Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q3 2021 (← Previous) (Next →)
Filing Date: Nov 15, 2021
Total Value: $7.217B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 7,387,900 | $1.178B | 16.3% | $71.73 | — | SPONSORED ADR | 04351P101 |
| NVAX | NOVAVAX INC | 2,097,794 | $435M | 6.0% | $84.76 | +160.0% | COM NEW | 670002401 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $236M | 3.3% | $20.66 | 0.0% | COM | 28658R106 |
| IVVD | ADAGIO THERAPEUTICS INC | 5,340,130 | $226M | 3.1% | $37.11 | 0.0% | COM | 00534A102 |
| — | FORMA THERAPEUTICS HLDGS INC | 9,011,651 | $209M | 2.9% | $46.49 | — | SHS | 34633R104 |
| CTKB | CYTEK BIOSCIENCES INC | 9,607,028 | $206M | 2.9% | $23.52 | 0.0% | COM | 23285D109 |
| AVIR | ATEA PHARMACEUTICALS INC | 5,427,655 | $190M | 2.6% | $32.19 | -13.8% | COM | 04683R106 |
| JANX | JANUX THERAPEUTICS INC | 8,670,644 | $188M | 2.6% | $22.27 | +29.2% | COM | 47103J105 |
| — | VOR BIOPHARMA INC | 11,120,973 | $174M | 2.4% | $43.10 | — | COM | 929033108 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $173M | 2.4% | $22.83 | — | COM | 008064107 |
| — | ICOSAVAX INC | 5,779,347 | $171M | 2.4% | $29.59 | — | COM | 45114M109 |
| — | DICE THERAPEUTICS INC | 5,208,911 | $171M | 2.4% | $32.75 | — | COM | 23345J104 |
| — | CONNECT BIOPHARMA HLDGS LTD | 6,991,003 | $169M | 2.3% | $19.09 | — | ADS | 207523101 |
| NKTX | NKARTA INC | 5,605,129 | $156M | 2.2% | $29.47 | +7.5% | COM | 65487U108 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 9,770,773 | $145M | 2.0% | $16.64 | 0.0% | COM | 00509G209 |
| TGTX | TG THERAPEUTICS INC | 4,098,332 | $136M | 1.9% | $15.45 | +100.2% | COM | 88322Q108 |
| TVTX | TRAVERE THERAPEUTICS INC | 5,614,428 | $136M | 1.9% | $24.15 | -23.9% | COM | 89422G107 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $127M | 1.8% | $19.11 | 0.0% | COM | 90240B106 |
| MGNX | MACROGENICS INC | 5,943,594 | $124M | 1.7% | $20.04 | +20.2% | COM | 556099109 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $119M | 1.7% | $24.67 | — | COM | 46565G104 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 4,965,588 | $118M | 1.6% | $20.76 | +15.4% | COM | 23954D109 |
| — | IMMUNOGEN INC | 18,417,458 | $104M | 1.4% | $5.36 | — | COM | 45253H101 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 3,115,008 | $99.99M | 1.4% | $25.67 | +29.4% | COM | 71722W107 |
| PCVX | VAXCYTE INC | 3,896,865 | $98.86M | 1.4% | $31.88 | -24.0% | COM | 92243G108 |
| — | 89BIO INC | 4,965,769 | $97.28M | 1.3% | $25.74 | — | COM | 282559103 |
| — | INSTIL BIO INC | 4,870,793 | $87.06M | 1.2% | $25.08 | — | COM | 45783C101 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 1,600,000 | $86.38M | 1.2% | $46.92 | 0.0% | COM NEW | 15117B202 |
| — | KINNATE BIOPHARMA INC | 3,593,052 | $82.71M | 1.1% | $39.78 | — | COM | 49705R105 |
| HOWL | WEREWOLF THERAPEUTICS INC | 4,291,881 | $73.65M | 1.0% | $13.70 | +24.6% | COM | 95075A107 |
| TNYA | TENAYA THERAPEUTICS INC | 3,551,508 | $73.34M | 1.0% | $21.49 | 0.0% | COM | 87990A106 |
| — | POINT BIOPHARMA GLOBAL | 8,856,018 | $68.1M | 0.9% | $7.69 | — | COM | 730541109 |
| GHRS | GH RESEARCH PLC | 3,013,957 | $66.49M | 0.9% | $20.42 | -0.3% | ORDINARY SHARES | G3855L106 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 4,871,067 | $63.62M | 0.9% | $24.79 | -38.4% | COM | 76243J105 |
| RCKT | ROCKET PHARMACEUTICALS INC COM | 2,107,149 | $62.98M | 0.9% | $36.45 | -0.2% | COM | 77313F106 |
| CCCC | C4 THERAPEUTICS INC | 1,377,569 | $61.55M | 0.9% | $29.00 | +47.7% | COM STK | 12529R107 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,577,094 | $59.74M | 0.8% | $18.67 | — | SPONSORED ADS | 152309100 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,150,404 | $59.27M | 0.8% | $46.89 | -42.4% | COM | 68062P106 |
| — | CYTEIR THERAPEUTICS INC | 3,350,506 | $58.8M | 0.8% | $21.28 | — | COM | 23284P103 |
| PMVP | PMV PHARMACEUTICALS INC | 1,710,265 | $50.97M | 0.7% | $36.80 | -13.2% | COM | 69353Y103 |
| — | ZOGENIX INC | 3,333,700 | $50.64M | 0.7% | $26.04 | — | COM NEW | 98978L204 |
| DYN | DYNE THERAPEUTICS INC | 2,805,045 | $45.55M | 0.6% | $21.96 | -19.3% | COM | 26818M108 |
| — | GRAPHITE BIO INC | 2,698,369 | $44.23M | 0.6% | $30.73 | — | COM | 38870X104 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,613,623 | $43.39M | 0.6% | $32.43 | -44.2% | COM | 28036F105 |
| — | VERVE THERAPEUTICS INC | 880,284 | $41.37M | 0.6% | $60.25 | — | COM | 92539P101 |
| GERN | GERON CORP | 30,126,299 | $41.27M | 0.6% | $1.49 | -10.7% | COM | 374163103 |
| — | ACHILLES THERAPEUTICS PLC | 5,014,687 | $39.06M | 0.5% | $11.66 | — | SPONSORED ADS | 00449L102 |
| RXST | RXSIGHT INC | 3,052,796 | $38.68M | 0.5% | $13.76 | 0.0% | COM | 78349D107 |
| WVE | WAVE LIFE SCIENCES LTD | 7,775,207 | $38.1M | 0.5% | $17.26 | -64.9% | SHS | Y95308105 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,930,322 | $33.68M | 0.5% | $26.18 | -22.6% | COM | 483497103 |
| DSGN | DESIGN THERAPEUTICS INC | 2,186,636 | $32.12M | 0.4% | $31.14 | -46.6% | COM | 25056L103 |
| — | BOLT BIOTHERAPEUTICS INC | 2,378,325 | $30.09M | 0.4% | $32.91 | — | COM | 097702104 |
| — | SOLID BIOSCIENCES INC | 12,367,873 | $29.56M | 0.4% | $7.59 | — | COM | 83422E105 |
| TNGX | TANGO THERAPEUTICS INC | 2,250,000 | $29.09M | 0.4% | $11.99 | 0.0% | COM | 87583X109 |
| — | KALA PHARMACEUTICALS INC | 10,874,613 | $28.49M | 0.4% | $10.65 | — | COM | 483119103 |
| — | VERONA PHARMA PLC | 5,100,000 | $27.95M | 0.4% | $6.24 | — | SPONSORED ADS | 925050106 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $27.56M | 0.4% | $13.11 | — | COM | 80405P107 |
| — | AKOUOS INC | 2,281,249 | $26.48M | 0.4% | $22.50 | — | COM | 00973J101 |
| — | ORCHARD THERAPEUTICS PLC | 11,028,722 | $25.37M | 0.4% | $10.43 | — | ADS | 68570P101 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 2,210,506 | $23.03M | 0.3% | $10.51 | -9.2% | COM NEW | 30233G209 |
| IPSC | CENTURY THERAPEUTICS INC | 914,094 | $23M | 0.3% | $25.37 | +6.7% | COM | 15673T100 |
| BDTX | BLACK DIAMOND THERAPEUTICS INC | 2,589,904 | $21.91M | 0.3% | $30.22 | -67.3% | COM | 09203E105 |
| — | SYNLOGIC INC | 6,666,666 | $20.33M | 0.3% | $3.05 | — | COM | 87166L100 |
| — | SCPHARMACEUTICALS INC | 2,731,170 | $18.16M | 0.3% | $10.74 | — | COM | 810648105 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,500,000 | $17.82M | 0.2% | $7.92 | -32.4% | COM | 23284F105 |
| LRMR | LARIMAR THERAPEUTICS INC | 1,515,151 | $17.47M | 0.2% | $11.65 | +3.0% | COM | 517125100 |
| SPRY | SILVERBACK THERAPEUTICS INC | 1,742,186 | $17.39M | 0.2% | $33.40 | -26.2% | COM | 82835W108 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 2,436,430 | $14.96M | 0.2% | $10.83 | -26.4% | COM | 63909J108 |
| — | DA32 LIFE SCNCE | 1,500,000 | $14.74M | 0.2% | $9.83 | — | CLASS A COM | 23312M106 |
| MIST | MILESTONE PHARMACEUTICALS INC | 2,246,503 | $12.83M | 0.2% | $7.17 | -21.3% | COM | 59935V107 |
| — | BCLS ACQUISITION CORP | 1,250,000 | $12.45M | 0.2% | $11.14 | — | COM CL A | G0904B105 |
| — | ASTRIA THERAPEUTICS INC | 1,262,193 | $11.16M | 0.2% | $8.84 | — | COM | 04635X102 |
| ENTX | ENTERA BIO LTD | 2,353,000 | $11.08M | 0.2% | $3.70 | +38.7% | SHS | M40527109 |
| TCRX | TSCAN THERAPEUTICS INC | 1,255,317 | $10.47M | 0.1% | $9.27 | 0.0% | COM | 89854M101 |
| RNAM | AVIDITY BIOSCIENCES INC | 423,616 | $10.43M | 0.1% | $21.74 | 0.0% | COM | 05370A108 |
| WHWK | AADI BIOSCIENCES INC | 347,668 | $10.21M | 0.1% | $30.48 | 0.0% | COM | 00032Q104 |
| — | FS DEVELOPMENT CORP II | 1,000,000 | $9.95M | 0.1% | $9.96 | — | COM CL A | 30318F100 |
| — | CONCERT PHARMACEUTICALS INC | 3,033,603 | $9.92M | 0.1% | $7.30 | — | COM | 206022105 |
| — | ARYA SCIENCES ACQUISITN CORP | 1,000,000 | $9.88M | 0.1% | $9.88 | — | CLASS A ORD SHS | G31658100 |
| — | FRAZIER LIFESCIENCES ACQUISITION CO | 1,000,000 | $9.82M | 0.1% | $10.38 | — | CL A SHS | G3710A121 |
| — | IKENA ONCOLOGY INC | 750,000 | $9.465M | 0.1% | $28.25 | — | COM | 45175G108 |
| — | PHASEBIO PHARMACEUTICALS INC | 2,850,000 | $8.864M | 0.1% | $3.46 | — | COM | 717224109 |
| HLTHQ | CUE HEALTH INC | 750,000 | $8.858M | 0.1% | $11.81 | — | COM | 229790100 |
| COGT | COGENT BIOSCIENCES INC | 1,025,641 | $8.626M | 0.1% | $10.99 | -30.3% | COM | 19240Q201 |
| CGEM | CULLINAN ONCOLOGY INC | 350,000 | $7.9M | 0.1% | $40.60 | -34.1% | COM | 230031106 |
| OCUL | OCULAR THERAPEUTIX INC | 750,000 | $7.5M | 0.1% | $6.63 | +69.5% | COM | 67576A100 |
| — | 5 01 ACQUISITION CORP | 750,000 | $7.365M | 0.1% | $10.17 | — | COM CL | 33836P105 |
| MLTX | HELIX ACQUISITION CORP | 700,000 | $6.965M | 0.1% | $11.37 | — | COM CL A | G4444C102 |
| — | HEALTH SCIENCES ACQ CORP 2 | 625,000 | $6.181M | 0.1% | $11.00 | — | ORD SHS | G4411D109 |
| BMEA | BIOMEA FUSION INC | 500,000 | $5.985M | 0.1% | $17.65 | -27.9% | COM | 09077A106 |
| CVRX | CVRX INC | 275,000 | $4.549M | 0.1% | $28.00 | -31.5% | COM | 126638105 |
| — | SYROS PHARMACEUTICALS INC | 900,000 | $4.023M | 0.1% | $7.48 | — | COM | 87184Q107 |
| — | CHEMOCENTRYX INC | 218,532 | $3.737M | 0.1% | $42.10 | — | COM | 16383L106 |
| — | OTONOMY INC | 1,631,635 | $3.133M | 0.0% | $1.92 | — | COM | 68906L105 |
| — | RENEO PHARMACEUTICALS INC | 62,217 | $464K | 0.0% | $9.32 | — | COM | 75974E103 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,034 | $17,000 | 0.0% | $18.72 | -21.7% | COM | 92790C104 |