Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q3 2024 (← Previous) (Next →)
Filing Date: Nov 14, 2024
Total Value: $8.674B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 9,710,428 | $1.45B | 16.7% | $149.31 | $79.32 | — | SH | 04351P101 |
| PCVX | VAXCYTE INC | 8,689,190 | $993M | 11.4% | $114.27 * | $39.63 | +127.4% | SH | 92243G108 |
| JANX | JANUX THERAPEUTICS INC | 9,165,652 | $416M | 4.8% | $45.43 * | $21.69 | +100.6% | SH | 47103J105 |
| LEGN | LEGEND BIOTECH CORP-ADR | 7,506,934 | $366M | 4.2% | $48.73 | $56.83 | — | SH | 52490G102 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,084,412 | $319M | 3.7% | $52.39 * | $25.92 | +84.9% | SH | 76243J105 |
| RNAM | AVIDITY BIOSCIENCES INC | 6,300,408 | $289M | 3.3% | $45.93 * | $24.52 | +77.0% | SH | 05370A108 |
| TYRA | TYRA BIOSCIENCES INC | 10,416,609 | $245M | 2.8% | $23.51 * | $18.29 | +14.8% | SH | 90240B106 |
| EVH | EVOLENT HEALTH INC - A | 8,514,862 | $241M | 2.8% | $28.28 * | $28.60 | -9.9% | SH | 30050B101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 8,909,091 | $238M | 2.7% | $26.69 * | $15.89 | +25.2% | SH | 28036F105 |
| BIIB | BIOGEN INC | 1,184,456 | $230M | 2.6% | $193.84 * | $218.45 | -4.2% | SH | 09062X103 |
| DYN | DYNE THERAPEUTICS INC | 6,381,144 | $229M | 2.6% | $35.92 * | $24.61 | +61.7% | SH | 26818M108 |
| RXST | RXSIGHT INC | 3,916,825 | $194M | 2.2% | $49.43 * | $20.42 | +150.9% | SH | 78349D107 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $177M | 2.0% | $25.47 | $25.50 | 0.0% | SH | 055477103 |
| CLYM | CLIMB BIO INC | 31,419,267 | $160M | 1.8% | $5.09 * | $12.52 | -43.5% | SH | 28658R106 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $157M | 1.8% | $14.50 * | $6.66 | +78.6% | SH | 82835W108 |
| ACLX | ARCELLX INC | 1,851,479 | $155M | 1.8% | $83.51 * | $55.99 | +18.9% | SH | 03940C100 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $152M | 1.8% | $15.45 * | $11.59 | 0.0% | SH | 04317A107 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $149M | 1.7% | $8.20 * | $8.66 | -31.0% | SH | Y95308105 |
| GERN | GERON CORP | 32,285,755 | $147M | 1.7% | $4.54 | $2.42 | +87.6% | SH | 374163103 |
| — | VERONA PHARMA PLC - ADR | 5,009,653 | $144M | 1.7% | $28.77 | $8.85 | — | SH | 925050106 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 8,064,000 | $134M | 1.5% | $16.60 * | $12.00 | +44.2% | SH | N62509109 |
| APGE | APOGEE THERAPEUTICS INC | 1,961,863 | $115M | 1.3% | $58.74 * | $22.03 | +117.5% | SH | 03770N101 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,871,721 | $110M | 1.3% | $13.93 * | $17.63 | -19.1% | SH | 23954D109 |
| — | 89BIO INC | 14,175,398 | $105M | 1.2% | $7.40 | $15.26 | — | SH | 282559103 |
| RXRX | RECURSION PHARMACEUTICALS-A | 15,384,615 | $101M | 1.2% | $6.59 * | $8.72 | -17.8% | SH | 75629V104 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $99.21M | 1.1% | $23.74 * | $20.79 | +6.8% | SH | 52635N103 |
| PEPG | PEPGEN INC | 10,689,545 | $91.4M | 1.1% | $8.55 * | $11.31 | +4.6% | SH | 713317105 |
| AXSM | AXSOME THERAPEUTICS INC | 1,000,000 | $89.87M | 1.0% | $89.87 * | $73.77 | +18.3% | SH | 05464T104 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,896,772 | $83.25M | 1.0% | $43.89 | $41.59 | — | SH | 86366E106 |
| — | TOURMALINE BIO INC | 2,538,925 | $65.28M | 0.8% | $25.71 | $12.86 | — | SH | 89157D105 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,333,000 | $63.88M | 0.7% | $27.38 | $21.73 | +28.2% | SH | 252828108 |
| MLYS | MINERALYS THERAPEUTICS INC | 4,850,984 | $58.75M | 0.7% | $12.11 | $15.29 | -20.8% | SH | 603170101 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $58.38M | 0.7% | $7.00 * | $10.73 | -26.6% | SH | 004890109 |
| — | ASTRIA THERAPEUTICS INC | 5,105,213 | $56.21M | 0.6% | $11.01 | $13.42 | — | SH | 04635X102 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 5,098,211 | $55.11M | 0.6% | $10.81 * | $19.29 | -14.0% | SH | 35104E100 |
| CGON | CG ONCOLOGY INC | 1,397,433 | $52.73M | 0.6% | $37.73 * | $40.84 | -14.2% | SH | 156944100 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 2,253,000 | $50.99M | 0.6% | $22.63 | $20.19 | — | SH | 088786108 |
| NKTX | NKARTA INC | 10,805,129 | $48.84M | 0.6% | $4.52 * | $20.85 | -72.7% | SH | 65487U108 |
| BIOA | BIOAGE LABS INC | 2,210,589 | $45.98M | 0.5% | $20.80 * | $20.04 | 0.0% | SH | 09077V100 |
| GHRS | GH RESEARCH PLC | 6,686,689 | $44.73M | 0.5% | $6.69 * | $16.57 | -38.1% | SH | G3855L106 |
| PRAX | PRAXIS PRECISION MEDICINES I | 761,955 | $43.84M | 0.5% | $57.54 * | $45.65 | +18.3% | SH | 74006W207 |
| IDYA | IDEAYA BIOSCIENCES INC | 1,347,252 | $42.68M | 0.5% | $31.68 * | $37.92 | 0.0% | SH | 45166A102 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $39.6M | 0.5% | $6.55 * | $7.79 | +3.1% | SH | 517125100 |
| MBX | MBX BIOSCIENCES INC | 1,511,334 | $39.26M | 0.5% | $25.98 * | $22.87 | 0.0% | SH | 55287L101 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $37.03M | 0.4% | $2.48 * | $13.02 | -79.2% | SH | 00509G209 |
| FULC | FULCRUM THERAPEUTICS INC | 10,229,099 | $36.52M | 0.4% | $3.57 * | $7.35 | +1.0% | SH | 359616109 |
| — | ITEOS THERAPEUTICS INC | 3,184,711 | $32.52M | 0.4% | $10.21 | $24.67 | — | SH | 46565G104 |
| SLDB | SOLID BIOSCIENCES INC | 4,330,446 | $30.18M | 0.3% | $6.97 * | $7.14 | +13.6% | SH | 83422E204 |
| CCCC | C4 THERAPEUTICS INC | 4,878,000 | $27.8M | 0.3% | $5.70 * | $2.28 | +163.9% | SH | 12529R107 |
| ELVN | ENLIVEN THERAPEUTICS INC | 1,061,233 | $27.1M | 0.3% | $25.54 * | $20.34 | +13.9% | SH | 29337E102 |
| ANRO | ALTO NEUROSCIENCE INC | 2,075,154 | $23.74M | 0.3% | $11.44 * | $14.77 | -17.1% | SH | 02157Q109 |
| SERA | SERA PROGNOSTICS INC-A | 3,032,808 | $23.66M | 0.3% | $7.80 * | $8.26 | -12.1% | SH | 81749D107 |
| TSHA | TAYSHA GENE THERAPIES INC | 10,872,503 | $21.85M | 0.3% | $2.01 * | $1.87 | +17.5% | SH | 877619106 |
| IMTX | IMMATICS NV | 1,750,000 | $19.97M | 0.2% | $11.41 * | $11.66 | +1.5% | SH | N44445109 |
| — | AEROVATE THERAPEUTICS INC | 9,192,092 | $19.21M | 0.2% | $2.09 | $20.69 | — | SH | 008064107 |
| NUVL | NUVALENT INC-A | 176,281 | $18.03M | 0.2% | $102.30 * | $74.92 | +10.7% | SH | 670703107 |
| — | THIRD HARMONIC BIO INC | 1,280,826 | $17.36M | 0.2% | $13.55 | $8.80 | — | SH | 88427A107 |
| — | VOR BIOPHARMA INC | 22,748,880 | $15.92M | 0.2% | $0.70 | $24.47 | — | SH | 929033108 |
| INSM | INSMED INC | 200,000 | $14.6M | 0.2% | $73.00 | $38.78 | +90.3% | SH | 457669307 |
| PLRX | PLIANT THERAPEUTICS INC | 1,281,000 | $14.36M | 0.2% | $11.21 * | $28.47 | -56.1% | SH | 729139105 |
| TNYA | TENAYA THERAPEUTICS INC | 6,982,587 | $13.48M | 0.2% | $1.93 * | $6.33 | -55.4% | SH | 87990A106 |
| ZURA | ZURA BIO LTD | 3,217,503 | $13.06M | 0.2% | $4.06 * | $4.08 | -8.4% | SH | G9TY5A101 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $13.03M | 0.2% | $2.12 * | $10.47 | -78.3% | SH | 95075A107 |
| CRVO | CERVOMED INC | 817,120 | $11.93M | 0.1% | $14.60 * | $13.35 | +16.1% | SH | 15713L109 |
| XNCR | XENCOR INC | 575,000 | $11.56M | 0.1% | $20.11 * | $18.77 | 0.0% | SH | 98401F105 |
| — | ADICET BIO INC | 7,541,000 | $10.86M | 0.1% | $1.44 | $2.35 | — | SH | 007002108 |
| ARVN | ARVINAS INC | 421,348 | $10.38M | 0.1% | $24.63 * | $23.38 | +11.7% | SH | 04335A105 |
| AVTX | AVALO THERAPEUTICS INC | 967,000 | $9.187M | 0.1% | $9.50 * | $10.31 | 0.0% | SH | 05338F306 |
| — | CHIMERIX INC | 8,800,000 | $8.184M | 0.1% | $0.93 | $0.96 | — | SH | 16934W106 |
| BOLD | BOUNDLESS BIO INC | 2,180,631 | $7.567M | 0.1% | $3.47 * | $14.25 | -74.6% | SH | 10170A100 |
| — | CIDARA THEREAPEUTICS INC | 703,080 | $7.558M | 0.1% | $10.75 | $10.75 | — | SH | 171757206 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.515M | 0.1% | $10.02 | $10.07 | -0.1% | SH | G70077105 |
| LXEO | LEXEO THERAPEUTICS INC | 546,554 | $4.941M | 0.1% | $9.04 * | $15.62 | -23.6% | SH | 52886X107 |
| TARA | PROTARA THERAPEUTIC INC | 1,900,000 | $3.477M | 0.0% | $1.83 * | $2.92 | -29.7% | SH | 74365U107 |
| ADGM | ADAGIO MEDICAL HOLDINGS INC | 1,333,926 | $3.442M | 0.0% | $2.58 * | $4.76 | 0.0% | SH | 00534B100 |
| SRZN | SURROZEN INC | 282,580 | $3.385M | 0.0% | $11.98 * | $10.32 | -14.4% | SH | 86889P208 |
| MGX | METAGENOMI INC | 1,305,239 | $2.832M | 0.0% | $2.17 * | $11.50 | -69.8% | SH | 59102M104 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $2.333M | 0.0% | $7.00 | $0.87 | — | SH | N62509117 |
| ANTX | AN2 THERAPEUTICS INC | 1,999,997 | $2.14M | 0.0% | $1.07 * | $13.91 | -87.5% | SH | 037326105 |
| — | REGULUS THERAPEUTICS INC | 766,834 | $1.204M | 0.0% | $1.57 | $2.88 | — | SH | 75915K309 |
| — | SCILEX HOLDING CO | 261,179 | $241K | 0.0% | $0.92 | $1.93 | — | SH | 80880W106 |