| RTW INVESTMENTS, LP | 6,576,306 | $50,769 |
| Deep Track Capital, LP | 5,740,850 | $44,319 |
| BlackRock, Inc. | 4,752,842 | $36,692 |
| VANGUARD GROUP INC | 4,152,706 | $32,059 |
| Polar Capital Holdings Plc | 3,925,126 | $30,302 |
| ARMISTICE CAPITAL, LLC | 3,536,000 | $27,298 |
| STATE STREET CORP | 3,219,295 | $24,853 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,195,726 | $24,671 |
| Foresite Capital Management VI LLC | 3,135,120 | $24,203 |
| Stonepine Capital Management, LLC | 2,732,079 | $21,092 |
| CITADEL ADVISORS LLC | 2,353,465 | $18,169 |
| SymBiosis Capital Partners, LLC | 2,000,000 | $15,440 |
| FARALLON CAPITAL MANAGEMENT LLC | 2,000,000 | $15,440 |
| MORGAN STANLEY | 1,871,562 | $14,448 |
| Rosalind Advisors, Inc. | 1,788,475 | $13,807 |
| Logos Global Management LP | 1,700,000 | $13,124 |
| GOLDMAN SACHS GROUP INC | 1,495,424 | $11,545 |
| ACORN CAPITAL ADVISORS, LLC | 1,469,153 | $11,342 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,392,822 | $10,755 |
| NEXTBio Capital Management LP | 1,307,330 | $10,093 |
| Vivo Capital, LLC | 1,106,524 | $8,542 |
| TANG CAPITAL MANAGEMENT LLC | 1,069,810 | $8,259 |
| Point72 Asset Management, L.P. | 995,026 | $7,682 |
| J. Goldman & Co LP | 947,303 | $7,313 |
| FRANKLIN RESOURCES INC | 926,011 | $7,149 |
| Jefferies Financial Group Inc. | 557,016 | $4,300 |
| MILLENNIUM MANAGEMENT LLC | 555,129 | $4,286 |
| UBS Group AG | 501,471 | $3,871 |
| TWO SIGMA INVESTMENTS, LP | 476,892 | $3,682 |
| Nantahala Capital Management, LLC | 462,140 | $3,568 |
| TORONTO DOMINION BANK | 460,413 | $3,554 |
| Exome Asset Management LLC | 401,743 | $3,101 |
| TWO SIGMA ADVISERS, LP | 398,992 | $3,080 |
| FMR LLC | 398,546 | $3,077 |
| NORTHERN TRUST CORP | 393,097 | $3,035 |
| Pinnacle Financial Partners, Inc. | 390,524 | $3,015 |
| SG Americas Securities, LLC | 390,325 | $3 |
| CITIGROUP INC | 364,436 | $2,813 |
| Y-Intercept (Hong Kong) Ltd | 364,283 | $2,812 |
| SPHERA FUNDS MANAGEMENT LTD. | 343,678 | $2,653 |
| D. E. Shaw & Co., Inc. | 338,853 | $2,616 |
| JANE STREET GROUP, LLC | 320,806 | $2,477 |
| BANK OF AMERICA CORP /DE/ | 316,862 | $2,446 |
| Squarepoint Ops LLC | 275,913 | $2,130 |
| Ishara Investments LP | 270,000 | $2,084 |
| Polymer Capital Management (HK) LTD | 266,812 | $2,060 |
| Qube Research & Technologies Ltd | 254,900 | $1,968 |
| PANAGORA ASSET MANAGEMENT INC | 244,067 | $1,884 |
| Torray Investment Partners LLC | 216,387 | $1,671 |
| Ikarian Capital, LLC | 213,865 | $1,651 |
| BARCLAYS PLC | 201,845 | $1,558 |
| RAYMOND JAMES FINANCIAL INC | 199,344 | $1,539 |
| Nuveen, LLC | 188,653 | $1,456 |
| Hennion & Walsh Asset Management, Inc. | 174,384 | $1,346 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,165 | $1,244 |
| Trexquant Investment LP | 154,768 | $1,195 |
| Birchview Capital, LP | 150,000 | $1,158 |
| WELLINGTON MANAGEMENT GROUP LLP | 145,512 | $1,123 |
| ACUTA CAPITAL PARTNERS, LLC | 143,446 | $1,107 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,318 | $1,106 |
| XTX Topco Ltd | 131,121 | $1,012 |
| Rafferty Asset Management, LLC | 129,333 | $998 |
| Burkehill Global Management, LP | 125,000 | $965 |
| Bank of New York Mellon Corp | 122,689 | $947 |
| ExodusPoint Capital Management, LP | 104,947 | $810 |
| Invesco Ltd. | 104,093 | $804 |
| ROYAL BANK OF CANADA | 96,046 | $741 |
| JANUS HENDERSON GROUP PLC | 88,851 | $686 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 74,221 | $573 |
| Caption Management, LLC | 70,405 | $544 |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,541 | $529 |
| ALLIANCEBERNSTEIN L.P. | 67,270 | $519 |
| WELLS FARGO & COMPANY/MN | 62,597 | $483 |
| RHUMBLINE ADVISERS | 60,504 | $467 |
| FOX RUN MANAGEMENT, L.L.C. | 57,137 | $441 |
| AQR CAPITAL MANAGEMENT LLC | 49,002 | $378 |
| PROFUND ADVISORS LLC | 47,665 | $368 |
| DEUTSCHE BANK AG\ | 45,570 | $352 |
| Cetera Investment Advisers | 43,378 | $335 |
| ENVESTNET ASSET MANAGEMENT INC | 42,469 | $328 |
| CANTOR FITZGERALD, L. P. | 42,251 | $326 |
| STIFEL FINANCIAL CORP | 39,772 | $307 |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,107 | $302 |
| VARCOV Co. | 33,775 | $261 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,351 | $248 |
| Aquatic Capital Management LLC | 30,930 | $239 |
| MetLife Investment Management, LLC | 28,929 | $223 |
| Virtus Investment Advisers, LLC | 27,682 | $214 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,236 | $0 |
| Quarry LP | 27,000 | $208 |
| Aries Wealth Management | 26,249 | $203 |
| NewEdge Wealth, LLC | 25,885 | $200 |
| Brevan Howard Capital Management LP | 25,172 | $194 |
| Graham Capital Management, L.P. | 23,438 | $181 |
| JPMORGAN CHASE & CO | 22,361 | $173 |
| Entropy Technologies, LP | 20,793 | $161 |
| OSAIC HOLDINGS, INC. | 20,476 | $158 |
| INTECH INVESTMENT MANAGEMENT LLC | 19,224 | $148 |
| GROUP ONE TRADING, L.P. | 17,887 | $138 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,410 | $127 |
| 41 other institutions | 133,108 | $920 |