1,155,964 | $28.98M | 0.6% | $25.07 | — | COM | 16383L106 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,930,322 | $28.45M | 0.6% | $26.18 | -45.1% | COM | 483497103 |
| LIANY | LIANBIO | 7,655,015 | $28.4M | 0.6% | $6.16 | — | SPONSORED ADS | 53000N108 |
| DYN | DYNE THERAPEUTICS INC | 2,805,045 | $27.04M | 0.6% | $21.96 | -61.2% | COM | 26818M108 |
| — | VERONA PHARMA PLC | 5,100,000 | $25.45M | 0.6% | $6.24 | — | SPONSORED ADS | 925050106 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,613,623 | $25.35M | 0.6% | $32.43 | -60.3% | COM | 28036F105 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $22.47M | 0.5% | $13.11 | — | COM | 80405P107 |
| — | CONNECT BIOPHARMA HLDGS LTD | 6,991,003 | $21.11M | 0.5% | $19.09 | — | ADS | 207523101 |
| HOWL | WEREWOLF THERAPEUTICS INC | 4,291,881 | $18.88M | 0.4% | $13.70 | -48.9% | COM | 95075A107 |
| — | 89BIO INC | 4,965,769 | $18.72M | 0.4% | $25.74 | — | COM | 282559103 |
| TNGX | TANGO THERAPEUTICS INC | 2,250,000 | $17.05M | 0.4% | $11.99 | -27.7% | COM | 87583X109 |
| RLAY | RELAY THERAPEUTICS INC | 549,055 | $16.43M | 0.4% | $31.60 | -23.2% | COM | 75943R102 |
| — | CHINOOK THERAPEUTICS INC | 1,000,000 | $16.36M | 0.4% | $16.31 | — | COM | 16961L106 |
| — | SYNLOGIC INC | 6,666,666 | $16M | 0.3% | $3.05 | — | COM | 87166L100 |
| WVE | WAVE LIFE SCIENCES LTD | 7,775,207 | $15.55M | 0.3% | $17.26 | -85.8% | SHS | Y95308105 |
| — | SCPHARMACEUTICALS INC | 2,658,583 | $15.1M | 0.3% | $10.74 | — | COM | 810648105 |
| — | KALA PHARMACEUTICALS INC | 10,874,613 | $15.01M | 0.3% | $10.65 | — | COM | 483119103 |
| — | SOLID BIOSCIENCES INC | 12,367,873 | $14.84M | 0.3% | $7.59 | — | COM | 83422E105 |
| — | ACHILLES THERAPEUTICS PLC | 5,014,687 | $14.74M | 0.3% | $11.66 | — | SPONSORED ADS | 00449L102 |
| — | DA32 LIFE SCNCE TEC ACQSTN C | 1,500,000 | $14.57M | 0.3% | $9.83 | — | CLASS A COM | 23312M106 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,246,503 | $14.42M | 0.3% | $7.17 | -12.8% | COM | 59935V107 |
| XLO | XILIO THERAPEUTICS INC | 2,002,217 | $14.16M | 0.3% | $17.03 | -33.7% | COM | 98422T100 |
| — | GRAPHITE BIO INC | 2,698,369 | $13.76M | 0.3% | $30.73 | — | COM | 38870X104 |
| — | OTONOMY INC | 5,600,000 | $13.44M | 0.3% | $2.03 | — | COM | 68906L105 |
| — | CYTEIR THERAPEUTICS INC | 3,350,506 | $12.63M | 0.3% | $21.28 | — | COM | 23284P103 |
| — | BCLS ACQUISITION CORP | 1,250,000 | $12.34M | 0.3% | $11.14 | — | COM CL A | G0904B105 |
| IPSC | CENTURY THERAPEUTICS INC | 914,094 | $11.51M | 0.3% | $25.37 | -47.8% | COM | 15673T100 |
| — | MORPHIC HLDG INC | 278,874 | $11.2M | 0.2% | $40.15 | — | COM | 61775R105 |
| — | AKOUOS INC | 2,281,249 | $10.84M | 0.2% | $22.50 | — | COM | 00973J101 |
| — | CONCERT PHARMACEUTICALS INC | 3,033,603 | $10.22M | 0.2% | $7.30 | — | COM | 206022105 |
| — | FRAZIER LIFESCIENCES ACQU CO | 1,000,000 | $9.99M | 0.2% | $10.38 | — | CL A SHS | G3710A121 |
| IOBT | IO BIOTECH INC | 1,857,755 | $9.846M | 0.2% | $9.66 | -31.6% | COM | 449778109 |
| — | ALLOVIR INC | 1,440,525 | $9.724M | 0.2% | $6.75 | — | COM | 019818103 |
| — | ARYA SCIENCES ACQUISITN | 1,000,000 | $9.71M | 0.2% | $9.88 | — | CLASS A ORD SHS | G31658100 |
| PYXS | PYXIS ONCOLOGY INC | 2,282,173 | $9.22M | 0.2% | $11.45 | -36.2% | COM | 747324101 |
| — | ASTRIA THERAPEUTICS INC | 1,262,193 | $8.469M | 0.2% | $8.84 | — | COM | 04635X102 |
| — | 5 01 ACQUISITION CORP | 750,000 | $7.388M | 0.2% | $10.17 | — | COM CL A | 33836P105 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 2,589,904 | $7.174M | 0.2% | $30.22 | -87.9% | COM | 09203E105 |
| — | VERVE THERAPEUTICS INC | 310,284 | $7.081M | 0.2% | $60.25 | — | COM | 92539P101 |
| — | ORCHARD THERAPEUTICS PLC | 9,694,789 | $6.903M | 0.2% | $10.43 | — | ADS | 68570P101 |
| ENTX | ENTERA BIO LTD | 2,353,000 | $6.753M | 0.1% | $3.70 | -35.1% | SHS | M40527109 |
| — | HEALTH SCIENCES ACQ CORP 2 | 625,000 | $6.194M | 0.1% | $11.00 | — | ORD SHS | G4411D109 |
| LRMR | LARIMAR THERAPEUTICS INC | 1,281,860 | $5.192M | 0.1% | $11.65 | -43.8% | COM | 517125100 |
| HLTHQ | CUE HEALTH INC | 750,000 | $4.838M | 0.1% | $11.81 | — | COM | 229790100 |
| — | PHASEBIO PHARMACEUTICALS INC | 2,850,000 | $3.762M | 0.1% | $3.46 | — | COM | 717224109 |
| CGEM | CULLINAN ONCOLOGY INC | 350,000 | $3.665M | 0.1% | $40.60 | -66.7% | COM | 230031106 |
| TCRX | TSCAN THERAPEUTICS INC | 1,021,764 | $2.861M | 0.1% | $9.27 | -53.4% | COM | 89854M101 |
| BMEA | BIOMEA FUSION INC | 500,000 | $2.23M | 0.0% | $17.65 | -63.3% | COM | 09077A106 |
| OLMA | OLEMA PHARMACEUTICALS INC | 504,505 | $2.149M | 0.0% | $46.89 | -88.2% | COM | 68062P106 |
| CVRX | CVRX INC | 275,000 | $1.647M | 0.0% | $28.00 | -71.2% | COM | 126638105 |
| CMPX | COMPASS THERAPEUTICS INC | 532,958 | $730K | 0.0% | $3.29 | -37.2% | COM | 20454B104 |