BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $17.08B (99.6% shares, 0.4% debt)

Holdings (86)

INCY Incyte Corporation 17.8%
Value $3.037B Shares 30,743,991 Est. Cost $72.80 Unrealized +32.9%
ONC BeOne Medicines Ltd. 15.7%
Value $2.673B Shares 8,799,053 Est. Cost $136.93 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 7.3%
Value $1.247B Shares 2,141,701 Est. Cost $139.37 Unrealized +266.5%
INSM Insmed Incorporated 6.7%
Value $1.147B Shares 6,592,746 Est. Cost $57.51 Unrealized +217.3%
ACAD ACADIA Pharmaceuticals Inc. 6.7%
Value $1.146B Shares 42,896,690 Est. Cost $18.93 Unrealized +26.2%
CELC Celcuity Inc. 4.6%
Value $790M Shares 7,915,792 Est. Cost $21.19 Unrealized +287.9%
RVMD Revolution Medicines, Inc. 4.4%
Value $753M Shares 9,455,357 Est. Cost $29.36 Unrealized +123.4%
KYMR Kymera Therapeutics, Inc. 3.9%
Value $674M Shares 8,657,242 Est. Cost $37.74 Unrealized +78.9%
SMMT Summit Therapeutics Inc. 3.7%
Value $636M Shares 36,391,063 Est. Cost $11.11 Unrealized +69.3%
RYTM Rhythm Pharmaceuticals, Inc. 3.5%
Value $600M Shares 5,604,483 Est. Cost $23.49 Unrealized +351.7%
KOD Kodiak Sciences Inc. 3.3%
Value $557M Shares 19,919,186 Est. Cost $29.02 Unrealized -29.4%
PRAX Praxis Precision Medicines, Inc. 1.9%
Value $332M Shares 1,126,488 Est. Cost $99.31 Unrealized +87.5%
ALKS Alkermes plc 1.6%
Value $280M Shares 10,012,267 Est. Cost $27.44 Unrealized +9.2%
GRAL GRAIL, Inc. 1.0%
Value $178M Shares 2,085,333 Est. Cost $31.57 Unrealized +173.7%
EWTX Edgewise Therapeutics, Inc. 1.0%
Value $163M Shares 6,575,940 Est. Cost $14.29 Unrealized +40.4%
ARWR Arrowhead Pharmaceuticals, Inc. 0.8%
Value $144M Shares 2,175,645 Est. Cost $24.96 Unrealized +96.4%
IONS Ionis Pharmaceuticals, Inc. 0.8%
Value $142M Shares 1,791,841 Est. Cost $66.92 Unrealized +12.5%
IMVT Immunovant, Inc. 0.8%
Value $139M Shares 5,457,881 Est. Cost $22.96 Unrealized -2.9%
IMTX Immatics N.V. 0.7%
Value $127M Shares 12,094,094 Est. Cost $8.55 Unrealized +18.0%
IDYA IDEAYA Biosciences, Inc. 0.7%
Value $125M Shares 3,618,826 Est. Cost $20.65 Unrealized +54.4%
ROIV Roivant Sciences Ltd. 0.7%
Value $121M Shares 5,555,017 Est. Cost $12.94 Unrealized +52.5%
ABVX Abivax S.A. 0.7%
Value $118M Shares 875,796 Est. Cost $84.90 Unrealized
KNSA Kiniksa Pharmaceuticals International, plc 0.7%
Value $117M Shares 2,826,246 Est. Cost $18.73 Unrealized +114.1%
REPL Replimune Group, Inc. 0.6%
Value $107M Shares 11,045,336 Est. Cost $14.45 Unrealized -41.2%
STOK Stoke Therapeutics, Inc. 0.6%
Value $106M Shares 3,336,697 Est. Cost $9.30 Unrealized +223.1%
GPCR Structure Therapeutics Inc. 0.6%
Value $99.63M Shares 1,432,529 Est. Cost $22.23 Unrealized
ABCL AbCellera Biologics Inc. 0.6%
Value $94.14M Shares 27,525,640 Est. Cost $21.02 Unrealized -78.8%
NRIX Nurix Therapeutics, Inc. 0.5%
Value $88.37M Shares 4,658,556 Est. Cost $20.95 Unrealized -31.4%
IMCR Immunocore Holdings plc 0.5%
Value $80.62M Shares 2,322,656 Est. Cost $38.09 Unrealized
BCYC Bicycle Therapeutics plc 0.5%
Value $77.07M Shares 10,885,357 Est. Cost $20.78 Unrealized
CRNX Crinetics Pharmaceuticals, Inc. 0.4%
Value $76.75M Shares 1,648,869 Est. Cost $42.20 Unrealized +5.5%
GLUE Monte Rosa Therapeutics, Inc. 0.4%
Value $68.14M Shares 4,345,736 Est. Cost $6.49 Unrealized +107.5%
Celcuity Inc. 0.4%
Value $66.58M Shares 30,750,000 Est. Cost $1.33 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.4%
Value $63.77M Shares 2,772,692 Est. Cost $52.13 Unrealized -36.9%
DNLI Denali Therapeutics Inc. 0.4%
Value $61.61M Shares 3,731,695 Est. Cost $23.78 Unrealized -29.0%
VRDN Viridian Therapeutics, Inc. 0.4%
Value $61.36M Shares 1,971,678 Est. Cost $15.17 Unrealized +80.8%
TRDA Entrada Therapeutics, Inc. 0.3%
Value $52.15M Shares 5,072,730 Est. Cost $16.68 Unrealized
RAPP Rapport Therapeutics, Inc. 0.3%
Value $46.94M Shares 1,547,090 Est. Cost $15.27 Unrealized +81.3%
TERN Terns Pharmaceuticals, Inc. 0.2%
Value $38.38M Shares 950,000 Est. Cost $23.11 Unrealized 0.0%
BNTX BioNTech SE 0.2%
Value $35.12M Shares 368,923 Est. Cost $107.38 Unrealized
SYRE Spyre Therapeutics, Inc. 0.2%
Value $32.76M Shares 1,000,000 Est. Cost $15.36 Unrealized +70.1%
DNTH Dianthus Therapeutics, Inc. 0.2%
Value $32.55M Shares 789,759 Est. Cost $18.76 Unrealized +106.7%
PRLD Prelude Therapeutics Inc. 0.2%
Value $29.36M Shares 10,123,824 Est. Cost $28.24 Unrealized -94.0%
DBVT DBV Technologies S.A. 0.2%
Value $28.02M Shares 1,461,425 Est. Cost $3.09 Unrealized
IRON Disc Medicine, Inc. 0.2%
Value $26.77M Shares 337,050 Est. Cost $49.46 Unrealized +70.9%
JBIO Jade Biosciences, Inc. 0.1%
Value $25.32M Shares 1,641,137 Est. Cost $11.73 Unrealized 0.0%
TSHA Taysha Gene Therapies, Inc. 0.1%
Value $22.03M Shares 4,004,756 Est. Cost $1.91 Unrealized +153.6%
BCRX BioCryst Pharmaceuticals, Inc. 0.1%
Value $22.02M Shares 2,822,727 Est. Cost $7.23 Unrealized 0.0%
VTYX Ventyx Biosciences, Inc. 0.1%
Value $21.21M Shares 2,349,280 Est. Cost $5.37 Unrealized +39.1%
ARGX argenx SE 0.1%
Value $21.17M Shares 25,174 Est. Cost $79.01 Unrealized
DSGN Design Therapeutics, Inc. 0.1%
Value $20.95M Shares 2,233,099 Est. Cost $11.07 Unrealized -29.3%
CERS Cerus Corporation 0.1%
Value $20.62M Shares 10,008,345 Est. Cost $4.19 Unrealized -58.6%
NGNE Neurogene Inc. 0.1%
Value $20.43M Shares 991,691 Est. Cost $19.35 Unrealized +28.6%
TECX Tectonic Therapeutic, Inc. 0.1%
Value $18.84M Shares 903,400 Est. Cost $20.13 Unrealized -7.7%
CTMX CytomX Therapeutics, Inc. 0.1%
Value $18.11M Shares 4,250,826 Est. Cost $1.73 Unrealized +119.9%
CLDX Celldex Therapeutics, Inc. 0.1%
Value $18.07M Shares 665,370 Est. Cost $23.17 Unrealized +13.7%
XNCR Xencor, Inc. 0.1%
Value $16.87M Shares 1,102,106 Est. Cost $16.65 Unrealized -10.2%
CNTA Centessa Pharmaceuticals plc 0.1%
Value $16.78M Shares 670,751 Est. Cost $25.01 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.1%
Value $16.59M Shares 370,208 Est. Cost $19.37 Unrealized +116.8%
SION Sionna Therapeutics, Inc. 0.1%
Value $16.46M Shares 400,000 Est. Cost $16.34 Unrealized +132.1%
CTNM Contineum Therapeutics, Inc. 0.1%
Value $16.24M Shares 1,420,838 Est. Cost $11.67 Unrealized -2.2%
SERA Sera Prognostics, Inc. 0.1%
Value $16.22M Shares 5,498,170 Est. Cost $3.09 Unrealized +4.2%
DYN Dyne Therapeutics, Inc. 0.1%
Value $15.91M Shares 813,449 Est. Cost $18.94 Unrealized 0.0%
ALMS Alumis Inc. 0.1%
Value $15.25M Shares 1,562,500 Est. Cost $13.30 Unrealized -47.5%
NUVL Nuvalent, Inc. 0.1%
Value $14.48M Shares 143,937 Est. Cost $73.17 Unrealized +34.8%
PHVS Pharvaris N.V. 0.1%
Value $10.41M Shares 375,000 Est. Cost $22.18 Unrealized +8.6%
RLAY Relay Therapeutics, Inc. 0.1%
Value $9.815M Shares 1,160,117 Est. Cost $13.78 Unrealized -48.2%
ABSI Absci Corporation 0.0%
Value $7.45M Shares 2,134,803 Est. Cost $3.64 Unrealized 0.0%
RCUS Arcus Biosciences, Inc. 0.0%
Value $6.434M Shares 270,000 Est. Cost $20.40 Unrealized 0.0%
MPLT MapLight Therapeutics, Inc. 0.0%
Value $6.406M Shares 364,705 Est. Cost $16.75 Unrealized 0.0%
VTVT vTv Therapeutics, Inc. 0.0%
Value $5.931M Shares 148,314 Est. Cost $14.29 Unrealized +94.0%
WVE Wave Life Sciences Ltd. 0.0%
Value $5.849M Shares 344,063 Est. Cost $5.98 Unrealized +70.0%
SGMT Sagimet Biosciences Inc. 0.0%
Value $5.642M Shares 952,996 Est. Cost $9.53 Unrealized -24.6%
TARA Protara Therapeutics, Inc. 0.0%
Value $5.179M Shares 971,614 Est. Cost $9.86 Unrealized -43.6%
LBRX LB Pharmaceuticals Inc. 0.0%
Value $4.452M Shares 200,000 Est. Cost $15.87 Unrealized +10.1%
ELVN Enliven Therapeutics, Inc. 0.0%
Value $4.18M Shares 271,406 Est. Cost $17.98 Unrealized +10.8%
FDMT 4D Molecular Therapeutics, Inc. 0.0%
Value $3.568M Shares 475,737 Est. Cost $10.14 Unrealized 0.0%
VIR Vir Biotechnology, Inc. 0.0%
Value $3.272M Shares 542,539 Est. Cost $7.89 Unrealized -24.5%
TCRX TScan Therapeutics, Inc. 0.0%
Value $2.785M Shares 2,784,792 Est. Cost $6.08 Unrealized -76.2%
SANA Sana Biotechnology, Inc. 0.0%
Value $1.264M Shares 310,483 Est. Cost $4.55 Unrealized -1.7%
SKYE Skye Bioscience, Inc. 0.0%
Value $1.088M Shares 1,450,638 Est. Cost $7.74 Unrealized -81.1%
KALA KALA BIO, Inc. 0.0%
Value $1.003M Shares 1,804,055 Est. Cost $4.62 Unrealized -80.6%
ALGS Aligos Therapeutics, Inc. 0.0%
Value $774K Shares 83,055 Est. Cost $12.44 Unrealized -24.2%
TYRA Tyra Biosciences, Inc. 0.0%
Value $279K Shares 10,607 Est. Cost $12.95 Unrealized +41.9%
ACRV Acrivon Therapeutics, Inc. 0.0%
Value $54,970 Shares 22,809 Est. Cost $4.64 Unrealized -53.2%
SRZNW Surrozen, Inc. 0.0%
Value $16,667 Shares 833,333 Est. Cost $1.14 Unrealized