Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q2 2017 (← Previous) (Next →)

Filing Date: Aug 14, 2017

Total Value ($000): $239,398 (100.0% shares, 0.0% debt)

Holdings (41)

— BLUEPRINT MEDICINES 18.6%

Value ($000) $44,589 Shares 880,000 Est. Cost $27.77 Unrealized —

AXGN AXOGEN INC 13.8%

Value ($000) $32,997 Shares 1,970,000 Est. Cost $3.33 Unrealized +305.4%

— FIBROGEN INC 4.9%

Value ($000) $11,628 Shares 360,000 Est. Cost $26.18 Unrealized —

— LOXO ONCOLOGY 4.4%

Value ($000) $10,425 Shares 130,000 Est. Cost $27.48 Unrealized —

— STRONGBRIDGE BIOPHARMA PLC 3.5%

Value ($000) $8,437 Shares 1,180,000 Est. Cost $2.44 Unrealized —

CDXS CODEXIS INC 3.3%

Value ($000) $8,011 Shares 1,470,000 Est. Cost $2.52 Unrealized +82.8%

— IMMUNOMEDICS INC 3.3%

Value ($000) $7,947 Shares 900,000 Est. Cost $6.47 Unrealized —

— MOMENTA PHARMACEUTICALS INC 3.2%

Value ($000) $7,605 Shares 450,000 Est. Cost $14.68 Unrealized —

TBPH THERAVANCE BIOPHARMA INC 3.0%

Value ($000) $7,171 Shares 180,000 Est. Cost $31.13 Unrealized +23.5%

CTMX CYTOMX THERAPEUTICS INC 3.0%

Value ($000) $7,130 Shares 460,000 Est. Cost $13.03 Unrealized +15.7%

— CHIMERIX INC 2.9%

Value ($000) $6,976 Shares 1,280,000 Est. Cost $5.05 Unrealized —

— NOVELION THERAPEUTICS INC 2.9%

Value ($000) $6,922 Shares 750,000 Est. Cost $10.70 Unrealized —

AGIO AGIOS PHARMACEUTICALS 2.8%

Value ($000) $6,688 Shares 130,000 Est. Cost $43.03 Unrealized +18.8%

— CORIUM INTERNATIONAL INC 2.2%

Value ($000) $5,334 Shares 715,000 Est. Cost $7.54 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 2.2%

Value ($000) $5,266 Shares 1,135,000 Est. Cost $5.96 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 2.1%

Value ($000) $5,104 Shares 580,000 Est. Cost $3.76 Unrealized +70.8%

— ADAMAS PHARMACEUTICALS INC 2.1%

Value ($000) $5,072 Shares 290,000 Est. Cost $18.61 Unrealized —

EGRX EAGLE PHARMACEUTICALS INC 2.0%

Value ($000) $4,733 Shares 60,000 Est. Cost $69.67 Unrealized +17.4%

PRTA PROTHENA CORP PLC 1.9%

Value ($000) $4,600 Shares 85,000 Est. Cost $54.16 Unrealized -1.6%

ENTA ENANTA PHARMACEUTICALS INC 1.5%

Value ($000) $3,598 Shares 100,000 Est. Cost $28.91 Unrealized +10.6%

— NEURODERM LTD 1.5%

Value ($000) $3,597 Shares 120,300 Est. Cost $16.69 Unrealized —

— ACCELERON PHARMA INC 1.3%

Value ($000) $3,039 Shares 100,000 Est. Cost $30.39 Unrealized —

— AUDENTES THERAPEUTICS INC 1.2%

Value ($000) $2,869 Shares 150,000 Est. Cost $19.13 Unrealized —

— IMPRIMIS PHARMACEUTICALS INC 1.2%

Value ($000) $2,864 Shares 895,000 Est. Cost $2371.00 Unrealized —

ARDX ARDELYX 1.2%

Value ($000) $2,787 Shares 546,500 Est. Cost $8.48 Unrealized 0.0%

— TETRAPHASE PHARMACEUTICALS I 1.0%

Value ($000) $2,353 Shares 330,000 Est. Cost $7.13 Unrealized —

WVE WAVE LIFE SCIENCES LTD 1.0%

Value ($000) $2,325 Shares 125,000 Est. Cost $25.55 Unrealized -15.6%

— ARATANA THERAPEUTICS INC 1.0%

Value ($000) $2,279 Shares 350,200 Est. Cost $6.51 Unrealized —

XOMA XOMA CORP DEL 0.9%

Value ($000) $2,217 Shares 317,200 Est. Cost $6.46 Unrealized +3.0%

— MIRNA THERAPEUTICS INC 0.8%

Value ($000) $1,917 Shares 1,148,100 Est. Cost $1.67 Unrealized —

— SYROS PHARMACEUTICALS INC 0.7%

Value ($000) $1,762 Shares 109,500 Est. Cost $16.05 Unrealized —

— ZOSANO PHARMA CORP 0.7%

Value ($000) $1,727 Shares 1,225,000 Est. Cost $1.90 Unrealized —

— TONIX PHARMACEUTICALS HOLDING 0.7%

Value ($000) $1,602 Shares 370,000 Est. Cost $4.54 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 0.6%

Value ($000) $1,537 Shares 1,835,000 Est. Cost $1.32 Unrealized —

— EDGE THERAPEUTICS INC 0.6%

Value ($000) $1,334 Shares 130,000 Est. Cost $9.54 Unrealized —

— ARQULE INC 0.5%

Value ($000) $1,203 Shares 970,000 Est. Cost $1.14 Unrealized —

— GLOBAL BLOOD THERAPEUTICS IN 0.5%

Value ($000) $1,094 Shares 40,000 Est. Cost $27.35 Unrealized —

— INTRA CELLULAR THERAPIES INC 0.4%

Value ($000) $1,056 Shares 85,000 Est. Cost $12.42 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.4%

Value ($000) $1,026 Shares 380,000 Est. Cost $4.10 Unrealized —

— NEOS THERAPEUTICS INC 0.2%

Value ($000) $365 Shares 50,000 Est. Cost $7.30 Unrealized —

— BIOLINERX LTD 0.1%

Value ($000) $212 Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	BLUEPRINT MEDICINES	880,000	$44,589	18.6%	$27.77	—	COM	09627Y109
AXGN	AXOGEN INC	1,970,000	$32,997	13.8%	$3.33	+305.4%	COM	05463X106
—	FIBROGEN INC	360,000	$11,628	4.9%	$26.18	—	COM	31572Q808
—	LOXO ONCOLOGY	130,000	$10,425	4.4%	$27.48	—	COM	548862101
—	STRONGBRIDGE BIOPHARMA PLC	1,180,000	$8,437	3.5%	$2.44	—	COM	G85347105
CDXS	CODEXIS INC	1,470,000	$8,011	3.3%	$2.52	+82.8%	COM	192005106
—	IMMUNOMEDICS INC	900,000	$7,947	3.3%	$6.47	—	COM	452907108
—	MOMENTA PHARMACEUTICALS INC	450,000	$7,605	3.2%	$14.68	—	COM	60877T100
TBPH	THERAVANCE BIOPHARMA INC	180,000	$7,171	3.0%	$31.13	+23.5%	COM	G8807B106
CTMX	CYTOMX THERAPEUTICS INC	460,000	$7,130	3.0%	$13.03	+15.7%	COM	23284F105
—	CHIMERIX INC	1,280,000	$6,976	2.9%	$5.05	—	COM	16934W106
—	NOVELION THERAPEUTICS INC	750,000	$6,922	2.9%	$10.70	—	COM NEW	67001K202
AGIO	AGIOS PHARMACEUTICALS	130,000	$6,688	2.8%	$43.03	+18.8%	COM	00847X104
—	CORIUM INTERNATIONAL INC	715,000	$5,334	2.2%	$7.54	—	COM	21887L107
—	FOAMIX PHARMACEUTICALS LTD	1,135,000	$5,266	2.2%	$5.96	—	SHS	M46135105
SGMO	SANGAMO BIOSCIENCES INC	580,000	$5,104	2.1%	$3.76	+70.8%	COM	800677106
—	ADAMAS PHARMACEUTICALS INC	290,000	$5,072	2.1%	$18.61	—	COM	00548A106
EGRX	EAGLE PHARMACEUTICALS INC	60,000	$4,733	2.0%	$69.67	+17.4%	COM	269796108
PRTA	PROTHENA CORP PLC	85,000	$4,600	1.9%	$54.16	-1.6%	SHS	G72800108
ENTA	ENANTA PHARMACEUTICALS INC	100,000	$3,598	1.5%	$28.91	+10.6%	COM	29251M106
—	NEURODERM LTD	120,300	$3,597	1.5%	$16.69	—	ORD SHS	M74231107
—	ACCELERON PHARMA INC	100,000	$3,039	1.3%	$30.39	—	COM	00434H108
—	AUDENTES THERAPEUTICS INC	150,000	$2,869	1.2%	$19.13	—	COM	05070R104
—	IMPRIMIS PHARMACEUTICALS INC	895,000	$2,864	1.2%	$2371.00	—	COM NEW	45323A201
ARDX	ARDELYX	546,500	$2,787	1.2%	$8.48	0.0%	COM	039697107
—	TETRAPHASE PHARMACEUTICALS I	330,000	$2,353	1.0%	$7.13	—	COM	88165N105
WVE	WAVE LIFE SCIENCES LTD	125,000	$2,325	1.0%	$25.55	-15.6%	SHS	Y95308105
—	ARATANA THERAPEUTICS INC	350,200	$2,279	1.0%	$6.51	—	COM	03874P101
XOMA	XOMA CORP DEL	317,200	$2,217	0.9%	$6.46	+3.0%	COM NEW	98419J206
—	MIRNA THERAPEUTICS INC	1,148,100	$1,917	0.8%	$1.67	—	COM	60470J103
—	SYROS PHARMACEUTICALS INC	109,500	$1,762	0.7%	$16.05	—	COM	87184Q107
—	ZOSANO PHARMA CORP	1,225,000	$1,727	0.7%	$1.90	—	COM	98979H103
—	TONIX PHARMACEUTICALS HOLDING	370,000	$1,602	0.7%	$4.54	—	COM NEW	890260201
—	PROTALIX BIOTHERAPEUTICS INC	1,835,000	$1,537	0.6%	$1.32	—	COM	74365AAB7
—	EDGE THERAPEUTICS INC	130,000	$1,334	0.6%	$9.54	—	COM	279870109
—	ARQULE INC	970,000	$1,203	0.5%	$1.14	—	COM	04269E107
—	GLOBAL BLOOD THERAPEUTICS IN	40,000	$1,094	0.5%	$27.35	—	COM	37890U108
—	INTRA CELLULAR THERAPIES INC	85,000	$1,056	0.4%	$12.42	—	COM	04611X101
—	SUNESIS PHARMACEUTICALS INC	380,000	$1,026	0.4%	$4.10	—	COM PAR	867328700
—	NEOS THERAPEUTICS INC	50,000	$365	0.2%	$7.30	—	COM	64052L106
—	BIOLINERX LTD	250,000	$212	0.1%	$1426.15	—	SPONSORED ADR	09071M106