ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value ($000): $5,227,458 (99.6% shares, 0.4% debt)

Holdings (115)

SVA SINOVAC BIOTECH LTD 6.5%
Value ($000) $340,000 Shares 2,718,735 Est. Cost $6.47 Unrealized 0.0%
UNH UNITEDHEALTH GROUP INC 3.9%
Value ($000) $201,733 Shares 380,500 Est. Cost $373.58 Unrealized +34.0%
BMY BRISTOL-MYERS SQUIBB CO 3.6%
Value ($000) $185,984 Shares 2,584,900 Est. Cost $48.14 Unrealized +35.5%
BSX BOSTON SCIENTIFIC CORP 3.5%
Value ($000) $180,370 Shares 3,898,200 Est. Cost $25.28 Unrealized +71.3%
HUM HUMANA INC 3.4%
Value ($000) $178,601 Shares 348,700 Est. Cost $319.09 Unrealized +59.2%
BMRN BIOMARIN PHARMACEUTICAL INC 3.2%
Value ($000) $167,158 Shares 1,615,210 Est. Cost $82.79 Unrealized +13.4%
ISRG INTUITIVE SURGICAL INC 3.1%
Value ($000) $164,650 Shares 620,500 Est. Cost $272.47 Unrealized -10.5%
SPRINGWORKS THERAPEUTICS INC 2.6%
Value ($000) $136,553 Shares 5,250,000 Est. Cost $21.68 Unrealized
EWTX EDGEWISE THERAPEUTICS INC 2.5%
Value ($000) $130,231 Shares 14,567,176 Est. Cost $31.69 Unrealized -70.4%
SRPT SAREPTA THERAPEUTICS INC 2.4%
Value ($000) $125,991 Shares 972,300 Est. Cost $101.72 Unrealized +13.9%
VERONA PHARMA PLC 2.3%
Value ($000) $119,474 Shares 4,572,289 Est. Cost $7.45 Unrealized
SYK STRYKER CORPORATION 2.2%
Value ($000) $117,600 Shares 481,000 Est. Cost $212.84 Unrealized +3.3%
SEAGEN INC 2.2%
Value ($000) $117,434 Shares 913,812 Est. Cost $153.62 Unrealized
CMPX COMPASS THERAPEUTICS INC 2.2%
Value ($000) $112,485 Shares 22,362,850 Est. Cost $3.29 Unrealized +21.4%
TMO THERMO FISHER SCIENTIFIC INC 2.1%
Value ($000) $111,350 Shares 202,200 Est. Cost $377.58 Unrealized +39.0%
THESEUS PHARMACEUTICALS INC 1.6%
Value ($000) $85,824 Shares 17,233,668 Est. Cost $12.58 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 1.6%
Value ($000) $82,139 Shares 687,700 Est. Cost $91.89 Unrealized +27.5%
KROS KEROS THERAPEUTICS INC 1.5%
Value ($000) $80,646 Shares 1,679,417 Est. Cost $30.81 Unrealized +51.6%
EVH EVOLENT HEALTH INC 1.5%
Value ($000) $79,321 Shares 2,824,832 Est. Cost $28.26 Unrealized +1.4%
VRTX VERTEX PHARMACEUTICALS INC 1.5%
Value ($000) $78,404 Shares 271,500 Est. Cost $151.18 Unrealized +101.6%
NTRA NATERA INC 1.5%
Value ($000) $78,185 Shares 1,946,353 Est. Cost $33.28 Unrealized +23.8%
TERN TERNS PHARMACEUTICALS INC 1.5%
Value ($000) $77,563 Shares 7,619,135 Est. Cost $12.83 Unrealized -48.1%
IONS IONIS PHARMACEUTICALS INC 1.4%
Value ($000) $75,298 Shares 1,993,600 Est. Cost $41.08 Unrealized +2.4%
SPRY ARS PHARMACEUTICALS INC 1.4%
Value ($000) $74,560 Shares 8,740,887 Est. Cost $33.40 Unrealized -80.6%
BIIB BIOGEN INC 1.4%
Value ($000) $71,501 Shares 258,200 Est. Cost $267.86 Unrealized +5.4%
PFE PFIZER INC 1.4%
Value ($000) $71,408 Shares 1,393,600 Est. Cost $40.97 Unrealized -1.9%
ADICET BIO INC 1.3%
Value ($000) $66,577 Shares 7,447,140 Est. Cost $12.13 Unrealized
EW EDWARDS LIFESCIENCES CORP 1.2%
Value ($000) $64,202 Shares 860,500 Est. Cost $72.41 Unrealized +6.4%
PCVX VAXCYTE INC 1.2%
Value ($000) $61,526 Shares 1,283,126 Est. Cost $31.90 Unrealized +23.0%
VECTIVBIO HLDG AG 1.2%
Value ($000) $60,714 Shares 7,006,861 Est. Cost $10.21 Unrealized
PRLD PRELUDE THERAPEUTICS INC 1.2%
Value ($000) $60,640 Shares 10,039,691 Est. Cost $28.24 Unrealized -77.3%
THC TENET HEALTHCARE CORP 1.1%
Value ($000) $59,538 Shares 1,220,300 Est. Cost $62.18 Unrealized -25.7%
CRNX CRINETICS PHARMACEUTICALS IN 1.1%
Value ($000) $58,503 Shares 3,196,876 Est. Cost $25.44 Unrealized -30.7%
MIRATI THERAPEUTICS INC 1.1%
Value ($000) $58,164 Shares 1,283,692 Est. Cost $103.83 Unrealized
PMVP PMV PHARMACEUTICALS INC 1.1%
Value ($000) $57,099 Shares 6,563,077 Est. Cost $36.80 Unrealized -71.0%
CHINOOK THERAPEUTICS INC 1.0%
Value ($000) $53,168 Shares 2,029,300 Est. Cost $16.29 Unrealized
MERSANA THERAPEUTICS INC 1.0%
Value ($000) $52,807 Shares 9,011,437 Est. Cost $7.39 Unrealized
IKENA ONCOLOGY INC 1.0%
Value ($000) $51,512 Shares 12,147,877 Est. Cost $34.81 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 1.0%
Value ($000) $51,065 Shares 2,006,500 Est. Cost $18.07 Unrealized +29.0%
REPARE THERAPEUTICS INC 0.9%
Value ($000) $48,874 Shares 3,322,488 Est. Cost $31.02 Unrealized
XTNT XTANT MED HLDGS INC 0.9%
Value ($000) $48,256 Shares 73,114,592 Est. Cost $1.96 Unrealized -66.7%
89BIO INC 0.9%
Value ($000) $46,577 Shares 3,658,869 Est. Cost $26.29 Unrealized
SIBN SI-BONE INC 0.9%
Value ($000) $45,805 Shares 3,368,000 Est. Cost $20.84 Unrealized -30.0%
XENE XENON PHARMACEUTICALS INC 0.9%
Value ($000) $45,309 Shares 1,149,100 Est. Cost $23.80 Unrealized +53.0%
ACRS ACLARIS THERAPEUTICS INC 0.8%
Value ($000) $43,445 Shares 2,758,434 Est. Cost $15.70 Unrealized +2.5%
IRON DISC MEDICINE INC 0.8%
Value ($000) $42,981 Shares 2,160,941 Est. Cost $49.79 Unrealized 0.0%
ABCL ABCELLERA BIOLOGICS INC 0.8%
Value ($000) $42,351 Shares 4,180,768 Est. Cost $45.73 Unrealized -74.7%
SCPHARMACEUTICALS INC 0.8%
Value ($000) $39,862 Shares 5,559,528 Est. Cost $10.23 Unrealized
QURE UNIQURE NV 0.8%
Value ($000) $39,617 Shares 1,747,555 Est. Cost $31.46 Unrealized -31.4%
BELLUS HEALTH INC NEW 0.7%
Value ($000) $38,659 Shares 4,708,900 Est. Cost $9.25 Unrealized
JANX JANUX THERAPEUTICS INC 0.7%
Value ($000) $37,355 Shares 2,836,386 Est. Cost $22.27 Unrealized -34.3%
ARQT ARCUTIS BIOTHERAPEUTICS INC 0.7%
Value ($000) $36,410 Shares 2,460,108 Est. Cost $26.32 Unrealized -33.6%
TELA TELA BIO INC 0.7%
Value ($000) $34,817 Shares 3,027,542 Est. Cost $12.23 Unrealized -26.7%
ALXO ALX ONCOLOGY HLDGS INC 0.6%
Value ($000) $32,356 Shares 2,871,000 Est. Cost $15.18 Unrealized -26.0%
KEZAR LIFE SCIENCES INC 0.6%
Value ($000) $32,274 Shares 4,584,322 Est. Cost $7.54 Unrealized
PGNY PROGYNY INC 0.6%
Value ($000) $32,240 Shares 1,035,000 Est. Cost $36.54 Unrealized -1.1%
VTYX VENTYX BIOSCIENCES INC 0.6%
Value ($000) $30,331 Shares 925,000 Est. Cost $27.02 Unrealized +9.6%
ALPINE IMMUNE SCIENCES INC 0.6%
Value ($000) $30,000 Shares 4,081,592 Est. Cost $11.01 Unrealized
TVTX TRAVERE THERAPEUTICS INC 0.5%
Value ($000) $26,353 Shares 1,253,130 Est. Cost $25.41 Unrealized -16.6%
THIRD HARMONIC BIO INC 0.5%
Value ($000) $24,850 Shares 5,779,071 Est. Cost $18.97 Unrealized
RAPT THERAPEUTICS INC 0.5%
Value ($000) $24,771 Shares 1,251,070 Est. Cost $23.67 Unrealized
KINNATE BIOPHARMA INC 0.5%
Value ($000) $24,666 Shares 4,043,629 Est. Cost $38.40 Unrealized
CINCOR PHARMA INC 0.4%
Value ($000) $23,425 Shares 1,906,000 Est. Cost $15.67 Unrealized
AEROVATE THERAPEUTICS INC 0.4%
Value ($000) $22,255 Shares 759,540 Est. Cost $20.34 Unrealized
HORIZON THERAPEUTICS PUB L 0.4%
Value ($000) $19,460 Shares 171,000 Est. Cost $113.80 Unrealized
GRACELL BIOTECHNOLOGIES INC 0.3%
Value ($000) $18,135 Shares 7,884,870 Est. Cost $15.40 Unrealized
IMARA INC 0.3%
Value ($000) $17,941 Shares 4,386,568 Est. Cost $11.49 Unrealized
GHRS GH RESEARCH PLC 0.3%
Value ($000) $15,766 Shares 1,622,060 Est. Cost $19.54 Unrealized -44.7%
RXST RXSIGHT INC 0.3%
Value ($000) $15,240 Shares 1,202,833 Est. Cost $13.60 Unrealized -10.5%
MRNA MODERNA INC 0.3%
Value ($000) $14,828 Shares 82,550 Est. Cost $163.51 Unrealized 0.0%
IOVA IOVANCE BIOTHERAPEUTICS INC 0.2%
Value ($000) $12,828 Shares 2,007,458 Est. Cost $10.93 Unrealized -28.6%
BRIDGEBIO PHARMA INC 0.2%
Value ($000) $12,600 Shares 30,000,000 Est. Cost $0.48 Unrealized
PASSAGE BIO INC 0.2%
Value ($000) $12,326 Shares 8,931,999 Est. Cost $12.83 Unrealized
FUSION PHARMACEUTICALS INC 0.2%
Value ($000) $10,158 Shares 3,224,770 Est. Cost $17.47 Unrealized
DECIBEL THERAPEUTICS INC 0.2%
Value ($000) $10,138 Shares 4,945,192 Est. Cost $11.36 Unrealized
2SEVENTY BIO INC 0.2%
Value ($000) $9,757 Shares 1,041,300 Est. Cost $14.55 Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.2%
Value ($000) $9,469 Shares 1,607,568 Est. Cost $31.92 Unrealized -89.4%
CHEMOMAB THERAPEUTICS LTD 0.2%
Value ($000) $8,250 Shares 2,578,174 Est. Cost $28.71 Unrealized
SRRK SCHOLAR ROCK HLDG CORP 0.2%
Value ($000) $7,955 Shares 879,003 Est. Cost $7.38 Unrealized +8.6%
MREO MEREO BIOPHARMA GROUP PLC 0.2%
Value ($000) $7,954 Shares 10,605,522 Est. Cost $3.31 Unrealized
BRIDGEBIO PHARMA INC 0.2%
Value ($000) $7,950 Shares 20,000,000 Est. Cost $0.60 Unrealized
IVVD INVIVYD INC 0.2%
Value ($000) $7,906 Shares 5,270,400 Est. Cost $35.34 Unrealized -92.1%
IKENA ONCOLOGY INC 0.1%
Value ($000) $7,804 Shares 2,933,941 Est. Cost $28.25 Unrealized
CGEM CULLINAN ONCOLOGY INC 0.1%
Value ($000) $6,723 Shares 637,287 Est. Cost $40.60 Unrealized -70.1%
VERASTEM INC 0.1%
Value ($000) $6,643 Shares 16,503,237 Est. Cost $0.85 Unrealized
XBI SPDR SER TR 0.1%
Value ($000) $6,341 Shares 76,400 Est. Cost $134.22 Unrealized
FOLD AMICUS THERAPEUTICS INC 0.1%
Value ($000) $6,300 Shares 516,000 Est. Cost $11.26 Unrealized 0.0%
ARGX ARGENX SE 0.1%
Value ($000) $6,137 Shares 16,200 Est. Cost $331.61 Unrealized
NPCE NEUROPACE INC 0.1%
Value ($000) $5,978 Shares 4,012,281 Est. Cost $23.21 Unrealized -90.4%
CRVS CORVUS PHARMACEUTICALS INC 0.1%
Value ($000) $5,902 Shares 6,943,654 Est. Cost $11.24 Unrealized -92.1%
X4 PHARMACEUTICALS INC 0.1%
Value ($000) $5,777 Shares 5,817,726 Est. Cost $4.45 Unrealized
VIGIL NEUROSCIENCE INC 0.1%
Value ($000) $5,611 Shares 448,891 Est. Cost $7.49 Unrealized
BNTX BIONTECH SE 0.1%
Value ($000) $5,453 Shares 36,300 Est. Cost $150.22 Unrealized
SNY SANOFI 0.1%
Value ($000) $4,843 Shares 100,000 Est. Cost Unrealized
GALECTO INC 0.1%
Value ($000) $4,705 Shares 4,090,937 Est. Cost $12.51 Unrealized
SYNLOGIC INC 0.1%
Value ($000) $4,583 Shares 6,029,995 Est. Cost $7.51 Unrealized
NEXTCURE INC 0.1%
Value ($000) $3,823 Shares 2,711,013 Est. Cost $14.98 Unrealized
AMRX AMNEAL PHARMACEUTICALS INC 0.1%
Value ($000) $3,151 Shares 1,583,490 Est. Cost $2.80 Unrealized -20.0%
AFIB ACUTUS MED INC 0.1%
Value ($000) $3,046 Shares 2,648,386 Est. Cost $30.36 Unrealized -97.3%
BCAB BIOATLA INC 0.1%
Value ($000) $2,742 Shares 332,372 Est. Cost $8.30 Unrealized 0.0%
APPLIED THERAPEUTICS INC 0.0%
Value ($000) $2,319 Shares 3,050,921 Est. Cost $0.95 Unrealized
TARA PROTARA THERAPEUTICS INC 0.0%
Value ($000) $2,226 Shares 830,641 Est. Cost $15.72 Unrealized -79.9%
GRAYBUG VISION INC 0.0%
Value ($000) $2,082 Shares 4,163,347 Est. Cost $12.71 Unrealized
GDRX GOODRX HLDGS INC 0.0%
Value ($000) $1,806 Shares 387,567 Est. Cost $4.93 Unrealized 0.0%
EYPT EYEPOINT PHARMACEUTICALS INC 0.0%
Value ($000) $1,707 Shares 487,642 Est. Cost $9.46 Unrealized -53.3%
CYBIN INC 0.0%
Value ($000) $1,652 Shares 5,386,299 Est. Cost $2.19 Unrealized
PYXS PYXIS ONCOLOGY INC 0.0%
Value ($000) $1,137 Shares 848,252 Est. Cost $2.61 Unrealized -42.6%
HARPOON THERAPEUTICS INC 0.0%
Value ($000) $1,101 Shares 1,516,496 Est. Cost $11.25 Unrealized
SINGULAR GENOMICS SYSTEMS IN 0.0%
Value ($000) $1,087 Shares 540,697 Est. Cost $24.94 Unrealized
BOLT BIOTHERAPEUTICS INC 0.0%
Value ($000) $1,002 Shares 771,059 Est. Cost $1.48 Unrealized
ESSA PHARMA INC 0.0%
Value ($000) $921 Shares 365,300 Est. Cost $1.82 Unrealized
MERRIMACK PHARMACEUTICALS IN 0.0%
Value ($000) $843 Shares 73,600 Est. Cost $11.46 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.0%
Value ($000) $809 Shares 1,797,221 Est. Cost $7.60 Unrealized
BIOMX INC 0.0%
Value ($000) $525 Shares 2,813,489 Est. Cost $8.51 Unrealized
GLUE MONTE ROSA THERAPEUTICS INC 0.0%
Value ($000) $208 Shares 27,369 Est. Cost $9.19 Unrealized -9.3%