BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $13,838,782 (99.7% shares, 0.3% debt)

Holdings (91)

ONC BeOne Medicines Ltd. 21.7%
Value ($000) $2,997,837 Shares 8,799,053 Est. Cost $136.93 Unrealized
INCY Incyte Corporation 18.8%
Value ($000) $2,607,370 Shares 30,743,663 Est. Cost $72.80 Unrealized +8.6%
MDGL Madrigal Pharmaceuticals, Inc. 7.1%
Value ($000) $982,313 Shares 2,141,701 Est. Cost $139.37 Unrealized +167.7%
INSM Insmed Incorporated 7.0%
Value ($000) $965,369 Shares 6,703,484 Est. Cost $57.51 Unrealized +113.0%
ACAD ACADIA Pharmaceuticals Inc. 6.6%
Value ($000) $915,415 Shares 42,896,690 Est. Cost $18.93 Unrealized +24.9%
SMMT Summit Therapeutics Inc. 5.0%
Value ($000) $696,717 Shares 33,722,974 Est. Cost $10.51 Unrealized +130.8%
RYTM Rhythm Pharmaceuticals, Inc. 4.1%
Value ($000) $565,997 Shares 5,604,483 Est. Cost $23.49 Unrealized +295.3%
RVMD Revolution Medicines, Inc. 3.2%
Value ($000) $441,565 Shares 9,455,357 Est. Cost $29.36 Unrealized +33.4%
CELC Celcuity Inc. 2.8%
Value ($000) $391,040 Shares 7,915,792 Est. Cost $21.19 Unrealized +88.9%
KYMR Kymera Therapeutics, Inc. 2.7%
Value ($000) $376,471 Shares 6,651,429 Est. Cost $28.76 Unrealized +56.8%
KOD Kodiak Sciences Inc. 2.0%
Value ($000) $283,373 Shares 17,310,490 Est. Cost $30.30 Unrealized -71.6%
ALKS Alkermes plc 1.8%
Value ($000) $242,741 Shares 8,091,351 Est. Cost $26.84 Unrealized +5.1%
ABCL AbCellera Biologics Inc. 1.0%
Value ($000) $138,454 Shares 27,525,640 Est. Cost $21.02 Unrealized -79.0%
EWTX Edgewise Therapeutics, Inc. 0.9%
Value ($000) $118,502 Shares 7,305,940 Est. Cost $14.29 Unrealized -0.8%
KNSA Kiniksa Pharmaceuticals International, plc 0.8%
Value ($000) $109,682 Shares 2,824,669 Est. Cost $18.73 Unrealized +73.4%
STOK Stoke Therapeutics, Inc. 0.8%
Value ($000) $108,895 Shares 4,633,838 Est. Cost $9.30 Unrealized +84.2%
IMTX Immatics N.V. 0.7%
Value ($000) $103,042 Shares 12,094,094 Est. Cost $8.55 Unrealized -28.0%
GRAL GRAIL, Inc. 0.7%
Value ($000) $96,389 Shares 1,630,125 Est. Cost $16.26 Unrealized +135.0%
IDYA IDEAYA Biosciences, Inc. 0.6%
Value ($000) $89,125 Shares 3,275,444 Est. Cost $19.47 Unrealized +24.2%
IMVT Immunovant, Inc. 0.6%
Value ($000) $87,981 Shares 5,457,881 Est. Cost $22.96 Unrealized -29.5%
IMCR Immunocore Holdings plc 0.6%
Value ($000) $84,382 Shares 2,322,656 Est. Cost $38.09 Unrealized
BCYC Bicycle Therapeutics plc 0.6%
Value ($000) $84,253 Shares 10,885,357 Est. Cost $20.78 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.6%
Value ($000) $83,403 Shares 2,772,692 Est. Cost $52.13 Unrealized -42.5%
ABVX Abivax S.A. 0.5%
Value ($000) $74,355 Shares 875,796 Est. Cost $84.90 Unrealized
ARWR Arrowhead Pharmaceuticals, Inc. 0.4%
Value ($000) $57,625 Shares 1,670,762 Est. Cost $17.69 Unrealized +24.3%
ROIV Roivant Sciences Ltd. 0.4%
Value ($000) $57,006 Shares 3,767,773 Est. Cost $9.71 Unrealized +27.4%
DNLI Denali Therapeutics Inc. 0.4%
Value ($000) $54,184 Shares 3,731,695 Est. Cost $23.78 Unrealized -39.6%
Merus N.V. 0.4%
Value ($000) $54,078 Shares 574,377 Est. Cost $52.94 Unrealized
NTLA Intellia Therapeutics, Inc. 0.3%
Value ($000) $47,435 Shares 2,746,674 Est. Cost $10.05 Unrealized +22.5%
REPL Replimune Group, Inc. 0.3%
Value ($000) $46,280 Shares 11,045,336 Est. Cost $14.45 Unrealized -55.8%
RAPP Rapport Therapeutics, Inc. 0.3%
Value ($000) $45,949 Shares 1,547,090 Est. Cost $15.27 Unrealized +16.8%
GPCR Structure Therapeutics Inc. 0.3%
Value ($000) $43,571 Shares 1,556,109 Est. Cost $22.23 Unrealized
Celcuity Inc. 0.3%
Value ($000) $40,905 Shares 30,750,000 Est. Cost $1.33 Unrealized
VRDN Viridian Therapeutics, Inc. 0.3%
Value ($000) $37,644 Shares 1,744,406 Est. Cost $13.57 Unrealized +32.9%
IONS Ionis Pharmaceuticals, Inc. 0.3%
Value ($000) $37,080 Shares 566,798 Est. Cost $48.82 Unrealized 0.0%
PRAX Praxis Precision Medicines, Inc. 0.3%
Value ($000) $36,543 Shares 689,488 Est. Cost $44.22 Unrealized +9.6%
GLUE Monte Rosa Therapeutics, Inc. 0.3%
Value ($000) $36,428 Shares 4,916,095 Est. Cost $6.49 Unrealized -18.4%
BNTX BioNTech SE 0.3%
Value ($000) $36,383 Shares 368,923 Est. Cost $107.38 Unrealized
NRIX Nurix Therapeutics, Inc. 0.3%
Value ($000) $35,871 Shares 3,882,125 Est. Cost $22.27 Unrealized -53.4%
DNTH Dianthus Therapeutics, Inc. 0.2%
Value ($000) $31,077 Shares 789,759 Est. Cost $18.76 Unrealized +36.2%
TRDA Entrada Therapeutics, Inc. 0.2%
Value ($000) $28,222 Shares 4,865,819 Est. Cost $16.96 Unrealized
ARGX argenx SE 0.2%
Value ($000) $27,850 Shares 37,760 Est. Cost $79.01 Unrealized
RNAM Avidity Biosciences, Inc. 0.2%
Value ($000) $27,231 Shares 625,000 Est. Cost $40.43 Unrealized 0.0%
PCVX Vaxcyte, Inc. 0.2%
Value ($000) $23,085 Shares 640,885 Est. Cost $76.85 Unrealized -56.9%
IRON Disc Medicine, Inc. 0.2%
Value ($000) $22,272 Shares 337,050 Est. Cost $49.46 Unrealized +20.3%
Cidara Therapeutics, Inc. 0.2%
Value ($000) $21,764 Shares 227,272 Est. Cost $48.71 Unrealized
CLDX Celldex Therapeutics, Inc. 0.1%
Value ($000) $17,213 Shares 665,370 Est. Cost $23.17 Unrealized +0.0%
NGNE Neurogene Inc. 0.1%
Value ($000) $17,186 Shares 991,691 Est. Cost $19.35 Unrealized +3.8%
SERA Sera Prognostics, Inc. 0.1%
Value ($000) $16,824 Shares 5,498,170 Est. Cost $3.09 Unrealized -8.0%
SYRE Spyre Therapeutics, Inc. 0.1%
Value ($000) $16,760 Shares 1,000,000 Est. Cost $15.36 Unrealized +6.2%
CERS Cerus Corporation 0.1%
Value ($000) $15,913 Shares 10,008,345 Est. Cost $4.19 Unrealized -67.7%
Akero Therapeutics, Inc. 0.1%
Value ($000) $15,413 Shares 324,630 Est. Cost $32.79 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.1%
Value ($000) $14,864 Shares 370,208 Est. Cost $19.37 Unrealized +81.8%
DBVT DBV Technologies S.A. 0.1%
Value ($000) $14,614 Shares 1,461,425 Est. Cost $3.09 Unrealized
PRLD Prelude Therapeutics Inc. 0.1%
Value ($000) $14,578 Shares 10,123,824 Est. Cost $28.24 Unrealized -96.5%
ACLX Arcellx, Inc. 0.1%
Value ($000) $13,696 Shares 166,825 Est. Cost $62.26 Unrealized +15.6%
CTMX CytomX Therapeutics, Inc. 0.1%
Value ($000) $13,560 Shares 4,250,826 Est. Cost $1.73 Unrealized +30.4%
TSHA Taysha Gene Therapies, Inc. 0.1%
Value ($000) $13,096 Shares 4,004,756 Est. Cost $1.91 Unrealized +47.9%
XNCR Xencor, Inc. 0.1%
Value ($000) $12,928 Shares 1,102,106 Est. Cost $16.65 Unrealized -47.9%
DSGN Design Therapeutics, Inc. 0.1%
Value ($000) $12,898 Shares 1,712,882 Est. Cost $12.06 Unrealized -58.5%
NUVL Nuvalent, Inc. 0.1%
Value ($000) $12,448 Shares 143,937 Est. Cost $73.17 Unrealized +8.1%
SION Sionna Therapeutics, Inc. 0.1%
Value ($000) $11,764 Shares 400,000 Est. Cost $16.34 Unrealized +33.1%
CRNX Crinetics Pharmaceuticals, Inc. 0.1%
Value ($000) $11,662 Shares 280,000 Est. Cost $30.88 Unrealized +3.5%
VKTX Viking Therapeutics, Inc. 0.1%
Value ($000) $9,621 Shares 366,083 Est. Cost $29.83 Unrealized 0.0%
PHVS Pharvaris N.V. 0.1%
Value ($000) $9,356 Shares 375,000 Est. Cost $22.18 Unrealized 0.0%
AGIO Agios Pharmaceuticals, Inc. 0.1%
Value ($000) $7,621 Shares 189,866 Est. Cost $30.31 Unrealized +24.1%
SANA Sana Biotechnology, Inc. 0.1%
Value ($000) $7,210 Shares 2,030,949 Est. Cost $4.55 Unrealized -20.6%
SGMT Sagimet Biosciences Inc. 0.0%
Value ($000) $6,538 Shares 952,996 Est. Cost $9.53 Unrealized -14.9%
ALMS Alumis Inc. 0.0%
Value ($000) $6,234 Shares 1,562,500 Est. Cost $13.30 Unrealized -69.0%
RLAY Relay Therapeutics, Inc. 0.0%
Value ($000) $6,056 Shares 1,160,117 Est. Cost $13.78 Unrealized -72.3%
SKYE Skye Bioscience, Inc. 0.0%
Value ($000) $5,701 Shares 1,450,638 Est. Cost $7.74 Unrealized -51.2%
HRTX Heron Therapeutics, Inc. 0.0%
Value ($000) $5,357 Shares 4,251,951 Est. Cost $1.59 Unrealized 0.0%
TCRX TScan Therapeutics, Inc. 0.0%
Value ($000) $5,068 Shares 2,784,792 Est. Cost $6.08 Unrealized -70.9%
MBX MBX Biosciences, Inc. 0.0%
Value ($000) $4,861 Shares 277,777 Est. Cost $13.37 Unrealized 0.0%
VTVT vTv Therapeutics, Inc. 0.0%
Value ($000) $3,463 Shares 148,314 Est. Cost $14.29 Unrealized +21.1%
VTYX Ventyx Biosciences, Inc. 0.0%
Value ($000) $3,182 Shares 1,023,130 Est. Cost $2.65 Unrealized 0.0%
LBRX LB Pharmaceuticals Inc. 0.0%
Value ($000) $3,158 Shares 200,000 Est. Cost $15.87 Unrealized 0.0%
VIR Vir Biotechnology, Inc. 0.0%
Value ($000) $3,098 Shares 542,539 Est. Cost $7.89 Unrealized -35.2%
WVE Wave Life Sciences Ltd. 0.0%
Value ($000) $2,519 Shares 344,063 Est. Cost $5.98 Unrealized +35.4%
ELVN Enliven Therapeutics, Inc. 0.0%
Value ($000) $2,351 Shares 114,833 Est. Cost $15.34 Unrealized +31.4%
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $2,335 Shares 536,832 Est. Cost $13.35 Unrealized -75.7%
TECX Tectonic Therapeutic, Inc. 0.0%
Value ($000) $1,569 Shares 100,000 Est. Cost $32.59 Unrealized -36.7%
KALA KALA BIO, Inc. 0.0%
Value ($000) $1,507 Shares 985,093 Est. Cost $7.72 Unrealized +28.5%
Generation Bio Co. 0.0%
Value ($000) $1,190 Shares 194,493 Est. Cost $6.12 Unrealized
CTNM Contineum Therapeutics, Inc. 0.0%
Value ($000) $913 Shares 77,670 Est. Cost $16.10 Unrealized -49.9%
ALGS Aligos Therapeutics, Inc. 0.0%
Value ($000) $814 Shares 83,055 Est. Cost $12.44 Unrealized -26.5%
VYNE VYNE Therapeutics Inc. 0.0%
Value ($000) $285 Shares 851,353 Est. Cost $0.65 Unrealized 0.0%
TYRA Tyra Biosciences, Inc. 0.0%
Value ($000) $148 Shares 10,607 Est. Cost $12.95 Unrealized -11.9%
ACRV Acrivon Therapeutics, Inc. 0.0%
Value ($000) $41 Shares 22,809 Est. Cost $4.64 Unrealized -69.7%
SRZNW Surrozen, Inc. 0.0%
Value ($000) $15 Shares 833,333 Est. Cost $1.14 Unrealized
OPTEY Opthea Limited 0.0%
Value ($000) $0 Shares 2,087,320 Est. Cost $11.12 Unrealized