Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q2 2025 (← Previous) (Next →)
Filing Date: Aug 14, 2025
Total Value: $5.936B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $1.775B | 29.9% | $172.60 | $82.85 | — | SH | 04351P101 |
| PCVX | VAXCYTE INC | 11,965,991 | $389M | 6.6% | $32.51 | $51.21 | -36.0% | SH | 92243G108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,561,359 | $351M | 5.9% | $63.19 * | $25.92 | +136.2% | SH | 76243J105 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $258M | 4.4% | $23.10 * | $26.21 | +0.5% | SH | 47103J105 |
| RNAM | AVIDITY BIOSCIENCES INC | 7,266,031 | $206M | 3.5% | $28.40 * | $25.22 | +18.2% | SH | 05370A108 |
| ACLX | ARCELLX INC | 3,036,527 | $200M | 3.4% | $65.85 * | $66.33 | -6.1% | SH | 03940C100 |
| — | 89BIO INC | 19,889,683 | $195M | 3.3% | $9.82 | $12.96 | — | SH | 282559103 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $190M | 3.2% | $17.45 * | $6.66 | +116.7% | SH | 82835W108 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 10,138,938 | $184M | 3.1% | $18.11 | $14.02 | +30.1% | SH | N62509109 |
| SION | SIONNA THERAPEUTICS INC | 10,445,322 | $181M | 3.1% | $17.35 * | $16.34 | -19.8% | SH | 829401108 |
| — | CIDARA THERAPEUTICS INC | 3,365,523 | $164M | 2.8% | $48.71 | $38.25 | — | SH | 171757206 |
| EWTX | EDGEWISE THERAPEUTICS INC | 9,902,633 | $130M | 2.2% | $13.11 * | $15.75 | -8.4% | SH | 28036F105 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $122M | 2.1% | $29.31 * | $20.79 | +30.9% | SH | 52635N103 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $118M | 2.0% | $6.50 | $8.66 | -23.8% | SH | Y95308105 |
| TYRA | TYRA BIOSCIENCES INC | 12,198,625 | $117M | 2.0% | $9.57 | $17.16 | -44.6% | SH | 90240B106 |
| GHRS | GH RESEARCH PLC | 7,676,697 | $93.58M | 1.6% | $12.19 * | $15.85 | -30.8% | SH | G3855L106 |
| DYN | DYNE THERAPEUTICS INC | 9,714,392 | $92.48M | 1.6% | $9.52 * | $21.08 | -47.8% | SH | 26818M108 |
| GERN | GERON CORP | 60,379,366 | $85.13M | 1.4% | $1.41 | $2.43 | -41.6% | SH | 374163103 |
| IRON | DISC MEDICINE INC | 1,577,106 | $83.52M | 1.4% | $52.96 * | $55.60 | -15.5% | SH | 254604101 |
| MLYS | MINERALYS THERAPEUTICS INC | 6,147,280 | $83.17M | 1.4% | $13.53 * | $14.49 | +0.0% | SH | 603170101 |
| SEPN | SEPTERNA INC | 6,995,858 | $73.95M | 1.2% | $10.57 * | $23.65 | -65.2% | SH | 81734D104 |
| FULC | FULCRUM THERAPEUTICS INC | 10,229,099 | $70.38M | 1.2% | $6.88 * | $7.35 | -27.2% | SH | 359616109 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $64.62M | 1.1% | $9.29 * | $25.50 | -53.3% | SH | 055477103 |
| — | VOR BIOPHARMA INC | 39,646,039 | $64.23M | 1.1% | $1.62 | $14.51 | — | SH | 929033108 |
| TSHA | TAYSHA GENE THERAPIES INC | 23,555,648 | $54.41M | 0.9% | $2.31 * | $2.03 | +6.9% | SH | 877619106 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,866,733 | $53.41M | 0.9% | $18.63 | $21.84 | -14.1% | SH | 252828108 |
| RXST | RXSIGHT INC | 3,702,967 | $48.14M | 0.8% | $13.00 * | $20.42 | -26.4% | SH | 78349D107 |
| — | TOURMALINE BIO INC | 2,538,925 | $40.6M | 0.7% | $15.99 | $12.86 | — | SH | 89157D105 |
| SRRK | SCHOLAR ROCK HOLDING CORP | 1,136,453 | $40.25M | 0.7% | $35.42 * | $38.38 | -18.2% | SH | 80706P103 |
| CLYM | CLIMB BIO INC | 31,419,267 | $38.96M | 0.7% | $1.24 | $12.52 | -90.1% | SH | 28658R106 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,517,418 | $31.47M | 0.5% | $20.74 | $41.59 | — | SH | 86366E106 |
| SLDB | SOLID BIOSCIENCES INC | 5,811,323 | $28.3M | 0.5% | $4.87 * | $6.22 | -43.2% | SH | 83422E204 |
| — | METSERA INC | 675,525 | $19.22M | 0.3% | $28.45 | $27.22 | — | SH | 59267L107 |
| MNPR | MONOPAR THERAPEUTICS INC | 511,207 | $18.29M | 0.3% | $35.78 | $16.78 | +116.4% | SH | 61023L207 |
| NKTX | NKARTA INC | 10,805,129 | $17.94M | 0.3% | $1.66 * | $20.85 | -91.2% | SH | 65487U108 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $17.47M | 0.3% | $2.89 * | $7.79 | -70.3% | SH | 517125100 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $17.32M | 0.3% | $1.16 * | $13.02 | -91.7% | SH | 00509G209 |
| ELVN | ENLIVEN THERAPEUTICS INC | 848,986 | $17.03M | 0.3% | $20.06 * | $20.34 | -6.9% | SH | 29337E102 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,150,000 | $17.02M | 0.3% | $14.80 * | $17.69 | -6.3% | SH | 89422G107 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | $16.93M | 0.3% | $3.71 * | $19.29 | -81.8% | SH | 35104E100 |
| HNGE | HINGE HEALTH INC-A | 300,000 | $15.53M | 0.3% | $51.75 * | $40.42 | 0.0% | SH | 433313103 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $14.88M | 0.3% | $1.51 * | $11.59 | -81.9% | SH | 04317A107 |
| PEPG | PEPGEN INC | 10,689,545 | $11.87M | 0.2% | $1.11 * | $11.31 | -87.5% | SH | 713317105 |
| JBIO | JADE BIOSCIENCES INC | 1,062,326 | $10.61M | 0.2% | $9.99 * | $33.31 | 0.0% | SH | 008064206 |
| TNGX | TANGO THERAPEUTICS INC | 2,000,000 | $10.24M | 0.2% | $5.12 * | $2.47 | 0.0% | SH | 87583X109 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $9.925M | 0.2% | $1.19 * | $10.73 | -87.2% | SH | 004890109 |
| ELDN | ELEDON PHARMACEUTICALS INC | 3,566,338 | $9.665M | 0.2% | $2.71 * | $3.94 | -23.9% | SH | 28617K101 |
| RCUS | ARCUS BIOSCIENCES INC | 1,136,364 | $9.25M | 0.2% | $8.14 * | $11.59 | -26.3% | SH | 03969F109 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.965M | 0.1% | $10.62 | $10.07 | +3.8% | SH | G70077105 |
| OMDA | OMADA HEALTH INC | 400,000 | $7.32M | 0.1% | $18.30 * | $17.31 | 0.0% | SH | 68170A108 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,681,307 | $7.283M | 0.1% | $1.09 * | $9.71 | -89.4% | SH | 95075A107 |
| BBNX | BETA BIONICS INC | 500,000 | $7.28M | 0.1% | $14.56 * | $18.64 | -24.1% | SH | 08659B102 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,661,331 | $6.041M | 0.1% | $2.27 * | $1.30 | +24.2% | SH | 23284F105 |
| TXG | 10X GENOMICS INC-CLASS A | 475,343 | $5.504M | 0.1% | $11.58 * | $15.78 | -42.2% | SH | 88025U109 |
| SRZN | SURROZEN INC | 602,626 | $5.387M | 0.1% | $8.94 * | $11.08 | -17.5% | SH | 86889P208 |
| WGS | GENEDX HOLDINGS CORP | 58,044 | $5.358M | 0.1% | $92.31 * | $78.50 | 0.0% | SH | 81663L200 |
| AVTX | AVALO THERAPEUTICS INC | 932,973 | $4.656M | 0.1% | $4.99 * | $10.31 | -54.7% | SH | 05338F306 |
| — | ADICET BIO INC | 7,541,000 | $4.6M | 0.1% | $0.61 | $2.35 | — | SH | 007002108 |
| MBX | MBX BIOSCIENCES INC | 377,841 | $4.311M | 0.1% | $11.41 * | $22.87 | -55.5% | SH | 55287L101 |
| TARA | PROTARA THERAPEUTIC INC | 1,039,295 | $3.149M | 0.1% | $3.03 * | $3.06 | +12.8% | SH | 74365U107 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $2.667M | 0.0% | $8.00 | $0.87 | — | SH | N62509117 |
| ACHC | ACADIA HEALTHCARE CO INC | 89,262 | $2.025M | 0.0% | $22.69 * | $38.10 | -37.8% | SH | 00404A109 |
| IFRX | INFLARX NV | 1,973,233 | $1.559M | 0.0% | $0.79 * | $1.18 | 0.0% | SH | N44821101 |