ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $5,387,000 (99.5% shares, 0.5% debt)

Holdings (131)

SVA SINOVAC BIOTECH LTD 6.3%
Value ($000) $340,500 Shares 2,718,735 Est. Cost $6.47 Unrealized 0.0%
BMY BRISTOL-MYERS SQUIBB CO 3.4%
Value ($000) $183,761 Shares 2,584,900 Est. Cost $48.14 Unrealized +29.4%
HUM HUMANA INC 3.1%
Value ($000) $169,186 Shares 348,700 Est. Cost $319.09 Unrealized +47.1%
SPRINGWORKS THERAPEUTICS INC 2.9%
Value ($000) $157,655 Shares 5,525,926 Est. Cost $21.68 Unrealized
BSX BOSTON SCIENTIFIC CORP 2.8%
Value ($000) $150,977 Shares 3,898,200 Est. Cost $25.28 Unrealized +58.7%
BMRN BIOMARIN PHARMACEUTICAL INC 2.7%
Value ($000) $145,576 Shares 1,717,310 Est. Cost $82.79 Unrealized +7.6%
EWTX EDGEWISE THERAPEUTICS INC 2.7%
Value ($000) $143,341 Shares 14,567,176 Est. Cost $31.69 Unrealized -68.1%
UNH UNITEDHEALTH GROUP INC 2.5%
Value ($000) $134,947 Shares 267,200 Est. Cost $319.80 Unrealized +54.8%
PFE PFIZER INC 2.1%
Value ($000) $113,732 Shares 2,599,000 Est. Cost $40.97 Unrealized -1.4%
THIRD HARMONIC BIO INC 2.0%
Value ($000) $109,629 Shares 5,779,071 Est. Cost $18.97 Unrealized
VRTX VERTEX PHARMACEUTICALS INC 2.0%
Value ($000) $108,056 Shares 373,200 Est. Cost $151.18 Unrealized +90.3%
TRICIDA INC 2.0%
Value ($000) $107,744 Shares 10,280,947 Est. Cost $28.76 Unrealized
ISRG INTUITIVE SURGICAL INC 2.0%
Value ($000) $107,347 Shares 572,700 Est. Cost $274.86 Unrealized -21.9%
ADICET BIO INC 2.0%
Value ($000) $105,898 Shares 7,447,140 Est. Cost $12.13 Unrealized
SEAGEN INC 1.9%
Value ($000) $104,347 Shares 762,600 Est. Cost $158.60 Unrealized
TMO THERMO FISHER SCIENTIFIC INC 1.9%
Value ($000) $102,554 Shares 202,200 Est. Cost $377.58 Unrealized +46.8%
SRPT SAREPTA THERAPEUTICS INC 1.9%
Value ($000) $101,531 Shares 918,500 Est. Cost $100.90 Unrealized -0.1%
MIRATI THERAPEUTICS INC 1.8%
Value ($000) $99,095 Shares 1,418,892 Est. Cost $103.83 Unrealized
THESEUS PHARMACEUTICALS INC 1.8%
Value ($000) $98,842 Shares 17,041,668 Est. Cost $12.67 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 1.8%
Value ($000) $95,222 Shares 896,545 Est. Cost $91.89 Unrealized +10.4%
ARGX ARGENX SE 1.8%
Value ($000) $95,218 Shares 269,700 Est. Cost $331.61 Unrealized
SYK STRYKER CORPORATION 1.6%
Value ($000) $85,695 Shares 423,100 Est. Cost $211.90 Unrealized -4.2%
ABBV ABBVIE INC 1.5%
Value ($000) $80,526 Shares 600,000 Est. Cost $81.40 Unrealized +56.2%
EW EDWARDS LIFESCIENCES CORP 1.5%
Value ($000) $79,845 Shares 966,300 Est. Cost $72.41 Unrealized +32.9%
PMVP PMV PHARMACEUTICALS INC 1.4%
Value ($000) $78,101 Shares 6,563,077 Est. Cost $36.80 Unrealized -60.7%
EVH EVOLENT HEALTH INC 1.3%
Value ($000) $71,670 Shares 1,994,717 Est. Cost $28.09 Unrealized +25.4%
PRLD PRELUDE THERAPEUTICS INC 1.2%
Value ($000) $66,362 Shares 10,039,691 Est. Cost $28.24 Unrealized -76.1%
NTRA NATERA INC 1.2%
Value ($000) $65,956 Shares 1,505,153 Est. Cost $30.96 Unrealized +53.8%
KROS KEROS THERAPEUTICS INC 1.2%
Value ($000) $63,180 Shares 1,679,417 Est. Cost $30.81 Unrealized +12.5%
CRNX CRINETICS PHARMACEUTICALS IN 1.2%
Value ($000) $62,787 Shares 3,196,876 Est. Cost $25.44 Unrealized -19.8%
MERSANA THERAPEUTICS INC 1.1%
Value ($000) $60,917 Shares 9,011,437 Est. Cost $7.39 Unrealized
IKENA ONCOLOGY INC 1.1%
Value ($000) $60,506 Shares 12,147,877 Est. Cost $34.81 Unrealized
BIIB BIOGEN INC 1.1%
Value ($000) $59,968 Shares 224,600 Est. Cost $265.68 Unrealized -20.1%
SIBN SI-BONE INC 1.1%
Value ($000) $58,805 Shares 3,368,000 Est. Cost $20.84 Unrealized -23.3%
VERONA PHARMA PLC 1.1%
Value ($000) $58,201 Shares 5,694,841 Est. Cost $7.45 Unrealized
ARQT ARCUTIS BIOTHERAPEUTICS INC 1.0%
Value ($000) $53,508 Shares 2,800,000 Est. Cost $26.32 Unrealized -13.9%
GH GUARDANT HEALTH INC 1.0%
Value ($000) $53,421 Shares 992,400 Est. Cost $124.49 Unrealized -58.8%
XTNT XTANT MED HLDGS INC 1.0%
Value ($000) $52,628 Shares 73,114,592 Est. Cost $1.96 Unrealized -72.1%
ALNY ALNYLAM PHARMACEUTICALS INC 0.9%
Value ($000) $50,140 Shares 250,500 Est. Cost $190.74 Unrealized 0.0%
CMPX COMPASS THERAPEUTICS INC 0.9%
Value ($000) $50,071 Shares 21,960,850 Est. Cost $3.27 Unrealized -15.4%
BELLUS HEALTH INC NEW 0.9%
Value ($000) $48,971 Shares 4,634,900 Est. Cost $9.27 Unrealized
KINNATE BIOPHARMA INC 0.9%
Value ($000) $48,321 Shares 4,043,629 Est. Cost $38.40 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.9%
Value ($000) $48,216 Shares 2,006,500 Est. Cost $18.07 Unrealized +24.1%
SPRY SILVERBACK THERAPEUTICS INC 0.9%
Value ($000) $46,152 Shares 8,740,887 Est. Cost $33.40 Unrealized -85.2%
TERN TERNS PHARMACEUTICALS INC 0.8%
Value ($000) $44,064 Shares 7,481,204 Est. Cost $12.94 Unrealized -71.3%
ACRS ACLARIS THERAPEUTICS INC 0.8%
Value ($000) $43,418 Shares 2,758,434 Est. Cost $15.70 Unrealized +0.4%
PGNY PROGYNY INC 0.8%
Value ($000) $42,028 Shares 1,134,053 Est. Cost $36.54 Unrealized +2.5%
ABCL ABCELLERA BIOLOGICS INC 0.8%
Value ($000) $41,348 Shares 4,180,768 Est. Cost $45.73 Unrealized -76.0%
XENE XENON PHARMACEUTICALS INC 0.8%
Value ($000) $41,057 Shares 1,137,300 Est. Cost $23.67 Unrealized +51.9%
REPARE THERAPEUTICS INC 0.7%
Value ($000) $40,302 Shares 3,322,488 Est. Cost $31.02 Unrealized
CHINOOK THERAPEUTICS INC 0.7%
Value ($000) $39,896 Shares 2,029,300 Est. Cost $16.29 Unrealized
VECTIVBIO HLDG AG 0.7%
Value ($000) $38,841 Shares 6,473,561 Est. Cost $10.34 Unrealized
JANX JANUX THERAPEUTICS INC 0.7%
Value ($000) $38,405 Shares 2,836,386 Est. Cost $22.27 Unrealized -40.0%
IONS IONIS PHARMACEUTICALS INC 0.6%
Value ($000) $34,008 Shares 768,900 Est. Cost $39.52 Unrealized +6.6%
THC TENET HEALTHCARE CORP 0.6%
Value ($000) $33,181 Shares 643,300 Est. Cost $76.50 Unrealized -22.4%
SCPHARMACEUTICALS INC 0.6%
Value ($000) $31,277 Shares 4,797,148 Est. Cost $10.72 Unrealized
TVTX TRAVERE THERAPEUTICS INC 0.6%
Value ($000) $30,877 Shares 1,253,130 Est. Cost $25.41 Unrealized +1.7%
RAPT THERAPEUTICS INC 0.6%
Value ($000) $30,101 Shares 1,251,070 Est. Cost $23.67 Unrealized
QURE UNIQURE NV 0.6%
Value ($000) $29,960 Shares 1,597,000 Est. Cost $32.39 Unrealized -35.1%
ALPINE IMMUNE SCIENCES INC 0.5%
Value ($000) $29,387 Shares 4,081,592 Est. Cost $11.01 Unrealized
ALXO ALX ONCOLOGY HLDGS INC 0.5%
Value ($000) $27,475 Shares 2,871,000 Est. Cost $15.18 Unrealized -23.2%
BIOHAVEN PHARMACTL HLDG CO L 0.5%
Value ($000) $25,815 Shares 170,769 Est. Cost $118.57 Unrealized
TELA TELA BIO INC 0.5%
Value ($000) $25,795 Shares 3,027,542 Est. Cost $12.23 Unrealized -32.2%
GRACELL BIOTECHNOLOGIES INC 0.5%
Value ($000) $25,389 Shares 7,884,870 Est. Cost $15.40 Unrealized
89BIO INC 0.4%
Value ($000) $21,185 Shares 3,658,869 Est. Cost $26.29 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 0.4%
Value ($000) $19,231 Shares 2,007,458 Est. Cost $10.93 Unrealized +5.5%
GHRS GH RESEARCH PLC 0.3%
Value ($000) $18,848 Shares 1,622,060 Est. Cost $19.54 Unrealized -35.4%
MGTX MEIRAGTX HLDGS PLC 0.3%
Value ($000) $17,729 Shares 2,108,143 Est. Cost $15.88 Unrealized -44.5%
PCVX VAXCYTE INC 0.3%
Value ($000) $17,230 Shares 717,900 Est. Cost $26.11 Unrealized -2.9%
DECIBEL THERAPEUTICS INC 0.3%
Value ($000) $17,110 Shares 4,945,192 Est. Cost $11.36 Unrealized
IVVD INVIVYD INC 0.3%
Value ($000) $16,496 Shares 5,270,400 Est. Cost $35.34 Unrealized -88.7%
KEZAR LIFE SCIENCES INC 0.3%
Value ($000) $15,254 Shares 1,771,700 Est. Cost $8.34 Unrealized
2SEVENTY BIO INC 0.3%
Value ($000) $15,151 Shares 1,041,300 Est. Cost $14.55 Unrealized
KALV KALVISTA PHARMACEUTICALS INC 0.3%
Value ($000) $15,119 Shares 1,042,000 Est. Cost $13.45 Unrealized +3.9%
NPCE NEUROPACE INC 0.3%
Value ($000) $15,046 Shares 4,012,281 Est. Cost $23.21 Unrealized -79.2%
VERASTEM INC 0.3%
Value ($000) $14,620 Shares 17,200,000 Est. Cost $0.85 Unrealized
RXST RXSIGHT INC 0.3%
Value ($000) $14,434 Shares 1,202,833 Est. Cost $13.60 Unrealized +1.0%
AEROVATE THERAPEUTICS INC 0.2%
Value ($000) $13,181 Shares 795,000 Est. Cost $20.34 Unrealized
BRIDGEBIO PHARMA INC 0.2%
Value ($000) $12,509 Shares 30,000,000 Est. Cost $0.48 Unrealized
BRIDGEBIO PHARMA INC 0.2%
Value ($000) $11,760 Shares 20,000,000 Est. Cost $0.60 Unrealized
PASSAGE BIO INC 0.2%
Value ($000) $11,165 Shares 8,931,999 Est. Cost $12.83 Unrealized
MIRM MIRUM PHARMACEUTICALS INC 0.2%
Value ($000) $10,965 Shares 521,891 Est. Cost $23.65 Unrealized +1.8%
IKENA ONCOLOGY INC 0.2%
Value ($000) $10,415 Shares 2,933,941 Est. Cost $28.25 Unrealized
CINCOR PHARMA INC 0.2%
Value ($000) $10,312 Shares 314,202 Est. Cost $32.82 Unrealized
IMARA INC 0.2%
Value ($000) $10,001 Shares 4,386,568 Est. Cost $11.49 Unrealized
FUSION PHARMACEUTICALS INC 0.2%
Value ($000) $9,707 Shares 3,224,770 Est. Cost $17.47 Unrealized
GEMINI THERAPEUTICS INC 0.2%
Value ($000) $9,555 Shares 5,826,223 Est. Cost $13.55 Unrealized
MREO MEREO BIOPHARMA GROUP PLC 0.2%
Value ($000) $9,132 Shares 10,605,522 Est. Cost $3.31 Unrealized
X4 PHARMACEUTICALS INC 0.2%
Value ($000) $8,596 Shares 5,026,817 Est. Cost $5.00 Unrealized
CGEM CULLINAN ONCOLOGY INC 0.2%
Value ($000) $8,170 Shares 637,287 Est. Cost $40.60 Unrealized -66.8%
RCUS ARCUS BIOSCIENCES INC 0.1%
Value ($000) $7,926 Shares 303,000 Est. Cost $26.45 Unrealized 0.0%
VTYX VENTYX BIOSCIENCES INC 0.1%
Value ($000) $7,855 Shares 225,000 Est. Cost $18.95 Unrealized +16.8%
GALECTO INC 0.1%
Value ($000) $7,732 Shares 4,090,937 Est. Cost $12.51 Unrealized
EYPT EYEPOINT PHARMACEUTICALS INC 0.1%
Value ($000) $7,680 Shares 970,860 Est. Cost $9.46 Unrealized -1.8%
NEXTCURE INC 0.1%
Value ($000) $7,455 Shares 2,711,013 Est. Cost $14.98 Unrealized
LUNG PULMONX CORP 0.1%
Value ($000) $7,247 Shares 435,000 Est. Cost $42.11 Unrealized -56.3%
JOUNCE THERAPEUTICS INC 0.1%
Value ($000) $6,854 Shares 2,928,900 Est. Cost $9.09 Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.1%
Value ($000) $6,680 Shares 2,087,568 Est. Cost $31.92 Unrealized -87.5%
CHEMOMAB THERAPEUTICS LTD 0.1%
Value ($000) $6,420 Shares 2,578,174 Est. Cost $28.71 Unrealized
XBI SPDR SER TR 0.1%
Value ($000) $6,060 Shares 76,400 Est. Cost $134.22 Unrealized
PCVX VAXCYTE INC 0.1%
Value ($000) $6,000 Shares 250,000 Est. Cost $26.11 Unrealized -2.9%
SYNLOGIC INC 0.1%
Value ($000) $5,728 Shares 6,029,995 Est. Cost $7.51 Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.1%
Value ($000) $5,683 Shares 6,943,654 Est. Cost $11.24 Unrealized -91.5%
CYBIN INC 0.1%
Value ($000) $5,082 Shares 10,453,600 Est. Cost $2.19 Unrealized
LLY LILLY ELI & CO 0.1%
Value ($000) $4,850 Shares 15,000 Est. Cost Unrealized
HRTX HERON THERAPEUTICS INC 0.1%
Value ($000) $4,739 Shares 1,123,000 Est. Cost $3.91 Unrealized 0.0%
SRRK SCHOLAR ROCK HLDG CORP 0.1%
Value ($000) $4,629 Shares 667,943 Est. Cost $7.18 Unrealized +16.0%
APPLIED THERAPEUTICS INC 0.1%
Value ($000) $3,953 Shares 4,250,000 Est. Cost $0.95 Unrealized
GRAYBUG VISION INC 0.1%
Value ($000) $3,915 Shares 4,163,347 Est. Cost $12.71 Unrealized
VIGIL NEUROSCIENCE INC 0.1%
Value ($000) $3,742 Shares 411,191 Est. Cost $7.03 Unrealized
SEAGEN INC 0.1%
Value ($000) $3,421 Shares 25,000 Est. Cost $158.60 Unrealized
ACHILLES THERAPEUTICS PLC 0.1%
Value ($000) $3,307 Shares 1,463,251 Est. Cost $16.55 Unrealized
AMRX AMNEAL PHARMACEUTICALS INC 0.1%
Value ($000) $3,199 Shares 1,583,490 Est. Cost $2.80 Unrealized 0.0%
MAGENTA THERAPEUTICS INC 0.1%
Value ($000) $3,174 Shares 2,250,953 Est. Cost $9.74 Unrealized
BURNING ROCK BIOTECH LTD 0.1%
Value ($000) $3,066 Shares 1,282,816 Est. Cost $27.01 Unrealized
HARPOON THERAPEUTICS INC 0.1%
Value ($000) $2,935 Shares 3,025,908 Est. Cost $11.25 Unrealized
DYN DYNE THERAPEUTICS INC 0.1%
Value ($000) $2,799 Shares 220,400 Est. Cost $11.47 Unrealized 0.0%
GRAPHITE BIO INC 0.0%
Value ($000) $2,689 Shares 848,412 Est. Cost $26.23 Unrealized
TARA PROTARA THERAPEUTICS INC 0.0%
Value ($000) $2,459 Shares 830,641 Est. Cost $15.72 Unrealized -78.4%
AFIB ACUTUS MED INC 0.0%
Value ($000) $2,331 Shares 2,648,386 Est. Cost $30.36 Unrealized -96.0%
LOGICBIO THERAPEUTICS INC 0.0%
Value ($000) $2,307 Shares 8,466,783 Est. Cost $9.75 Unrealized
PYXS PYXIS ONCOLOGY INC 0.0%
Value ($000) $1,671 Shares 848,252 Est. Cost $2.61 Unrealized 0.0%
ONCOCYTE CORP 0.0%
Value ($000) $1,374 Shares 1,882,768 Est. Cost $4.29 Unrealized
SINGULAR GENOMICS SYSTEMS IN 0.0%
Value ($000) $1,352 Shares 540,697 Est. Cost $24.94 Unrealized
ESSA PHARMA INC 0.0%
Value ($000) $1,166 Shares 640,645 Est. Cost $1.82 Unrealized
BOLT BIOTHERAPEUTICS INC 0.0%
Value ($000) $1,141 Shares 771,059 Est. Cost $1.48 Unrealized
GLUE MONTE ROSA THERAPEUTICS INC 0.0%
Value ($000) $960 Shares 117,455 Est. Cost $9.19 Unrealized 0.0%
BIOMX INC 0.0%
Value ($000) $957 Shares 2,813,489 Est. Cost $8.51 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.0%
Value ($000) $945 Shares 1,797,221 Est. Cost $7.60 Unrealized
VOR BIOPHARMA INC 0.0%
Value ($000) $445 Shares 111,808 Est. Cost $43.10 Unrealized
LONGBOARD PHARMACEUTICALS IN 0.0%
Value ($000) $422 Shares 113,500 Est. Cost $16.38 Unrealized