Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $5.227B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| SVA | SINOVAC BIOTECH LTD | 2,718,735 | $340M | 6.5% | — | — | COM | P8696W104 |
| UNH | UNITEDHEALTH GROUP INC | 380,500 | $202M | 3.9% | — | — | COM | 91324P102 |
| BMY | BRISTOL-MYERS SQUIBB CO | 2,584,900 | $186M | 3.6% | — | — | COM | 110122108 |
| BSX | BOSTON SCIENTIFIC CORP | 3,898,200 | $180M | 3.5% | — | — | COM | 101137107 |
| HUM | HUMANA INC | 348,700 | $179M | 3.4% | — | — | COM | 444859102 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 1,615,210 | $167M | 3.2% | — | — | COM | 09061G101 |
| ISRG | INTUITIVE SURGICAL INC | 620,500 | $165M | 3.1% | — | — | COM NEW | 46120E602 |
| — | SPRINGWORKS THERAPEUTICS INC | 5,250,000 | $137M | 2.6% | — | — | COM | 85205L107 |
| EWTX | EDGEWISE THERAPEUTICS INC | 14,567,176 | $130M | 2.5% | — | — | COM | 28036F105 |
| SRPT | SAREPTA THERAPEUTICS INC | 972,300 | $126M | 2.4% | — | — | COM | 803607100 |
| — | VERONA PHARMA PLC | 4,572,289 | $119M | 2.3% | — | — | SPONSORED ADS | 925050106 |
| SYK | STRYKER CORPORATION | 481,000 | $118M | 2.2% | — | — | COM | 863667101 |
| — | SEAGEN INC | 913,812 | $117M | 2.2% | — | — | COM | 81181C104 |
| CMPX | COMPASS THERAPEUTICS INC | 22,362,850 | $112M | 2.2% | — | — | COM | 20454B104 |
| TMO | THERMO FISHER SCIENTIFIC INC | 202,200 | $111M | 2.1% | — | — | COM | 883556102 |
| — | THESEUS PHARMACEUTICALS INC | 17,233,668 | $85.82M | 1.6% | — | — | COM | 88369M101 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 687,700 | $82.14M | 1.6% | — | — | COM | 64125C109 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $80.65M | 1.5% | — | — | COM | 492327101 |
| EVH | EVOLENT HEALTH INC | 2,824,832 | $79.32M | 1.5% | — | — | CL A | 30050B101 |
| VRTX | VERTEX PHARMACEUTICALS INC | 271,500 | $78.4M | 1.5% | — | — | COM | 92532F100 |
| NTRA | NATERA INC | 1,946,353 | $78.19M | 1.5% | — | — | COM | 632307104 |
| TERN | TERNS PHARMACEUTICALS INC | 7,619,135 | $77.56M | 1.5% | — | — | COM | 880881107 |
| IONS | IONIS PHARMACEUTICALS INC | 1,993,600 | $75.3M | 1.4% | — | — | COM | 462222100 |
| SPRY | ARS PHARMACEUTICALS INC | 8,740,887 | $74.56M | 1.4% | — | — | COM | 82835W108 |
| BIIB | BIOGEN INC | 258,200 | $71.5M | 1.4% | — | — | COM | 09062X103 |
| PFE | PFIZER INC | 1,393,600 | $71.41M | 1.4% | — | — | COM | 717081103 |
| — | ADICET BIO INC | 7,447,140 | $66.58M | 1.3% | — | — | COM | 007002108 |
| EW | EDWARDS LIFESCIENCES CORP | 860,500 | $64.2M | 1.2% | — | — | COM | 28176E108 |
| PCVX | VAXCYTE INC | 1,283,126 | $61.53M | 1.2% | — | — | COM | 92243G108 |
| — | VECTIVBIO HLDG AG | 7,006,861 | $60.71M | 1.2% | — | — | ORD SHS | H9060V101 |
| PRLD | PRELUDE THERAPEUTICS INC | 10,039,691 | $60.64M | 1.2% | — | — | COM | 74065P101 |
| THC | TENET HEALTHCARE CORP | 1,220,300 | $59.54M | 1.1% | — | — | COM NEW | 88033G407 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,196,876 | $58.5M | 1.1% | — | — | COM | 22663K107 |
| — | MIRATI THERAPEUTICS INC | 1,283,692 | $58.16M | 1.1% | — | — | COM | 60468T105 |
| PMVP | PMV PHARMACEUTICALS INC | 6,563,077 | $57.1M | 1.1% | — | — | COM | 69353Y103 |
| — | CHINOOK THERAPEUTICS INC | 2,029,300 | $53.17M | 1.0% | — | — | COM | 16961L106 |
| — | MERSANA THERAPEUTICS INC | 9,011,437 | $52.81M | 1.0% | — | — | COM | 59045L106 |
| — | IKENA ONCOLOGY INC | 12,147,877 | $51.51M | 1.0% | — | — | NONVOTING | 000000000 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 2,006,500 | $51.07M | 1.0% | — | — | COM | 87164F105 |
| — | REPARE THERAPEUTICS INC | 3,322,488 | $48.87M | 0.9% | — | — | COM | 760273102 |
| XTNT | XTANT MED HLDGS INC | 73,114,592 | $48.26M | 0.9% | — | — | COM NEW | 98420P308 |
| — | 89BIO INC | 3,658,869 | $46.58M | 0.9% | — | — | COM | 282559103 |
| SIBN | SI-BONE INC | 3,368,000 | $45.8M | 0.9% | — | — | COM | 825704109 |
| XENE | XENON PHARMACEUTICALS INC | 1,149,100 | $45.31M | 0.9% | — | — | COM | 98420N105 |
| ACRS | ACLARIS THERAPEUTICS INC | 2,758,434 | $43.45M | 0.8% | — | — | COM | 00461U105 |
| IRON | DISC MEDICINE INC | 2,160,941 | $42.98M | 0.8% | — | — | COM | 254604101 |
| ABCL | ABCELLERA BIOLOGICS INC | 4,180,768 | $42.35M | 0.8% | — | — | COM | 00288U106 |
| — | SCPHARMACEUTICALS INC | 5,559,528 | $39.86M | 0.8% | — | — | COM | 810648105 |
| QURE | UNIQURE NV | 1,747,555 | $39.62M | 0.8% | — | — | SHS | N90064101 |
| — | BELLUS HEALTH INC NEW | 4,708,900 | $38.66M | 0.7% | — | — | COM NEW | 07987C204 |
| JANX | JANUX THERAPEUTICS INC | 2,836,386 | $37.36M | 0.7% | — | — | COM | 47103J105 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 2,460,108 | $36.41M | 0.7% | — | — | COM | 03969K108 |
| TELA | TELA BIO INC | 3,027,542 | $34.82M | 0.7% | — | — | COM | 872381108 |
| ALXO | ALX ONCOLOGY HLDGS INC | 2,871,000 | $32.36M | 0.6% | — | — | COM | 00166B105 |
| — | KEZAR LIFE SCIENCES INC | 4,584,322 | $32.27M | 0.6% | — | — | COM | 49372L100 |
| PGNY | PROGYNY INC | 1,035,000 | $32.24M | 0.6% | — | — | COM | 74340E103 |
| VTYX | VENTYX BIOSCIENCES INC | 925,000 | $30.33M | 0.6% | — | — | COM | 92332V107 |
| — | ALPINE IMMUNE SCIENCES INC | 4,081,592 | $30M | 0.6% | — | — | COM | 02083G100 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,253,130 | $26.35M | 0.5% | — | — | COM | 89422G107 |
| — | THIRD HARMONIC BIO INC | 5,779,071 | $24.85M | 0.5% | — | — | COM | 88427A107 |
| — | RAPT THERAPEUTICS INC | 1,251,070 | $24.77M | 0.5% | — | — | COM | 75382E109 |
| — | KINNATE BIOPHARMA INC | 4,043,629 | $24.67M | 0.5% | — | — | COM | 49705R105 |
| — | CINCOR PHARMA INC | 1,906,000 | $23.42M | 0.4% | — | — | COM | 17240Y109 |
| — | AEROVATE THERAPEUTICS INC | 759,540 | $22.25M | 0.4% | — | — | COM | 008064107 |
| — | HORIZON THERAPEUTICS PUB L | 171,000 | $19.46M | 0.4% | — | — | SHS | G46188101 |
| — | GRACELL BIOTECHNOLOGIES INC | 7,884,870 | $18.14M | 0.3% | — | — | SPONSORED ADS | 38406L103 |
| — | IMARA INC | 4,386,568 | $17.94M | 0.3% | — | — | COM | 45249V107 |
| GHRS | GH RESEARCH PLC | 1,622,060 | $15.77M | 0.3% | — | — | ORDINARY SHARES | G3855L106 |
| RXST | RXSIGHT INC | 1,202,833 | $15.24M | 0.3% | — | — | COM | 78349D107 |
| MRNA | MODERNA INC | 82,550 | $14.83M | 0.3% | — | — | COM | 60770K107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 2,007,458 | $12.83M | 0.2% | — | — | COM | 462260100 |
| — | BRIDGEBIO PHARMA INC | 30,000,000 | $12.6M | 0.2% | — | — | NOTE 2.250% 2/0 | 10806XAD4 |
| — | PASSAGE BIO INC | 8,931,999 | $12.33M | 0.2% | — | — | COM | 702712100 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $10.16M | 0.2% | — | — | COM | 36118A100 |
| — | DECIBEL THERAPEUTICS INC | 4,945,192 | $10.14M | 0.2% | — | — | COM | 24343R106 |
| — | 2SEVENTY BIO INC | 1,041,300 | $9.757M | 0.2% | — | — | COMMON STOCK | 901384107 |
| ORIC | ORIC PHARMACEUTICALS INC | 1,607,568 | $9.469M | 0.2% | — | — | COM | 68622P109 |
| — | CHEMOMAB THERAPEUTICS LTD | 2,578,174 | $8.25M | 0.2% | — | — | SPONSORED ADS | 16385C104 |
| SRRK | SCHOLAR ROCK HLDG CORP | 879,003 | $7.955M | 0.2% | — | — | COM | 80706P103 |
| MREO | MEREO BIOPHARMA GROUP PLC | 10,605,522 | $7.954M | 0.2% | — | — | SPON ADS | 589492107 |
| — | BRIDGEBIO PHARMA INC | 20,000,000 | $7.95M | 0.2% | — | — | NOTE 2.500% 3/1 | 10806XAB8 |
| IVVD | INVIVYD INC | 5,270,400 | $7.906M | 0.2% | — | — | COM | 00534A102 |
| — | IKENA ONCOLOGY INC | 2,933,941 | $7.804M | 0.1% | — | — | COM | 45175G108 |
| CGEM | CULLINAN ONCOLOGY INC | 637,287 | $6.723M | 0.1% | — | — | COM | 230031106 |
| — | VERASTEM INC | 16,503,237 | $6.643M | 0.1% | — | — | COM | 92337C104 |
| XBI | SPDR SER TR | 76,400 | $6.341M | 0.1% | — | — | S&P BIOTECH | 78464A870 |
| FOLD | AMICUS THERAPEUTICS INC | 516,000 | $6.3M | 0.1% | — | — | COM | 03152W109 |
| ARGX | ARGENX SE | 16,200 | $6.137M | 0.1% | — | — | SPONSORED ADR | 04016X101 |
| NPCE | NEUROPACE INC | 4,012,281 | $5.978M | 0.1% | — | — | COM | 641288105 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,943,654 | $5.902M | 0.1% | — | — | COM | 221015100 |
| — | X4 PHARMACEUTICALS INC | 5,817,726 | $5.777M | 0.1% | — | — | COM | 98420X103 |
| — | VIGIL NEUROSCIENCE INC | 448,891 | $5.611M | 0.1% | — | — | COM | 92673K108 |
| BNTX | BIONTECH SE | 36,300 | $5.453M | 0.1% | — | — | SPONSORED ADS | 09075V102 |
| SNY | SANOFI | 100,000 | $4.843M | 0.1% | — | — | Call | 80105N105 |
| — | GALECTO INC | 4,090,937 | $4.705M | 0.1% | — | — | COM | 36322Q107 |
| — | SYNLOGIC INC | 6,029,995 | $4.583M | 0.1% | — | — | COM | 87166L100 |
| — | NEXTCURE INC | 2,711,013 | $3.823M | 0.1% | — | — | COM | 65343E108 |
| AMRX | AMNEAL PHARMACEUTICALS INC | 1,583,490 | $3.151M | 0.1% | — | — | COM STK CL A | 03168L105 |
| AFIB | ACUTUS MED INC | 2,648,386 | $3.046M | 0.1% | — | — | COM | 005111109 |
| BCAB | BIOATLA INC | 332,372 | $2.742M | 0.1% | — | — | COM | 09077B104 |
| — | APPLIED THERAPEUTICS INC | 3,050,921 | $2.319M | 0.0% | — | — | COM | 03828A101 |
| TARA | PROTARA THERAPEUTICS INC | 830,641 | $2.226M | 0.0% | — | — | COM STK | 74365U107 |
| — | GRAYBUG VISION INC | 4,163,347 | $2.082M | 0.0% | — | — | COMMON | 38942Q103 |
| GDRX | GOODRX HLDGS INC | 387,567 | $1.806M | 0.0% | — | — | COM CL A | 38246G108 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 487,642 | $1.707M | 0.0% | — | — | COM NEW | 30233G209 |
| — | CYBIN INC | 5,386,299 | $1.652M | 0.0% | — | — | COM | 23256X100 |
| PYXS | PYXIS ONCOLOGY INC | 848,252 | $1.137M | 0.0% | — | — | COMMON STOCK | 747324101 |
| — | HARPOON THERAPEUTICS INC | 1,516,496 | $1.101M | 0.0% | — | — | COM | 41358P106 |
| — | SINGULAR GENOMICS SYSTEMS IN | 540,697 | $1.087M | 0.0% | — | — | COM | 82933R100 |
| — | BOLT BIOTHERAPEUTICS INC | 771,059 | $1.002M | 0.0% | — | — | COM | 097702104 |
| — | ESSA PHARMA INC | 365,300 | $921K | 0.0% | — | — | COM NEW | 29668H708 |
| — | MERRIMACK PHARMACEUTICALS IN | 73,600 | $843K | 0.0% | — | — | COM NEW | 590328209 |
| — | AEGLEA BIOTHERAPEUTICS INC | 1,797,221 | $809K | 0.0% | — | — | COM | 00773J103 |
| — | BIOMX INC | 2,813,489 | $525K | 0.0% | — | — | COM | 09090D103 |
| GLUE | MONTE ROSA THERAPEUTICS INC | 27,369 | $208K | 0.0% | — | — | COM | 61225M102 |