Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q4 2024 (← Previous) (Next →)
Filing Date: Feb 14, 2025
Total Value: $7.514B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,112,744 | $1.392B | 18.5% | $137.67 | $81.64 | — | SH | 04351P101 |
| PCVX | VAXCYTE INC | 8,689,190 | $711M | 9.5% | $81.86 * | $39.63 | +150.5% | SH | 92243G108 |
| JANX | JANUX THERAPEUTICS INC | 10,365,652 | $555M | 7.4% | $53.54 | $25.30 | +109.0% | SH | 47103J105 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,084,412 | $341M | 4.5% | $55.98 | $25.92 | +113.1% | SH | 76243J105 |
| LEGN | LEGEND BIOTECH CORP-ADR | 7,506,934 | $244M | 3.3% | $32.54 | $56.83 | — | SH | 52490G102 |
| EWTX | EDGEWISE THERAPEUTICS INC | 8,909,091 | $238M | 3.2% | $26.70 * | $15.89 | +100.3% | SH | 28036F105 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 8,845,000 | $227M | 3.0% | $25.70 * | $12.81 | +65.8% | SH | N62509109 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $225M | 3.0% | $12.37 * | $8.66 | +54.1% | SH | Y95308105 |
| ACLX | ARCELLX INC | 2,787,327 | $214M | 2.8% | $76.69 * | $66.20 | +30.5% | SH | 03940C100 |
| RNAM | AVIDITY BIOSCIENCES INC | 6,300,408 | $183M | 2.4% | $29.08 * | $24.52 | +70.4% | SH | 05370A108 |
| SEPN | SEPTERNA INC | 6,995,858 | $160M | 2.1% | $22.90 * | $23.65 | 0.0% | SH | 81734D104 |
| DYN | DYNE THERAPEUTICS INC | 6,381,144 | $150M | 2.0% | $23.56 * | $24.61 | +20.2% | SH | 26818M108 |
| TYRA | TYRA BIOSCIENCES INC | 10,637,290 | $148M | 2.0% | $13.90 * | $18.28 | -0.7% | SH | 90240B106 |
| RXST | RXSIGHT INC | 3,743,018 | $129M | 1.7% | $34.38 * | $20.42 | +120.8% | SH | 78349D107 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $121M | 1.6% | $17.42 * | $25.50 | -18.4% | SH | 055477103 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $121M | 1.6% | $28.87 * | $20.79 | +46.6% | SH | 52635N103 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $115M | 1.5% | $10.55 * | $6.66 | +110.4% | SH | 82835W108 |
| — | 89BIO INC | 14,175,398 | $111M | 1.5% | $7.82 | $15.26 | — | SH | 282559103 |
| XBI | SPDR S&P BIOTECH ETF | 1,228,240 | $111M | 1.5% | $90.06 | $90.06 | — | SH | 78464A870 |
| GERN | GERON CORP | 30,009,536 | $106M | 1.4% | $3.54 * | $2.42 | +64.8% | SH | 374163103 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $99.32M | 1.3% | $10.08 * | $11.59 | +3.6% | SH | 04317A107 |
| AXSM | AXSOME THERAPEUTICS INC | 1,000,000 | $84.61M | 1.1% | $84.61 * | $73.77 | +24.7% | SH | 05464T104 |
| — | VERONA PHARMA PLC - ADR | 1,766,830 | $82.05M | 1.1% | $46.44 | $8.85 | — | SH | 925050106 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 5,755,577 | $72.92M | 1.0% | $12.67 * | $17.63 | -21.1% | SH | 23954D109 |
| APGE | APOGEE THERAPEUTICS INC | 1,569,491 | $71.1M | 0.9% | $45.30 * | $22.03 | +131.5% | SH | 03770N101 |
| MLYS | MINERALYS THERAPEUTICS INC | 4,850,984 | $59.72M | 0.8% | $12.31 * | $15.29 | -14.5% | SH | 603170101 |
| PRAX | PRAXIS PRECISION MEDICINES I | 761,955 | $58.64M | 0.8% | $76.96 * | $45.65 | +58.5% | SH | 74006W207 |
| CLYM | CLIMB BIO INC | 31,419,267 | $56.55M | 0.8% | $1.80 * | $12.52 | -71.1% | SH | 28658R106 |
| RXRX | RECURSION PHARMACEUTICALS-A | 7,725,096 | $52.22M | 0.7% | $6.76 | $8.72 | -22.9% | SH | 75629V104 |
| — | TOURMALINE BIO INC | 2,538,925 | $51.49M | 0.7% | $20.28 | $12.86 | — | SH | 89157D105 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $50.21M | 0.7% | $6.02 * | $10.73 | -32.3% | SH | 004890109 |
| FULC | FULCRUM THERAPEUTICS INC | 10,229,099 | $48.08M | 0.6% | $4.70 * | $7.35 | -49.8% | SH | 359616109 |
| TXG | 10X GENOMICS INC-CLASS A | 3,279,401 | $47.09M | 0.6% | $14.36 * | $15.78 | 0.0% | SH | 88025U109 |
| GHRS | GH RESEARCH PLC | 6,686,689 | $46.81M | 0.6% | $7.00 * | $16.57 | -51.5% | SH | G3855L106 |
| — | ASTRIA THERAPEUTICS INC | 5,105,213 | $45.64M | 0.6% | $8.94 | $13.42 | — | SH | 04635X102 |
| — | VOR BIOPHARMA INC | 39,646,039 | $44.01M | 0.6% | $1.11 | $14.51 | — | SH | 929033108 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,517,418 | $41.15M | 0.5% | $27.12 | $41.59 | — | SH | 86366E106 |
| DNTH | DIANTHUS THERAPEUTICS INC | 1,866,400 | $40.69M | 0.5% | $21.80 * | $21.73 | +18.3% | SH | 252828108 |
| PEPG | PEPGEN INC | 10,689,545 | $40.51M | 0.5% | $3.79 * | $11.31 | -44.9% | SH | 713317105 |
| EVH | EVOLENT HEALTH INC - A | 3,577,197 | $40.24M | 0.5% | $11.25 * | $28.60 | -38.5% | SH | 30050B101 |
| KURA | KURA ONCOLOGY INC | 4,451,041 | $38.77M | 0.5% | $8.71 * | $14.39 | 0.0% | SH | 50127T109 |
| IDYA | IDEAYA BIOSCIENCES INC | 1,347,252 | $34.62M | 0.5% | $25.70 * | $37.92 | -25.3% | SH | 45166A102 |
| ZLAB | ZAI LAB LTD-ADR | 1,295,040 | $33.92M | 0.5% | $26.19 | $26.19 | — | SH | 98887Q104 |
| — | CHIMERIX INC | 8,800,000 | $30.62M | 0.4% | $3.48 | $0.96 | — | SH | 16934W106 |
| — | CIDARA THERAPEUTICS INC | 1,092,796 | $29.37M | 0.4% | $26.88 | $16.50 | — | SH | 171757206 |
| MBX | MBX BIOSCIENCES INC | 1,511,334 | $27.85M | 0.4% | $18.43 * | $22.87 | -6.8% | SH | 55287L101 |
| NKTX | NKARTA INC | 10,805,129 | $26.9M | 0.4% | $2.49 * | $20.85 | -85.2% | SH | 65487U108 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $25.68M | 0.3% | $1.72 * | $13.02 | -81.5% | SH | 00509G209 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | $25.42M | 0.3% | $5.57 * | $19.29 | -59.3% | SH | 35104E100 |
| NRIX | NURIX THERAPEUTICS INC | 1,333,333 | $25.12M | 0.3% | $18.84 * | $22.92 | 0.0% | SH | 67080M103 |
| SERA | SERA PROGNOSTICS INC-A | 3,032,808 | $24.69M | 0.3% | $8.14 * | $8.26 | -11.0% | SH | 81749D107 |
| — | AEROVATE THERAPEUTICS INC | 9,192,092 | $24.36M | 0.3% | $2.65 | $20.69 | — | SH | 008064107 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,181,818 | $23.7M | 0.3% | $7.45 * | $9.31 | 0.0% | SH | 30233G209 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $23.4M | 0.3% | $3.87 * | $7.79 | -15.3% | SH | 517125100 |
| CBLL | CERIBELL INC | 824,582 | $21.34M | 0.3% | $25.88 * | $27.25 | 0.0% | SH | 15678C102 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,150,000 | $20.03M | 0.3% | $17.42 | $17.69 | 0.0% | SH | 89422G107 |
| ELVN | ENLIVEN THERAPEUTICS INC | 848,986 | $19.1M | 0.3% | $22.50 * | $20.34 | +27.5% | SH | 29337E102 |
| TSHA | TAYSHA GENE THERAPIES INC | 10,872,503 | $18.81M | 0.3% | $1.73 * | $1.87 | +11.1% | SH | 877619106 |
| ALEC | ALECTOR INC | 9,695,228 | $18.32M | 0.2% | $1.89 * | $3.76 | 0.0% | SH | 014442107 |
| TARA | PROTARA THERAPEUTIC INC | 3,400,000 | $17.95M | 0.2% | $5.28 * | $3.06 | +5.6% | SH | 74365U107 |
| CCCC | C4 THERAPEUTICS INC | 4,878,000 | $17.56M | 0.2% | $3.60 * | $2.28 | +118.1% | SH | 12529R107 |
| SLDB | SOLID BIOSCIENCES INC | 4,330,446 | $17.32M | 0.2% | $4.00 * | $7.14 | -23.1% | SH | 83422E204 |
| PLRX | PLIANT THERAPEUTICS INC | 1,281,000 | $16.87M | 0.2% | $13.17 * | $28.47 | -52.0% | SH | 729139105 |
| DRUG | Bright Minds Biosciences Inc | 460,829 | $16.6M | 0.2% | $36.02 * | $35.19 | 0.0% | SH | 10919W405 |
| — | ITEOS THERAPEUTICS INC | 2,092,259 | $16.07M | 0.2% | $7.68 | $24.67 | — | SH | 46565G104 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 1,093,477 | $15.31M | 0.2% | $14.00 | $20.19 | — | SH | 088786108 |
| ELDN | ELEDON PHARMACEUTICALS INC | 3,566,338 | $14.69M | 0.2% | $4.12 * | $3.94 | 0.0% | SH | 28617K101 |
| INSM | INSMED INC | 200,000 | $13.81M | 0.2% | $69.04 * | $38.78 | +85.7% | SH | 457669307 |
| XNCR | XENCOR INC | 575,000 | $13.21M | 0.2% | $22.98 | $18.77 | +22.4% | SH | 98401F105 |
| IMTX | IMMATICS NV | 1,750,000 | $12.44M | 0.2% | $7.11 * | $11.66 | -26.3% | SH | N44445109 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,666,667 | $11.57M | 0.2% | $2.48 | $2.49 | 0.0% | SH | 00461U105 |
| MNPR | MONOPAR THERAPEUTICS INC | 511,207 | $11.25M | 0.1% | $22.00 * | $16.78 | 0.0% | SH | 61023L207 |
| — | THIRD HARMONIC BIO INC | 960,620 | $9.885M | 0.1% | $10.29 | $8.80 | — | SH | 88427A107 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $9.094M | 0.1% | $1.48 * | $10.47 | -80.5% | SH | 95075A107 |
| ARVN | ARVINAS INC | 421,348 | $8.077M | 0.1% | $19.17 * | $23.38 | +3.9% | SH | 04335A105 |
| ZURA | ZURA BIO LTD | 3,217,503 | $8.044M | 0.1% | $2.50 * | $4.08 | -12.6% | SH | G9TY5A101 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.635M | 0.1% | $10.18 | $10.07 | +0.3% | SH | G70077105 |
| BIOA | BIOAGE LABS INC | 1,310,589 | $7.588M | 0.1% | $5.79 * | $20.04 | -13.9% | SH | 09077V100 |
| — | ADICET BIO INC | 7,541,000 | $7.254M | 0.1% | $0.96 | $2.35 | — | SH | 007002108 |
| AVTX | AVALO THERAPEUTICS INC | 967,000 | $7.185M | 0.1% | $7.43 * | $10.31 | +3.7% | SH | 05338F306 |
| BOLD | BOUNDLESS BIO INC | 2,180,631 | $6.324M | 0.1% | $2.90 | $14.25 | -79.6% | SH | 10170A100 |
| ENTA | ENANTA PHARMACEUTICALS INC | 1,038,000 | $5.968M | 0.1% | $5.75 * | $9.59 | 0.0% | SH | 29251M106 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $4.75M | 0.1% | $14.25 | $0.87 | — | SH | N62509117 |
| SRZN | SURROZEN INC | 282,580 | $4.055M | 0.1% | $14.35 * | $10.32 | +2.8% | SH | 86889P208 |
| LXEO | LEXEO THERAPEUTICS INC | 546,554 | $3.596M | 0.0% | $6.58 * | $15.62 | -49.6% | SH | 52886X107 |
| — | ALLAKOS INC | 1,129,931 | $1.367M | 0.0% | $1.21 | $1.21 | — | SH | 01671P100 |
| SRRK | SCHOLAR ROCK HOLDING CORP | 17,616 | $761K | 0.0% | $43.22 * | $32.56 | 0.0% | SH | 80706P103 |
| — | REGULUS THERAPEUTICS INC | 336,843 | $532K | 0.0% | $1.58 | $2.88 | — | SH | 75915K309 |
| — | SCILEX HOLDING CO | 1,036,218 | $442K | 0.0% | $0.43 | $0.81 | — | SH | 80880W106 |