CIK: 0001055951 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: Feb 14, 2022
Total Value ($000): $7,778,455 (99.3% shares, 0.7% debt)
| Ticker | Issuer | Shares | Value ($000) | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | SPRINGWORKS THERAPEUTICS INC | 6,028,307 | $373,634 | 4.8% | $21.68 | — | COM | 85205L107 |
| BMY | BRISTOL-MYERS SQUIBB CO | 4,339,800 | $270,587 | 3.5% | $47.77 | +3.1% | COM | 110122108 |
| — | HORIZON THERAPEUTICS PUB L | 2,500,055 | $269,406 | 3.5% | $42.12 | — | SHS | G46188101 |
| BSX | BOSTON SCIENTIFIC CORP | 5,552,300 | $235,862 | 3.0% | $25.28 | +66.2% | COM | 101137107 |
| — | THESEUS PHARMACEUTICALS INC | 16,838,668 | $213,514 | 2.7% | $12.68 | — | COM | 88369M101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 13,944,680 | $213,075 | 2.7% | $32.43 | -44.5% | COM | 28036F105 |
| — | MIRATI THERAPEUTICS INC | 1,426,400 | $209,239 | 2.7% | $118.63 | — | COM | 60468T105 |
| PMVP | PMV PHARMACEUTICALS INC | 7,330,423 | $169,333 | 2.2% | $36.80 | -34.3% | COM | 69353Y103 |
| PFE | PFIZER INC | 2,615,400 | $154,439 | 2.0% | $40.23 | 0.0% | COM | 717081103 |
| — | IKENA ONCOLOGY INC | 11,895,652 | $148,660 | 1.9% | $35.45 | — | NONVOTING | 000000000 |
| HUM | HUMANA INC | 318,300 | $147,647 | 1.9% | $302.53 | +40.4% | COM | 444859102 |
| ABBV | ABBVIE INC | 1,068,800 | $144,716 | 1.9% | $81.40 | +24.9% | COM | 00287Y109 |
| VRTX | VERTEX PHARMACEUTICALS INC | 658,100 | $144,519 | 1.9% | $151.18 | +28.6% | COM | 92532F100 |
| EW | EDWARDS LIFESCIENCES CORP | 1,076,200 | $139,422 | 1.8% | $72.41 | +61.1% | COM | 28176E108 |
| MRK | MERCK & CO INC | 1,779,300 | $136,366 | 1.8% | $52.98 | +31.9% | COM | 58933Y105 |
| UNH | UNITEDHEALTH GROUP INC | 271,000 | $136,080 | 1.7% | $308.55 | +36.8% | COM | 91324P102 |
| ISRG | INTUITIVE SURGICAL INC | 373,800 | $134,306 | 1.7% | $276.66 | +24.4% | COM NEW | 46120E602 |
| NTRA | NATERA INC | 1,413,985 | $132,052 | 1.7% | $26.94 | +285.3% | COM | 632307104 |
| — | ADICET BIO INC | 7,447,141 | $130,250 | 1.7% | $12.13 | — | COM | 007002108 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $125,972 | 1.6% | $26.32 | -24.4% | COM | 03969K108 |
| PRLD | PRELUDE THERAPEUTICS INC | 10,039,691 | $124,994 | 1.6% | $28.24 | -42.4% | COM | 74065P101 |
| SYK | STRYKER CORPORATION | 465,300 | $124,431 | 1.6% | $211.90 | +18.5% | COM | 863667101 |
| GH | GUARDANT HEALTH INC | 1,227,400 | $122,765 | 1.6% | $128.96 | -19.8% | COM | 40131M109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 6,337,700 | $120,987 | 1.6% | $10.72 | +105.3% | COM | 462260100 |
| XBI | SPDR SER TR | 1,009,700 | $113,046 | 1.5% | $134.22 | — | S&P BIOTECH | 78464A870 |
| — | SEAGEN INC | 655,600 | $101,356 | 1.3% | $160.81 | — | COM | 81181C104 |
| — | TURNING POINT THERAPEUTICS I | 2,106,450 | $100,478 | 1.3% | $40.50 | — | COM | 90041T108 |
| HCA | HCA HEALTHCARE INC | 389,500 | $100,070 | 1.3% | $235.68 | +0.1% | COM | 40412C101 |
| — | TRICIDA INC | 10,280,947 | $98,286 | 1.3% | $28.76 | — | COM | 89610F101 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $98,263 | 1.3% | $30.81 | +61.9% | COM | 492327101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,196,876 | $90,823 | 1.2% | $25.44 | -3.1% | COM | 22663K107 |
| MGTX | MEIRAGTX HLDGS PLC | 3,727,466 | $88,490 | 1.1% | $15.88 | +20.5% | COM | G59665102 |
| DXCM | DEXCOM INC | 152,900 | $82,100 | 1.1% | $53.97 | +166.2% | COM | 252131107 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 931,915 | $79,371 | 1.0% | $91.36 | +0.7% | COM | 64125C109 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 860,880 | $76,059 | 1.0% | $82.05 | +0.6% | COM | 09061G101 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $72,700 | 0.9% | $4.60 | +40.7% | SHS | P8696W104 |
| ZBH | ZIMMER BIOMET HOLDINGS INC | 564,300 | $71,689 | 0.9% | $141.64 | -10.9% | COM | 98956P102 |
| — | REPARE THERAPEUTICS INC | 3,322,488 | $70,071 | 0.9% | $31.02 | — | COM | 760273102 |
| CMPX | COMPASS THERAPEUTICS INC | 21,642,975 | $68,608 | 0.9% | $3.29 | 0.0% | COM | 20454B104 |
| — | KINNATE BIOPHARMA INC | 3,847,929 | $68,185 | 0.9% | $39.78 | — | COM | 49705R105 |
| TBPH | THERAVANCE BIOPHARMA INC | 5,974,535 | $66,019 | 0.8% | $19.08 | -54.3% | COM | G8807B106 |
| TMO | THERMO FISHER SCIENTIFIC INC | 94,700 | $63,188 | 0.8% | $149.40 | +313.1% | COM | 883556102 |
| ABCL | ABCELLERA BIOLOGICS INC | 4,180,768 | $59,785 | 0.8% | $45.73 | -66.8% | COM | 00288U106 |
| SPRY | SILVERBACK THERAPEUTICS INC | 8,740,887 | $58,214 | 0.7% | $33.40 | -75.7% | COM | 82835W108 |
| — | ALPINE IMMUNE SCIENCES INC | 4,081,592 | $56,530 | 0.7% | $11.01 | — | COM | 02083G100 |
| JANX | JANUX THERAPEUTICS INC | 2,836,386 | $55,962 | 0.7% | $22.27 | -5.9% | COM | 47103J105 |
| BIIB | BIOGEN INC | 230,200 | $55,230 | 0.7% | $319.64 | -19.6% | COM | 09062X103 |
| SIBN | SI-BONE INC | 2,305,300 | $51,201 | 0.7% | $21.28 | +1.2% | COM | 825704109 |
| — | 89BIO INC | 3,729,442 | $48,744 | 0.6% | $26.29 | — | COM | 282559103 |
| — | GRACELL BIOTECHNOLOGIES INC | 7,884,870 | $47,625 | 0.6% | $15.40 | — | SPONSORED ADS | 38406L103 |
| — | PASSAGE BIO INC | 6,962,899 | $44,214 | 0.6% | $15.75 | — | COM | 702712100 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 1,981,300 | $43,371 | 0.6% | $18.30 | +1.0% | COM | 87164F105 |
| — | OAK STR HEALTH INC | 1,290,300 | $42,761 | 0.5% | $55.82 | — | COM | 67181A107 |
| XTNT | XTANT MED HLDGS INC | 72,873,494 | $40,809 | 0.5% | $1.96 | -51.9% | COM NEW | 98420P308 |
| NPCE | NEUROPACE INC | 4,012,281 | $40,444 | 0.5% | $23.21 | -44.0% | COM | 641288105 |
| GLPG | GALAPAGOS NV | 717,257 | $39,542 | 0.5% | $60.42 | — | SPON ADR | 36315X101 |
| TELA | TELA BIO INC | 3,027,542 | $38,753 | 0.5% | $12.23 | +3.6% | COM | 872381108 |
| — | VERONA PHARMA PLC | 5,694,841 | $38,269 | 0.5% | $7.45 | — | SPONSORED ADS | 925050106 |
| — | IKENA ONCOLOGY INC | 2,933,941 | $36,792 | 0.5% | $28.25 | — | COM | 45175G108 |
| SEM | SELECT MED HLDGS CORP | 1,233,600 | $36,268 | 0.5% | $19.14 | -17.2% | COM | 81619Q105 |
| IVVD | ADAGIO THERAPEUTICS INC | 4,983,500 | $36,180 | 0.5% | $37.11 | -29.9% | COM | 00534A102 |
| ORIC | ORIC PHARMACEUTICALS INC | 2,337,574 | $34,362 | 0.4% | $31.92 | -51.1% | COM | 68622P109 |
| — | NANOSTRING TECHNOLOGIES INC | 807,100 | $34,084 | 0.4% | $37.75 | — | COM | 63009R109 |
| GHRS | GH RESEARCH PLC | 1,428,732 | $33,332 | 0.4% | $20.43 | +7.6% | ORDINARY SHARES | G3855L106 |
| — | SIERRA ONCOLOGY INC | 1,477,320 | $32,117 | 0.4% | $9.82 | — | COM NEW | 82640U404 |
| CTKB | CYTEK BIOSCIENCES INC | 1,923,139 | $31,386 | 0.4% | $23.52 | -11.0% | COM | 23285D109 |
| — | IMMUNOGEN INC | 3,868,786 | $28,706 | 0.4% | $7.11 | — | COM | 45253H101 |
| MREO | MEREO BIOPHARMA GROUP PLC | 17,264,764 | $27,624 | 0.4% | $3.54 | — | ADS | 589492107 |
| TERN | TERNS PHARMACEUTICALS INC | 3,791,204 | $26,804 | 0.3% | $21.92 | -62.0% | COM | 880881107 |
| PCVX | VAXCYTE INC | 1,096,700 | $26,090 | 0.3% | $27.73 | -16.1% | COM | 92243G108 |
| ERAS | ERASCA INC | 1,667,693 | $25,983 | 0.3% | $20.63 | -17.0% | COM | 29479A108 |
| EVH | EVOLENT HEALTH INC | 938,000 | $25,954 | 0.3% | $26.97 | +6.4% | CL A | 30050B101 |
| — | VECTIVBIO HLDG AG | 5,223,804 | $25,649 | 0.3% | $11.53 | — | ORD SHS | H9060V101 |
| VTYX | VENTYX BIOSCIENCES INC | 1,289,280 | $25,605 | 0.3% | $18.95 | 0.0% | COM | 92332V107 |
| — | VISTAGEN THERAPEUTICS INC | 12,909,283 | $25,173 | 0.3% | $2.44 | — | COM NEW | 92840H202 |
| THC | TENET HEALTHCARE CORP | 299,000 | $24,425 | 0.3% | $70.93 | +3.0% | COM NEW | 88033G407 |
| — | SINGULAR GENOMICS SYSTEMS IN | 2,104,359 | $24,326 | 0.3% | $26.68 | — | COM | 82933R100 |
| — | SCPHARMACEUTICALS INC | 4,797,148 | $24,082 | 0.3% | $10.72 | — | COM | 810648105 |
| — | JOUNCE THERAPEUTICS INC | 2,859,900 | $23,880 | 0.3% | $9.24 | — | COM | 481116101 |
| — | CHINOOK THERAPEUTICS INC | 1,418,300 | $23,132 | 0.3% | $15.57 | — | COM | 16961L106 |
| — | DECIBEL THERAPEUTICS INC | 4,945,192 | $22,995 | 0.3% | $11.36 | — | COM | 24343R106 |
| — | HARPOON THERAPEUTICS INC | 2,903,508 | $21,921 | 0.3% | $11.54 | — | COM | 41358P106 |
| GILD | GILEAD SCIENCES INC | 287,600 | $20,883 | 0.3% | $53.85 | +9.2% | COM | 375558103 |
| — | APPLIED THERAPEUTICS INC | 2,313,681 | $20,707 | 0.3% | $24.32 | — | COM | 03828A101 |
| XENE | XENON PHARMACEUTICALS INC | 631,000 | $19,712 | 0.3% | $16.42 | +81.9% | COM | 98420N105 |
| — | LOGICBIO THERAPEUTICS INC | 8,466,783 | $19,558 | 0.3% | $9.75 | — | COM | 54142F102 |
| — | GRAPHITE BIO INC | 1,565,812 | $19,463 | 0.3% | $26.23 | — | COM | 38870X104 |
| — | MERSANA THERAPEUTICS INC | 2,888,847 | $17,969 | 0.2% | $13.67 | — | COM | 59045L106 |
| — | CHEMOMAB THERAPEUTICS LTD | 2,578,174 | $17,789 | 0.2% | $28.71 | — | SPONSORED ADS | 16385C104 |
| — | DANAHER CORPORATION | 10,000 | $17,382 | 0.2% | $1738.20 | — | 5% CONV PFD B | 235851409 |
| — | CURIS INC | 3,634,800 | $17,302 | 0.2% | $6.43 | — | COM NEW | 231269200 |
| ILMN | ILLUMINA INC | 45,100 | $17,158 | 0.2% | $378.89 | 0.0% | COM | 452327109 |
| — | GEMINI THERAPEUTICS INC | 5,826,224 | $16,954 | 0.2% | $13.55 | — | COM | 36870G105 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,583,821 | $16,924 | 0.2% | $6.79 | -11.8% | COM | 59935V107 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,943,654 | $16,734 | 0.2% | $11.24 | -65.5% | COM | 221015100 |
| — | NEXTCURE INC | 2,711,013 | $16,266 | 0.2% | $14.98 | — | COM | 65343E108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 406,100 | $15,692 | 0.2% | $46.92 | -7.1% | COM NEW | 15117B202 |
| RXST | RXSIGHT INC | 1,383,500 | $15,564 | 0.2% | $13.60 | -11.6% | COM | 78349D107 |
| LAB | FLUIDIGM CORP DEL | 3,819,348 | $14,972 | 0.2% | $4.51 | +3.8% | COM | 34385P108 |
| — | SYNLOGIC INC | 6,029,995 | $14,593 | 0.2% | $7.51 | — | COM | 87166L100 |
| ACRS | ACLARIS THERAPEUTICS INC | 985,900 | $14,335 | 0.2% | $18.19 | -16.7% | COM | 00461U105 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,956,124 | $14,042 | 0.2% | $7.60 | — | COM | 00773J103 |
| LUNG | PULMONX CORP | 435,000 | $13,950 | 0.2% | $42.11 | -13.3% | COM | 745848101 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,214,509 | $13,919 | 0.2% | $6.72 | -12.8% | COM | 23284F105 |
| — | BURNING ROCK BIOTECH LTD | 1,452,402 | $13,841 | 0.2% | $27.01 | — | SPONSORED ADS | 12233L107 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $13,447 | 0.2% | $17.47 | — | COM | 36118A100 |
| AMGN | AMGEN INC | 57,100 | $12,846 | 0.2% | $99.69 | +85.7% | COM | 031162100 |
| — | CYBIN INC | 10,524,300 | $12,481 | 0.2% | $2.19 | — | COM | 23256X100 |
| CGEM | CULLINAN ONCOLOGY INC | 805,041 | $12,422 | 0.2% | $40.60 | -50.9% | COM | 230031106 |
| — | GALECTO INC | 4,090,937 | $12,396 | 0.2% | $12.51 | — | COM | 36322Q107 |
| QURE | UNIQURE NV | 585,574 | $12,145 | 0.2% | $55.64 | -48.5% | SHS | N90064101 |
| — | BELLUS HEALTH INC NEW | 1,454,800 | $11,698 | 0.2% | $6.42 | — | COM NEW | 07987C204 |
| — | SONENDO INC | 1,968,180 | $11,337 | 0.1% | $5.76 | — | COM | 835431107 |
| — | 9 METERS BIOPHARMA INC | 10,275,887 | $10,057 | 0.1% | $0.64 | — | COM | 654405109 |
| — | MAGENTA THERAPEUTICS INC | 2,250,953 | $9,972 | 0.1% | $9.74 | — | COM | 55910K108 |
| — | PROMETHEUS BIOSCIENCES INC | 250,000 | $9,885 | 0.1% | $18.26 | — | COM | 74349U108 |
| — | IMARA INC | 4,386,568 | $9,870 | 0.1% | $11.49 | — | COM | 45249V107 |
| — | VOR BIOPHARMA INC | 833,333 | $9,683 | 0.1% | $43.10 | — | COM | 929033108 |
| AFIB | ACUTUS MED INC | 2,648,386 | $9,031 | 0.1% | $30.36 | -81.4% | COM | 005111109 |
| CVRX | CVRX INC | 723,055 | $8,843 | 0.1% | $23.59 | -38.5% | COM | 126638105 |
| — | RAPT THERAPEUTICS INC | 217,000 | $7,970 | 0.1% | $36.73 | — | COM | 75382E109 |
| — | ACHILLES THERAPEUTICS PLC | 1,584,845 | $7,940 | 0.1% | $16.55 | — | SPONSORED ADS | 00449L102 |
| GOSS | GOSSAMER BIO INC | 683,000 | $7,725 | 0.1% | $11.88 | 0.0% | COM | 38341P102 |
| — | GRAYBUG VISION INC | 4,163,347 | $7,619 | 0.1% | $12.71 | — | COM SHS | 38942Q103 |
| — | ONCOCYTE CORP | 3,493,800 | $7,582 | 0.1% | $4.29 | — | COM | 68235C107 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 1,452,774 | $7,525 | 0.1% | $10.83 | -50.6% | COM | 63909J108 |
| — | NANOSTRING TECHNOLOGIES INC | 6,000,000 | $7,172 | 0.1% | $1.62 | — | NOTE 2.625% 3/0 | 63009RAD1 |
| — | AEROVATE THERAPEUTICS INC | 535,714 | $6,316 | 0.1% | $22.83 | — | COM | 008064107 |
| NTLA | INTELLIA THERAPEUTICS INC | 53,200 | $6,290 | 0.1% | $151.40 | -17.3% | COM | 45826J105 |
| — | SYROS PHARMACEUTICALS INC | 1,837,500 | $5,990 | 0.1% | $10.35 | — | COM | 87184Q107 |
| TARA | PROTARA THERAPEUTICS INC | 830,641 | $5,607 | 0.1% | $15.72 | -56.1% | COM STK | 74365U107 |
| NRIX | NURIX THERAPEUTICS INC | 184,468 | $5,340 | 0.1% | $27.93 | +8.6% | COM | 67080M103 |
| SRPT | SAREPTA THERAPEUTICS INC | 58,700 | $5,286 | 0.1% | $105.48 | -19.0% | COM | 803607100 |
| NBP | I MAB | 111,120 | $5,266 | 0.1% | $77.79 | — | SPONSORED ADS | 44975P103 |
| — | HEALTH SCIENCES ACQ CORP 2 | 500,000 | $5,040 | 0.1% | $11.00 | — | ORD SHS | G4411D109 |
| IPSC | CENTURY THERAPEUTICS INC | 307,047 | $4,870 | 0.1% | $25.37 | -26.0% | COM | 15673T100 |
| — | BIOMX INC | 2,813,489 | $4,502 | 0.1% | $8.51 | — | COM | 09090D103 |
| ALXO | ALX ONCOLOGY HLDGS INC | 207,600 | $4,461 | 0.1% | $55.43 | -22.2% | COM | 00166B105 |
| IFRX | INFLARX NV | 875,297 | $4,166 | 0.1% | $4.38 | -8.2% | COM | N44821101 |
| — | TALARIS THERAPEUTICS INC | 247,240 | $3,780 | 0.0% | $14.69 | — | COM | 87410C104 |
| — | FIELD TRIP HEALTH LTD | 1,538,470 | $3,722 | 0.0% | $4.55 | — | COM | 31656R102 |
| — | INOZYME PHARMA INC | 526,600 | $3,591 | 0.0% | $11.44 | — | COM | 45790W108 |
| SGHT | SIGHT SCIENCES INC | 200,000 | $3,514 | 0.0% | $32.87 | -33.3% | COM | 82657M105 |
| — | X4 PHARMACEUTICALS INC | 1,373,849 | $3,146 | 0.0% | $13.74 | — | COM | 98420X103 |
| WHWK | AADI BIOSCIENCE INC | 127,600 | $3,082 | 0.0% | $30.48 | -17.6% | COM | 00032Q104 |
| — | EXSCIENTIA PLC | 125,000 | $2,470 | 0.0% | $19.76 | — | ADS | 30223G102 |
| — | SURFACE ONCOLOGY INC | 467,945 | $2,237 | 0.0% | $7.57 | — | COM | 86877M209 |
| — | ASLAN PHARMACEUTICALS LTD | 1,970,000 | $2,206 | 0.0% | $3.35 | — | ADS | 04522R101 |
| — | BRIGHT MINDS BIOSCIENCES INC | 660,600 | $2,131 | 0.0% | $3.23 | — | COM | 10919W108 |
| ADAG | ADAGENE INC | 263,176 | $2,123 | 0.0% | $17.95 | — | ADS | 005329107 |
| — | APTINYX INC | 749,500 | $2,001 | 0.0% | $2.60 | — | COM | 03836N103 |
| — | CATALYST BIOSCIENCES INC | 1,729,402 | $1,581 | 0.0% | $4.84 | — | COM NEW | 14888D208 |
| PYXS | PYXIS ONCOLOGY INC | 143,640 | $1,576 | 0.0% | $11.45 | 0.0% | COMMON STOCK | 747324101 |
| — | LANDOS BIOPHARMA INC | 283,217 | $1,359 | 0.0% | $9.63 | — | COM | 515069102 |
| CABA | CABALETTA BIO INC | 302,509 | $1,147 | 0.0% | $9.22 | +15.7% | COM | 12674W109 |
| — | LONGBOARD PHARMACEUTICALS IN | 113,500 | $554 | 0.0% | $16.38 | — | COM | 54300N103 |
| — | AUGMEDIX INC | 88,363 | $278 | 0.0% | $3.15 | — | COM | 05105P107 |
| OWLTW | OWLET INC | 220,704 | $86 | 0.0% | $0.39 | — | *W EXP 09/14/202 | 69120X115 |