Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q3 2014 (← Previous) (Next →)

Filing Date: Nov 14, 2014

Total Value ($000): $128,295,606 (100.0% shares, 0.0% debt)

Holdings (30)

— CHIMERIX INC 16.3%

Value ($000) $20,853,100 Shares 755,000 Est. Cost $22.55 Unrealized —

— PHARMACYCLICS INC 7.8%

Value ($000) $9,981,550 Shares 85,000 Est. Cost $108000.00 Unrealized —

— RETROPHIN INC 7.0%

Value ($000) $9,020,000 Shares 1,000,000 Est. Cost $20.71 Unrealized —

— ARIAD PHARMACEUTICALS INC 6.3%

Value ($000) $8,100,000 Shares 1,500,000 Est. Cost $7100.00 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 5.4%

Value ($000) $6,963,225 Shares 113,500 Est. Cost $40.76 Unrealized +5.7%

— CLOVIS ONCOLOGY INC. 4.8%

Value ($000) $6,210,400 Shares 140,000 Est. Cost $3206.92 Unrealized —

— CEMPRA INC 4.3%

Value ($000) $5,532,608 Shares 504,800 Est. Cost $9402.92 Unrealized —

— GENMARK DIAGNOSTICS INC 3.8%

Value ($000) $4,933,500 Shares 550,000 Est. Cost $824.92 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 3.7%

Value ($000) $4,811,000 Shares 85,000 Est. Cost $45.48 Unrealized +10.6%

— INSYS THERAPEUTICS INC NEWS 3.7%

Value ($000) $4,750,550 Shares 122,500 Est. Cost $11640.05 Unrealized —

— INSPIREMD INC 3.6%

Value ($000) $4,594,700 Shares 2,088,500 Est. Cost $1354.42 Unrealized —

CDXS CODEXIS INC 3.1%

Value ($000) $3,937,700 Shares 1,690,000 Est. Cost $1.97 Unrealized +8.8%

— BIND THERAPEUTICS INC 3.0%

Value ($000) $3,865,500 Shares 450,000 Est. Cost $4324.41 Unrealized —

— IMPRIMIS PHARMACEUTICALS INC 2.9%

Value ($000) $3,728,550 Shares 502,500 Est. Cost $7420.00 Unrealized —

PRTA PROTHENA CORP PLC 2.7%

Value ($000) $3,479,120 Shares 157,000 Est. Cost $21.52 Unrealized -1.5%

— TETRAPHASE PHARMACEUTICALS I 2.6%

Value ($000) $3,385,515 Shares 169,700 Est. Cost $11760.18 Unrealized —

CPRX CATALYST PHARM PARTNERS INC 2.5%

Value ($000) $3,237,000 Shares 975,000 Est. Cost $2.02 Unrealized +29.2%

— CARDIOVASCULAR SYS INC DEL 2.3%

Value ($000) $2,953,750 Shares 125,000 Est. Cost $33000.00 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 1.8%

Value ($000) $2,272,710 Shares 29,100 Est. Cost $63.25 Unrealized +2.0%

— CELGENE CORP 1.7%

Value ($000) $2,237,400 Shares 660,000 Est. Cost $2800.00 Unrealized —

— AEGERION PHARMACEUTICALS INC 1.5%

Value ($000) $1,919,350 Shares 57,500 Est. Cost $33380.00 Unrealized —

— ACCELERATE DIAGNOSTICS INC 1.5%

Value ($000) $1,916,016 Shares 89,200 Est. Cost $21480.00 Unrealized —

— DICERNA PHARMACEUTICALS INC 1.3%

Value ($000) $1,712,185 Shares 134,500 Est. Cost $12730.00 Unrealized —

LAB FLUIDIGM CORP DEL 1.3%

Value ($000) $1,641,500 Shares 67,000 Est. Cost $28.11 Unrealized 0.0%

GERN GERON CORP 1.3%

Value ($000) $1,640,000 Shares 820,000 Est. Cost $2.46 Unrealized 0.0%

— EVOKE PHARMA 1.1%

Value ($000) $1,468,367 Shares 267,000 Est. Cost $512.24 Unrealized —

— OPHTHOTECH CORP 1.1%

Value ($000) $1,362,550 Shares 35,000 Est. Cost $38930.00 Unrealized —

— CELATOR PHARMACEUTICALS INC 0.8%

Value ($000) $1,024,650 Shares 405,000 Est. Cost $2789.09 Unrealized —

— BIOLINERX LTD 0.6%

Value ($000) $754,600 Shares 490,000 Est. Cost $1426.15 Unrealized —

— KIPS BAY MED INC 0.0%

Value ($000) $8,510 Shares 50,000 Est. Cost $0.69 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	CHIMERIX INC	755,000	$20,853,100	16.3%	$22.55	—	COM	16934W106
—	PHARMACYCLICS INC	85,000	$9,981,550	7.8%	$108000.00	—	COM	716933106
—	RETROPHIN INC	1,000,000	$9,020,000	7.0%	$20.71	—	COM	761299106
—	ARIAD PHARMACEUTICALS INC	1,500,000	$8,100,000	6.3%	$7100.00	—	COM	04033A100
AGIO	AGIOS PHARMACEUTICALS INC	113,500	$6,963,225	5.4%	$40.76	+5.7%	COM	00847X104
—	CLOVIS ONCOLOGY INC.	140,000	$6,210,400	4.8%	$3206.92	—	COM	189464100
—	CEMPRA INC	504,800	$5,532,608	4.3%	$9402.92	—	COM	15130J109
—	GENMARK DIAGNOSTICS INC	550,000	$4,933,500	3.8%	$824.92	—	COM	372309104
RARE	ULTRAGENYX PHARMACEUTICAL IN	85,000	$4,811,000	3.7%	$45.48	+10.6%	COM	90400D108
—	INSYS THERAPEUTICS INC NEWS	122,500	$4,750,550	3.7%	$11640.05	—	COM	45824V209
—	INSPIREMD INC	2,088,500	$4,594,700	3.6%	$1354.42	—	COM	45779A309
CDXS	CODEXIS INC	1,690,000	$3,937,700	3.1%	$1.97	+8.8%	COM	192005106
—	BIND THERAPEUTICS INC	450,000	$3,865,500	3.0%	$4324.41	—	COM	05548N107
—	IMPRIMIS PHARMACEUTICALS INC	502,500	$3,728,550	2.9%	$7420.00	—	COM	45323A201
PRTA	PROTHENA CORP PLC	157,000	$3,479,120	2.7%	$21.52	-1.5%	COM	G72800108
—	TETRAPHASE PHARMACEUTICALS I	169,700	$3,385,515	2.6%	$11760.18	—	COM	88165N105
CPRX	CATALYST PHARM PARTNERS INC	975,000	$3,237,000	2.5%	$2.02	+29.2%	COM	14888U101
—	CARDIOVASCULAR SYS INC DEL	125,000	$2,953,750	2.3%	$33000.00	—	COM	141619106
ALNY	ALNYLAM PHARMACEUTICALS INC	29,100	$2,272,710	1.8%	$63.25	+2.0%	COM	02043Q107
—	CELGENE CORP	660,000	$2,237,400	1.7%	$2800.00	—	RIGHT 12/31/2030	151020112
—	AEGERION PHARMACEUTICALS INC	57,500	$1,919,350	1.5%	$33380.00	—	COM	00767E102
—	ACCELERATE DIAGNOSTICS INC	89,200	$1,916,016	1.5%	$21480.00	—	COM	00430H102
—	DICERNA PHARMACEUTICALS INC	134,500	$1,712,185	1.3%	$12730.00	—	COM	253031108
LAB	FLUIDIGM CORP DEL	67,000	$1,641,500	1.3%	$28.11	0.0%	COM	34385P108
GERN	GERON CORP	820,000	$1,640,000	1.3%	$2.46	0.0%	COM	374163103
—	EVOKE PHARMA	267,000	$1,468,367	1.1%	$512.24	—	COM	30049G104
—	OPHTHOTECH CORP	35,000	$1,362,550	1.1%	$38930.00	—	COM	683745103
—	CELATOR PHARMACEUTICALS INC	405,000	$1,024,650	0.8%	$2789.09	—	COM	15089R102
—	BIOLINERX LTD	490,000	$754,600	0.6%	$1426.15	—	COM	09071M106
—	KIPS BAY MED INC	50,000	$8,510	0.0%	$0.69	—	COM	49726K105