BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q1 2015 (← Previous) (Next →)

Filing Date: May 15, 2015

Total Value ($000): $12,022,854 (78.0% shares, 22.0% debt)

Holdings (130)

Pharmacyclics Inc. 19.2%
Value ($000) $2,313,699 Shares 9,039,652 Est. Cost $80.38 Unrealized
INCY Incyte Corp. 11.3%
Value ($000) $1,360,744 Shares 14,845,559 Est. Cost $21.85 Unrealized +278.4%
Synageva Biopharma Corp. 9.5%
Value ($000) $1,137,242 Shares 11,660,432 Est. Cost $49.99 Unrealized
Seattle Genetics, Inc. 8.5%
Value ($000) $1,020,792 Shares 28,876,712 Est. Cost $32.54 Unrealized
Salix Pharmaceuticals Inc. 2.75% 5/15/15 6.7%
Value ($000) $801,152 Shares 216,077,000 Est. Cost $1.52 Unrealized
ACAD Acadia Pharmaceuticals Inc. 5.6%
Value ($000) $667,490 Shares 20,481,442 Est. Cost $14.07 Unrealized +144.3%
BMRN Biomarin Pharmaceuticals Inc. 4.4%
Value ($000) $523,461 Shares 4,200,456 Est. Cost $75.89 Unrealized +39.6%
Incyte Corp. Notes 1.25% 11/15/2020 144A 4.2%
Value ($000) $508,427 Shares 274,500,000 Est. Cost $1.21 Unrealized
Incyte Corp. Notes 0.375% 11/15/2018 144A 3.9%
Value ($000) $471,944 Shares 259,000,000 Est. Cost $1.20 Unrealized
Incyte Corp. Notes 4.75% 10/1/2015 144A 3.5%
Value ($000) $421,673 Shares 40,446,000 Est. Cost $6.08 Unrealized
Genomic Health Inc. 3.5%
Value ($000) $417,220 Shares 13,656,942 Est. Cost $31.71 Unrealized
Anacor Pharmaceuticals Inc. 2.0%
Value ($000) $243,242 Shares 4,204,702 Est. Cost $19.02 Unrealized
Biomarin Pharmaceuticals Inc. Notes 1.875% 4/23/2017 1.1%
Value ($000) $136,987 Shares 22,379,000 Est. Cost $2.76 Unrealized
Invitae Corp. 0.9%
Value ($000) $109,861 Shares 6,554,967 Est. Cost $16.76 Unrealized
Spark Therapeutics, Inc. 0.9%
Value ($000) $102,878 Shares 1,327,451 Est. Cost $77.50 Unrealized
Dyax Corp. 0.8%
Value ($000) $100,890 Shares 6,021,485 Est. Cost $8.91 Unrealized
Bellicum Pharmaceuticals, Inc. 0.8%
Value ($000) $97,096 Shares 4,190,594 Est. Cost $23.04 Unrealized
BCRX Biocryst Pharmaceuticals Inc. 0.8%
Value ($000) $94,618 Shares 10,478,204 Est. Cost $5.72 Unrealized +80.9%
Gilead Sciences Inc. 1.625% 5/1/16 0.8%
Value ($000) $90,193 Shares 20,944,000 Est. Cost $2.26 Unrealized
Medivation Inc. 2.625% 4/1/17 0.7%
Value ($000) $84,927 Shares 33,889,000 Est. Cost $1.27 Unrealized
Mirati Therapeutics Inc. 0.7%
Value ($000) $82,245 Shares 2,805,074 Est. Cost $17.51 Unrealized
Acorda Therapeutics Inc. Notes 1.75% 6/15/2021 0.5%
Value ($000) $60,762 Shares 59,583,000 Est. Cost $1.04 Unrealized
CERS Cerus Corp. 0.5%
Value ($000) $56,517 Shares 13,553,275 Est. Cost $4.68 Unrealized +9.3%
Versartis Inc. 0.5%
Value ($000) $54,694 Shares 2,977,396 Est. Cost $23.84 Unrealized
Xoma Corp. 0.4%
Value ($000) $53,539 Shares 14,708,613 Est. Cost $3.73 Unrealized
Xenoport Inc. 0.4%
Value ($000) $46,341 Shares 6,508,622 Est. Cost $5.27 Unrealized
Array Biopharma Inc. 0.3%
Value ($000) $41,705 Shares 5,658,755 Est. Cost $6.65 Unrealized
Salix Pharmaceuticals Inc. 1.5% 3/15/19 0.3%
Value ($000) $38,948 Shares 14,668,000 Est. Cost $1.49 Unrealized
HRTX Heron Therapeutics, Inc. 0.3%
Value ($000) $37,943 Shares 2,607,784 Est. Cost $12.49 Unrealized -9.8%
DBV Technologies Inc. 0.3%
Value ($000) $35,489 Shares 1,519,229 Est. Cost $27.12 Unrealized
INSM Insmed Inc. 0.3%
Value ($000) $32,937 Shares 1,583,490 Est. Cost $14.99 Unrealized +17.6%
CPRX Catalyst Pharmaceuticals, Inc. 0.3%
Value ($000) $32,758 Shares 7,565,462 Est. Cost $2.58 Unrealized +39.7%
HALO Halozyme Therapeutics Inc. 0.3%
Value ($000) $32,104 Shares 2,248,152 Est. Cost $6.50 Unrealized +121.9%
TGTX TG Therapeutics Inc. 0.3%
Value ($000) $31,739 Shares 2,050,313 Est. Cost $4.61 Unrealized +228.8%
Derma Sciences Inc. 0.2%
Value ($000) $29,288 Shares 3,457,841 Est. Cost $12.84 Unrealized
Progenics Pharmaceuticals, Inc. 0.2%
Value ($000) $26,018 Shares 4,350,808 Est. Cost $4.44 Unrealized
Idera Pharmaceuticals Inc. 0.2%
Value ($000) $25,842 Shares 6,965,432 Est. Cost $3.05 Unrealized
Alder Biopharmaceuticals Inc. 0.2%
Value ($000) $25,385 Shares 879,581 Est. Cost $27.33 Unrealized
Acorda Therapeutics, Inc. 0.2%
Value ($000) $24,591 Shares 738,916 Est. Cost $37.91 Unrealized
GILD Gilead Sciences Inc. 0.2%
Value ($000) $24,532 Shares 249,995 Est. Cost $36.21 Unrealized +94.8%
SGMO Sangamo Biosciences, Inc. 0.2%
Value ($000) $22,023 Shares 1,404,544 Est. Cost $13.54 Unrealized +14.3%
NBIX Neurocrine Biosciences, Inc. 0.2%
Value ($000) $21,532 Shares 542,236 Est. Cost $16.53 Unrealized +116.4%
Biomarin Pharmaceuticals Inc. Notes 0.75% 10/15/2018 0.1%
Value ($000) $17,970 Shares 12,228,000 Est. Cost $1.06 Unrealized
Kythera Biopharmaceuticals Inc. 0.1%
Value ($000) $17,766 Shares 354,265 Est. Cost $37.55 Unrealized
Bluebird Bio Inc. 0.1%
Value ($000) $17,703 Shares 146,581 Est. Cost $25.09 Unrealized
Repros Therapeutics Inc. 0.1%
Value ($000) $17,180 Shares 2,000,000 Est. Cost $18.45 Unrealized
Foamix Pharmaceuticals Ltd. 0.1%
Value ($000) $16,853 Shares 1,821,967 Est. Cost $7.12 Unrealized
VNDA Vanda Pharmaceuticals, Inc. 0.1%
Value ($000) $16,277 Shares 1,750,230 Est. Cost $7.51 Unrealized +50.4%
Novavax Inc. 0.1%
Value ($000) $16,091 Shares 1,945,687 Est. Cost $5.05 Unrealized
Lion Biotechnologies Inc. 0.1%
Value ($000) $16,046 Shares 1,325,000 Est. Cost $12.11 Unrealized
Clovis Oncology Inc. 0.1%
Value ($000) $15,041 Shares 202,630 Est. Cost $56.00 Unrealized
AGIO Agios Pharmaceuticals Inc. 0.1%
Value ($000) $14,141 Shares 149,954 Est. Cost $27.47 Unrealized +307.9%
OMER Omeros Corp. 0.1%
Value ($000) $14,043 Shares 637,446 Est. Cost $7.65 Unrealized +198.6%
XNCR Xencor Inc. 0.1%
Value ($000) $13,360 Shares 872,072 Est. Cost $11.07 Unrealized +42.6%
Threshold Pharmaceuticals Inc. 0.1%
Value ($000) $11,878 Shares 2,925,519 Est. Cost $4.38 Unrealized
Alcobra Ltd. 0.1%
Value ($000) $10,077 Shares 1,789,871 Est. Cost $5.32 Unrealized
Aquinox Pharmaceuticals, Inc. 0.1%
Value ($000) $9,763 Shares 1,187,666 Est. Cost $12.73 Unrealized
MGNX Macrogenics, Inc. 0.1%
Value ($000) $9,569 Shares 305,043 Est. Cost $22.61 Unrealized +49.9%
Aerie Pharmaceuticals Inc. 0.1%
Value ($000) $9,382 Shares 299,356 Est. Cost $17.96 Unrealized
RARE Ultragenyx Pharmaceuticals Inc. 0.1%
Value ($000) $9,245 Shares 148,894 Est. Cost $51.09 Unrealized +8.7%
Immunogen, Inc. 0.1%
Value ($000) $8,945 Shares 999,496 Est. Cost $8.95 Unrealized
Osiris Therapeutics Inc. 0.1%
Value ($000) $8,776 Shares 499,193 Est. Cost $16.34 Unrealized
PRQR ProQR Therapeutics NV 0.1%
Value ($000) $8,752 Shares 400,000 Est. Cost $16.02 Unrealized +28.9%
Arrowhead Research Corp. 0.1%
Value ($000) $8,728 Shares 1,290,187 Est. Cost $9.76 Unrealized
Sunesis Pharmaceuticals, Inc. 0.1%
Value ($000) $7,840 Shares 3,200,000 Est. Cost $2.55 Unrealized
La Jolla Pharmaceuticals, Co. 0.1%
Value ($000) $7,540 Shares 412,008 Est. Cost $10.24 Unrealized
Concert Pharmaceuticals, Inc. 0.1%
Value ($000) $7,511 Shares 495,908 Est. Cost $10.71 Unrealized
Celladon Corp 0.1%
Value ($000) $6,947 Shares 366,806 Est. Cost $10.46 Unrealized
Karyopharm Therapeutics Inc. 0.1%
Value ($000) $6,642 Shares 216,990 Est. Cost $31.09 Unrealized
Juno Therapeutics Inc. 0.1%
Value ($000) $6,066 Shares 100,000 Est. Cost $52.22 Unrealized
Foundation Medicine Inc. 0.0%
Value ($000) $5,978 Shares 124,255 Est. Cost $25.16 Unrealized
Ignyta Inc. 0.0%
Value ($000) $5,681 Shares 571,000 Est. Cost $8.30 Unrealized
LGND Ligand Pharmaceuticals Inc. 0.0%
Value ($000) $5,659 Shares 73,386 Est. Cost $41.68 Unrealized -8.1%
Transition Therapeutics, Inc. 0.0%
Value ($000) $5,254 Shares 769,230 Est. Cost $6.83 Unrealized
Amarin Corp. PLC 0.0%
Value ($000) $5,161 Shares 2,205,710 Est. Cost $2.34 Unrealized
Stemline Therapeutics Inc. 0.0%
Value ($000) $4,826 Shares 333,497 Est. Cost $23.84 Unrealized
Cytrx Corp. 0.0%
Value ($000) $4,448 Shares 1,319,989 Est. Cost $3.49 Unrealized
Epizyme Inc. 0.0%
Value ($000) $4,366 Shares 232,481 Est. Cost $21.12 Unrealized
Chimerix Inc. 0.0%
Value ($000) $4,342 Shares 115,216 Est. Cost $40.26 Unrealized
INFIQ Infinity Pharmaceuticals Inc. 0.0%
Value ($000) $4,264 Shares 305,037 Est. Cost $13.42 Unrealized +13.9%
Discovery Laboratories Inc. 0.0%
Value ($000) $4,248 Shares 3,569,643 Est. Cost $1.95 Unrealized
Receptos Inc. 0.0%
Value ($000) $3,941 Shares 23,900 Est. Cost $19.89 Unrealized
Sage Therapeutics Inc. 0.0%
Value ($000) $3,767 Shares 75,000 Est. Cost $31.51 Unrealized
Array Biopharma, Inc. Notes 3.0% 6/1/2020 0.0%
Value ($000) $3,759 Shares 3,000,000 Est. Cost $1.25 Unrealized
Zafgen, Inc. 0.0%
Value ($000) $3,753 Shares 94,745 Est. Cost $39.61 Unrealized
Isis Pharmaceuticals, Inc. 0.0%
Value ($000) $3,638 Shares 57,140 Est. Cost $26.87 Unrealized
Lipocine Inc. 0.0%
Value ($000) $3,375 Shares 489,175 Est. Cost $6.10 Unrealized
Neuroderm Ltd. 0.0%
Value ($000) $3,355 Shares 250,000 Est. Cost $14.04 Unrealized
Assembly Biosciences, Inc. 0.0%
Value ($000) $3,310 Shares 250,000 Est. Cost $13.24 Unrealized
Bellerophon Therapeutics, Inc. 0.0%
Value ($000) $3,213 Shares 350,000 Est. Cost $9.18 Unrealized
Tekmira Pharmaceuticals Corp. 0.0%
Value ($000) $3,153 Shares 180,582 Est. Cost $7.97 Unrealized
Zogenix, Inc. 0.0%
Value ($000) $3,149 Shares 2,298,466 Est. Cost $2.18 Unrealized
AUPH Aurinia Pharmaceuticals, Inc. 0.0%
Value ($000) $3,118 Shares 711,499 Est. Cost $3.55 Unrealized +11.7%
IRWD Ironwood Pharmaceuticals Inc. 0.0%
Value ($000) $2,707 Shares 169,163 Est. Cost $11.63 Unrealized +12.8%
BioDelivery Sciences Intl. Inc. 0.0%
Value ($000) $2,686 Shares 255,866 Est. Cost $5.21 Unrealized
Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18 0.0%
Value ($000) $2,612 Shares 3,500,000 Est. Cost $0.76 Unrealized
Affimed N.V. 0.0%
Value ($000) $2,520 Shares 400,000 Est. Cost $6.30 Unrealized
Auspex Pharmaceuticals, Inc. 0.0%
Value ($000) $2,507 Shares 25,000 Est. Cost $100.28 Unrealized
Intra Cellular Therapies Inc. 0.0%
Value ($000) $2,487 Shares 104,166 Est. Cost $23.88 Unrealized
ENTA Enanta Pharmaceuticals Inc. 0.0%
Value ($000) $2,307 Shares 75,357 Est. Cost $19.50 Unrealized +99.6%
Mast Therapeutics, Inc. 0.0%
Value ($000) $2,283 Shares 4,707,464 Est. Cost $0.56 Unrealized
Vitae Pharmaceuticals Inc. 0.0%
Value ($000) $2,197 Shares 187,597 Est. Cost $11.71 Unrealized
Achillion Pharmaceuticals, Inc. 0.0%
Value ($000) $2,112 Shares 214,237 Est. Cost $8.18 Unrealized
Palatin Technologies Inc. 0.0%
Value ($000) $2,091 Shares 2,050,000 Est. Cost $0.73 Unrealized
Ziopharm Oncology Inc. 0.0%
Value ($000) $2,038 Shares 189,259 Est. Cost $2.11 Unrealized
Proteon Therapeutics, Inc. 0.0%
Value ($000) $2,011 Shares 172,917 Est. Cost $10.40 Unrealized
Biota Pharmaceuticals Inc. 0.0%
Value ($000) $1,985 Shares 863,184 Est. Cost $4.19 Unrealized
Marinus Pharmaceuticals Inc. 0.0%
Value ($000) $1,798 Shares 200,000 Est. Cost $6.47 Unrealized
ASND Ascendis Pharma SA 0.0%
Value ($000) $1,735 Shares 100,000 Est. Cost $17.35 Unrealized
CLLS Cellectis SA 0.0%
Value ($000) $1,729 Shares 50,000 Est. Cost $34.58 Unrealized
Ophthotech Corp. 0.0%
Value ($000) $1,659 Shares 35,649 Est. Cost $32.35 Unrealized
Mediwound Ltd. 0.0%
Value ($000) $1,629 Shares 225,000 Est. Cost $11.38 Unrealized
Dermira Inc. 0.0%
Value ($000) $1,535 Shares 100,000 Est. Cost $18.11 Unrealized
OSUR Orasure Technologies Inc. 0.0%
Value ($000) $1,500 Shares 229,397 Est. Cost $4.46 Unrealized +86.2%
ALDX Aldeyra Therapeutics, Inc. 0.0%
Value ($000) $1,446 Shares 142,000 Est. Cost $10.20 Unrealized 0.0%
Rigel Pharmaceuticals Inc. 0.0%
Value ($000) $1,275 Shares 357,187 Est. Cost $3.58 Unrealized
Loxo Oncology Inc. 0.0%
Value ($000) $1,245 Shares 100,000 Est. Cost $13.13 Unrealized
ALNY Alnylam Pharmaceuticals, Inc. 0.0%
Value ($000) $1,184 Shares 11,340 Est. Cost $77.42 Unrealized +30.9%
Acceleron Pharma Inc. 0.0%
Value ($000) $1,095 Shares 28,765 Est. Cost $39.60 Unrealized
Achaogen Inc. 0.0%
Value ($000) $976 Shares 100,000 Est. Cost $15.46 Unrealized
Synta Pharmaceuticals Corp. 0.0%
Value ($000) $949 Shares 489,053 Est. Cost $4.99 Unrealized
Ohr Pharmaceuticals, Inc. 0.0%
Value ($000) $941 Shares 370,370 Est. Cost $2.54 Unrealized
QURE UniQure N.V. 0.0%
Value ($000) $730 Shares 30,000 Est. Cost $15.95 Unrealized +36.8%
Five Prime Therapeutics Inc. 0.0%
Value ($000) $440 Shares 19,247 Est. Cost $16.80 Unrealized
Aegerion Pharmaceuticals, Inc. 0.0%
Value ($000) $374 Shares 14,300 Est. Cost $26.15 Unrealized
Chemocentryx Inc. 0.0%
Value ($000) $370 Shares 49,064 Est. Cost $14.14 Unrealized
Aptose Biosciences, Inc. 0.0%
Value ($000) $181 Shares 33,397 Est. Cost $5.91 Unrealized
Cyclacel Pharmaceuticals Inc. 0.0%
Value ($000) $86 Shares 13,253 Est. Cost $7.20 Unrealized
Biotime Inc. 0.0%
Value ($000) $40 Shares 20,084 Est. Cost $1.07 Unrealized
Biodel Inc. 0.0%
Value ($000) $36 Shares 30,179 Est. Cost $1.19 Unrealized