Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q1 2025 (← Previous) (Next →)
Filing Date: May 15, 2025
Total Value: $5.988B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $1.602B | 26.8% | $155.86 | $82.85 | — | SH | 04351P101 |
| PCVX | VAXCYTE INC | 12,189,149 | $460M | 7.7% | $37.76 * | $51.21 | +56.1% | SH | 92243G108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,084,412 | $322M | 5.4% | $52.97 * | $25.92 | +114.1% | SH | 76243J105 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $302M | 5.0% | $27.00 * | $26.21 | +43.8% | SH | 47103J105 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 10,138,938 | $208M | 3.5% | $20.47 * | $14.02 | +58.6% | SH | N62509109 |
| ACLX | ARCELLX INC | 3,036,527 | $199M | 3.3% | $65.60 * | $66.33 | +2.1% | SH | 03940C100 |
| EWTX | EDGEWISE THERAPEUTICS INC | 8,909,091 | $196M | 3.3% | $22.00 * | $15.89 | +65.0% | SH | 28036F105 |
| RNAM | AVIDITY BIOSCIENCES INC | 6,300,408 | $186M | 3.1% | $29.52 * | $24.52 | +27.0% | SH | 05370A108 |
| WVE | WAVE LIFE SCIENCES LTD | 18,202,009 | $147M | 2.5% | $8.08 * | $8.66 | +26.3% | SH | Y95308105 |
| — | 89BIO INC | 19,889,683 | $145M | 2.4% | $7.27 | $12.96 | — | SH | 282559103 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $137M | 2.3% | $12.58 * | $6.66 | +80.7% | SH | 82835W108 |
| SION | SIONNA THERAPEUTICS INC | 10,445,322 | $109M | 1.8% | $10.46 * | $16.34 | 0.0% | SH | 829401108 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $107M | 1.8% | $25.71 * | $20.79 | +18.5% | SH | 52635N103 |
| DYN | DYNE THERAPEUTICS INC | 9,714,392 | $102M | 1.7% | $10.46 * | $21.08 | -32.1% | SH | 26818M108 |
| TYRA | TYRA BIOSCIENCES INC | 10,637,290 | $98.93M | 1.7% | $9.30 * | $18.28 | -29.2% | SH | 90240B106 |
| MLYS | MINERALYS THERAPEUTICS INC | 6,147,280 | $97.62M | 1.6% | $15.88 * | $14.49 | -20.6% | SH | 603170101 |
| GERN | GERON CORP | 60,379,366 | $96M | 1.6% | $1.59 * | $2.43 | +0.2% | SH | 374163103 |
| RXST | RXSIGHT INC | 3,743,018 | $94.51M | 1.6% | $25.25 * | $20.42 | +45.5% | SH | 78349D107 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $90.64M | 1.5% | $13.03 | $25.50 | -47.9% | SH | 055477103 |
| IRON | DISC MEDICINE INC | 1,577,106 | $78.29M | 1.3% | $49.64 * | $55.60 | 0.0% | SH | 254604101 |
| GHRS | GH RESEARCH PLC | 6,944,648 | $76.6M | 1.3% | $11.03 | $16.37 | -31.7% | SH | G3855L106 |
| APGE | APOGEE THERAPEUTICS INC | 1,569,491 | $58.64M | 1.0% | $37.36 * | $22.03 | +75.5% | SH | 03770N101 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,866,733 | $52M | 0.9% | $18.14 * | $21.84 | +0.9% | SH | 252828108 |
| ZLAB | ZAI LAB LTD-ADR | 1,295,040 | $46.8M | 0.8% | $36.14 | $26.19 | — | SH | 98887Q104 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 5,755,577 | $45.64M | 0.8% | $7.93 * | $17.63 | -38.9% | SH | 23954D109 |
| SEPN | SEPTERNA INC | 6,995,858 | $40.51M | 0.7% | $5.79 * | $23.65 | -51.7% | SH | 81734D104 |
| — | TOURMALINE BIO INC | 2,538,925 | $38.62M | 0.6% | $15.21 | $12.86 | — | SH | 89157D105 |
| CLYM | CLIMB BIO INC | 31,419,267 | $38.33M | 0.6% | $1.22 * | $12.52 | -87.0% | SH | 28658R106 |
| SRRK | SCHOLAR ROCK HOLDING CORP | 1,136,453 | $36.54M | 0.6% | $32.15 * | $38.38 | +0.2% | SH | 80706P103 |
| URGN | UROGEN PHARMA LTD | 3,206,271 | $35.46M | 0.6% | $11.06 * | $10.66 | 0.0% | SH | M96088105 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $29.56M | 0.5% | $3.00 * | $11.59 | -53.4% | SH | 04317A107 |
| FULC | FULCRUM THERAPEUTICS INC | 10,229,099 | $29.46M | 0.5% | $2.88 * | $7.35 | -50.0% | SH | 359616109 |
| — | VOR BIOPHARMA INC | 39,646,039 | $28.45M | 0.5% | $0.72 | $14.51 | — | SH | 929033108 |
| — | ASTRIA THERAPEUTICS INC | 5,105,213 | $27.26M | 0.5% | $5.34 | $13.42 | — | SH | 04635X102 |
| KURA | KURA ONCOLOGY INC | 4,004,610 | $26.43M | 0.4% | $6.60 * | $14.39 | -45.8% | SH | 50127T109 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,517,418 | $26.27M | 0.4% | $17.31 | $41.59 | — | SH | 86366E106 |
| — | CIDARA THERAPEUTICS INC | 1,092,796 | $23.54M | 0.4% | $21.54 | $16.50 | — | SH | 171757206 |
| — | AEROVATE THERAPEUTICS INC | 9,192,092 | $23.07M | 0.4% | $2.51 | $20.69 | — | SH | 008064107 |
| IDYA | IDEAYA BIOSCIENCES INC | 1,347,252 | $22.07M | 0.4% | $16.38 * | $37.92 | -43.8% | SH | 45166A102 |
| — | ITEOS THERAPEUTICS INC | 3,649,057 | $21.78M | 0.4% | $5.97 | $16.69 | — | SH | 46565G104 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,150,000 | $20.61M | 0.3% | $17.92 * | $17.69 | +14.7% | SH | 89422G107 |
| NKTX | NKARTA INC | 10,805,129 | $19.88M | 0.3% | $1.84 * | $20.85 | -90.2% | SH | 65487U108 |
| GKOS | GLAUKOS CORP | 190,256 | $18.72M | 0.3% | $98.42 * | $133.38 | 0.0% | SH | 377322102 |
| MNPR | MONOPAR THERAPEUTICS INC | 511,207 | $18.61M | 0.3% | $36.41 | $16.78 | +114.7% | SH | 61023L207 |
| — | METSERA INC | 675,525 | $18.39M | 0.3% | $27.22 | $27.22 | — | SH | 59267L107 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,181,818 | $17.25M | 0.3% | $5.42 * | $9.31 | -24.8% | SH | 30233G209 |
| TXG | 10X GENOMICS INC-CLASS A | 1,944,247 | $16.97M | 0.3% | $8.73 * | $15.78 | -20.1% | SH | 88025U109 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $16.93M | 0.3% | $2.03 * | $10.73 | -49.8% | SH | 004890109 |
| ELVN | ENLIVEN THERAPEUTICS INC | 848,986 | $16.71M | 0.3% | $19.68 * | $20.34 | +5.8% | SH | 29337E102 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $16.43M | 0.3% | $1.10 * | $13.02 | -89.0% | SH | 00509G209 |
| SLDB | SOLID BIOSCIENCES INC | 4,330,446 | $16.02M | 0.3% | $3.70 * | $7.14 | -40.0% | SH | 83422E204 |
| CBLL | CERIBELL INC | 824,582 | $15.84M | 0.3% | $19.21 * | $27.25 | -18.4% | SH | 15678C102 |
| NRIX | NURIX THERAPEUTICS INC | 1,333,333 | $15.84M | 0.3% | $11.88 * | $22.92 | -27.0% | SH | 67080M103 |
| INSM | INSMED INC | 200,000 | $15.26M | 0.3% | $76.29 | $38.78 | +97.2% | SH | 457669307 |
| TSHA | TAYSHA GENE THERAPIES INC | 10,872,503 | $15.11M | 0.3% | $1.39 * | $1.87 | -10.4% | SH | 877619106 |
| PEPG | PEPGEN INC | 10,689,545 | $15.02M | 0.3% | $1.41 * | $11.31 | -81.8% | SH | 713317105 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | $14.74M | 0.2% | $3.23 * | $19.29 | -75.6% | SH | 35104E100 |
| TARA | PROTARA THERAPEUTIC INC | 3,400,000 | $14.48M | 0.2% | $4.26 * | $3.06 | +46.0% | SH | 74365U107 |
| LRMR | LARIMAR THERAPEUTICS INC | 6,045,351 | $13M | 0.2% | $2.15 * | $7.79 | -59.4% | SH | 517125100 |
| ELDN | ELEDON PHARMACEUTICALS INC | 3,566,338 | $12.09M | 0.2% | $3.39 * | $3.94 | +4.4% | SH | 28617K101 |
| ALEC | ALECTOR INC | 9,695,228 | $11.93M | 0.2% | $1.23 * | $3.76 | -56.7% | SH | 014442107 |
| SERA | SERA PROGNOSTICS INC-A | 3,032,808 | $11.16M | 0.2% | $3.68 * | $8.26 | -38.4% | SH | 81749D107 |
| MBX | MBX BIOSCIENCES INC | 1,511,334 | $11.15M | 0.2% | $7.38 * | $22.87 | -53.8% | SH | 55287L101 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 1,093,477 | $9.284M | 0.2% | $8.49 | $20.19 | — | SH | 088786108 |
| RCUS | ARCUS BIOSCIENCES INC | 1,136,364 | $8.92M | 0.1% | $7.85 * | $11.59 | 0.0% | SH | 03969F109 |
| SRZN | SURROZEN INC | 679,130 | $7.919M | 0.1% | $11.66 | $11.08 | +4.9% | SH | 86889P208 |
| IMTX | IMMATICS NV | 1,750,000 | $7.893M | 0.1% | $4.51 * | $11.66 | -55.3% | SH | N44445109 |
| AVTX | AVALO THERAPEUTICS INC | 967,000 | $7.746M | 0.1% | $8.01 * | $10.31 | -26.5% | SH | 05338F306 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $7.725M | 0.1% | $10.30 | $10.07 | +1.8% | SH | G70077105 |
| DRUG | Bright Minds Biosciences Inc | 206,427 | $7.446M | 0.1% | $36.07 | $35.19 | +4.0% | SH | 10919W405 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,666,667 | $7.14M | 0.1% | $1.53 * | $2.49 | -14.3% | SH | 00461U105 |
| ACHC | ACADIA HEALTHCARE CO INC | 217,000 | $6.579M | 0.1% | $30.32 * | $38.10 | 0.0% | SH | 00404A109 |
| BBNX | BETA BIONICS INC | 500,000 | $6.12M | 0.1% | $12.24 * | $18.64 | 0.0% | SH | 08659B102 |
| XNCR | XENCOR INC | 575,000 | $6.118M | 0.1% | $10.64 * | $18.77 | -12.0% | SH | 98401F105 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,144,881 | $5.974M | 0.1% | $0.97 * | $10.47 | -87.5% | SH | 95075A107 |
| — | ADICET BIO INC | 7,541,000 | $5.693M | 0.1% | $0.76 | $2.35 | — | SH | 007002108 |
| HUMA | HUMACYTE INC | 3,312,356 | $5.648M | 0.1% | $1.71 * | $3.75 | 0.0% | SH | 44486Q103 |
| ZURA | ZURA BIO LTD | 3,217,503 | $4.151M | 0.1% | $1.29 * | $4.08 | -61.3% | SH | G9TY5A101 |
| BIOA | BIOAGE LABS INC | 1,052,494 | $3.957M | 0.1% | $3.76 * | $20.04 | -76.9% | SH | 09077V100 |
| BOLD | BOUNDLESS BIO INC | 2,180,631 | $3.293M | 0.1% | $1.51 * | $14.25 | -85.5% | SH | 10170A100 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $2.997M | 0.1% | $8.99 | $0.87 | — | SH | N62509117 |
| — | SUTRO BIOPHARMA INC | 4,434,637 | $2.885M | 0.0% | $0.65 | $0.65 | — | SH | 869367102 |
| LXEO | LEXEO THERAPEUTICS INC | 546,554 | $1.897M | 0.0% | $3.47 * | $15.62 | -71.6% | SH | 52886X107 |
| CTMX | CYTOMX THERAPEUTICS INC | 1,000,000 | $636K | 0.0% | $0.64 * | $0.78 | 0.0% | SH | 23284F105 |
| — | SCILEX HOLDING CO | 1,036,218 | $258K | 0.0% | $0.25 | $0.81 | — | SH | 80880W106 |