Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q1 2015 (← Previous) (Next →)
Filing Date: May 15, 2015
Total Value: $12.02B (78.0% shares, 22.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Pharmacyclics Inc. | 9,039,652 | $2.314B | 19.2% | $80.38 | — | COM | 716933106 |
| INCY | Incyte Corp. | 14,845,559 | $1.361B | 11.3% | $21.85 | +278.4% | COM | 45337C102 |
| — | Synageva Biopharma Corp. | 11,660,432 | $1.137B | 9.5% | $49.99 | — | COM | 87159A103 |
| — | Seattle Genetics, Inc. | 28,876,712 | $1.021B | 8.5% | $32.54 | — | COM | 812578102 |
| — | Salix Pharmaceuticals Inc. 2.75% 5/15/15 | 216,077,000 | $801M | 6.7% | $1.52 | — | CONV BONDS | 795435AC0 |
| ACAD | Acadia Pharmaceuticals Inc. | 20,481,442 | $667M | 5.6% | $14.07 | +144.3% | COM | 004225108 |
| BMRN | Biomarin Pharmaceuticals Inc. | 4,200,456 | $523M | 4.4% | $75.89 | +39.6% | COM | 09061G101 |
| — | Incyte Corp. Notes 1.25% 11/15/2020 144A | 274,500,000 | $508M | 4.2% | $1.21 | — | CONV BONDS | 45337CAL6 |
| — | Incyte Corp. Notes 0.375% 11/15/2018 144A | 259,000,000 | $472M | 3.9% | $1.20 | — | CONV BONDS | 45337CAK8 |
| — | Incyte Corp. Notes 4.75% 10/1/2015 144A | 40,446,000 | $422M | 3.5% | $6.08 | — | CONV BONDS | 45337CAJ1 |
| — | Genomic Health Inc. | 13,656,942 | $417M | 3.5% | $31.71 | — | COM | 37244C101 |
| — | Anacor Pharmaceuticals Inc. | 4,204,702 | $243M | 2.0% | $19.02 | — | COM | 032420101 |
| — | Biomarin Pharmaceuticals Inc. Notes 1.875% 4/23/2017 | 22,379,000 | $137M | 1.1% | $2.76 | — | CONV BONDS | 09061GAD3 |
| — | Invitae Corp. | 6,554,967 | $110M | 0.9% | $16.76 | — | COM | 46185L103 |
| — | Spark Therapeutics, Inc. | 1,327,451 | $103M | 0.9% | $77.50 | — | COM | 84652J103 |
| — | Dyax Corp. | 6,021,485 | $101M | 0.8% | $8.91 | — | COM | 26746E103 |
| — | Bellicum Pharmaceuticals, Inc. | 4,190,594 | $97.1M | 0.8% | $23.04 | — | COM | 079481107 |
| BCRX | Biocryst Pharmaceuticals Inc. | 10,478,204 | $94.62M | 0.8% | $5.72 | +80.9% | COM | 09058V103 |
| — | Gilead Sciences Inc. 1.625% 5/1/16 | 20,944,000 | $90.19M | 0.8% | $2.26 | — | CONV BONDS | 375558AP8 |
| — | Medivation Inc. 2.625% 4/1/17 | 33,889,000 | $84.93M | 0.7% | $1.27 | — | CONV BONDS | 58501NAA9 |
| — | Mirati Therapeutics Inc. | 2,805,074 | $82.25M | 0.7% | $17.51 | — | COM | 60468T105 |
| — | Acorda Therapeutics Inc. Notes 1.75% 6/15/2021 | 59,583,000 | $60.76M | 0.5% | $1.04 | — | CONV BONDS | 00484MAA4 |
| CERS | Cerus Corp. | 13,553,275 | $56.52M | 0.5% | $4.68 | +9.3% | COM | 157085101 |
| — | Versartis Inc. | 2,977,396 | $54.69M | 0.5% | $23.84 | — | COM | 92529L102 |
| — | Xoma Corp. | 14,708,613 | $53.54M | 0.4% | $3.73 | — | COM | 98419J107 |
| — | Xenoport Inc. | 6,508,622 | $46.34M | 0.4% | $5.27 | — | COM | 98411C100 |
| — | Array Biopharma Inc. | 5,658,755 | $41.7M | 0.3% | $6.65 | — | COM | 04269X105 |
| — | Salix Pharmaceuticals Inc. 1.5% 3/15/19 | 14,668,000 | $38.95M | 0.3% | $1.49 | — | CONV BONDS | 795435AE6 |
| HRTX | Heron Therapeutics, Inc. | 2,607,784 | $37.94M | 0.3% | $12.49 | -9.8% | COM | 427746102 |
| — | DBV Technologies Inc. | 1,519,229 | $35.49M | 0.3% | $27.12 | — | SPONSORED ADR | 23306J101 |
| INSM | Insmed Inc. | 1,583,490 | $32.94M | 0.3% | $14.99 | +17.6% | COM | 457669307 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 7,565,462 | $32.76M | 0.3% | $2.58 | +39.7% | COM | 14888U101 |
| HALO | Halozyme Therapeutics Inc. | 2,248,152 | $32.1M | 0.3% | $6.50 | +121.9% | COM | 40637H109 |
| TGTX | TG Therapeutics Inc. | 2,050,313 | $31.74M | 0.3% | $4.61 | +228.8% | COM | 88322Q108 |
| — | Derma Sciences Inc. | 3,457,841 | $29.29M | 0.2% | $12.84 | — | COM | 249827502 |
| — | Progenics Pharmaceuticals, Inc. | 4,350,808 | $26.02M | 0.2% | $4.44 | — | COM | 743187106 |
| — | Idera Pharmaceuticals Inc. | 6,965,432 | $25.84M | 0.2% | $3.05 | — | COM | 45168K306 |
| — | Alder Biopharmaceuticals Inc. | 879,581 | $25.39M | 0.2% | $27.33 | — | COM | 014339105 |
| — | Acorda Therapeutics, Inc. | 738,916 | $24.59M | 0.2% | $37.91 | — | COM | 00484M106 |
| GILD | Gilead Sciences Inc. | 249,995 | $24.53M | 0.2% | $36.21 | +94.8% | COM | 375558103 |
| SGMO | Sangamo Biosciences, Inc. | 1,404,544 | $22.02M | 0.2% | $13.54 | +14.3% | COM | 800677106 |
| NBIX | Neurocrine Biosciences, Inc. | 542,236 | $21.53M | 0.2% | $16.53 | +116.4% | COM | 64125C109 |
| — | Biomarin Pharmaceuticals Inc. Notes 0.75% 10/15/2018 | 12,228,000 | $17.97M | 0.1% | $1.06 | — | CONV BONDS | 09061GAE1 |
| — | Kythera Biopharmaceuticals Inc. | 354,265 | $17.77M | 0.1% | $37.55 | — | COM | 501570105 |
| — | Bluebird Bio Inc. | 146,581 | $17.7M | 0.1% | $25.09 | — | COM | 09609G100 |
| — | Repros Therapeutics Inc. | 2,000,000 | $17.18M | 0.1% | $18.45 | — | COM | 76028H209 |
| — | Foamix Pharmaceuticals Ltd. | 1,821,967 | $16.85M | 0.1% | $7.12 | — | SHS | M46135105 |
| VNDA | Vanda Pharmaceuticals, Inc. | 1,750,230 | $16.28M | 0.1% | $7.51 | +50.4% | COM | 921659108 |
| — | Novavax Inc. | 1,945,687 | $16.09M | 0.1% | $5.05 | — | COM | 670002104 |
| — | Lion Biotechnologies Inc. | 1,325,000 | $16.05M | 0.1% | $12.11 | — | COM | 53619R102 |
| — | Clovis Oncology Inc. | 202,630 | $15.04M | 0.1% | $56.00 | — | COM | 189464100 |
| AGIO | Agios Pharmaceuticals Inc. | 149,954 | $14.14M | 0.1% | $27.47 | +307.9% | COM | 00847X104 |
| OMER | Omeros Corp. | 637,446 | $14.04M | 0.1% | $7.65 | +198.6% | COM | 682143102 |
| XNCR | Xencor Inc. | 872,072 | $13.36M | 0.1% | $11.07 | +42.6% | COM | 98401F105 |
| — | Threshold Pharmaceuticals Inc. | 2,925,519 | $11.88M | 0.1% | $4.38 | — | COM | 885807206 |
| — | Alcobra Ltd. | 1,789,871 | $10.08M | 0.1% | $5.32 | — | SHS | M2239P109 |
| — | Aquinox Pharmaceuticals, Inc. | 1,187,666 | $9.763M | 0.1% | $12.73 | — | COM | 03842B101 |
| MGNX | Macrogenics, Inc. | 305,043 | $9.569M | 0.1% | $22.61 | +49.9% | COM | 556099109 |
| — | Aerie Pharmaceuticals Inc. | 299,356 | $9.382M | 0.1% | $17.96 | — | COM | 00771V108 |
| RARE | Ultragenyx Pharmaceuticals Inc. | 148,894 | $9.245M | 0.1% | $51.09 | +8.7% | COM | 90400D108 |
| — | Immunogen, Inc. | 999,496 | $8.945M | 0.1% | $8.95 | — | COM | 45253H101 |
| — | Osiris Therapeutics Inc. | 499,193 | $8.776M | 0.1% | $16.34 | — | COM | 68827R108 |
| PRQR | ProQR Therapeutics NV | 400,000 | $8.752M | 0.1% | $16.02 | +28.9% | SHS | N71542109 |
| — | Arrowhead Research Corp. | 1,290,187 | $8.728M | 0.1% | $9.76 | — | COM | 042797209 |
| — | Sunesis Pharmaceuticals, Inc. | 3,200,000 | $7.84M | 0.1% | $2.55 | — | COM | 867328601 |
| — | La Jolla Pharmaceuticals, Co. | 412,008 | $7.54M | 0.1% | $10.24 | — | COM | 503459604 |
| — | Concert Pharmaceuticals, Inc. | 495,908 | $7.511M | 0.1% | $10.71 | — | COM | 206022105 |
| — | Celladon Corp | 366,806 | $6.947M | 0.1% | $10.46 | — | COM | 15117E107 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $6.642M | 0.1% | $31.09 | — | COM | 48576U106 |
| — | Juno Therapeutics Inc. | 100,000 | $6.066M | 0.1% | $52.22 | — | COM | 48205A109 |
| — | Foundation Medicine Inc. | 124,255 | $5.978M | 0.0% | $25.16 | — | COM | 350465100 |
| — | Ignyta Inc. | 571,000 | $5.681M | 0.0% | $8.30 | — | COM | 451731103 |
| LGND | Ligand Pharmaceuticals Inc. | 73,386 | $5.659M | 0.0% | $41.68 | -8.1% | COM | 53220K504 |
| — | Transition Therapeutics, Inc. | 769,230 | $5.254M | 0.0% | $6.83 | — | COM | 893716209 |
| — | Amarin Corp. PLC | 2,205,710 | $5.161M | 0.0% | $2.34 | — | SPONSORED ADR | 023111206 |
| — | Stemline Therapeutics Inc. | 333,497 | $4.826M | 0.0% | $23.84 | — | COM | 85858C107 |
| — | Cytrx Corp. | 1,319,989 | $4.448M | 0.0% | $3.49 | — | COM | 232828509 |
| — | Epizyme Inc. | 232,481 | $4.366M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | Chimerix Inc. | 115,216 | $4.342M | 0.0% | $40.26 | — | COM | 16934W106 |
| INFIQ | Infinity Pharmaceuticals Inc. | 305,037 | $4.264M | 0.0% | $13.42 | +13.9% | COM | 45665G303 |
| — | Discovery Laboratories Inc. | 3,569,643 | $4.248M | 0.0% | $1.95 | — | COM | 254668403 |
| — | Receptos Inc. | 23,900 | $3.941M | 0.0% | $19.89 | — | COM | 756207106 |
| — | Sage Therapeutics Inc. | 75,000 | $3.767M | 0.0% | $31.51 | — | COM | 78667J108 |
| — | Array Biopharma, Inc. Notes 3.0% 6/1/2020 | 3,000,000 | $3.759M | 0.0% | $1.25 | — | CONV BONDS | 04269XAA3 |
| — | Zafgen, Inc. | 94,745 | $3.753M | 0.0% | $39.61 | — | COM | 98885E103 |
| — | Isis Pharmaceuticals, Inc. | 57,140 | $3.638M | 0.0% | $26.87 | — | COM | 464330109 |
| — | Lipocine Inc. | 489,175 | $3.375M | 0.0% | $6.10 | — | COM | 53630X104 |
| — | Neuroderm Ltd. | 250,000 | $3.355M | 0.0% | $14.04 | — | ORD SHS | M74231107 |
| — | Assembly Biosciences, Inc. | 250,000 | $3.31M | 0.0% | $13.24 | — | COM | 045396108 |
| — | Bellerophon Therapeutics, Inc. | 350,000 | $3.213M | 0.0% | $9.18 | — | COM | 078771102 |
| — | Tekmira Pharmaceuticals Corp. | 180,582 | $3.153M | 0.0% | $7.97 | — | COM | 87911B209 |
| — | Zogenix, Inc. | 2,298,466 | $3.149M | 0.0% | $2.18 | — | COM | 98978L105 |
| AUPH | Aurinia Pharmaceuticals, Inc. | 711,499 | $3.118M | 0.0% | $3.55 | +11.7% | COM | 05156V102 |
| IRWD | Ironwood Pharmaceuticals Inc. | 169,163 | $2.707M | 0.0% | $11.63 | +12.8% | COM | 46333X108 |
| — | BioDelivery Sciences Intl. Inc. | 255,866 | $2.686M | 0.0% | $5.21 | — | COM | 09060J106 |
| — | Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18 | 3,500,000 | $2.612M | 0.0% | $0.76 | — | CONV BONDS | 74365AAB7 |
| — | Affimed N.V. | 400,000 | $2.52M | 0.0% | $6.30 | — | COM | N01045108 |
| — | Auspex Pharmaceuticals, Inc. | 25,000 | $2.507M | 0.0% | $100.28 | — | COM | 05211J102 |
| — | Intra Cellular Therapies Inc. | 104,166 | $2.487M | 0.0% | $23.88 | — | COM | 46116X101 |
| ENTA | Enanta Pharmaceuticals Inc. | 75,357 | $2.307M | 0.0% | $19.50 | +99.6% | COM | 29251M106 |
| — | Mast Therapeutics, Inc. | 4,707,464 | $2.283M | 0.0% | $0.56 | — | COM | 576314108 |
| — | Vitae Pharmaceuticals Inc. | 187,597 | $2.197M | 0.0% | $11.71 | — | COM | 92847N103 |
| — | Achillion Pharmaceuticals, Inc. | 214,237 | $2.112M | 0.0% | $8.18 | — | COM | 00448Q201 |
| — | Palatin Technologies Inc. | 2,050,000 | $2.091M | 0.0% | $0.73 | — | COM | 696077403 |
| — | Ziopharm Oncology Inc. | 189,259 | $2.038M | 0.0% | $2.11 | — | COM | 98973P101 |
| — | Proteon Therapeutics, Inc. | 172,917 | $2.011M | 0.0% | $10.40 | — | COM | 74371L109 |
| — | Biota Pharmaceuticals Inc. | 863,184 | $1.985M | 0.0% | $4.19 | — | COM | 090694100 |
| — | Marinus Pharmaceuticals Inc. | 200,000 | $1.798M | 0.0% | $6.47 | — | COM | 56854Q101 |
| ASND | Ascendis Pharma SA | 100,000 | $1.735M | 0.0% | $17.35 | — | SPONSORED ADR | 04351P101 |
| CLLS | Cellectis SA | 50,000 | $1.729M | 0.0% | $34.58 | — | SPONSORED ADR | 15117K103 |
| — | Ophthotech Corp. | 35,649 | $1.659M | 0.0% | $32.35 | — | COM | 683745103 |
| — | Mediwound Ltd. | 225,000 | $1.629M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | Dermira Inc. | 100,000 | $1.535M | 0.0% | $18.11 | — | COM | 24983L104 |
| OSUR | Orasure Technologies Inc. | 229,397 | $1.5M | 0.0% | $4.46 | +86.2% | COM | 68554V108 |
| ALDX | Aldeyra Therapeutics, Inc. | 142,000 | $1.446M | 0.0% | $10.20 | 0.0% | COM | 01438T106 |
| — | Rigel Pharmaceuticals Inc. | 357,187 | $1.275M | 0.0% | $3.58 | — | COM | 766559603 |
| — | Loxo Oncology Inc. | 100,000 | $1.245M | 0.0% | $13.13 | — | COM | 548862101 |
| ALNY | Alnylam Pharmaceuticals, Inc. | 11,340 | $1.184M | 0.0% | $77.42 | +30.9% | COM | 02043Q107 |
| — | Acceleron Pharma Inc. | 28,765 | $1.095M | 0.0% | $39.60 | — | COM | 00434H108 |
| — | Achaogen Inc. | 100,000 | $976K | 0.0% | $15.46 | — | COM | 004449104 |
| — | Synta Pharmaceuticals Corp. | 489,053 | $949K | 0.0% | $4.99 | — | COM | 87162T206 |
| — | Ohr Pharmaceuticals, Inc. | 370,370 | $941K | 0.0% | $2.54 | — | COM | 67778H200 |
| QURE | UniQure N.V. | 30,000 | $730K | 0.0% | $15.95 | +36.8% | SHS | N90064101 |
| — | Five Prime Therapeutics Inc. | 19,247 | $440K | 0.0% | $16.80 | — | COM | 33830X104 |
| — | Aegerion Pharmaceuticals, Inc. | 14,300 | $374K | 0.0% | $26.15 | — | COM | 00767E102 |
| — | Chemocentryx Inc. | 49,064 | $370K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | Aptose Biosciences, Inc. | 33,397 | $181K | 0.0% | $5.91 | — | COM | 03835T200 |
| — | Cyclacel Pharmaceuticals Inc. | 13,253 | $86,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | Biotime Inc. | 20,084 | $40,000 | 0.0% | $1.07 | — | WARRANTS | 09066L162 |
| — | Biodel Inc. | 30,179 | $36,000 | 0.0% | $1.19 | — | COM | 09064M204 |