BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q4 2014 (← Previous) (Next →)

Filing Date: Feb 17, 2015

Total Value ($000): $9,797,208 (79.0% shares, 21.0% debt)

Holdings (121)

Pharmacyclics Inc. 11.4%
Value ($000) $1,116,140 Shares 9,129,231 Est. Cost $80.38 Unrealized
INCY Incyte Corp. 11.1%
Value ($000) $1,085,359 Shares 14,845,559 Est. Cost $21.85 Unrealized +199.0%
Synageva Biopharma Corp. 10.1%
Value ($000) $989,182 Shares 10,660,432 Est. Cost $45.53 Unrealized
Seattle Genetics, Inc. 9.1%
Value ($000) $895,197 Shares 27,861,720 Est. Cost $32.44 Unrealized
Avanir Pharmaceuticals 6.7%
Value ($000) $652,807 Shares 38,513,713 Est. Cost $10.98 Unrealized
ACAD Acadia Pharmaceuticals Inc. 6.6%
Value ($000) $650,286 Shares 20,481,442 Est. Cost $14.07 Unrealized +101.5%
Salix 2.75% 5/15/15 5.5%
Value ($000) $542,741 Shares 219,440,000 Est. Cost $1.52 Unrealized
Genomic Health Inc. 4.5%
Value ($000) $436,592 Shares 13,656,318 Est. Cost $31.71 Unrealized
Incyte Corporation Notes 1.25% 11/15/2020 144A 4.3%
Value ($000) $421,613 Shares 274,500,000 Est. Cost $1.21 Unrealized
Incyte Corporation Notes 0.375% 11/15/2018 144A 4.0%
Value ($000) $388,039 Shares 259,000,000 Est. Cost $1.20 Unrealized
Incyte Corporation Notes 4.75% 10/1/2015 144A 3.4%
Value ($000) $336,182 Shares 40,446,000 Est. Cost $6.08 Unrealized
BMRN Biomarin Pharmaceuticals 3.4%
Value ($000) $335,741 Shares 3,713,950 Est. Cost $71.95 Unrealized +15.6%
Anacor Pharmaceuticals 1.4%
Value ($000) $135,602 Shares 4,204,702 Est. Cost $19.02 Unrealized
BCRX Biocryst Pharmaceuticals Inc. 1.3%
Value ($000) $130,278 Shares 10,713,686 Est. Cost $5.72 Unrealized +93.0%
Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 1.0%
Value ($000) $102,104 Shares 22,898,000 Est. Cost $2.76 Unrealized
Bellicum Pharmaceuticals, Inc. 1.0%
Value ($000) $98,697 Shares 4,283,732 Est. Cost $23.04 Unrealized
Gilead 1.625% 5/1/16 0.9%
Value ($000) $88,977 Shares 21,500,000 Est. Cost $2.26 Unrealized
Dyax Corp. 0.9%
Value ($000) $86,579 Shares 6,157,789 Est. Cost $8.91 Unrealized
CERS Cerus 0.7%
Value ($000) $73,025 Shares 11,702,727 Est. Cost $4.62 Unrealized -1.7%
Salix Pharmaceuticals 0.7%
Value ($000) $73,024 Shares 635,321 Est. Cost $114.73 Unrealized
Acorda Therapeutics Notes 1.75% 6/15/2021 0.7%
Value ($000) $69,839 Shares 60,900,000 Est. Cost $1.04 Unrealized
Medivation 2.625% 4/1/17 0.7%
Value ($000) $67,334 Shares 34,720,000 Est. Cost $1.27 Unrealized
VNDA Vanda Pharmaceuticals, Inc. 0.7%
Value ($000) $64,041 Shares 4,472,153 Est. Cost $7.51 Unrealized +57.5%
Xoma Corp. 0.6%
Value ($000) $60,757 Shares 16,924,013 Est. Cost $3.73 Unrealized
Xenoport 0.6%
Value ($000) $60,545 Shares 6,903,628 Est. Cost $5.27 Unrealized
Versartis Inc. 0.5%
Value ($000) $51,225 Shares 2,281,744 Est. Cost $25.50 Unrealized
Mirati Therapeutics Inc. 0.4%
Value ($000) $44,079 Shares 2,380,074 Est. Cost $15.40 Unrealized
DBV Technologies Inc. 0.4%
Value ($000) $41,201 Shares 1,519,229 Est. Cost $27.12 Unrealized
Progenics Pharmaceuticals, Inc. 0.3%
Value ($000) $33,640 Shares 4,449,797 Est. Cost $4.44 Unrealized
Derma Sciences 0.3%
Value ($000) $32,931 Shares 3,537,137 Est. Cost $12.84 Unrealized
TGTX TG Therapeutics 0.3%
Value ($000) $32,477 Shares 2,050,313 Est. Cost $4.61 Unrealized +182.7%
Acorda Therapeutics, Inc. 0.3%
Value ($000) $30,879 Shares 755,534 Est. Cost $37.91 Unrealized
Salix 1.5% 3/15/19 0.3%
Value ($000) $27,339 Shares 15,000,000 Est. Cost $1.49 Unrealized
HALO Halozyme Therapeutics Inc. 0.3%
Value ($000) $26,790 Shares 2,776,143 Est. Cost $6.50 Unrealized +36.7%
HRTX Heron Therapeutics, Inc. 0.3%
Value ($000) $26,234 Shares 2,607,784 Est. Cost $12.49 Unrealized -34.7%
GILD Gilead Sciences Inc. 0.2%
Value ($000) $24,141 Shares 256,108 Est. Cost $36.21 Unrealized +98.4%
CPRX Catalyst Pharmaceuticals, Inc. 0.2%
Value ($000) $19,945 Shares 6,715,462 Est. Cost $2.45 Unrealized +11.9%
Repros Therapeutics 0.2%
Value ($000) $19,940 Shares 2,000,000 Est. Cost $18.45 Unrealized
AGIO Agios Pharmaceuticals 0.2%
Value ($000) $18,307 Shares 163,393 Est. Cost $27.47 Unrealized +225.0%
INSM Insmed Inc. 0.2%
Value ($000) $17,138 Shares 1,107,850 Est. Cost $13.86 Unrealized +2.4%
OMER Omeros Corp. 0.2%
Value ($000) $16,060 Shares 648,101 Est. Cost $7.65 Unrealized +138.3%
Biomarin Pharmaceuticals Notes 0.75% 10/15/2018 0.2%
Value ($000) $14,715 Shares 12,500,000 Est. Cost $1.06 Unrealized
SGMO Sangamo Biosciences, Inc. 0.1%
Value ($000) $14,531 Shares 955,332 Est. Cost $12.63 Unrealized -3.9%
Bluebird Bio Inc. 0.1%
Value ($000) $13,758 Shares 150,000 Est. Cost $25.09 Unrealized
NBIX Neurocrine Biosciences, Inc. 0.1%
Value ($000) $12,390 Shares 554,590 Est. Cost $16.53 Unrealized +14.6%
Clovis Oncology 0.1%
Value ($000) $11,347 Shares 202,630 Est. Cost $56.00 Unrealized
MGNX Macrogenics, Inc. 0.1%
Value ($000) $10,938 Shares 311,891 Est. Cost $22.61 Unrealized +10.3%
Kythera Biopharmaceuticals 0.1%
Value ($000) $9,927 Shares 286,255 Est. Cost $34.55 Unrealized
XNCR Xencor 0.1%
Value ($000) $9,486 Shares 591,371 Est. Cost $8.83 Unrealized +31.4%
Arrowhead Research Corp. 0.1%
Value ($000) $9,083 Shares 1,230,802 Est. Cost $9.90 Unrealized
Aquinox Pharmaceuticals, Inc. 0.1%
Value ($000) $9,078 Shares 1,210,350 Est. Cost $12.73 Unrealized
Aerie Pharmaceuticals 0.1%
Value ($000) $8,738 Shares 299,356 Est. Cost $17.96 Unrealized
PRQR ProQR Therapeutics NV 0.1%
Value ($000) $8,668 Shares 400,000 Est. Cost $16.02 Unrealized -5.3%
Osiris Therapeutics Inc. 0.1%
Value ($000) $8,165 Shares 510,606 Est. Cost $16.34 Unrealized
Sunesis Pharmaceuticals Inc. 0.1%
Value ($000) $8,160 Shares 3,200,000 Est. Cost $2.55 Unrealized
La Jolla Pharmaceuticals, Inc. 0.1%
Value ($000) $7,779 Shares 421,631 Est. Cost $10.24 Unrealized
Tekmira Pharmaceuticals Corp. 0.1%
Value ($000) $7,335 Shares 484,156 Est. Cost $7.97 Unrealized
Celladon Corp 0.1%
Value ($000) $7,324 Shares 375,000 Est. Cost $10.46 Unrealized
Novavax Inc. 0.1%
Value ($000) $7,255 Shares 1,223,362 Est. Cost $3.15 Unrealized
Idera Pharmaceuticals Inc. 0.1%
Value ($000) $7,181 Shares 1,628,172 Est. Cost $0.91 Unrealized
Foamix Pharmaceuticals Ltd. 0.1%
Value ($000) $7,161 Shares 1,021,600 Est. Cost $5.45 Unrealized
Chimerix 0.1%
Value ($000) $6,941 Shares 172,414 Est. Cost $40.26 Unrealized
Threshold Pharma 0.1%
Value ($000) $6,855 Shares 2,155,516 Est. Cost $4.49 Unrealized
Array Biopharma Inc. 0.1%
Value ($000) $6,782 Shares 1,433,797 Est. Cost $4.54 Unrealized
Concert Pharmaceuticals, Inc. 0.1%
Value ($000) $6,732 Shares 505,418 Est. Cost $10.71 Unrealized
RARE Ultragenyx Pharmaceuticals 0.1%
Value ($000) $6,582 Shares 150,000 Est. Cost $51.09 Unrealized -10.3%
QLT Inc. 0.1%
Value ($000) $6,159 Shares 1,535,863 Est. Cost $4.39 Unrealized
Isis Pharmaceuticals, Inc. 0.1%
Value ($000) $5,946 Shares 96,303 Est. Cost $26.87 Unrealized
Stemline Therapeutics Inc. 0.1%
Value ($000) $5,778 Shares 338,671 Est. Cost $23.84 Unrealized
Achillion 0.1%
Value ($000) $5,370 Shares 438,337 Est. Cost $8.18 Unrealized
IRWD Ironwood Pharmaceuticals 0.1%
Value ($000) $5,303 Shares 346,160 Est. Cost $11.63 Unrealized -1.6%
INFIQ Infinity Pharmaceuticals Inc. 0.1%
Value ($000) $5,270 Shares 312,025 Est. Cost $13.42 Unrealized +8.5%
Juno Therapeutics Inc. 0.1%
Value ($000) $5,222 Shares 100,000 Est. Cost $52.22 Unrealized
Mallinckrodt PUB LTD CO 0.0%
Value ($000) $4,621 Shares 46,666 Est. Cost $90.15 Unrealized
Alder Biopharmaceutical Inc. 0.0%
Value ($000) $4,461 Shares 153,350 Est. Cost $20.07 Unrealized
Discovery Laboratories Inc. 0.0%
Value ($000) $4,236 Shares 3,652,117 Est. Cost $1.95 Unrealized
FOLD Amicus Therapeutics 0.0%
Value ($000) $4,008 Shares 481,697 Est. Cost $3.07 Unrealized +123.3%
Ignyta 0.0%
Value ($000) $3,911 Shares 571,000 Est. Cost $8.30 Unrealized
LGND Ligand Pharmaceuticals 0.0%
Value ($000) $3,906 Shares 73,400 Est. Cost $41.68 Unrealized -22.0%
ENTA Enanta Pharmaceuticals 0.0%
Value ($000) $3,832 Shares 75,357 Est. Cost $19.50 Unrealized +129.6%
Epizyme Inc. 0.0%
Value ($000) $3,811 Shares 201,963 Est. Cost $21.47 Unrealized
Cytrx Corp. 0.0%
Value ($000) $3,699 Shares 1,350,000 Est. Cost $3.49 Unrealized
Karyopharm Therapeutics 0.0%
Value ($000) $3,522 Shares 94,095 Est. Cost $31.71 Unrealized
Neuroderm Ltd. 0.0%
Value ($000) $3,510 Shares 250,000 Est. Cost $14.04 Unrealized
Celsus Therapeutics 0.0%
Value ($000) $3,235 Shares 673,887 Est. Cost $6.49 Unrealized
Zogenix, Inc. 0.0%
Value ($000) $3,220 Shares 2,350,400 Est. Cost $2.18 Unrealized
Synergy Pharmaceuticals 0.0%
Value ($000) $2,968 Shares 973,245 Est. Cost $4.32 Unrealized
Receptos Inc. 0.0%
Value ($000) $2,928 Shares 23,900 Est. Cost $19.89 Unrealized
Aptose Biosciences, Inc. 0.0%
Value ($000) $2,833 Shares 479,164 Est. Cost $5.91 Unrealized
Foundation Medicine Inc. 0.0%
Value ($000) $2,803 Shares 126,147 Est. Cost $25.16 Unrealized
Sage Therapeutics Inc. 0.0%
Value ($000) $2,745 Shares 75,000 Est. Cost $31.51 Unrealized
Mast Therapeutics, Inc. 0.0%
Value ($000) $2,674 Shares 4,774,434 Est. Cost $0.56 Unrealized
Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18 0.0%
Value ($000) $2,645 Shares 3,500,000 Est. Cost $0.76 Unrealized
Lipocine Inc. 0.0%
Value ($000) $2,630 Shares 500,000 Est. Cost $6.10 Unrealized
AUPH Aurinia Pharmaceuticals, Inc. 0.0%
Value ($000) $2,599 Shares 727,669 Est. Cost $3.55 Unrealized -0.9%
BioDelivery Sciences Intl. Inc. 0.0%
Value ($000) $2,524 Shares 210,021 Est. Cost $4.06 Unrealized
Affimed Therapeutics B.V. 0.0%
Value ($000) $2,480 Shares 400,000 Est. Cost $6.30 Unrealized
Biota Pharmaceuticals 0.0%
Value ($000) $2,479 Shares 1,106,910 Est. Cost $4.19 Unrealized
OSUR Orasure Technologies Inc. 0.0%
Value ($000) $2,379 Shares 234,664 Est. Cost $4.46 Unrealized +100.9%
Marinus Pharmaceuticals Inc. 0.0%
Value ($000) $2,161 Shares 204,476 Est. Cost $6.47 Unrealized
Dermira 0.0%
Value ($000) $1,811 Shares 100,000 Est. Cost $18.11 Unrealized
Proteon Therapeutics, Inc. 0.0%
Value ($000) $1,798 Shares 172,917 Est. Cost $10.40 Unrealized
Ophthotech Corp. 0.0%
Value ($000) $1,650 Shares 36,776 Est. Cost $32.35 Unrealized
Mediwound Ltd. 0.0%
Value ($000) $1,499 Shares 225,000 Est. Cost $11.38 Unrealized
Palatin Technologies Inc. 0.0%
Value ($000) $1,497 Shares 2,050,000 Est. Cost $0.73 Unrealized
Synta Pharmaceuticals 0.0%
Value ($000) $1,325 Shares 500,000 Est. Cost $4.99 Unrealized
GERN Geron Corp. 0.0%
Value ($000) $1,309 Shares 402,629 Est. Cost $1.08 Unrealized +155.1%
Achaogen Inc. 0.0%
Value ($000) $1,305 Shares 100,000 Est. Cost $15.46 Unrealized
Loxo Oncology Inc. 0.0%
Value ($000) $1,175 Shares 100,000 Est. Cost $13.13 Unrealized
Tesaro Inc. 0.0%
Value ($000) $1,161 Shares 31,218 Est. Cost $32.74 Unrealized
ALNY Alnylam Pharmaceuticals, Inc. 0.0%
Value ($000) $1,125 Shares 11,600 Est. Cost $77.42 Unrealized +19.7%
Acceleron Pharma Inc. 0.0%
Value ($000) $1,121 Shares 28,765 Est. Cost $39.60 Unrealized
Rigel Pharmaceuticals 0.0%
Value ($000) $1,094 Shares 481,972 Est. Cost $3.58 Unrealized
Alcobra Ltd. 0.0%
Value ($000) $1,081 Shares 289,871 Est. Cost $3.73 Unrealized
Ziopharm Oncology Inc. 0.0%
Value ($000) $982 Shares 193,640 Est. Cost $2.11 Unrealized
Five Prime Therapeutics Inc. 0.0%
Value ($000) $535 Shares 19,823 Est. Cost $16.80 Unrealized
QURE UniQure B.V. 0.0%
Value ($000) $454 Shares 30,672 Est. Cost $15.95 Unrealized -23.3%
Chemocentryx Inc. 0.0%
Value ($000) $342 Shares 50,000 Est. Cost $14.14 Unrealized
Cyclacel Pharmaceuticals Pfd. Conv. Ex 6% 0.0%
Value ($000) $82 Shares 13,253 Est. Cost $7.20 Unrealized
Asterias Biotherapeutics, Inc. 0.0%
Value ($000) $54 Shares 16,775 Est. Cost $3.22 Unrealized
Biotime Inc. Rights 0.0%
Value ($000) $22 Shares 20,525 Est. Cost $1.07 Unrealized