Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q3 2017 (← Previous) (Next →)

Filing Date: Nov 14, 2017

Total Value: $283M (100.0% shares, 0.0% debt)

Holdings (34)

— BLUEPRINT MEDICINES 18.1%

Value $51.21M Shares 735,000 Est. Cost $27.77 Unrealized —

AXGN AXOGEN INC 13.5%

Value $38.12M Shares 1,970,000 Est. Cost $3.33 Unrealized +405.2%

— FIBROGEN INC 6.8%

Value $19.37M Shares 360,000 Est. Cost $26.18 Unrealized —

— IMMUNOMEDICS INC 4.4%

Value $12.56M Shares 898,800 Est. Cost $6.47 Unrealized —

— LOXO ONCOLOGY 4.2%

Value $11.97M Shares 130,000 Est. Cost $27.48 Unrealized —

CDXS CODEXIS INC 4.0%

Value $11.31M Shares 1,700,600 Est. Cost $2.93 Unrealized +89.2%

— CORIUM INTERNATIONAL INC 3.6%

Value $10.19M Shares 920,000 Est. Cost $8.33 Unrealized —

— MOMENTA PHARMACEUTICALS INC 3.3%

Value $9.25M Shares 500,000 Est. Cost $15.06 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 3.1%

Value $8.7M Shares 580,000 Est. Cost $3.76 Unrealized +194.3%

AGIO AGIOS PHARMACEUTICALS 3.1%

Value $8.677M Shares 130,000 Est. Cost $43.03 Unrealized +39.6%

CTMX CYTOMX THERAPEUTICS INC 2.9%

Value $8.176M Shares 450,000 Est. Cost $13.03 Unrealized +19.8%

— STRONGBRIDGE BIOPHARMA PLC 2.9%

Value $8.142M Shares 1,180,000 Est. Cost $2.44 Unrealized —

EGRX EAGLE PHARMACEUTICALS INC 2.7%

Value $7.753M Shares 130,000 Est. Cost $64.73 Unrealized -6.5%

— CHIMERIX INC 2.6%

Value $7.365M Shares 1,403,000 Est. Cost $5.07 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 2.2%

Value $6.338M Shares 1,142,000 Est. Cost $5.96 Unrealized —

XOMA XOMA CORP DEL 2.2%

Value $6.292M Shares 320,200 Est. Cost $6.46 Unrealized +72.9%

TBPH THERAVANCE BIOPHARMA INC 2.2%

Value $6.163M Shares 180,000 Est. Cost $31.13 Unrealized +5.0%

— CYMABAY THERAPEUTICS INC 1.9%

Value $5.356M Shares 665,000 Est. Cost $8.05 Unrealized —

— AUDENTES THERAPEUTICS INC 1.8%

Value $5.041M Shares 180,000 Est. Cost $20.61 Unrealized —

— SYNLOGIC INC 1.7%

Value $4.753M Shares 250,000 Est. Cost $19.01 Unrealized —

ENTA ENANTA PHARMACEUTICALS INC 1.7%

Value $4.68M Shares 100,000 Est. Cost $28.91 Unrealized +39.0%

— DECIPHERA PHARMACEUTICALS INC 1.5%

Value $4.12M Shares 217,000 Est. Cost $18.99 Unrealized —

ARDX ARDELYX 1.4%

Value $3.92M Shares 700,000 Est. Cost $7.78 Unrealized -32.3%

— ACCELERON PHARMA INC 1.3%

Value $3.788M Shares 101,500 Est. Cost $30.49 Unrealized —

INSM INSMED INC 1.3%

Value $3.745M Shares 120,000 Est. Cost $19.05 Unrealized 0.0%

— INOTEK PHARMACEUTICALS CORP 1.1%

Value $3.207M Shares 1,802,000 Est. Cost $1.78 Unrealized —

— NEURODERM LTD 1.0%

Value $2.723M Shares 70,000 Est. Cost $16.69 Unrealized —

— ARATANA THERAPEUTICS INC 0.9%

Value $2.574M Shares 420,000 Est. Cost $6.44 Unrealized —

— SELECTA BIOSCIENCES INC 0.6%

Value $1.733M Shares 95,000 Est. Cost $18.24 Unrealized —

— SYROS PHARMACEUTICALS INC 0.6%

Value $1.716M Shares 116,574 Est. Cost $15.97 Unrealized —

— INTERCEPT PHARMACEUTICALS INC 0.6%

Value $1.648M Shares 28,400 Est. Cost $58.03 Unrealized —

— ARQULE INC 0.5%

Value $1.354M Shares 1,220,000 Est. Cost $1.13 Unrealized —

— QUOTIENT TECHNOLOGY INC 0.2%

Value $542K Shares 110,000 Est. Cost $4.93 Unrealized —

— BIOLINERX LTD 0.1%

Value $280K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	BLUEPRINT MEDICINES	735,000	$51.21M	18.1%	$27.77	—	COM	09627Y109
AXGN	AXOGEN INC	1,970,000	$38.12M	13.5%	$3.33	+405.2%	COM	05463X106
—	FIBROGEN INC	360,000	$19.37M	6.8%	$26.18	—	COM	31572Q808
—	IMMUNOMEDICS INC	898,800	$12.56M	4.4%	$6.47	—	COM	452907108
—	LOXO ONCOLOGY	130,000	$11.97M	4.2%	$27.48	—	COM	548862101
CDXS	CODEXIS INC	1,700,600	$11.31M	4.0%	$2.93	+89.2%	COM	192005106
—	CORIUM INTERNATIONAL INC	920,000	$10.19M	3.6%	$8.33	—	COM	21887L107
—	MOMENTA PHARMACEUTICALS INC	500,000	$9.25M	3.3%	$15.06	—	COM	60877T100
SGMO	SANGAMO BIOSCIENCES INC	580,000	$8.7M	3.1%	$3.76	+194.3%	COM	800677106
AGIO	AGIOS PHARMACEUTICALS	130,000	$8.677M	3.1%	$43.03	+39.6%	COM	00847X104
CTMX	CYTOMX THERAPEUTICS INC	450,000	$8.176M	2.9%	$13.03	+19.8%	COM	23284F105
—	STRONGBRIDGE BIOPHARMA PLC	1,180,000	$8.142M	2.9%	$2.44	—	COM	G85347105
EGRX	EAGLE PHARMACEUTICALS INC	130,000	$7.753M	2.7%	$64.73	-6.5%	COM	269796108
—	CHIMERIX INC	1,403,000	$7.365M	2.6%	$5.07	—	COM	16934W106
—	FOAMIX PHARMACEUTICALS LTD	1,142,000	$6.338M	2.2%	$5.96	—	SHS	M46135105
XOMA	XOMA CORP DEL	320,200	$6.292M	2.2%	$6.46	+72.9%	COM NEW	98419J206
TBPH	THERAVANCE BIOPHARMA INC	180,000	$6.163M	2.2%	$31.13	+5.0%	COM	G8807B106
—	CYMABAY THERAPEUTICS INC	665,000	$5.356M	1.9%	$8.05	—	COM	23257D103
—	AUDENTES THERAPEUTICS INC	180,000	$5.041M	1.8%	$20.61	—	COM	05070R104
—	SYNLOGIC INC	250,000	$4.753M	1.7%	$19.01	—	COM	87166L100
ENTA	ENANTA PHARMACEUTICALS INC	100,000	$4.68M	1.7%	$28.91	+39.0%	COM	29251M106
—	DECIPHERA PHARMACEUTICALS INC	217,000	$4.12M	1.5%	$18.99	—	COM	24344T101
ARDX	ARDELYX	700,000	$3.92M	1.4%	$7.78	-32.3%	COM	039697107
—	ACCELERON PHARMA INC	101,500	$3.788M	1.3%	$30.49	—	COM	00434H108
INSM	INSMED INC	120,000	$3.745M	1.3%	$19.05	0.0%	COM PAR $.01	457669307
—	INOTEK PHARMACEUTICALS CORP	1,802,000	$3.207M	1.1%	$1.78	—	COM	45780V102
—	NEURODERM LTD	70,000	$2.723M	1.0%	$16.69	—	ORD SHS	M74231107
—	ARATANA THERAPEUTICS INC	420,000	$2.574M	0.9%	$6.44	—	COM	03874P101
—	SELECTA BIOSCIENCES INC	95,000	$1.733M	0.6%	$18.24	—	COM	816212104
—	SYROS PHARMACEUTICALS INC	116,574	$1.716M	0.6%	$15.97	—	COM	87184Q107
—	INTERCEPT PHARMACEUTICALS INC	28,400	$1.648M	0.6%	$58.03	—	COM	45845P108
—	ARQULE INC	1,220,000	$1.354M	0.5%	$1.13	—	COM	04269E107
—	QUOTIENT TECHNOLOGY INC	110,000	$542K	0.2%	$4.93	—	COM	749119103
—	BIOLINERX LTD	250,000	$280K	0.1%	$1426.15	—	SPONSORED ADR	09071M106