Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q4 2014 (← Previous) (Next →)

Filing Date: Feb 13, 2015

Total Value: $198M (100.0% shares, 0.0% debt)

Holdings (36)

— CHIMERIX INC 16.4%

Value $32.41M Shares 805,000 Est. Cost $23.65 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 6.4%

Value $12.72M Shares 113,500 Est. Cost $40.76 Unrealized +119.0%

— CEMPRA INC 6.0%

Value $11.87M Shares 504,800 Est. Cost $9402.92 Unrealized —

— RETROPHIN INC 5.7%

Value $11.26M Shares 920,000 Est. Cost $20.71 Unrealized —

— ARIAD PHARMACEUTICALS INC 5.3%

Value $10.48M Shares 1,525,000 Est. Cost $6983.72 Unrealized —

— PHARMACYCLICS INC 5.3%

Value $10.39M Shares 85,000 Est. Cost $108000.00 Unrealized —

— CLOVIS ONCOLOGY INC. 4.0%

Value $7.84M Shares 140,000 Est. Cost $3206.92 Unrealized —

— TETRAPHASE PHARMACEUTICALS INC 3.8%

Value $7.533M Shares 189,700 Est. Cost $10524.49 Unrealized —

GERN GERON CORP 3.0%

Value $5.931M Shares 1,825,000 Est. Cost $2.63 Unrealized +5.2%

— VERSARTIS INC 2.7%

Value $5.276M Shares 235,000 Est. Cost $22.45 Unrealized —

— FIBROGEN INC 2.6%

Value $5.231M Shares 191,338 Est. Cost $27.34 Unrealized —

— INSYS THERAPEUTICS INC NEW 2.6%

Value $5.165M Shares 122,500 Est. Cost $11640.05 Unrealized —

RARE ULTRAGENYX PHARMACEUTICALS INC 2.4%

Value $4.66M Shares 106,200 Est. Cost $45.54 Unrealized +0.6%

— GENMARK DIAGNOSTICS INC 2.3%

Value $4.559M Shares 335,000 Est. Cost $824.92 Unrealized —

— OPHTHOTECH CORP 2.3%

Value $4.487M Shares 100,000 Est. Cost $13654.67 Unrealized —

— KITE PHARMA INC 2.2%

Value $4.383M Shares 76,000 Est. Cost $57.67 Unrealized —

CDXS CODEXIS INC 2.2%

Value $4.344M Shares 1,724,000 Est. Cost $1.98 Unrealized +20.3%

— MEDGENICS INC 2.2%

Value $4.301M Shares 850,000 Est. Cost $5.06 Unrealized —

— IMPRIMIS PHARMACEUTICALS INC 2.1%

Value $4.2M Shares 560,000 Est. Cost $6658.90 Unrealized —

— ONCOTHYREON INC 1.9%

Value $3.8M Shares 2,000,000 Est. Cost $1.90 Unrealized —

— CARDIOVASCULAR SYS INC DEL 1.9%

Value $3.76M Shares 125,000 Est. Cost $33000.00 Unrealized —

— FLAMEL TECHNOLOGIES SA 1.8%

Value $3.512M Shares 205,000 Est. Cost $17.13 Unrealized —

LAB FLUIDIGM CORP DEL 1.6%

Value $3.204M Shares 95,000 Est. Cost $28.17 Unrealized +0.5%

— PARATEK PHARMACEUTICALS INC 1.6%

Value $3.084M Shares 80,000 Est. Cost $38.55 Unrealized —

— TRILLIUM THERAPEUTICS INC 1.5%

Value $3M Shares 333,333 Est. Cost $9.00 Unrealized —

SUPN SUPERNUS PHARMACEUTICALS INC 1.5%

Value $2.905M Shares 350,000 Est. Cost $8.40 Unrealized 0.0%

CPRX CATALYST PHARM PARTNERS INC 1.5%

Value $2.896M Shares 975,000 Est. Cost $2.02 Unrealized +35.7%

— HORIZON PHARMA PLC 1.4%

Value $2.836M Shares 220,000 Est. Cost $12.89 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 1.4%

Value $2.823M Shares 29,100 Est. Cost $63.25 Unrealized +46.5%

— ACCELERATE DIAGNOSTICS 1.0%

Value $1.919M Shares 100,000 Est. Cost $19162.23 Unrealized —

— CELGENE CORP 0.9%

Value $1.811M Shares 575,000 Est. Cost $2800.00 Unrealized —

— TENAX THERAPEUTICS INC 0.9%

Value $1.69M Shares 440,000 Est. Cost $3.84 Unrealized —

— EVOKE PHARMA INC 0.7%

Value $1.416M Shares 240,000 Est. Cost $512.24 Unrealized —

NBIX NEUROCRINE BIOSCIENCES INC 0.5%

Value $1.005M Shares 45,000 Est. Cost $18.95 Unrealized 0.0%

— CARA THERAPEUTICS INC 0.4%

Value $798K Shares 80,000 Est. Cost $9.97 Unrealized —

— BIOLINERX LTD 0.2%

Value $405K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	CHIMERIX INC	805,000	$32.41M	16.4%	$23.65	—	COM	16934W106
AGIO	AGIOS PHARMACEUTICALS INC	113,500	$12.72M	6.4%	$40.76	+119.0%	COM	00847X104
—	CEMPRA INC	504,800	$11.87M	6.0%	$9402.92	—	COM	15130J109
—	RETROPHIN INC	920,000	$11.26M	5.7%	$20.71	—	COM	761299106
—	ARIAD PHARMACEUTICALS INC	1,525,000	$10.48M	5.3%	$6983.72	—	COM	04033A100
—	PHARMACYCLICS INC	85,000	$10.39M	5.3%	$108000.00	—	COM	716933106
—	CLOVIS ONCOLOGY INC.	140,000	$7.84M	4.0%	$3206.92	—	COM	189464100
—	TETRAPHASE PHARMACEUTICALS INC	189,700	$7.533M	3.8%	$10524.49	—	COM	88165N105
GERN	GERON CORP	1,825,000	$5.931M	3.0%	$2.63	+5.2%	COM	374163103
—	VERSARTIS INC	235,000	$5.276M	2.7%	$22.45	—	COM	92529L102
—	FIBROGEN INC	191,338	$5.231M	2.6%	$27.34	—	COM	31572Q808
—	INSYS THERAPEUTICS INC NEW	122,500	$5.165M	2.6%	$11640.05	—	COM NEW	45824V209
RARE	ULTRAGENYX PHARMACEUTICALS INC	106,200	$4.66M	2.4%	$45.54	+0.6%	COM	90400D108
—	GENMARK DIAGNOSTICS INC	335,000	$4.559M	2.3%	$824.92	—	COM	372309104
—	OPHTHOTECH CORP	100,000	$4.487M	2.3%	$13654.67	—	COM	683745103
—	KITE PHARMA INC	76,000	$4.383M	2.2%	$57.67	—	COM	49803L109
CDXS	CODEXIS INC	1,724,000	$4.344M	2.2%	$1.98	+20.3%	COM	192005106
—	MEDGENICS INC	850,000	$4.301M	2.2%	$5.06	—	COM NEW	58436Q203
—	IMPRIMIS PHARMACEUTICALS INC	560,000	$4.2M	2.1%	$6658.90	—	COM NEW	45323A201
—	ONCOTHYREON INC	2,000,000	$3.8M	1.9%	$1.90	—	COM	682234108
—	CARDIOVASCULAR SYS INC DEL	125,000	$3.76M	1.9%	$33000.00	—	COM	141619106
—	FLAMEL TECHNOLOGIES SA	205,000	$3.512M	1.8%	$17.13	—	COM	338488109
LAB	FLUIDIGM CORP DEL	95,000	$3.204M	1.6%	$28.17	+0.5%	COM	34385P108
—	PARATEK PHARMACEUTICALS INC	80,000	$3.084M	1.6%	$38.55	—	COM	699374302
—	TRILLIUM THERAPEUTICS INC	333,333	$3M	1.5%	$9.00	—	COM	89620X506
SUPN	SUPERNUS PHARMACEUTICALS INC	350,000	$2.905M	1.5%	$8.40	0.0%	COM	868459108
CPRX	CATALYST PHARM PARTNERS INC	975,000	$2.896M	1.5%	$2.02	+35.7%	COM	14888U101
—	HORIZON PHARMA PLC	220,000	$2.836M	1.4%	$12.89	—	COM	G4617B105
ALNY	ALNYLAM PHARMACEUTICALS INC	29,100	$2.823M	1.4%	$63.25	+46.5%	COM	02043Q107
—	ACCELERATE DIAGNOSTICS	100,000	$1.919M	1.0%	$19162.23	—	COM	00430H102
—	CELGENE CORP	575,000	$1.811M	0.9%	$2800.00	—	RIGHT 12/31/2030	151020112
—	TENAX THERAPEUTICS INC	440,000	$1.69M	0.9%	$3.84	—	COM	88032L100
—	EVOKE PHARMA INC	240,000	$1.416M	0.7%	$512.24	—	COM	30049G104
NBIX	NEUROCRINE BIOSCIENCES INC	45,000	$1.005M	0.5%	$18.95	0.0%	COM	64125C109
—	CARA THERAPEUTICS INC	80,000	$798K	0.4%	$9.97	—	COM	140755109
—	BIOLINERX LTD	250,000	$405K	0.2%	$1426.15	—	COM	09071M106