Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: Feb 14, 2022
Total Value: $5.672B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 7,567,900 | $1.018B | 17.9% | $134.53 | $73.22 | — | SPONSORED | 04351P101 |
| NVAX | NOVAVAX INC | 2,097,794 | $300M | 5.3% | $143.07 * | $84.76 | +102.7% | COM NEW | 670002401 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $206M | 3.6% | $46.56 | $24.67 | — | COM | 46565G104 |
| TVTX | TRAVERE THERAPEUTICS INC | 5,614,428 | $174M | 3.1% | $31.04 * | $24.15 | +16.6% | COM | 89422G107 |
| JANX | JANUX THERAPEUTICS INC | 8,670,644 | $171M | 3.0% | $19.73 * | $22.27 | -5.9% | COM | 47103J105 |
| CTKB | CYTEK BIOSCIENCES INC | 9,607,028 | $157M | 2.8% | $16.32 * | $23.52 | -11.0% | COM | 23285D109 |
| — | IMMUNOGEN INC | 20,241,458 | $150M | 2.6% | $7.42 | $5.55 | — | COM | 45253H101 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $138M | 2.4% | $10.46 * | $20.66 | -27.8% | COM | 28658R106 |
| — | ICOSAVAX INC | 5,779,347 | $132M | 2.3% | $22.88 | $29.59 | — | COM | 45114M109 |
| — | DICE THERAPEUTICS INC | 5,208,911 | $132M | 2.3% | $25.31 | $32.75 | — | COM | 23345J104 |
| — | VOR BIOPHARMA INC | 11,120,973 | $129M | 2.3% | $11.62 | $43.10 | — | COM | 929033108 |
| — | FORMA THERAPEUTICS | 9,011,651 | $128M | 2.3% | $14.22 | $46.49 | — | SHS | 34633R104 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $102M | 1.8% | $14.07 * | $19.11 | +3.9% | COM | 90240B106 |
| PCVX | VAXCYTE INC | 4,240,464 | $101M | 1.8% | $23.79 * | $31.18 | -25.4% | COM | 92243G108 |
| MGNX | MACROGENICS INC | 6,103,594 | $97.96M | 1.7% | $16.05 * | $20.01 | -6.0% | COM | 556099109 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $97.43M | 1.7% | $11.79 | $22.83 | — | COM | 008064107 |
| NKTX | NKARTA INC | 5,605,129 | $86.04M | 1.5% | $15.35 * | $29.47 | -41.8% | COM | 65487U108 |
| DAWN | DAY ONE BIOPHARMACEUTICALS | 4,965,588 | $83.67M | 1.5% | $16.85 * | $20.76 | -1.0% | COM | 23954D109 |
| — | INSTIL BIO INC | 4,870,793 | $83.34M | 1.5% | $17.11 | $25.08 | — | COM | 45783C101 |
| — | BELLUS HEALTH INC NEW | 10,230,274 | $82.35M | 1.5% | $8.05 | $8.05 | — | COM NEW | 07987C204 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 1,804,795 | $69.74M | 1.2% | $38.64 * | $46.55 | -6.4% | COM NEW | 15117B202 |
| TNYA | TENAYA THERAPEUTICS INC | 3,551,508 | $67.3M | 1.2% | $18.95 * | $21.49 | +1.4% | COM | 87990A106 |
| GHRS | GH RESEARCH PLC | 2,843,757 | $66.34M | 1.2% | $23.33 * | $20.42 | +7.6% | ORDINARY SHARES | G3855L106 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 9,770,773 | $66.05M | 1.2% | $6.76 * | $16.64 | -33.9% | COM | 00509G209 |
| — | 89BIO INC | 4,965,769 | $64.9M | 1.1% | $13.07 | $25.74 | — | COM | 282559103 |
| — | KINNATE BIOPHARMA INC | 3,593,052 | $63.67M | 1.1% | $17.72 | $39.78 | — | COM | 49705R105 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 3,115,008 | $61.27M | 1.1% | $19.67 * | $25.67 | -8.3% | COM | 71722W107 |
| — | MIRATI THERAPEUTICS INC | 381,046 | $55.9M | 1.0% | $146.69 | $146.69 | — | COM | 60468T105 |
| — | ZOGENIX INC | 3,333,700 | $54.17M | 1.0% | $16.25 | $26.04 | — | COM NEW | 98978L204 |
| — | PARDES BIOSCIENCES INC | 3,127,038 | $51.19M | 0.9% | $16.37 | $16.37 | — | Com | 69945Q105 |
| HOWL | WEREWOLF THERAPEUTICS INC | 4,291,881 | $51.12M | 0.9% | $11.91 * | $13.70 | +10.2% | COM | 95075A107 |
| — | POINT BIOPHARMA GLOBAL INC | 9,003,018 | $50.42M | 0.9% | $5.60 | $7.66 | — | COM | 730541109 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 4,871,067 | $48.61M | 0.9% | $9.98 * | $24.79 | -54.7% | COM | 76243J105 |
| LIANY | LIANBIO | 7,655,015 | $47.16M | 0.8% | $6.16 | $6.16 | — | SPONSORED ADS | 53000N108 |
| DSGN | DESIGN THERAPEUTICS INC | 2,186,636 | $46.82M | 0.8% | $21.41 * | $31.14 | -44.9% | COM | 25056L103 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,107,149 | $46M | 0.8% | $21.83 * | $36.45 | -25.2% | COM | 77313F106 |
| RLMD | RELMADA THERAPEUTICS | 2,000,000 | $45.06M | 0.8% | $22.53 | $22.24 | 0.0% | COM | 75955J402 |
| CCCC | C4 THERAPEUTICS INC | 1,377,569 | $44.36M | 0.8% | $32.20 * | $29.00 | +36.4% | COM STK | 12529R107 |
| TGTX | TG THERAPEUTICS INC | 2,210,145 | $41.99M | 0.7% | $19.00 * | $15.45 | +68.0% | COM | 88322Q108 |
| EYPT | EYEPOINT PHARMACEUTICALS | 3,370,506 | $41.26M | 0.7% | $12.24 * | $11.52 | +16.8% | COM NEW | 30233G209 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,577,094 | $40.28M | 0.7% | $11.26 | $18.67 | — | SPONSORED ADS | 152309100 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,613,623 | $39.94M | 0.7% | $15.28 * | $32.43 | -44.5% | COM | 28036F105 |
| PMVP | PMV PHARMACEUTICALS INC | 1,710,265 | $39.51M | 0.7% | $23.10 * | $36.80 | -34.3% | COM | 69353Y103 |
| — | CYTEIR THERAPEUTICS INC | 3,350,506 | $38.09M | 0.7% | $11.37 | $21.28 | — | COM | 23284P103 |
| GERN | GERON CORP | 30,126,299 | $36.75M | 0.6% | $1.22 * | $1.49 | -4.2% | COM | 374163103 |
| IVVD | ADAGIO THERAPEUTICS INC | 4,995,807 | $36.27M | 0.6% | $7.26 * | $37.11 | -29.9% | COM | 00534A102 |
| — | CONNECT BIOPHARMA HLDGS LTD | 6,991,003 | $36M | 0.6% | $5.15 | $19.09 | — | ADS | 207523101 |
| RXST | RXSIGHT INC | 3,052,796 | $34.34M | 0.6% | $11.25 * | $13.76 | -12.7% | COM | 78349D107 |
| — | VERONA PHARMA PLC | 5,100,000 | $34.27M | 0.6% | $6.72 | $6.24 | — | SPONSORED ADS | 925050106 |
| — | GRAPHITE BIO INC | 2,698,369 | $33.54M | 0.6% | $12.43 | $30.73 | — | COM | 38870X104 |
| DYN | DYNE THERAPEUTICS INC | 2,805,045 | $33.35M | 0.6% | $11.89 * | $21.96 | -36.0% | COM | 26818M108 |
| XLO | XILIO THERAPEUTICS INC | 2,002,217 | $32.03M | 0.6% | $16.00 * | $17.03 | 0.0% | COM | 98422T100 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $26.61M | 0.5% | $4.50 | $13.11 | — | COM | 80405P107 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,930,322 | $25.54M | 0.5% | $13.23 * | $26.18 | -39.2% | COM | 483497103 |
| — | ACHILLES THERAPEUTICS PLC | 5,014,687 | $25.12M | 0.4% | $5.01 | $11.66 | — | SPONSORED ADS | 00449L102 |
| PYXS | PYXIS ONCOLOGY INC | 2,282,173 | $25.04M | 0.4% | $10.97 * | $11.45 | 0.0% | COMMON STOCK | 747324101 |
| TNGX | TANGO THERAPEUTICS INC | 2,250,000 | $24.61M | 0.4% | $10.94 * | $11.99 | +0.3% | COM | 87583X109 |
| WVE | WAVE LIFE SCIENCES LTD | 7,775,207 | $24.41M | 0.4% | $3.14 * | $17.26 | -75.9% | SHS | Y95308105 |
| — | SOLID BIOSCIENCES INC | 12,367,873 | $21.64M | 0.4% | $1.75 | $7.59 | — | COM | 83422E105 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,150,404 | $20.13M | 0.4% | $9.36 * | $46.89 | -55.8% | COM | 68062P106 |
| — | AKOUOS INC | 2,281,249 | $19.39M | 0.3% | $8.50 | $22.50 | — | COM | 00973J101 |
| RLAY | RELAY THERAPEUTICS INC | 549,055 | $16.86M | 0.3% | $30.71 * | $31.60 | 0.0% | COM | 75943R102 |
| — | CHINOOK THERAPEUTICS | 1,000,000 | $16.31M | 0.3% | $16.31 | $16.31 | — | COM | 16961L106 |
| — | SYNLOGIC INC | 6,666,666 | $16.13M | 0.3% | $2.42 | $3.05 | — | COM | 87166L100 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,246,503 | $14.71M | 0.3% | $6.55 * | $7.17 | -16.5% | COM | 59935V107 |
| — | DA32 LIFE SCNCE | 1,500,000 | $14.71M | 0.3% | $9.81 | $9.83 | — | CLASS A COM | 23312M106 |
| IPSC | CENTURY THERAPEUTICS INC | 914,094 | $14.5M | 0.3% | $15.86 * | $25.37 | -26.0% | COM | 15673T100 |
| LRMR | LARIMAR THERAPEUTICS INC | 1,334,610 | $14.4M | 0.3% | $10.79 * | $11.65 | -4.5% | COM | 517125100 |
| BDTX | BLACK DIAMOND THERAPEUTICS INC | 2,589,904 | $13.8M | 0.2% | $5.33 * | $30.22 | -76.9% | COM | 09203E105 |
| — | SCPHARMACEUTICALS | 2,691,770 | $13.51M | 0.2% | $5.02 | $10.74 | — | COM | 810648105 |
| — | KALA PHARMACEUTICALS INC | 10,874,613 | $13.16M | 0.2% | $1.21 | $10.65 | — | COM | 483119103 |
| — | ORCHARD THERAPEUTICS PLC | 9,694,789 | $12.8M | 0.2% | $1.32 | $10.43 | — | ADS | 68570P101 |
| NAUT | NAUTILUS | 2,436,430 | $12.62M | 0.2% | $5.18 * | $10.83 | -50.6% | COM | 63909J108 |
| — | BCLS ACQUISITION CORP | 1,250,000 | $12.25M | 0.2% | $9.80 | $11.14 | — | COM CL A | G0904B105 |
| IOBT | IO BIOTECH INC | 1,857,755 | $11.89M | 0.2% | $6.40 * | $9.66 | 0.0% | COM | 449778109 |
| — | BOLT BIOTHERAPEUTICS INC | 2,378,325 | $11.65M | 0.2% | $4.90 | $32.91 | — | COM | 097702104 |
| — | OTONOMY INC | 5,600,000 | $11.65M | 0.2% | $2.08 | $2.03 | — | COM | 68906L105 |
| SPRY | SILVERBACK THERAPEUTICS INC | 1,742,186 | $11.6M | 0.2% | $6.66 * | $33.40 | -75.7% | COM | 82835W108 |
| — | VERVE THERAPEUTICS INC | 310,284 | $11.44M | 0.2% | $36.87 | $60.25 | — | COM | 92539P101 |
| RNAM | AVIDITY BIOSCIENCES INC | 423,616 | $10.07M | 0.2% | $23.77 | $21.74 | +9.9% | COM | 05370A108 |
| HLTHQ | CUE HEALTH INC | 750,000 | $10.06M | 0.2% | $13.41 | $11.81 | — | COM | 229790100 |
| — | FRAZIER LIFESCIENCES ACQU CO | 1,000,000 | $9.92M | 0.2% | $9.92 | $10.38 | — | CL A SHS | G3710A121 |
| — | ARYA SCIENCES ACQUISITN | 1,000,000 | $9.7M | 0.2% | $9.70 | $9.88 | — | CLASS A ORD SHS | G31658100 |
| — | CONCERT PHARMACEUTICALS INC | 3,033,603 | $9.556M | 0.2% | $3.15 | $7.30 | — | COM | 206022105 |
| — | IKENA ONCOLOGY INC | 750,000 | $9.405M | 0.2% | $12.54 | $28.25 | — | COM | 45175G108 |
| COGT | COGENT BIOSCIENCES INC | 1,025,641 | $8.8M | 0.2% | $8.58 | $10.99 | -20.9% | COM | 19240Q201 |
| — | PHASEBIO PHARMACEUTICALS INC | 2,850,000 | $7.439M | 0.1% | $2.61 | $3.46 | — | COM | 717224109 |
| — | 5 01 ACQUISITION CORP | 750,000 | $7.388M | 0.1% | $9.85 | $10.17 | — | COM CL | 33836P105 |
| — | ASTRIA THERAPEUTICS INC | 1,262,193 | $6.803M | 0.1% | $5.39 | $8.84 | — | COM | 04635X102 |
| ENTX | ENTERA BIO LTD | 2,353,000 | $6.624M | 0.1% | $2.82 * | $3.70 | +1.4% | SHS | M40527109 |
| — | HEALTH SCIENCES ACQ CORP 2 | 625,000 | $6.3M | 0.1% | $10.08 | $11.00 | — | ORD SHS | G4411D109 |
| CMPX | COMPASS THERAPEUTICS INC | 1,849,518 | $5.863M | 0.1% | $3.17 * | $3.29 | 0.0% | COM | 20454B104 |
| TCRX | TSCAN THERAPEUTICS INC | 1,255,317 | $5.649M | 0.1% | $4.50 * | $9.27 | -22.1% | COM | 89854M101 |
| CGEM | CULLINAN ONCOLOGY INC | 350,000 | $5.401M | 0.1% | $15.43 * | $40.60 | -50.9% | COM | 230031106 |
| BMEA | BIOMEA FUSION INC | 500,000 | $3.725M | 0.1% | $7.45 * | $17.65 | -40.1% | COM | 09077A106 |
| CVRX | CVRX INC | 275,000 | $3.363M | 0.1% | $12.23 * | $28.00 | -48.2% | COM | 126638105 |
| — | SYROS PHARMACEUTICALS INC | 900,000 | $2.934M | 0.1% | $3.26 | $7.48 | — | COM | 87184Q107 |