| RTW INVESTMENTS, LP | 17,687,772 | $62,084 |
| VANGUARD GROUP INC | 8,544,423 | $29,991 |
| BlackRock, Inc. | 7,906,071 | $27,750 |
| CITIGROUP INC | 5,246,349 | $18,415 |
| MORGAN STANLEY | 3,941,377 | $13,834 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,992,735 | $10,505 |
| Monaco Asset Management SAM | 2,987,296 | $10,485 |
| Newtyn Management, LLC | 2,650,000 | $9,302 |
| D. E. Shaw & Co., Inc. | 2,640,518 | $9,268 |
| MAVERICK CAPITAL LTD | 2,513,110 | $8,821 |
| TWO SIGMA INVESTMENTS, LP | 2,131,929 | $7,483 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,120,269 | $7,443 |
| TWO SIGMA ADVISERS, LP | 1,864,651 | $6,545 |
| MILLENNIUM MANAGEMENT LLC | 1,784,921 | $6,265 |
| STATE STREET CORP | 1,700,631 | $5,969 |
| MPM BioImpact LLC | 1,586,076 | $5,567 |
| JPMORGAN CHASE & CO | 1,475,624 | $5,179 |
| CITADEL ADVISORS LLC | 1,299,991 | $4,563 |
| Opaleye Management Inc. | 955,000 | $3,352 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 944,873 | $3 |
| GOLDMAN SACHS GROUP INC | 936,594 | $3,287 |
| FEDERATED HERMES, INC. | 881,249 | $3,093 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 744,286 | $2,612 |
| Prosight Management, LP | 743,942 | $2,611 |
| AQR CAPITAL MANAGEMENT LLC | 703,528 | $2,469 |
| NORTHERN TRUST CORP | 618,654 | $2,171 |
| JANE STREET GROUP, LLC | 602,580 | $2,115 |
| BANK OF AMERICA CORP /DE/ | 579,507 | $2,034 |
| Point72 Asset Management, L.P. | 507,909 | $1,783 |
| Walleye Capital LLC | 499,331 | $1,753 |
| ADAR1 Capital Management, LLC | 475,800 | $1,670 |
| DEUTSCHE BANK AG\ | 474,866 | $1,667 |
| Susquehanna Portfolio Strategies, LLC | 434,409 | $1,525 |
| RENAISSANCE TECHNOLOGIES LLC | 421,174 | $1,478 |
| BALYASNY ASSET MANAGEMENT L.P. | 400,706 | $1,406 |
| FMR LLC | 395,275 | $1,387 |
| M28 Capital Management LP | 385,680 | $1,354 |
| PANAGORA ASSET MANAGEMENT INC | 348,803 | $1,224 |
| DIMENSIONAL FUND ADVISORS LP | 338,830 | $1,189 |
| Hennion & Walsh Asset Management, Inc. | 309,247 | $1,085 |
| Invesco Ltd. | 304,437 | $1,069 |
| Bank of New York Mellon Corp | 250,962 | $881 |
| ACADIAN ASSET MANAGEMENT LLC | 242,169 | $1 |
| PDT Partners, LLC | 220,884 | $775 |
| Qube Research & Technologies Ltd | 219,973 | $772 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 193,430 | $679 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 187,401 | $693 |
| ExodusPoint Capital Management, LP | 178,926 | $628 |
| Amitell Capital Pte Ltd | 178,769 | $627 |
| Privium Fund Management B.V. | 170,146 | $597 |
| Creative Planning | 167,039 | $586 |
| Nuveen, LLC | 158,012 | $555 |
| ALLIANCEBERNSTEIN L.P. | 157,290 | $552 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,121 | $526 |
| BARCLAYS PLC | 153,049 | $537 |
| UBS Group AG | 151,432 | $532 |
| Schonfeld Strategic Advisors LLC | 149,413 | $524 |
| XTX Topco Ltd | 146,400 | $514 |
| MONIMUS CAPITAL MANAGEMENT, LP | 138,012 | $484 |
| RAYMOND JAMES FINANCIAL INC | 118,746 | $417 |
| Jump Financial, LLC | 118,200 | $415 |
| BNP PARIBAS ARBITRAGE, SA | 115,165 | $404 |
| RHUMBLINE ADVISERS | 113,420 | $398 |
| HRT FINANCIAL LP | 109,797 | $0 |
| WELLS FARGO & COMPANY/MN | 103,906 | $365 |
| TD Asset Management Inc | 102,538 | $360 |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | $351 |
| Ballentine Partners, LLC | 97,625 | $343 |
| EntryPoint Capital, LLC | 96,354 | $338 |
| Engineers Gate Manager LP | 96,009 | $337 |
| CANADA PENSION PLAN INVESTMENT BOARD | 95,100 | $334 |
| LPL Financial LLC | 94,256 | $331 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 92,795 | $326 |
| Jain Global LLC | 92,058 | $323 |
| BOOTHBAY FUND MANAGEMENT, LLC | 91,642 | $322 |
| DekaBank Deutsche Girozentrale | 89,700 | $3 |
| Brevan Howard Capital Management LP | 89,130 | $313 |
| Lion Point Capital, LP | 86,000 | $302 |
| RICE HALL JAMES & ASSOCIATES, LLC | 84,987 | $298 |
| Virtus Investment Advisers, LLC | 78,474 | $275 |
| BANK OF MONTREAL /CAN/ | 75,310 | $264 |
| Graham Capital Management, L.P. | 73,743 | $259 |
| Squarepoint Ops LLC | 68,317 | $240 |
| Concurrent Investment Advisors, LLC | 68,096 | $239 |
| Voleon Capital Management LP | 67,981 | $239 |
| Quadrature Capital Ltd | 65,376 | $229 |
| Rockefeller Capital Management L.P. | 64,222 | $225 |
| SG Americas Securities, LLC | 63,748 | $0 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 58,000 | $204 |
| Marex Group plc | 57,500 | $202 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 50,970 | $179 |
| PIER 88 INVESTMENT PARTNERS LLC | 47,880 | $168 |
| SIMPLEX TRADING, LLC | 42,495 | $149 |
| TUDOR INVESTMENT CORP ET AL | 42,411 | $149 |
| INTECH INVESTMENT MANAGEMENT LLC | 40,727 | $143 |
| Quantinno Capital Management LP | 40,397 | $142 |
| IEQ CAPITAL, LLC | 38,527 | $135 |
| Dynamic Technology Lab Private Ltd | 38,110 | $134 |
| GSA CAPITAL PARTNERS LLP | 36,836 | $0 |
| Atom Investors LP | 36,480 | $128 |
| 84 other institutions | 821,320 | $2,728 |