Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: Feb 14, 2022
Total Value: $7.778B (99.3% shares, 0.7% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | SPRINGWORKS THERAPEUTICS INC | 6,028,307 | $374M | 4.8% | — | — | COM | 85205L107 |
| BMY | BRISTOL-MYERS SQUIBB CO | 4,339,800 | $271M | 3.5% | — | — | COM | 110122108 |
| — | HORIZON THERAPEUTICS PUB L | 2,500,055 | $269M | 3.5% | — | — | SHS | G46188101 |
| BSX | BOSTON SCIENTIFIC CORP | 5,552,300 | $236M | 3.0% | — | — | COM | 101137107 |
| — | THESEUS PHARMACEUTICALS INC | 16,838,668 | $214M | 2.7% | — | — | COM | 88369M101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 13,944,680 | $213M | 2.7% | — | — | COM | 28036F105 |
| — | MIRATI THERAPEUTICS INC | 1,426,400 | $209M | 2.7% | — | — | COM | 60468T105 |
| PMVP | PMV PHARMACEUTICALS INC | 7,330,423 | $169M | 2.2% | — | — | COM | 69353Y103 |
| PFE | PFIZER INC | 2,615,400 | $154M | 2.0% | — | — | COM | 717081103 |
| — | IKENA ONCOLOGY INC | 11,895,652 | $149M | 1.9% | — | — | NONVOTING | 000000000 |
| HUM | HUMANA INC | 318,300 | $148M | 1.9% | — | — | COM | 444859102 |
| ABBV | ABBVIE INC | 1,068,800 | $145M | 1.9% | — | — | COM | 00287Y109 |
| VRTX | VERTEX PHARMACEUTICALS INC | 658,100 | $145M | 1.9% | — | — | COM | 92532F100 |
| EW | EDWARDS LIFESCIENCES CORP | 1,076,200 | $139M | 1.8% | — | — | COM | 28176E108 |
| MRK | MERCK & CO INC | 1,779,300 | $136M | 1.8% | — | — | COM | 58933Y105 |
| UNH | UNITEDHEALTH GROUP INC | 271,000 | $136M | 1.7% | — | — | COM | 91324P102 |
| ISRG | INTUITIVE SURGICAL INC | 373,800 | $134M | 1.7% | — | — | COM NEW | 46120E602 |
| NTRA | NATERA INC | 1,413,985 | $132M | 1.7% | — | — | COM | 632307104 |
| — | ADICET BIO INC | 7,447,141 | $130M | 1.7% | — | — | COM | 007002108 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $126M | 1.6% | — | — | COM | 03969K108 |
| PRLD | PRELUDE THERAPEUTICS INC | 10,039,691 | $125M | 1.6% | — | — | COM | 74065P101 |
| SYK | STRYKER CORPORATION | 465,300 | $124M | 1.6% | — | — | COM | 863667101 |
| GH | GUARDANT HEALTH INC | 1,227,400 | $123M | 1.6% | — | — | COM | 40131M109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 6,337,700 | $121M | 1.6% | — | — | COM | 462260100 |
| XBI | SPDR SER TR | 1,009,700 | $113M | 1.5% | — | — | S&P BIOTECH | 78464A870 |
| — | SEAGEN INC | 655,600 | $101M | 1.3% | — | — | COM | 81181C104 |
| — | TURNING POINT THERAPEUTICS I | 2,106,450 | $100M | 1.3% | — | — | COM | 90041T108 |
| HCA | HCA HEALTHCARE INC | 389,500 | $100M | 1.3% | — | — | COM | 40412C101 |
| — | TRICIDA INC | 10,280,947 | $98.29M | 1.3% | — | — | COM | 89610F101 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $98.26M | 1.3% | — | — | COM | 492327101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,196,876 | $90.82M | 1.2% | — | — | COM | 22663K107 |
| MGTX | MEIRAGTX HLDGS PLC | 3,727,466 | $88.49M | 1.1% | — | — | COM | G59665102 |
| DXCM | DEXCOM INC | 152,900 | $82.1M | 1.1% | — | — | COM | 252131107 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 931,915 | $79.37M | 1.0% | — | — | COM | 64125C109 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 860,880 | $76.06M | 1.0% | — | — | COM | 09061G101 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $72.7M | 0.9% | — | — | SHS | P8696W104 |
| ZBH | ZIMMER BIOMET HOLDINGS INC | 564,300 | $71.69M | 0.9% | — | — | COM | 98956P102 |
| — | REPARE THERAPEUTICS INC | 3,322,488 | $70.07M | 0.9% | — | — | COM | 760273102 |
| CMPX | COMPASS THERAPEUTICS INC | 21,642,975 | $68.61M | 0.9% | — | — | COM | 20454B104 |
| — | KINNATE BIOPHARMA INC | 3,847,929 | $68.19M | 0.9% | — | — | COM | 49705R105 |
| TBPH | THERAVANCE BIOPHARMA INC | 5,974,535 | $66.02M | 0.8% | — | — | COM | G8807B106 |
| TMO | THERMO FISHER SCIENTIFIC INC | 94,700 | $63.19M | 0.8% | — | — | COM | 883556102 |
| ABCL | ABCELLERA BIOLOGICS INC | 4,180,768 | $59.78M | 0.8% | — | — | COM | 00288U106 |
| SPRY | SILVERBACK THERAPEUTICS INC | 8,740,887 | $58.21M | 0.7% | — | — | COM | 82835W108 |
| — | ALPINE IMMUNE SCIENCES INC | 4,081,592 | $56.53M | 0.7% | — | — | COM | 02083G100 |
| JANX | JANUX THERAPEUTICS INC | 2,836,386 | $55.96M | 0.7% | — | — | COM | 47103J105 |
| BIIB | BIOGEN INC | 230,200 | $55.23M | 0.7% | — | — | COM | 09062X103 |
| SIBN | SI-BONE INC | 2,305,300 | $51.2M | 0.7% | — | — | COM | 825704109 |
| — | 89BIO INC | 3,729,442 | $48.74M | 0.6% | — | — | COM | 282559103 |
| — | GRACELL BIOTECHNOLOGIES INC | 7,884,870 | $47.63M | 0.6% | — | — | SPONSORED ADS | 38406L103 |
| — | PASSAGE BIO INC | 6,962,899 | $44.21M | 0.6% | — | — | COM | 702712100 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 1,981,300 | $43.37M | 0.6% | — | — | COM | 87164F105 |
| — | OAK STR HEALTH INC | 1,290,300 | $42.76M | 0.5% | — | — | COM | 67181A107 |
| XTNT | XTANT MED HLDGS INC | 72,873,494 | $40.81M | 0.5% | — | — | COM NEW | 98420P308 |
| NPCE | NEUROPACE INC | 4,012,281 | $40.44M | 0.5% | — | — | COM | 641288105 |
| GLPG | GALAPAGOS NV | 717,257 | $39.54M | 0.5% | — | — | SPON ADR | 36315X101 |
| TELA | TELA BIO INC | 3,027,542 | $38.75M | 0.5% | — | — | COM | 872381108 |
| — | VERONA PHARMA PLC | 5,694,841 | $38.27M | 0.5% | — | — | SPONSORED ADS | 925050106 |
| — | IKENA ONCOLOGY INC | 2,933,941 | $36.79M | 0.5% | — | — | COM | 45175G108 |
| SEM | SELECT MED HLDGS CORP | 1,233,600 | $36.27M | 0.5% | — | — | COM | 81619Q105 |
| IVVD | ADAGIO THERAPEUTICS INC | 4,983,500 | $36.18M | 0.5% | — | — | COM | 00534A102 |
| ORIC | ORIC PHARMACEUTICALS INC | 2,337,574 | $34.36M | 0.4% | — | — | COM | 68622P109 |
| — | NANOSTRING TECHNOLOGIES INC | 807,100 | $34.08M | 0.4% | — | — | COM | 63009R109 |
| GHRS | GH RESEARCH PLC | 1,428,732 | $33.33M | 0.4% | — | — | ORDINARY SHARES | G3855L106 |
| — | SIERRA ONCOLOGY INC | 1,477,320 | $32.12M | 0.4% | — | — | COM NEW | 82640U404 |
| CTKB | CYTEK BIOSCIENCES INC | 1,923,139 | $31.39M | 0.4% | — | — | COM | 23285D109 |
| — | IMMUNOGEN INC | 3,868,786 | $28.71M | 0.4% | — | — | COM | 45253H101 |
| MREO | MEREO BIOPHARMA GROUP PLC | 17,264,764 | $27.62M | 0.4% | — | — | ADS | 589492107 |
| TERN | TERNS PHARMACEUTICALS INC | 3,791,204 | $26.8M | 0.3% | — | — | COM | 880881107 |
| PCVX | VAXCYTE INC | 1,096,700 | $26.09M | 0.3% | — | — | COM | 92243G108 |
| ERAS | ERASCA INC | 1,667,693 | $25.98M | 0.3% | — | — | COM | 29479A108 |
| EVH | EVOLENT HEALTH INC | 938,000 | $25.95M | 0.3% | — | — | CL A | 30050B101 |
| — | VECTIVBIO HLDG AG | 5,223,804 | $25.65M | 0.3% | — | — | ORD SHS | H9060V101 |
| VTYX | VENTYX BIOSCIENCES INC | 1,289,280 | $25.61M | 0.3% | — | — | COM | 92332V107 |
| — | VISTAGEN THERAPEUTICS INC | 12,909,283 | $25.17M | 0.3% | — | — | COM NEW | 92840H202 |
| THC | TENET HEALTHCARE CORP | 299,000 | $24.43M | 0.3% | — | — | COM NEW | 88033G407 |
| — | SINGULAR GENOMICS SYSTEMS IN | 2,104,359 | $24.33M | 0.3% | — | — | COM | 82933R100 |
| — | SCPHARMACEUTICALS INC | 4,797,148 | $24.08M | 0.3% | — | — | COM | 810648105 |
| — | JOUNCE THERAPEUTICS INC | 2,859,900 | $23.88M | 0.3% | — | — | COM | 481116101 |
| — | CHINOOK THERAPEUTICS INC | 1,418,300 | $23.13M | 0.3% | — | — | COM | 16961L106 |
| — | DECIBEL THERAPEUTICS INC | 4,945,192 | $23M | 0.3% | — | — | COM | 24343R106 |
| — | HARPOON THERAPEUTICS INC | 2,903,508 | $21.92M | 0.3% | — | — | COM | 41358P106 |
| GILD | GILEAD SCIENCES INC | 287,600 | $20.88M | 0.3% | — | — | COM | 375558103 |
| — | APPLIED THERAPEUTICS INC | 2,313,681 | $20.71M | 0.3% | — | — | COM | 03828A101 |
| XENE | XENON PHARMACEUTICALS INC | 631,000 | $19.71M | 0.3% | — | — | COM | 98420N105 |
| — | LOGICBIO THERAPEUTICS INC | 8,466,783 | $19.56M | 0.3% | — | — | COM | 54142F102 |
| — | GRAPHITE BIO INC | 1,565,812 | $19.46M | 0.3% | — | — | COM | 38870X104 |
| — | MERSANA THERAPEUTICS INC | 2,888,847 | $17.97M | 0.2% | — | — | COM | 59045L106 |
| — | CHEMOMAB THERAPEUTICS LTD | 2,578,174 | $17.79M | 0.2% | — | — | SPONSORED ADS | 16385C104 |
| — | DANAHER CORPORATION | 10,000 | $17.38M | 0.2% | — | — | 5% CONV PFD B | 235851409 |
| — | CURIS INC | 3,634,800 | $17.3M | 0.2% | — | — | COM NEW | 231269200 |
| ILMN | ILLUMINA INC | 45,100 | $17.16M | 0.2% | — | — | COM | 452327109 |
| — | GEMINI THERAPEUTICS INC | 5,826,224 | $16.95M | 0.2% | — | — | COM | 36870G105 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,583,821 | $16.92M | 0.2% | — | — | COM | 59935V107 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,943,654 | $16.73M | 0.2% | — | — | COM | 221015100 |
| — | NEXTCURE INC | 2,711,013 | $16.27M | 0.2% | — | — | COM | 65343E108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 406,100 | $15.69M | 0.2% | — | — | COM NEW | 15117B202 |
| RXST | RXSIGHT INC | 1,383,500 | $15.56M | 0.2% | — | — | COM | 78349D107 |
| LAB | FLUIDIGM CORP DEL | 3,819,348 | $14.97M | 0.2% | — | — | COM | 34385P108 |
| — | SYNLOGIC INC | 6,029,995 | $14.59M | 0.2% | — | — | COM | 87166L100 |
| ACRS | ACLARIS THERAPEUTICS INC | 985,900 | $14.34M | 0.2% | — | — | COM | 00461U105 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,956,124 | $14.04M | 0.2% | — | — | COM | 00773J103 |
| LUNG | PULMONX CORP | 435,000 | $13.95M | 0.2% | — | — | COM | 745848101 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,214,509 | $13.92M | 0.2% | — | — | COM | 23284F105 |
| — | BURNING ROCK BIOTECH LTD | 1,452,402 | $13.84M | 0.2% | — | — | SPONSORED ADS | 12233L107 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $13.45M | 0.2% | — | — | COM | 36118A100 |
| AMGN | AMGEN INC | 57,100 | $12.85M | 0.2% | — | — | COM | 031162100 |
| — | CYBIN INC | 10,524,300 | $12.48M | 0.2% | — | — | COM | 23256X100 |
| CGEM | CULLINAN ONCOLOGY INC | 805,041 | $12.42M | 0.2% | — | — | COM | 230031106 |
| — | GALECTO INC | 4,090,937 | $12.4M | 0.2% | — | — | COM | 36322Q107 |
| QURE | UNIQURE NV | 585,574 | $12.14M | 0.2% | — | — | SHS | N90064101 |
| — | BELLUS HEALTH INC NEW | 1,454,800 | $11.7M | 0.2% | — | — | COM NEW | 07987C204 |
| — | SONENDO INC | 1,968,180 | $11.34M | 0.1% | — | — | COM | 835431107 |
| — | 9 METERS BIOPHARMA INC | 10,275,887 | $10.06M | 0.1% | — | — | COM | 654405109 |
| — | MAGENTA THERAPEUTICS INC | 2,250,953 | $9.972M | 0.1% | — | — | COM | 55910K108 |
| — | PROMETHEUS BIOSCIENCES INC | 250,000 | $9.885M | 0.1% | — | — | COM | 74349U108 |
| — | IMARA INC | 4,386,568 | $9.87M | 0.1% | — | — | COM | 45249V107 |
| — | VOR BIOPHARMA INC | 833,333 | $9.683M | 0.1% | — | — | COM | 929033108 |
| AFIB | ACUTUS MED INC | 2,648,386 | $9.031M | 0.1% | — | — | COM | 005111109 |
| CVRX | CVRX INC | 723,055 | $8.843M | 0.1% | — | — | COM | 126638105 |
| — | RAPT THERAPEUTICS INC | 217,000 | $7.97M | 0.1% | — | — | COM | 75382E109 |
| — | ACHILLES THERAPEUTICS PLC | 1,584,845 | $7.94M | 0.1% | — | — | SPONSORED ADS | 00449L102 |
| GOSS | GOSSAMER BIO INC | 683,000 | $7.725M | 0.1% | — | — | COM | 38341P102 |
| — | GRAYBUG VISION INC | 4,163,347 | $7.619M | 0.1% | — | — | COM SHS | 38942Q103 |
| — | ONCOCYTE CORP | 3,493,800 | $7.582M | 0.1% | — | — | COM | 68235C107 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 1,452,774 | $7.525M | 0.1% | — | — | COM | 63909J108 |
| — | NANOSTRING TECHNOLOGIES INC | 6,000,000 | $7.172M | 0.1% | — | — | NOTE 2.625% 3/0 | 63009RAD1 |
| — | AEROVATE THERAPEUTICS INC | 535,714 | $6.316M | 0.1% | — | — | COM | 008064107 |
| NTLA | INTELLIA THERAPEUTICS INC | 53,200 | $6.29M | 0.1% | — | — | COM | 45826J105 |
| — | SYROS PHARMACEUTICALS INC | 1,837,500 | $5.99M | 0.1% | — | — | COM | 87184Q107 |
| TARA | PROTARA THERAPEUTICS INC | 830,641 | $5.607M | 0.1% | — | — | COM STK | 74365U107 |
| NRIX | NURIX THERAPEUTICS INC | 184,468 | $5.34M | 0.1% | — | — | COM | 67080M103 |
| SRPT | SAREPTA THERAPEUTICS INC | 58,700 | $5.286M | 0.1% | — | — | COM | 803607100 |
| NBP | I MAB | 111,120 | $5.266M | 0.1% | — | — | SPONSORED ADS | 44975P103 |
| — | HEALTH SCIENCES ACQ CORP 2 | 500,000 | $5.04M | 0.1% | — | — | ORD SHS | G4411D109 |
| IPSC | CENTURY THERAPEUTICS INC | 307,047 | $4.87M | 0.1% | — | — | COM | 15673T100 |
| — | BIOMX INC | 2,813,489 | $4.502M | 0.1% | — | — | COM | 09090D103 |
| ALXO | ALX ONCOLOGY HLDGS INC | 207,600 | $4.461M | 0.1% | — | — | COM | 00166B105 |
| IFRX | INFLARX NV | 875,297 | $4.166M | 0.1% | — | — | COM | N44821101 |
| — | TALARIS THERAPEUTICS INC | 247,240 | $3.78M | 0.0% | — | — | COM | 87410C104 |
| — | FIELD TRIP HEALTH LTD | 1,538,470 | $3.722M | 0.0% | — | — | COM | 31656R102 |
| — | INOZYME PHARMA INC | 526,600 | $3.591M | 0.0% | — | — | COM | 45790W108 |
| SGHT | SIGHT SCIENCES INC | 200,000 | $3.514M | 0.0% | — | — | COM | 82657M105 |
| — | X4 PHARMACEUTICALS INC | 1,373,849 | $3.146M | 0.0% | — | — | COM | 98420X103 |
| WHWK | AADI BIOSCIENCE INC | 127,600 | $3.082M | 0.0% | — | — | COM | 00032Q104 |
| — | EXSCIENTIA PLC | 125,000 | $2.47M | 0.0% | — | — | ADS | 30223G102 |
| — | SURFACE ONCOLOGY INC | 467,945 | $2.237M | 0.0% | — | — | COM | 86877M209 |
| — | ASLAN PHARMACEUTICALS LTD | 1,970,000 | $2.206M | 0.0% | — | — | ADS | 04522R101 |
| — | BRIGHT MINDS BIOSCIENCES INC | 660,600 | $2.131M | 0.0% | — | — | COM | 10919W108 |
| ADAG | ADAGENE INC | 263,176 | $2.123M | 0.0% | — | — | ADS | 005329107 |
| — | APTINYX INC | 749,500 | $2.001M | 0.0% | — | — | COM | 03836N103 |
| — | CATALYST BIOSCIENCES INC | 1,729,402 | $1.581M | 0.0% | — | — | COM NEW | 14888D208 |
| PYXS | PYXIS ONCOLOGY INC | 143,640 | $1.576M | 0.0% | — | — | COMMON STOCK | 747324101 |
| — | LANDOS BIOPHARMA INC | 283,217 | $1.359M | 0.0% | — | — | COM | 515069102 |
| CABA | CABALETTA BIO INC | 302,509 | $1.147M | 0.0% | — | — | COM | 12674W109 |
| — | LONGBOARD PHARMACEUTICALS IN | 113,500 | $554K | 0.0% | — | — | COM | 54300N103 |
| — | AUGMEDIX INC | 88,363 | $278K | 0.0% | — | — | COM | 05105P107 |
| OWLTW | OWLET INC | 220,704 | $86,000 | 0.0% | — | — | *W EXP 09/14/202 | 69120X115 |