Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q2 2024 (← Previous) (Next →)
Filing Date: Aug 14, 2024
Total Value: $7.561B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,108,400 | $1.379B | 18.2% | $136.38 | $79.32 | — | SH | 04351P101 |
| PCVX | VAXCYTE INC | 8,203,754 | $619M | 8.2% | $75.51 * | $36.65 | +85.7% | SH | 92243G108 |
| JANX | JANUX THERAPEUTICS INC | 9,165,652 | $384M | 5.1% | $41.89 * | $21.69 | +116.5% | SH | 47103J105 |
| LEGN | LEGEND BIOTECH CORP-ADR | 7,506,934 | $332M | 4.4% | $44.29 | $56.83 | — | SH | 52490G102 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,084,412 | $250M | 3.3% | $41.06 * | $25.92 | +54.0% | SH | 76243J105 |
| BIIB | BIOGEN INC | 982,139 | $228M | 3.0% | $231.82 * | $220.35 | -1.4% | SH | 09062X103 |
| CLYM | ELIEM THERAPEUTICS INC | 31,419,267 | $223M | 3.0% | $7.11 * | $12.52 | -46.8% | SH | 28658R106 |
| RXST | RXSIGHT INC | 3,694,825 | $222M | 2.9% | $60.17 * | $18.57 | +207.7% | SH | 78349D107 |
| RNAM | AVIDITY BIOSCIENCES INC | 5,400,408 | $221M | 2.9% | $40.85 * | $21.38 | +34.2% | SH | 05370A108 |
| DYN | DYNE THERAPEUTICS INC | 6,049,204 | $213M | 2.8% | $35.29 * | $23.78 | +22.2% | SH | 26818M108 |
| GERN | GERON CORP | 46,202,425 | $196M | 2.6% | $4.24 * | $2.42 | +60.9% | SH | 374163103 |
| PEPG | PEPGEN INC | 10,689,545 | $171M | 2.3% | $15.96 * | $11.31 | +26.8% | SH | 713317105 |
| TYRA | TYRA BIOSCIENCES INC | 10,416,609 | $167M | 2.2% | $15.99 * | $18.29 | -5.9% | SH | 90240B106 |
| EVH | EVOLENT HEALTH INC - A | 8,514,862 | $163M | 2.2% | $19.12 * | $28.60 | -10.7% | SH | 30050B101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 8,909,091 | $160M | 2.1% | $18.01 * | $15.89 | +9.7% | SH | 28036F105 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 8,064,000 | $155M | 2.0% | $19.21 * | $12.00 | +67.2% | SH | N62509109 |
| RXRX | RECURSION PHARMACEUTICALS-A | 15,384,615 | $115M | 1.5% | $7.50 * | $8.72 | 0.0% | SH | 75629V104 |
| — | 89BIO INC | 14,175,398 | $114M | 1.5% | $8.01 | $15.26 | — | SH | 282559103 |
| — | VERONA PHARMA PLC - ADR | 7,632,646 | $110M | 1.5% | $14.46 | $8.85 | — | SH | 925050106 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,871,721 | $108M | 1.4% | $13.78 * | $17.63 | -17.0% | SH | 23954D109 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 5,098,211 | $107M | 1.4% | $20.99 * | $19.29 | +30.0% | SH | 35104E100 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $92.43M | 1.2% | $8.51 * | $6.66 | +33.3% | SH | 82835W108 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $90.83M | 1.2% | $4.99 * | $8.66 | -34.1% | SH | Y95308105 |
| — | LONGBOARD PHARMACEUTICALS IN | 3,289,119 | $88.9M | 1.2% | $27.03 | $21.60 | — | SH | 54300N103 |
| ACLX | ARCELLX INC | 1,604,014 | $88.53M | 1.2% | $55.19 | $54.36 | 0.0% | SH | 03940C100 |
| AXSM | AXSOME THERAPEUTICS INC | 1,000,000 | $80.5M | 1.1% | $80.50 * | $73.77 | +0.4% | SH | 05464T104 |
| APGE | APOGEE THERAPEUTICS INC | 1,961,863 | $77.2M | 1.0% | $39.35 * | $22.03 | +120.3% | SH | 03770N101 |
| GHRS | GH RESEARCH PLC | 6,601,689 | $76.98M | 1.0% | $11.66 * | $16.65 | -27.9% | SH | G3855L106 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,896,772 | $74.49M | 1.0% | $39.27 | $41.59 | — | SH | 86366E106 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $72.25M | 1.0% | $17.29 | $20.79 | -16.0% | SH | 52635N103 |
| FULC | FULCRUM THERAPEUTICS INC | 11,609,704 | $71.98M | 1.0% | $6.20 * | $7.35 | +3.1% | SH | 359616109 |
| NKTX | NKARTA INC | 10,805,129 | $63.86M | 0.8% | $5.91 * | $20.85 | -66.1% | SH | 65487U108 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,333,000 | $60.38M | 0.8% | $25.88 * | $21.73 | +10.6% | SH | 252828108 |
| MLYS | MINERALYS THERAPEUTICS INC | 4,850,984 | $56.76M | 0.8% | $11.70 * | $15.29 | -17.6% | SH | 603170101 |
| — | ITEOS THERAPEUTICS INC | 3,517,259 | $52.2M | 0.7% | $14.84 | $24.67 | — | SH | 46565G104 |
| URGN | UROGEN PHARMA LTD | 3,083,430 | $51.74M | 0.7% | $16.78 * | $14.46 | -1.6% | SH | M96088105 |
| PRAX | PRAXIS PRECISION MEDICINES I | 1,235,599 | $51.1M | 0.7% | $41.36 * | $45.65 | +3.5% | SH | 74006W207 |
| ELVN | ENLIVEN THERAPEUTICS INC | 2,122,465 | $49.6M | 0.7% | $23.37 * | $20.34 | +3.5% | SH | 29337E102 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $48.37M | 0.6% | $5.80 * | $10.73 | -24.9% | SH | 004890109 |
| — | ASTRIA THERAPEUTICS INC | 5,043,756 | $45.9M | 0.6% | $9.10 | $13.45 | — | SH | 04635X102 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 2,253,000 | $45.6M | 0.6% | $20.24 | $20.19 | — | SH | 088786108 |
| CGON | CG ONCOLOGY INC | 1,397,433 | $44.12M | 0.6% | $31.57 * | $40.84 | -15.1% | SH | 156944100 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $43.83M | 0.6% | $7.25 * | $7.79 | -1.7% | SH | 517125100 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $36.14M | 0.5% | $2.42 * | $13.02 | -75.6% | SH | 00509G209 |
| — | TOURMALINE BIO INC | 2,538,925 | $32.65M | 0.4% | $12.86 | $12.86 | — | SH | 89157D105 |
| — | THIRD HARMONIC BIO INC | 2,033,056 | $26.43M | 0.3% | $13.00 | $8.80 | — | SH | 88427A107 |
| SLDB | SOLID BIOSCIENCES INC | 4,330,446 | $24.55M | 0.3% | $5.67 * | $7.14 | +25.5% | SH | 83422E204 |
| TSHA | TAYSHA GENE THERAPIES INC | 10,872,503 | $24.35M | 0.3% | $2.24 * | $1.87 | +55.8% | SH | 877619106 |
| TNYA | TENAYA THERAPEUTICS INC | 7,622,347 | $23.63M | 0.3% | $3.10 * | $6.33 | -34.8% | SH | 87990A106 |
| — | VOR BIOPHARMA INC | 22,748,880 | $22.75M | 0.3% | $1.00 | $24.47 | — | SH | 929033108 |
| CCCC | C4 THERAPEUTICS INC | 4,878,000 | $22.54M | 0.3% | $4.62 * | $2.28 | +161.6% | SH | 12529R107 |
| ANRO | ALTO NEUROSCIENCE INC | 2,085,554 | $22.29M | 0.3% | $10.69 * | $14.77 | -11.9% | SH | 02157Q109 |
| IMTX | IMMATICS NV | 1,750,000 | $20.34M | 0.3% | $11.62 * | $11.66 | -3.4% | SH | N44445109 |
| SERA | SERA PROGNOSTICS INC-A | 3,032,808 | $17.95M | 0.2% | $5.92 * | $8.26 | +8.2% | SH | 81749D107 |
| — | AEROVATE THERAPEUTICS INC | 9,192,092 | $15.26M | 0.2% | $1.66 | $20.69 | — | SH | 008064107 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $14.99M | 0.2% | $2.44 * | $10.47 | -54.1% | SH | 95075A107 |
| CRVO | CERVOMED INC | 817,120 | $13.99M | 0.2% | $17.12 * | $13.35 | +63.8% | SH | 15713L109 |
| PLRX | PLIANT THERAPEUTICS INC | 1,281,000 | $13.77M | 0.2% | $10.75 * | $28.47 | -54.7% | SH | 729139105 |
| NRIX | NURIX THERAPEUTICS INC | 650,000 | $13.57M | 0.2% | $20.87 * | $15.57 | 0.0% | SH | 67080M103 |
| INSM | INSMED INC | 200,000 | $13.4M | 0.2% | $67.00 * | $38.78 | 0.0% | SH | 457669307 |
| ANTX | AN2 THERAPEUTICS INC | 5,551,295 | $11.94M | 0.2% | $2.15 * | $13.91 | -82.9% | SH | 037326105 |
| — | CYBIN INC | 44,004,464 | $11.93M | 0.2% | $0.27 | $0.41 | — | SH | 23256X100 |
| ZURA | ZURA BIO LTD | 3,217,503 | $11.26M | 0.1% | $3.50 * | $4.08 | 0.0% | SH | G9TY5A101 |
| ARVN | ARVINAS INC | 421,348 | $11.22M | 0.1% | $26.62 * | $23.38 | +36.3% | SH | 04335A105 |
| — | REGULUS THERAPEUTICS INC | 6,250,000 | $11.16M | 0.1% | $1.78 | $2.88 | — | SH | 75915K309 |
| LXEO | LEXEO THERAPEUTICS INC | 672,712 | $10.79M | 0.1% | $16.04 * | $15.62 | -7.0% | SH | 52886X107 |
| — | ADICET BIO INC | 7,541,000 | $9.125M | 0.1% | $1.21 | $2.35 | — | SH | 007002108 |
| NUVL | NUVALENT INC-A | 119,789 | $9.087M | 0.1% | $75.86 * | $71.13 | 0.0% | SH | 670703107 |
| MGNX | MACROGENICS INC | 2,082,021 | $8.849M | 0.1% | $4.25 * | $6.75 | +44.3% | SH | 556099109 |
| BOLD | BOUNDLESS BIO INC | 2,180,631 | $8.439M | 0.1% | $3.87 * | $14.25 | -32.9% | SH | 10170A100 |
| — | CHIMERIX INC | 8,800,000 | $7.709M | 0.1% | $0.88 | $0.96 | — | SH | 16934W106 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.545M | 0.1% | $10.06 | $10.07 | 0.0% | SH | G70077105 |
| MGX | METAGENOMI INC | 1,477,749 | $6.029M | 0.1% | $4.08 * | $11.50 | -40.2% | SH | 59102M104 |
| TARA | PROTARA THERAPEUTIC INC | 1,900,000 | $3.952M | 0.1% | $2.08 * | $2.92 | 0.0% | SH | 74365U107 |
| SRZN | SURROZEN INC | 282,580 | $3.094M | 0.0% | $10.95 * | $10.32 | 0.0% | SH | 86889P208 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $2.907M | 0.0% | $8.72 | $0.87 | — | SH | N62509117 |
| — | UNICYCIVE THERAPEUTICS INC | 2,632,200 | $1.319M | 0.0% | $0.50 | $0.86 | — | SH | 90466Y103 |
| — | SCILEX HOLDING CO | 261,179 | $504K | 0.0% | $1.93 | $1.93 | — | SH | 80880W106 |