Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $5.387B (99.5% shares, 0.5% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| SVA | SINOVAC BIOTECH LTD | 2,718,735 | $341M | 6.3% | — | — | SHS | P8696W104 |
| BMY | BRISTOL-MYERS SQUIBB CO | 2,584,900 | $184M | 3.4% | — | — | COM | 110122108 |
| HUM | HUMANA INC | 348,700 | $169M | 3.1% | — | — | COM | 444859102 |
| — | SPRINGWORKS THERAPEUTICS INC | 5,525,926 | $158M | 2.9% | — | — | COM | 85205L107 |
| BSX | BOSTON SCIENTIFIC CORP | 3,898,200 | $151M | 2.8% | — | — | COM | 101137107 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 1,717,310 | $146M | 2.7% | — | — | COM | 09061G101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 14,567,176 | $143M | 2.7% | — | — | COM | 28036F105 |
| UNH | UNITEDHEALTH GROUP INC | 267,200 | $135M | 2.5% | — | — | COM | 91324P102 |
| PFE | PFIZER INC | 2,599,000 | $114M | 2.1% | — | — | COM | 717081103 |
| — | THIRD HARMONIC BIO INC | 5,779,071 | $110M | 2.0% | — | — | COM | 88427A107 |
| VRTX | VERTEX PHARMACEUTICALS INC | 373,200 | $108M | 2.0% | — | — | COM | 92532F100 |
| — | TRICIDA INC | 10,280,947 | $108M | 2.0% | — | — | COM | 89610F101 |
| ISRG | INTUITIVE SURGICAL INC | 572,700 | $107M | 2.0% | — | — | COM NEW | 46120E602 |
| — | ADICET BIO INC | 7,447,140 | $106M | 2.0% | — | — | COM | 007002108 |
| — | SEAGEN INC | 762,600 | $104M | 1.9% | — | — | COM | 81181C104 |
| TMO | THERMO FISHER SCIENTIFIC INC | 202,200 | $103M | 1.9% | — | — | COM | 883556102 |
| SRPT | SAREPTA THERAPEUTICS INC | 918,500 | $102M | 1.9% | — | — | COM | 803607100 |
| — | MIRATI THERAPEUTICS INC | 1,418,892 | $99.09M | 1.8% | — | — | COM | 60468T105 |
| — | THESEUS PHARMACEUTICALS INC | 17,041,668 | $98.84M | 1.8% | — | — | COM | 88369M101 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 896,545 | $95.22M | 1.8% | — | — | COM | 64125C109 |
| ARGX | ARGENX SE | 269,700 | $95.22M | 1.8% | — | — | SPONSORED ADR | 04016X101 |
| SYK | STRYKER CORPORATION | 423,100 | $85.69M | 1.6% | — | — | COM | 863667101 |
| ABBV | ABBVIE INC | 600,000 | $80.53M | 1.5% | — | — | COM | 00287Y109 |
| EW | EDWARDS LIFESCIENCES CORP | 966,300 | $79.84M | 1.5% | — | — | COM | 28176E108 |
| PMVP | PMV PHARMACEUTICALS INC | 6,563,077 | $78.1M | 1.4% | — | — | COM | 69353Y103 |
| EVH | EVOLENT HEALTH INC | 1,994,717 | $71.67M | 1.3% | — | — | CL A | 30050B101 |
| PRLD | PRELUDE THERAPEUTICS INC | 10,039,691 | $66.36M | 1.2% | — | — | COM | 74065P101 |
| NTRA | NATERA INC | 1,505,153 | $65.96M | 1.2% | — | — | COM | 632307104 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $63.18M | 1.2% | — | — | COM | 492327101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,196,876 | $62.79M | 1.2% | — | — | COM | 22663K107 |
| — | MERSANA THERAPEUTICS INC | 9,011,437 | $60.92M | 1.1% | — | — | COM | 59045L106 |
| — | IKENA ONCOLOGY INC | 12,147,877 | $60.51M | 1.1% | — | — | NONVOTING | 000000000 |
| BIIB | BIOGEN INC | 224,600 | $59.97M | 1.1% | — | — | COM | 09062X103 |
| SIBN | SI-BONE INC | 3,368,000 | $58.8M | 1.1% | — | — | COM | 825704109 |
| — | VERONA PHARMA PLC | 5,694,841 | $58.2M | 1.1% | — | — | SPONSORED ADS | 925050106 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 2,800,000 | $53.51M | 1.0% | — | — | COM | 03969K108 |
| GH | GUARDANT HEALTH INC | 992,400 | $53.42M | 1.0% | — | — | COM | 40131M109 |
| XTNT | XTANT MED HLDGS INC | 73,114,592 | $52.63M | 1.0% | — | — | COM NEW | 98420P308 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 250,500 | $50.14M | 0.9% | — | — | COM | 02043Q107 |
| CMPX | COMPASS THERAPEUTICS INC | 21,960,850 | $50.07M | 0.9% | — | — | COM | 20454B104 |
| — | BELLUS HEALTH INC NEW | 4,634,900 | $48.97M | 0.9% | — | — | COM NEW | 07987C204 |
| — | KINNATE BIOPHARMA INC | 4,043,629 | $48.32M | 0.9% | — | — | COM | 49705R105 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 2,006,500 | $48.22M | 0.9% | — | — | COM | 87164F105 |
| SPRY | SILVERBACK THERAPEUTICS INC | 8,740,887 | $46.15M | 0.9% | — | — | COM | 82835W108 |
| TERN | TERNS PHARMACEUTICALS INC | 7,481,204 | $44.06M | 0.8% | — | — | COM | 880881107 |
| ACRS | ACLARIS THERAPEUTICS INC | 2,758,434 | $43.42M | 0.8% | — | — | COM | 00461U105 |
| PGNY | PROGYNY INC | 1,134,053 | $42.03M | 0.8% | — | — | COM | 74340E103 |
| ABCL | ABCELLERA BIOLOGICS INC | 4,180,768 | $41.35M | 0.8% | — | — | COM | 00288U106 |
| XENE | XENON PHARMACEUTICALS INC | 1,137,300 | $41.06M | 0.8% | — | — | COM | 98420N105 |
| — | REPARE THERAPEUTICS INC | 3,322,488 | $40.3M | 0.7% | — | — | COM | 760273102 |
| — | CHINOOK THERAPEUTICS INC | 2,029,300 | $39.9M | 0.7% | — | — | COM | 16961L106 |
| — | VECTIVBIO HLDG AG | 6,473,561 | $38.84M | 0.7% | — | — | ORD SHS | H9060V101 |
| JANX | JANUX THERAPEUTICS INC | 2,836,386 | $38.41M | 0.7% | — | — | COM | 47103J105 |
| IONS | IONIS PHARMACEUTICALS INC | 768,900 | $34.01M | 0.6% | — | — | COM | 462222100 |
| THC | TENET HEALTHCARE CORP | 643,300 | $33.18M | 0.6% | — | — | COM NEW | 88033G407 |
| — | SCPHARMACEUTICALS INC | 4,797,148 | $31.28M | 0.6% | — | — | COM | 810648105 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,253,130 | $30.88M | 0.6% | — | — | COM | 89422G107 |
| — | RAPT THERAPEUTICS INC | 1,251,070 | $30.1M | 0.6% | — | — | COM | 75382E109 |
| QURE | UNIQURE NV | 1,597,000 | $29.96M | 0.6% | — | — | SHS | N90064101 |
| — | ALPINE IMMUNE SCIENCES INC | 4,081,592 | $29.39M | 0.5% | — | — | COM | 02083G100 |
| ALXO | ALX ONCOLOGY HLDGS INC | 2,871,000 | $27.48M | 0.5% | — | — | COM | 00166B105 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 170,769 | $25.82M | 0.5% | — | — | COM | G11196105 |
| TELA | TELA BIO INC | 3,027,542 | $25.8M | 0.5% | — | — | COM | 872381108 |
| — | GRACELL BIOTECHNOLOGIES INC | 7,884,870 | $25.39M | 0.5% | — | — | SPONSORED ADS | 38406L103 |
| — | 89BIO INC | 3,658,869 | $21.18M | 0.4% | — | — | COM | 282559103 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 2,007,458 | $19.23M | 0.4% | — | — | COM | 462260100 |
| GHRS | GH RESEARCH PLC | 1,622,060 | $18.85M | 0.3% | — | — | ORDINARY SHARES | G3855L106 |
| MGTX | MEIRAGTX HLDGS PLC | 2,108,143 | $17.73M | 0.3% | — | — | COM | G59665102 |
| PCVX | VAXCYTE INC | 717,900 | $17.23M | 0.3% | — | — | COM | 92243G108 |
| — | DECIBEL THERAPEUTICS INC | 4,945,192 | $17.11M | 0.3% | — | — | COM | 24343R106 |
| IVVD | INVIVYD INC | 5,270,400 | $16.5M | 0.3% | — | — | COM | 00534A102 |
| — | KEZAR LIFE SCIENCES INC | 1,771,700 | $15.25M | 0.3% | — | — | COM | 49372L100 |
| — | 2SEVENTY BIO INC | 1,041,300 | $15.15M | 0.3% | — | — | COMMON STOCK | 901384107 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,042,000 | $15.12M | 0.3% | — | — | COM | 483497103 |
| NPCE | NEUROPACE INC | 4,012,281 | $15.05M | 0.3% | — | — | COM | 641288105 |
| — | VERASTEM INC | 17,200,000 | $14.62M | 0.3% | — | — | COM | 92337C104 |
| RXST | RXSIGHT INC | 1,202,833 | $14.43M | 0.3% | — | — | COM | 78349D107 |
| — | AEROVATE THERAPEUTICS INC | 795,000 | $13.18M | 0.2% | — | — | COM | 008064107 |
| — | BRIDGEBIO PHARMA INC | 30,000,000 | $12.51M | 0.2% | — | — | NOTE 2.250% 2/0 | 10806XAD4 |
| — | BRIDGEBIO PHARMA INC | 20,000,000 | $11.76M | 0.2% | — | — | NOTE 2.500% 3/1 | 10806XAB8 |
| — | PASSAGE BIO INC | 8,931,999 | $11.16M | 0.2% | — | — | COM | 702712100 |
| MIRM | MIRUM PHARMACEUTICALS INC | 521,891 | $10.96M | 0.2% | — | — | COM | 604749101 |
| — | IKENA ONCOLOGY INC | 2,933,941 | $10.41M | 0.2% | — | — | COM | 45175G108 |
| — | CINCOR PHARMA INC | 314,202 | $10.31M | 0.2% | — | — | COM | 17240Y109 |
| — | IMARA INC | 4,386,568 | $10M | 0.2% | — | — | COM | 45249V107 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $9.707M | 0.2% | — | — | COM | 36118A100 |
| — | GEMINI THERAPEUTICS INC | 5,826,223 | $9.555M | 0.2% | — | — | COM | 36870G105 |
| MREO | MEREO BIOPHARMA GROUP PLC | 10,605,522 | $9.132M | 0.2% | — | — | SPON ADS | 589492107 |
| — | X4 PHARMACEUTICALS INC | 5,026,817 | $8.596M | 0.2% | — | — | COM | 98420X103 |
| CGEM | CULLINAN ONCOLOGY INC | 637,287 | $8.17M | 0.2% | — | — | COM | 230031106 |
| RCUS | ARCUS BIOSCIENCES INC | 303,000 | $7.926M | 0.1% | — | — | COM | 03969F109 |
| VTYX | VENTYX BIOSCIENCES INC | 225,000 | $7.855M | 0.1% | — | — | COM | 92332V107 |
| — | GALECTO INC | 4,090,937 | $7.732M | 0.1% | — | — | COM | 36322Q107 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 970,860 | $7.68M | 0.1% | — | — | COM NEW | 30233G209 |
| — | NEXTCURE INC | 2,711,013 | $7.455M | 0.1% | — | — | COM | 65343E108 |
| LUNG | PULMONX CORP | 435,000 | $7.247M | 0.1% | — | — | COM | 745848101 |
| — | JOUNCE THERAPEUTICS INC | 2,928,900 | $6.854M | 0.1% | — | — | COM | 481116101 |
| ORIC | ORIC PHARMACEUTICALS INC | 2,087,568 | $6.68M | 0.1% | — | — | COM | 68622P109 |
| — | CHEMOMAB THERAPEUTICS LTD | 2,578,174 | $6.42M | 0.1% | — | — | SPONSORED ADS | 16385C104 |
| XBI | SPDR SER TR | 76,400 | $6.06M | 0.1% | — | — | S&P BIOTECH | 78464A870 |
| PCVX | VAXCYTE INC | 250,000 | $6M | 0.1% | — | — | Call | 92243G108 |
| — | SYNLOGIC INC | 6,029,995 | $5.728M | 0.1% | — | — | COM | 87166L100 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,943,654 | $5.683M | 0.1% | — | — | COM | 221015100 |
| — | CYBIN INC | 10,453,600 | $5.082M | 0.1% | — | — | COM | 23256X100 |
| LLY | LILLY ELI & CO | 15,000 | $4.85M | 0.1% | — | — | Call | 532457108 |
| HRTX | HERON THERAPEUTICS INC | 1,123,000 | $4.739M | 0.1% | — | — | COM | 427746102 |
| SRRK | SCHOLAR ROCK HLDG CORP | 667,943 | $4.629M | 0.1% | — | — | COM | 80706P103 |
| — | APPLIED THERAPEUTICS INC | 4,250,000 | $3.953M | 0.1% | — | — | COM | 03828A101 |
| — | GRAYBUG VISION INC | 4,163,347 | $3.915M | 0.1% | — | — | COMMON | 38942Q103 |
| — | VIGIL NEUROSCIENCE INC | 411,191 | $3.742M | 0.1% | — | — | COM | 92673K108 |
| — | SEAGEN INC | 25,000 | $3.421M | 0.1% | — | — | Call | 81181C104 |
| — | ACHILLES THERAPEUTICS PLC | 1,463,251 | $3.307M | 0.1% | — | — | SPONSORED ADS | 00449L102 |
| AMRX | AMNEAL PHARMACEUTICALS INC | 1,583,490 | $3.199M | 0.1% | — | — | COM STK CL A | 03168L105 |
| — | MAGENTA THERAPEUTICS INC | 2,250,953 | $3.174M | 0.1% | — | — | COM | 55910K108 |
| — | BURNING ROCK BIOTECH LTD | 1,282,816 | $3.066M | 0.1% | — | — | SPONSORED ADS | 12233L107 |
| — | HARPOON THERAPEUTICS INC | 3,025,908 | $2.935M | 0.1% | — | — | COM | 41358P106 |
| DYN | DYNE THERAPEUTICS INC | 220,400 | $2.799M | 0.1% | — | — | COM | 26818M108 |
| — | GRAPHITE BIO INC | 848,412 | $2.689M | 0.0% | — | — | COM | 38870X104 |
| TARA | PROTARA THERAPEUTICS INC | 830,641 | $2.459M | 0.0% | — | — | COM STK | 74365U107 |
| AFIB | ACUTUS MED INC | 2,648,386 | $2.331M | 0.0% | — | — | COM | 005111109 |
| — | LOGICBIO THERAPEUTICS INC | 8,466,783 | $2.307M | 0.0% | — | — | COM | 54142F102 |
| PYXS | PYXIS ONCOLOGY INC | 848,252 | $1.671M | 0.0% | — | — | COMMON STOCK | 747324101 |
| — | ONCOCYTE CORP | 1,882,768 | $1.374M | 0.0% | — | — | COM | 68235C107 |
| — | SINGULAR GENOMICS SYSTEMS IN | 540,697 | $1.352M | 0.0% | — | — | COM | 82933R100 |
| — | ESSA PHARMA INC | 640,645 | $1.166M | 0.0% | — | — | COM NEW | 29668H708 |
| — | BOLT BIOTHERAPEUTICS INC | 771,059 | $1.141M | 0.0% | — | — | COM | 097702104 |
| GLUE | MONTE ROSA THERAPEUTICS INC | 117,455 | $960K | 0.0% | — | — | COM | 61225M102 |
| — | BIOMX INC | 2,813,489 | $957K | 0.0% | — | — | COM | 09090D103 |
| — | AEGLEA BIOTHERAPEUTICS INC | 1,797,221 | $945K | 0.0% | — | — | COM | 00773J103 |
| — | VOR BIOPHARMA INC | 111,808 | $445K | 0.0% | — | — | COM | 929033108 |
| — | LONGBOARD PHARMACEUTICALS IN | 113,500 | $422K | 0.0% | — | — | COM | 54300N103 |