ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

New Positions (41)

Increased Positions (69)

PERCEPTIVE ADVISORS LLC
Value ($000) $85,885 (+140.5%) Shares 3,261,850 (+56.0%)
Rubric Capital Management LP
Value ($000) $151,398 (+88.2%) Shares 5,750,000 (+22.1%)
ALGERT GLOBAL LLC
Value ($000) $11 (+214.1%) Shares 423,646 (+103.7%)
Opaleye Management Inc.
Value ($000) $2,868 (+67.9%) Shares 108,929 (+8.9%)
Schonfeld Strategic Advisors LLC
Value ($000) $7,598 (+312.7%) Shares 288,571 (+167.7%)
TEMA ETFS LLC
Value ($000) $2,000 (+84.0%) Shares 75,975 (+19.3%)
Hillsdale Investment Management Inc.
Value ($000) $6,264 (+69.5%) Shares 237,922 (+9.9%)
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
Value ($000) $18,431 (+243.9%) Shares 700,002 (+123.1%)
Qube Research & Technologies Ltd
Value ($000) $12,488 (+186.7%) Shares 474,290 (+86.0%)
PICTON MAHONEY ASSET MANAGEMENT
Value ($000) $6,446 (+182803.8%) Shares 244,798 (+18.6%)
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $17,471 (+81.4%) Shares 663,546 (+17.6%)
Virtus Investment Advisers, LLC
Value ($000) $275 (+85.3%) Shares 10,441 (+20.2%)
FMR LLC
Value ($000) $14,747 (+24471.9%) Shares 560,086 (+15838.7%)
BlackRock, Inc.
Value ($000) $121,001 (+77.6%) Shares 4,595,548 (+15.2%)
Susquehanna Portfolio Strategies, LLC
Value ($000) $2,628 (+82.7%) Shares 99,795 (+18.5%)
UBS Group AG
Value ($000) $7,342 (+729.2%) Shares 278,854 (+437.9%)
Invesco Ltd.
Value ($000) $6,782 (+324.0%) Shares 257,580 (+175.0%)
D. E. Shaw & Co., Inc.
Value ($000) $5,892 (+171.8%) Shares 223,786 (+76.3%)
VANGUARD GROUP INC
Value ($000) $61,315 (+66.6%) Shares 2,328,727 (+8.1%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $4,636 (+421.5%) Shares 176,088 (+238.3%)

Decreased Positions (59)

Redmile Group, LLC
Value ($000) $12,945 (-79.5%) Shares 491,654 (-86.7%)
Prosight Management, LP
Value ($000) $13,965 (+9.1%) Shares 530,393 (-29.2%)
Vestal Point Capital, LP
Value ($000) $22,775 (-24.5%) Shares 865,000 (-51.0%)
TANG CAPITAL MANAGEMENT LLC
Value ($000) $912 (-95.1%) Shares 34,631 (-96.9%)
Granahan Investment Management, LLC
Value ($000) $5,909 (+0.2%) Shares 224,408 (-35.0%)
PLATINUM INVESTMENT MANAGEMENT LTD
Value ($000) $2,769 (+29.9%) Shares 105,184 (-15.7%)
North Growth Management Ltd.
Value ($000) $1 (-16.0%) Shares 45,000 (-45.1%)
JUPITER ASSET MANAGEMENT LTD
Value ($000) $3,305 (-44.8%) Shares 125,506 (-64.2%)
Assenagon Asset Management S.A.
Value ($000) $17,045 (-24.8%) Shares 647,374 (-51.2%)
SILVERCREST ASSET MANAGEMENT GROUP LLC
Value ($000) $4,787 (+2.7%) Shares 181,790 (-33.4%)
UBS ASSET MANAGEMENT AMERICAS INC
Value ($000) $8,432 (-71.1%) Shares 320,261 (-81.3%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $10,048 (-46.8%) Shares 381,621 (-65.5%)
RENAISSANCE TECHNOLOGIES LLC
Value ($000) $5,816 (-21.1%) Shares 220,877 (-48.8%)
MORGAN STANLEY
Value ($000) $68,276 (+0.3%) Shares 2,593,080 (-34.9%)
Quarry LP
Value ($000) $2 (-95.3%) Shares 90 (-96.9%)
Man Group plc
Value ($000) $1,983 (-26.8%) Shares 75,318 (-52.5%)
VIRGINIA RETIREMENT SYSTEMS ET AL
Value ($000) $736 (-23.1%) Shares 27,935 (-50.1%)
Tower Research Capital LLC (TRC)
Value ($000) $36 (-81.5%) Shares 1,353 (-88.0%)
PANAGORA ASSET MANAGEMENT INC
Value ($000) $2,063 (+13.8%) Shares 78,336 (-26.1%)
SCHRODER INVESTMENT MANAGEMENT GROUP
Value ($000) $2,598 (-6.6%) Shares 97,907 (-39.4%)

Exited Positions (21)