Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $8.116B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.044B | 25.2% | $82.85 | — | SH | 04351P101 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,681,359 | $574M | 7.1% | $27.33 | +239.7% | SH | 76243J105 |
| PCVX | VAXCYTE INC | 11,965,991 | $431M | 5.3% | $51.21 | -35.3% | SH | 92243G108 |
| RNAM | AVIDITY BIOSCIENCES INC | 8,641,031 | $376M | 4.6% | $27.64 | +46.2% | SH | 05370A108 |
| — | CIDARA THERAPEUTICS INC | 3,365,523 | $322M | 4.0% | $38.25 | — | SH | 171757206 |
| SION | SIONNA THERAPEUTICS INC | 10,445,322 | $307M | 3.8% | $16.34 | +33.1% | SH | 829401108 |
| — | 89BIO INC | 19,889,683 | $292M | 3.6% | $12.96 | — | SH | 282559103 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 10,138,938 | $288M | 3.6% | $14.02 | +71.0% | SH | N62509109 |
| MLYS | MINERALYS THERAPEUTICS INC | 7,323,750 | $278M | 3.4% | $15.64 | +38.3% | SH | 603170101 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $273M | 3.4% | $26.21 | -7.1% | SH | 47103J105 |
| ACLX | ARCELLX INC | 3,036,527 | $249M | 3.1% | $66.33 | +8.5% | SH | 03940C100 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $195M | 2.4% | $20.79 | +76.9% | SH | 52635N103 |
| TYRA | TYRA BIOSCIENCES INC | 12,198,625 | $171M | 2.1% | $17.16 | -33.5% | SH | 90240B106 |
| EWTX | EDGEWISE THERAPEUTICS INC | 10,428,437 | $169M | 2.1% | $15.67 | -9.5% | SH | 28036F105 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $133M | 1.6% | $8.66 | -6.6% | SH | Y95308105 |
| SEPN | SEPTERNA INC | 6,995,858 | $132M | 1.6% | $23.65 | -44.5% | SH | 81734D104 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,866,733 | $113M | 1.4% | $21.84 | +17.0% | SH | 252828108 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $110M | 1.4% | $25.50 | -56.1% | SH | 055477103 |
| GHRS | GH RESEARCH PLC | 7,676,697 | $110M | 1.4% | $15.85 | -11.7% | SH | G3855L106 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $109M | 1.3% | $6.66 | +115.6% | SH | 82835W108 |
| NUVL | NUVALENT INC-A | 1,246,456 | $108M | 1.3% | $79.06 | 0.0% | SH | 670703107 |
| IRON | DISC MEDICINE INC | 1,577,106 | $104M | 1.3% | $55.60 | +7.0% | SH | 254604101 |
| VOR | VOR BIOPHARMA INC | 1,982,301 | $96.58M | 1.2% | $40.21 | 0.0% | SH | 929033207 |
| FULC | FULCRUM THERAPEUTICS INC | 10,229,099 | $94.11M | 1.2% | $7.35 | -1.5% | SH | 359616109 |
| PEPG | PEPGEN INC | 20,064,545 | $92.7M | 1.1% | $6.78 | -76.2% | SH | 713317105 |
| GERN | GERON CORP | 60,379,366 | $82.72M | 1.0% | $2.43 | -45.2% | SH | 374163103 |
| TSHA | TAYSHA GENE THERAPIES INC | 23,555,648 | $77.03M | 0.9% | $2.03 | +39.4% | SH | 877619106 |
| BLTE | BELITE BIO INC - ADR | 875,000 | $64.75M | 0.8% | $74.00 | — | SH | 07782B104 |
| CLYM | CLIMB BIO INC | 31,419,267 | $63.15M | 0.8% | $12.52 | -85.2% | SH | 28658R106 |
| SRRK | SCHOLAR ROCK HOLDING CORP | 1,166,788 | $43.45M | 0.5% | $38.29 | -8.7% | SH | 80706P103 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,517,418 | $42.49M | 0.5% | $41.59 | — | SH | 86366E106 |
| MNPR | MONOPAR THERAPEUTICS INC | 511,207 | $41.75M | 0.5% | $16.78 | +166.4% | SH | 61023L207 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | $39.65M | 0.5% | $19.29 | -69.0% | SH | 35104E100 |
| SLDB | SOLID BIOSCIENCES INC | 5,811,423 | $35.86M | 0.4% | $6.22 | -6.0% | SH | 83422E204 |
| — | METSERA INC | 675,525 | $35.35M | 0.4% | $27.22 | — | SH | 59267L107 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $28.28M | 0.3% | $11.59 | -76.9% | SH | 04317A107 |
| LBRX | LB PHARMACEUTICALS INC | 1,776,958 | $28.06M | 0.3% | $15.87 | 0.0% | SH | 50180M108 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,150,000 | $27.48M | 0.3% | $17.69 | +6.3% | SH | 89422G107 |
| ASMB | ASSEMBLY BIOSCIENCES INC | 1,020,410 | $26.12M | 0.3% | $21.94 | 0.0% | SH | 045396207 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $25.53M | 0.3% | $13.02 | -89.4% | SH | 00509G209 |
| CTNM | CONTINEUM THERAPEUTICS INC-A | 2,122,000 | $24.93M | 0.3% | $8.06 | 0.0% | SH | 21217B100 |
| NKTX | NKARTA INC | 10,805,129 | $22.37M | 0.3% | $20.85 | -90.2% | SH | 65487U108 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $19.53M | 0.2% | $7.79 | -51.9% | SH | 517125100 |
| IVVD | INVIVYD INC | 17,119,096 | $18.83M | 0.2% | $0.89 | 0.0% | SH | 00534A102 |
| TNGX | TANGO THERAPEUTICS INC | 2,000,000 | $16.8M | 0.2% | $2.47 | +173.7% | SH | 87583X109 |
| PRME | PRIME MEDICINE INC | 3,000,000 | $16.62M | 0.2% | $4.06 | 0.0% | SH | 74168J101 |
| RCUS | ARCUS BIOSCIENCES INC | 1,136,364 | $15.45M | 0.2% | $11.59 | -10.3% | SH | 03969F109 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $15.1M | 0.2% | $10.73 | -86.9% | SH | 004890109 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,681,307 | $13.16M | 0.2% | $9.71 | -85.9% | SH | 95075A107 |
| QURE | UNIQURE NV | 200,000 | $11.67M | 0.1% | $18.16 | 0.0% | SH | N90064101 |
| ELDN | ELEDON PHARMACEUTICALS INC | 3,566,338 | $9.237M | 0.1% | $3.94 | -25.9% | SH | 28617K101 |
| JBIO | JADE BIOSCIENCES INC | 1,062,326 | $9.168M | 0.1% | $33.31 | -75.5% | SH | 008064206 |
| SABS | SAB BIOTHERAPEUTICS INC | 4,401,500 | $8.847M | 0.1% | $2.26 | 0.0% | SH | 78397T202 |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 114,901 | $8.526M | 0.1% | $101.25 | 0.0% | SH | 457730109 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,661,331 | $8.49M | 0.1% | $1.30 | +73.6% | SH | 23284F105 |
| AVTX | AVALO THERAPEUTICS INC | 662,968 | $8.426M | 0.1% | $10.31 | -16.6% | SH | 05338F306 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.95M | 0.1% | $10.07 | +5.1% | SH | G70077105 |
| SRZN | SURROZEN INC | 602,626 | $7.765M | 0.1% | $11.08 | -5.4% | SH | 86889P208 |
| WGS | GENEDX HOLDINGS CORP | 58,044 | $6.254M | 0.1% | $78.50 | +38.8% | SH | 81663L200 |
| — | ADICET BIO INC | 7,541,000 | $6.11M | 0.1% | $2.35 | — | SH | 007002108 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $5.703M | 0.1% | $0.87 | — | SH | N62509117 |
| EVH | EVOLENT HEALTH INC - A | 579,052 | $4.899M | 0.1% | $9.70 | 0.0% | SH | 30050B101 |
| GKOS | GLAUKOS CORP | 54,180 | $4.418M | 0.1% | $91.83 | 0.0% | SH | 377322102 |
| DSGN | DESIGN THERAPEUTICS INC | 475,699 | $3.582M | 0.0% | $5.01 | 0.0% | SH | 25056L103 |
| EXAS | EXACT SCIENCES CORP | 54,939 | $3.006M | 0.0% | $49.96 | 0.0% | SH | 30063P105 |
| IFRX | INFLARX NV | 1,973,233 | $2.644M | 0.0% | $1.18 | -10.2% | SH | N44821101 |
| PGNY | PROGYNY INC | 96,628 | $2.079M | 0.0% | $22.73 | 0.0% | SH | 74340E103 |