| BlackRock, Inc. | 9,192,447 | $35.12M |
| ARMISTICE CAPITAL, LLC | 7,024,000 | $26.83M |
| RTW INVESTMENTS, LP | 6,635,793 | $25.35M |
| Deep Track Capital, LP | 5,740,850 | $21.93M |
| STATE STREET CORP | 5,133,859 | $19.61M |
| Rosalind Advisors, Inc. | 3,986,509 | $15.23M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,851,508 | $14.71M |
| Nantahala Capital Management, LLC | 3,584,820 | $13.69M |
| Stonepine Capital Management, LLC | 3,349,627 | $12.8M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,266,870 | $12.48M |
| Foresite Capital Management VI LLC | 3,146,631 | $12.02M |
| GOLDMAN SACHS GROUP INC | 2,721,178 | $10.39M |
| BAKER BROS. ADVISORS LP | 2,499,338 | $9.547M |
| Alyeska Investment Group, L.P. | 2,289,625 | $8.746M |
| MILLENNIUM MANAGEMENT LLC | 2,078,003 | $7.938M |
| GEODE CAPITAL MANAGEMENT, LLC | 2,074,145 | $7.925M |
| AIGH Capital Management LLC | 1,927,000 | $7.361M |
| Opaleye Management Inc. | 1,800,000 | $6.876M |
| BALYASNY ASSET MANAGEMENT L.P. | 1,686,575 | $6.443M |
| Qube Research & Technologies Ltd | 1,628,488 | $6.221M |
| ACORN CAPITAL ADVISORS, LLC | 1,469,153 | $5.612M |
| NEXTBio Capital Management LP | 1,306,800 | $4.992M |
| FRANKLIN RESOURCES INC | 1,105,021 | $4.221M |
| Pinnacle Financial Partners, Inc. | 1,086,440 | $4.15M |
| AQR CAPITAL MANAGEMENT LLC | 934,565 | $3.57M |
| BANK OF AMERICA CORP /DE/ | 889,975 | $3.4M |
| MORGAN STANLEY | 715,822 | $2.734M |
| PANAGORA ASSET MANAGEMENT INC | 666,874 | $2.547M |
| NORTHERN TRUST CORP | 651,495 | $2.489M |
| J. Goldman & Co LP | 650,074 | $2.483M |
| SPHERA FUNDS MANAGEMENT LTD. | 632,632 | $2.417M |
| FMR LLC | 626,298 | $2.392M |
| VANGUARD FIDUCIARY TRUST CO | 616,862 | $2.356M |
| UBS Group AG | 604,480 | $2.309M |
| Hennion & Walsh Asset Management, Inc. | 569,195 | $2.174M |
| XTX Topco Ltd | 561,791 | $2.146M |
| Jefferies Financial Group Inc. | 496,529 | $1.897M |
| TORRAY INVESTMENT PARTNERS LLC | 477,455 | $1.824M |
| TORONTO DOMINION BANK | 460,413 | $1.759M |
| Exome Asset Management LLC | 429,041 | $1.639M |
| CITADEL ADVISORS LLC | 317,327 | $1.212M |
| Palo Alto Investors LP | 309,685 | $1.183M |
| Jump Financial, LLC | 307,500 | $1.175M |
| Virtus Investment Advisers, LLC | 283,630 | $1.083M |
| Diametric Capital, LP | 265,539 | $1.014M |
| Nuveen, LLC | 258,933 | $989K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 243,950 | $932K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 238,429 | $911K |
| DIMENSIONAL FUND ADVISORS LP | 235,207 | $898K |
| Ikarian Capital, LLC | 213,865 | $817K |
| RAYMOND JAMES FINANCIAL INC | 198,837 | $760K |
| Bank of New York Mellon Corp | 184,944 | $706K |
| SG Americas Securities, LLC | 172,266 | $658K |
| Knott David M Jr | 155,000 | $592K |
| Janney Montgomery Scott LLC | 152,439 | $582K |
| CANTOR FITZGERALD, L. P. | 140,000 | $535K |
| Invesco Ltd. | 125,077 | $478K |
| CITIGROUP INC | 120,235 | $459K |
| ALLIANCEBERNSTEIN L.P. | 117,090 | $621K |
| ROYAL BANK OF CANADA | 108,863 | $415K |
| ExodusPoint Capital Management, LP | 99,236 | $379K |
| Rafferty Asset Management, LLC | 94,204 | $360K |
| BARCLAYS PLC | 93,408 | $357K |
| DEUTSCHE BANK AG\ | 87,668 | $335K |
| RHUMBLINE ADVISERS | 83,678 | $320K |
| Virtu Financial LLC | 82,263 | $314K |
| WELLS FARGO & COMPANY/MN | 80,687 | $308K |
| ADAR1 Capital Management, LLC | 75,800 | $290K |
| Brevan Howard Capital Management LP | 72,383 | $276K |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,541 | $262K |
| Man Group plc | 67,597 | $258K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 65,565 | $251K |
| HSBC HOLDINGS PLC | 59,466 | $232K |
| MetLife Investment Management, LLC | 59,249 | $226K |
| Jain Global LLC | 55,238 | $211K |
| WELLINGTON MANAGEMENT GROUP LLP | 51,700 | $197K |
| ALGERT GLOBAL LLC | 51,300 | $196K |
| TWO SIGMA INVESTMENTS, LP | 49,954 | $191K |
| Creative Planning | 47,588 | $182K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,568 | $182K |
| PROFUND ADVISORS LLC | 47,484 | $181K |
| Quadrature Capital Ltd | 46,982 | $179K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 46,874 | $179K |
| Quantinno Capital Management LP | 46,337 | $177K |
| ENVESTNET ASSET MANAGEMENT INC | 44,581 | $170K |
| Cetera Investment Advisers | 43,412 | $166K |
| MERCER GLOBAL ADVISORS INC /ADV | 42,803 | $164K |
| Graham Capital Management, L.P. | 40,131 | $153K |
| STIFEL FINANCIAL CORP | 38,353 | $147K |
| Quantbot Technologies LP | 36,639 | $140K |
| JPMORGAN CHASE & CO | 35,387 | $135K |
| Diversified Trust Co | 32,245 | $123K |
| Aries Wealth Management | 30,833 | $118K |
| Vanguard Global Advisers, LLC | 30,520 | $117K |
| MIZUHO SECURITIES USA LLC | 30,000 | $159K |
| NewEdge Wealth, LLC | 27,826 | $106K |
| Russell Investments Group, Ltd. | 27,757 | $106K |
| SEI INVESTMENTS CO | 26,622 | $102K |
| Verdad Advisers, LP | 24,237 | $92,585 |
| WINTON GROUP Ltd | 24,200 | $92,444 |
| 58 other institutions | 296,698 | $1.167M |